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      • KCI등재

        혐오의 관점에서 ‘선한 사마리아인의 비유’ 톺아보기

        한규현,권혁남 인문사회 21 2023 인문사회 21 Vol.14 No.2

        The purpose of this study is to examine the ways to overcome hatred by diagnosing the ills of modern society where hatred is rampant through ‘The Parable of Good Samaritan’ and presenting Christian values of neighborly love. To this end, the parable is examined through The New Hermeneutic parable interpretation method. The New Hermeneutic emphasizes that the content of a parable should be a ‘linguistic event’ experienced as an event in the life of the listener. The hearer of the parable, the expert in the law, is identified with the heartless priest and the Levites in the parable. At this time, the listener is discovered as a subject of hatred and experiences a cultural and authoritative hatred for the Samaritan and a complex hatred for the man who met the robbers. This reflects Jesus’ intention to face the hatred inherent in himself. Therefore, readers of the present era should be able to enter the parable and face themselves as the subject of hatred. For readers who discover themselves as the subject of hatred, the parable suggests the value of ‘love for neighbors’ as a way to overcome hatred. The Christian values of loving my neighbor as myself are expected to be a good prescription for a hateful society.

      • KCI등재

        A Case of Invasive Pulmonary Aspergillosis with Direct Invasion of the Mediastinum and the Left Atrium in an Immunocompetent Patient

        한규현,김은경,김정현,신선영,정혜윤,주지민,김학수,김대진,심민정,조상호 대한결핵및호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.1

        We report a case of invasive pulmonary aspergillosis invading the mediastinum and the left atrium. A 70-year-old woman was hospitalized for dyspnea. She had been well controlled for her diabetes mellitus and hypertension. The chest X-ray disclosed mediastinal widening, and the computed tomography scan of the chest showed that there was a large mediastinal mass and this lesion extended into the left atrium and right bronchus. The cardiac echocardiography showed that a huge mediastinal cystic mass compressed in the right atrium and a hyperechoic polypoid lesion in the left. The pathology from the bronchoscopic biopsy observed abundant fungal hyphae which was stained with periodic acid-Schiff and Gomori's methenamine silver. Despite the treatment with antifungal agents, she died from cardiac tamponade after three months. Invasive pulmonary aspergillosis, which involves the mediastinum and the heart, is very rare in immunocompetent patients.

      • KCI등재후보

        Ectopic expression of Bcl-2 or Bcl-xL suppresses p-fluorophenylalanine-induced apoptosis through blocking mitochondria-dependent caspase cascade in human Jurkat T cells

        한규현,오현지,전도연,김영호,Han, Kyu-Hyun,Oh, Hyun-Ji,Jun, Do-Youn,Kim, Young-Ho Korean Society of Life Science 2003 생명과학회지 Vol.13 No.1

        Phenylalanine의 구조유사체인 p-fluotophenylalanine (FPA)은 인체 급성백혈병세포주인 Jurkat T 세포의 세포자살을 유도한다. FPA에 의한 세포자살에 미치는 Bcl-2 또는 Bcl-xL의 영향을 조사하기 위해, Bcl-2 또는 Bcl-xL을 stable transfection하거나 empty vectors만을 Transfection한 Jurkat 세포를 이용하여 FPA의 세포독성과 FPA에 의한 세포내 세포자살 신호전달경로를 비교 분석하였다. Jurkt T 세포에 0.63∼3.0 mLf의 FPA를 처리하였을 때 세포의 생육도는 농도에 비례하여 감소하였다. 또한 세포자살관련 DNA fragmentation, caspase-8 activatoin, Bid cleavage, mitochondria로 부터의 cytochrome c 방출, caspase-9 및 -3 activation, PARP degradation 등이 유도되었다. 한편, FPA에 의해 유도되는 이러한 일련의 생화학적 현상들은 Bcl-2 또는 Bcl-xL의 overexpression에 의해 현저히 저해되었다. 이상의 결과들은 caspase-8 activation, Bid cleavage, mitochondnal cytochrome c 방출에 의해 활성화되는 casuase cascade 등의 현상이, Bcl-2 또는 Bcl-xL에 의해 억제됨을 나타내며 FPA에 의해 유도되는 세포자살에 필요한 과정임을 시사한다. $\rho$-Fluorophenylalanine (FPA), a phenylalanine analog, is able to induce apoptotic cell death of human acute leukemia Jurkat T cells. To better understand the mechanism by which FPA induces apoptotic cell death, the effect of ectopic expression of antiapoptotic proteins, Bcl-2 and Bcl-xL, on FPA-induced apoptosis was investigated by employing lurkat T cells transfected with Bcl-2 gene (JT/Bcl-2) or Bcl-xL gene (1/Bcl-xL) and Jurkat T cells transfected with vector (JT/Neo or J/Neo). When Jurkat T cells, JT/Neo or J/Neo, were exposed to FPA at concentrations ranging from 0.63 to 5.0 mM, the cell viability determined by MTT assay declined in a dose-dependent manner. In addition, apoptotic DNA fragmentation along with several apoptotic events such as caspase-8 activation, Bid cleavage, mitochondrial cytochrome c release, caspase-9 activation, caspase-3 activation, and degradation of PARP was induced. However, the FPA-induced cytotoxic effect, activation of caspase-8, and cleavage of Bid were significantly abrogated by ectopic expression of Bcl-2 or Bcl-xL. At the same time, there was marked reduction in the level of cytochrome c release from mitorhondria, caspase-9 activation, caspase-3 activation, and degradation of PARP. These results indicate that caspase-8 activation, Bid cleavage, and mitochondrial cytochrome c release with subsequent activation of the caspase cascade are negatively regulated by Bcl-2 or Bcl-xL, and are thus required for FPA-induced apoptosis in Jurkat T cells

      • KCI등재후보
      • KCI등재

        과제해결원리의 동일 여부의 판단 방법

        한규현 사법발전재단 2020 사법 Vol.1 No.54

        Supreme Court Decision 2017Hu424 decided January 31, 2019 considers not only the known art described in the specification of a patent invention, but also the publicly known art other than the specification (the prior art), and substantially explores what is the core of the technological idea on which the solution specific to the patent invention is based in contrast to the prior art. Therefore, it grasps the problem-solving principle of the patent invention broadly or narrowly according to the degree to which the patent invention contributed to technological development, and then determines whether the problem-solving principle of the object allegedly infringing the patent invention is the same as that of the patent invention. In my opinion, it is reasonable to understand objectively by exploring the core of the technological idea on which the solution unique to the patent invention is based, compared to the known art shown in the specification of the patent invention. It is unnecessary to figure out the problem-solving principle by taking into account the prior art other than the specification. If you take into account it, there may be a risk of developing problems such as change, enlargement, reduction, or distortion of the problem-solving principle. Whether the problem-solving principle is unique compared to the prior art can be evaluated, but this does not mean that the problem-solving principle itself is broadly or narrowly identified depending on whether it is unique. Even if the prior art other than the specification is considered, it should be taken into account not in determining the width of the problem-solving principle itself, but in determining the sameness of the problem-solving principle. Even in a case where you follow the position to take into account the prior art other than the specification as the aforementioned Supreme Court Decision suggested, it is desirable to judge whether the problem-solving principle is the same as follows. ① The core of the technical idea of ​​the patent invention has to be understood based on the specification of the patent invention. ② The prior art other than the specification is considered in determining whether the problem-solving principle is the same. The width of sameness of the problem-solving principle is determined based on the extent to which the patent invention contributed to technological development, taking into account the prior art other than the specification. ③ The core of the technological idea of ​the patent invention is compared with that of the technological idea of the object allegedly infringing the patent invention. If there is no difference from the patent invention in the core of technological idea despite the changes in the composition of the object, it will be judged that the problem-solving principles of the two are the same, while if there is a difference, it will be determined that the problem-solving principles are different. 대법원 2019. 1. 31. 선고 2017후424 판결은 특허발명의 명세서에 기재된 공지기술뿐만 아니라 명세서 외 공지기술까지 참작하여 선행기술과 대비하여 볼 때 특허발명에 특유한 해결수단이 기초하고 있는 기술사상의 핵심이 무엇인가를 실질적으로 탐구하여, 특허발명이 기술발전에 기여한 정도에 따라 특허발명의 과제해결원리를 넓게 또는 좁게 파악한 다음, 과제해결원리의 동일 여부를 판단하고 있다. 사견으로는 과제해결원리는 특허발명의 명세서에 근거하여 명세서에 나타난 종래기술과 대비하여 볼 때 특허발명에 특유한 해결수단이 기초하고 있는 기술사상의 핵심을 탐구하여 객관적으로 파악함이 타당하다. 명세서 외 공지기술까지 참작하여 과제해결원리를 파악할 필요는 없다. 명세서 외 공지기술까지 참작하게 되면, 과제해결원리의 변경·확대·축소·왜곡 등의 문제가 생길 위험이 있다. 과제해결원리를 명세서 외 공지기술과 대비하여 특유한지 여부는 평가할 수 있으나, 그렇다고 하여 과제해결원리 그 자체가 특유 여부에 따라 넓게 파악된다거나 좁게 파악된다고는 할 수 없다. 명세서 외 공지기술을 참작하더라도 명세서 외 공지기술은 과제해결원리의 동일 범위 판단에 고려하여야 하고, 과제해결원리 그 자체의 광협을 정하는 데에 고려하는 것은 곤란하다. 2017후424 판결처럼 명세서 외 공지기술을 참작하는 입장에 따르는 경우에도 과제해결원리의 동일 여부 판단은 다음과 같이 운용함이 바람직하다. ① 특허발명의 기술사상의 핵심은 명세서에 기초하여 파악한다. ② 명세서 외 공지기술은 과제해결원리의 동일 범위 판단에 고려한다. 명세서 외 공지기술을 참작하여 특허발명이 그 기술발전에 기여한 정도에 따라 상위개념화 여부 및 정도를 평가하여 과제해결원리 동일 범위의 광협을 정한다. ③ 이러한 사고를 전제로, 특허발명의 기술사상의 핵심과 대상물건 등의 기술사상의 핵심을 대비한다. 대상물건 등이 구성의 변경에도 불구하고 기술사상의 핵심에서 특허발명과 차이가 없으면, 양 발명의 과제해결원리가 동일하다고 판단하고, 차이가 있으면 과제해결원리가 동일하지 않다고 판단한다.

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