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녹음 구어 제시가 중도정신지체 성인여성의 목욕 능력 개선에 미치는 효과
鄭如意,陳明聰,陳政見 대구대학교 특수교육재활과학연구소 2006 再活科學硏究 Vol.24 No.2
1. This study aimed to explore the effect of recorded auditory prompts on helping an adult with profound mental retardation to take bath independently. 「A-B-C-A-C」design, a kind of single-subject experiment was adopted. Three phases, baseline phase, intervention phase(B): auditory prompt, and intervention phase(C): recorded auditory prompt were included. A female with profound mental retardation participated in the experiment. It took over seven months to finishing the intervention. The results of the experiment indicated that auditory prompts, whether human auditory prompt or recorded prompt, could help the client to take bath more independently. The families of the client also regarded recorded auditory prompt was a feasible solution. Based on the result, there were some suggestions for the further research. 본 연구의 목적은 녹음 구어 제시를 이용해서 극 중도 지능장애 성인 여성 스스로 목욕 동작을 완성 할 수 있도록 도와주는 효과에 대한 연구입니다. 본 연구에 사용하는 연구법은 ⌜A-B-A-C-A-C⌟역 설계이다. 기선기의(A)개입一(B)인공구어제시 개입二(C)녹음 구어 제시로 나누어졌다. 실험기간은 모두 7개월 반이었다. 연구결과는 피 실험자가 스스로 목욕할 때와 비교했을 때 인공구어 제시와 녹음구어 제시는 모두 피 실험자가 목욕 동작을 완성 하는 데에 효과가 있는 것으로 나타났다. 이 외에도 녹음 구어 제시는 피 실험자 가족들도 받아들일 수 있다. 본 연구 결과에 근거해서 연구자들은 미래 응용과 연구에 대한 건의도 제출하였다.
A New Stilbene Glucoside from the Roots of Polygonum multiflorum Thunb.
Ming-Lu Xu,Ming Shan Zheng,Yeon-Kyong Lee,문동철,Chong-Soon Lee,우미희,정병선,Eung Seok Lee,장영동,장현욱,이승호,손종근 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.11
One new stilbene glucoside (6), along with five known compounds (1-5), were isolated from the roots of Polygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound 3 showed DNA topoisomerase I and II inhibitory activities.
Ming Zheng,Xiangdong Wang,Mingyu Bo,Kuiji Wang,Yan Zhao,Fei He,Feifei Cao,Luo Zhang,Claus Bachert 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.2
Purpose: The aim of the present study was to compare the prevalence of self-reported and confirmable allergic rhinitis (AR) with positive skin pricktest (SPT) results among adults living in urban and rural areas of China. Methods: Adults from a community in Beijing and a village in Baoding wereselected as representative urban and rural dwellers, respectively. All eligible residents were enrolled from the population register and received aface-to-face interview using modified validated questionnaires. Equal sets of randomly selected self-reporting AR-positive and AR-negative participantswho responded to the questionnaires were also investigated using skin prick tests. Results: A total of 803 participants in the rural area and atotal of 1,499 participants in the urban area completed the questionnaires, with response rates being 75.9% and 81.5% respectively. The prevalenceof self-reported AR of the rural area (19.1%) was significantly higher than that of the urban area (13.5%). The elementary school of educational levelincreased the risk of having AR (adjusted OR=2.198, 95% CI=1.072-2.236) .The positive SPT rates among subjects with self-reported AR in therural and urban areas were 32.5% and 53.3%, respectively; the confirmable AR prevalence of 6.2% and 7.2% among the rural and urban adults, respectively. Conclusions: The prevalence of confirmable AR is similar between rural and urban areas in China, although there is a higher prevalenceof self-reported AR in the former. Purpose: The aim of the present study was to compare the prevalence of self-reported and confirmable allergic rhinitis (AR) with positive skin prick test (SPT) results among adults living in urban and rural areas of China. Methods: Adults from a community in Beijing and a village in Baoding were selected as representative urban and rural dwellers, respectively. All eligible residents were enrolled from the population register and received a face-to-face interview using modified validated questionnaires. Equal sets of randomly selected self-reporting AR-positive and AR-negative participants who responded to the questionnaires were also investigated using skin prick tests. Results: A total of 803 participants in the rural area and a total of 1,499 participants in the urban area completed the questionnaires, with response rates being 75.9% and 81.5% respectively. The prevalence of self-reported AR of the rural area (19.1%) was significantly higher than that of the urban area (13.5%). The elementary school of educational level increased the risk of having AR (adjusted OR=2.198, 95% CI=1.072-2.236) .The positive SPT rates among subjects with self-reported AR in the rural and urban areas were 32.5% and 53.3%, respectively; the confirmable AR prevalence of 6.2% and 7.2% among the rural and urban adults, respectively. Conclusions: The prevalence of confirmable AR is similar between rural and urban areas in China, although there is a higher prevalence of self-reported AR in the former.
Solubility of D(−)-p-Hydroxyphenylglycine dane salt in binary methanol+isopropanol solvent mixtures
Zheng-Ming Yi,Qun-Sheng Li,Wei-Zhong Liu,Xu-Feng Sun 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.3
The solubility of D(−)-p-Hydroxyphenylglycine Dane Salt (HPGDane Salt) in binary methanol and isopropanol solvent mixtures was measured using a laser technique with the temperature range from 283.15 K to 323.15 K and mole fraction (x2) range from 0.0000 to 1.0000. The results were correlated with a semi-empirical equation.
Protective Constituents against Sepsis in Mice from the Root Barks of Ulmus davidiana var. japonica
Ming Shan Zheng,Jong Keun Son,Gao Li,Ying Li,서창섭,Yeun-Kyung Lee,Jun-Sub Jung,송동근,Hong-Beom Bae,Sang-Hyun Kwak,Hyun-Wook Chang,김재룡 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.9
In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (-)-catechin (1), catechin-7-O-β-apiofuranoside (2), catechin-7-O-α-Lrhamnopyranoside (3), catechin-3-O-α-L-rhamnopyranoside (4), catechin-7-O-β-D-glucopyranoside (5), butyl (+)-5'-methoxyisolariciresinol-9'-O-β-D-xylopyranoside (6), lyoniside (7), nudiposide (8), α-nigerose (9), butyl α-D-fructofuranoside (10), and procyanidin B3 (11) were isolated from the root barks of Ulmus davidiana var. japonica. Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/D-GalN ranged from 80%-100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-α, IL-10 and ALT activity.
Ming-feng Jiang,Sheng-wei Li,Min Chen,Ying-fan Cai,Yong-fang Xie,Biao Li,Quan Sun,Huai-zhong Jiang,Zheng Pan,Yun-ling Gao,You-Lu Yuan,Yu-zheng Shi 한국식물학회 2009 Journal of Plant Biology Vol.52 No.5
A cDNA encoding a novel cysteine proteinase inhibitor (CPI) was isolated from a gland mutant Xiangmian-18 of upland cotton during the pigments gland forming stage. The cDNA comprises 378 bp and encodes 125 amino acid residues with molecular mass of 13.8 kDa. It contains the conserved motif of cysteine protease inhibitors and belongs to the cystatin superfamily (Gln- Val-Val-Ala-Gly). The deduced amino acid sequences of the domains are highly similar to the normal upland cotton (96.8%). SDS-PAGE and western hybridization analysis showed that the expressed recombinant protein was recombinant CPI. The inhibitory activity of recombinant CPI was 46 u/μg which was measured by inhibiting the protease activity of papain. RT-PCR results indicated that the expression level of developing gland stage was higher than that of undeveloped gland stage.
Chemical Constituents of Melandrium firmum Rohrbach and Their Anti-Inflammatory Activity
Zheng, Ming Shan,Hwang, Nam-Kyung,Kim, Do-Hoon,Moon, Tae-Chul,Son, Jong-Keun,Chag, Hyeun-Wook 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
In our ongoing search for anti-inflammatory agents originating from Korean medicinal plants, we found that the hexane and BuOH fractions of the MeOH extract from the whole plants of Melandrium firmum Rohrbach inhibited 5-lipoxygenase (5-LOX) activity. By activity-guided fractionation, eleven compounds, ${\alpha}-spinaterol$ (1), ursolic acid (2), ergosterol peroxide (3), ${\alpha}-spinaterol$ glucoside (4), 2-methoxy-9-${\beta}$-D-ribofuranosyl purine (5), aristeromycin (6), ecdysteron (7), polypodoaurein (8), (-)-bornesitol (9), mannitol (10) and cytisoside (11) were isolated from the hexane and BuOH fractions using column chromatography. Compounds 2, 5, 6, 8, 9, 10 and 11 were isolated for the first time from this plant. Compounds 1, 3, 4 and 7 inhibited 5-LOX activity with $IC_{50}$ values of 21.04 ${\mu}M$, 42.30 ${\mu}M$, 32.82 ${\mu}M$, and 17.18 ${\mu}M$, respectively.
Ming, Jun,Ming, Hai,Kwak, Won-Jin,Shin, Changdae,Zheng, Junwei,Sun, Yang-Kook The Royal Society of Chemistry 2014 Chemical communications Vol.50 No.87
<P>A positive effect of the polyacrylic acid (PAA)–carboxymethyl cellulose (CMC) binder to enhance the performance of an oxide-based anode was reported in batteries. A series of super high capacity and cycling ability oxide powders rarely achieved before was obtained, particularly most of them without any specific carbon modification and/or morphology control.</P> <P>Graphic Abstract</P><P>A positive effect of the polyacrylic acid–carboxymethyl cellulose binder to enhance the performance of an oxide-based anode was reported in batteries. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc02657h'> </P>
Effect of Cornus Officinalis Extract on the Differentiation of MC3T3-E1 Osteoblast-like Cells
Ming-Zhen Zheng,이숙영,유상준,김병옥 한국조직공학과 재생의학회 2015 조직공학과 재생의학 Vol.12 No.4
Cornus officinalis has been widely used as herbal medicine exerting various pharmacological actions such as diuretic, anti-allergic, hypotensive and antibiotic activities. Thus we studied the effect of Cornus officinalis on the proliferation, differentiation and matrix mineralization of MC3T3-E1 osteoblast-like cell line. To do the experiments, Cornus officinalis extract (COE) was prepared using ethanol at different concentrations. The cytotoxic effect and the osteogenic differentiation were examined using MTT assay, alkaline phosphatase (ALP) activity, ALP staining, Alizarin red S staining and reverse transcriptase-polymerase chain reaction for osteogenic differentiation markers such as collagen type I (Col-I), ostoecalcin (OCN). The results indicated that there was no effect on cell proliferation on both 1st and 3rd days after treatment in MC3T-E1 cells. The level of ALP, Col-I mRNA, OCN mRNA and mineralized nodule were significantly higher in COE treated group than no treated group. Our results suggest that the COE promotes the osteoblast differentiation and mineralization without observable cytotoxicity. Therefore, it may play an important role in osteoblastic bone formation, and may possibly to be an effective measure for bone regeneration.