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MicroRNA-203 Induces Apoptosis by Targeting<i>Bmi-1</i>in YD-38 Oral Cancer Cells
KIM, JAE-SUNG,CHOI, DAE WOO,KIM, CHUN SUNG,YU, SUN-KYOUNG,KIM, HEUNG-JOONG,GO, DAE-SAN,LEE, SEUL AH,MOON, SUNG MIN,KIM, SU GWAN,CHUN, HONG SUNG,KIM, JEONGSUN,KIM, JONG-KEUN,KIM, DO KYUNG Potamitis Press 2018 Anticancer research Vol.38 No.6
Jeongsun Kim,Seon-Ho Cho,Jong-Tae Park,Sun-Kyoung Yu,Su-Gwan Kim,Do Kyung Kim KOREAN ACADAMY OF ORAL BIOLOGY 2014 International Journal of Oral Biology Vol.39 No.2
Sambucus sieboldiana (SS) is a member of the familyCaprifoliaceae and has been recommended as a functionalmaterial because of its several bioactivities. Althoughnumerous literatures are available on the pharmacological andbiological activities, the biological activity of SS in boneregeneration process has not yet been well-defined. Therefore,in this study, the effect of SS was investigated in the proliferationand differentiation of MC3T3-E1 osteoblastic cell line. Thetreatment of SS did not significantly affect the cell proliferationin MC3T3-E1 cells. SS significantly accelerated themineralization and significantly increased the expression ofalkaline phosphatase (ALP) and osteocalcin (OC) mRNAs,compared to the control, in the differentiation of MC3T3-E1cells. SS significantly accelerated the decrease of osteonectin(ON) mRNA expression as compared with the control in atime-dependent manner in the differentiation of MC3T3-E1cells. These results suggest that the SS facilitate the osteoblastdifferentiation and mineralization in MC3T3-E1 osteoblastic cells. Therefore, there may be potential properties fordevelopment and clinical application of bone regenerationmaterials.
Apoptotic Activity of Curcumin and EF-24 in HTB-41 Human Salivary Gland Epidermoid Carcinoma Cells
Ji-Won Kim,Seul Ah Lee,Dae-San Go,Byung-Sun Park,Su-Gwan Kim,Sun-Kyoung Yu,Ji-Su Oh,Chun Sung Kim,Jeongsun Kim,Jong-Tae Park,Do Kyung Kim 대한구강생물학회 2015 International Journal of Oral Biology Vol.40 No.2
Curcumin (diferuloylmethane), a constituent of turmeric powder derived from the rhizome of Curcuma longa, has been shown to inhibit the growth of various types of cancer cells by regulating cell proliferation and apoptosis. However, a need exists to design more effective analogs because of curcumin's poor intestinal absorption. EF-24 (diphenyl difluoroketone), the monoketone analog of curcumin, has shown good efficacy in anticancer screens. However, the effects of curcumin and EF-24 on salivary gland epidermoid carcinoma cells are not clearly established. The main goal of this study was to investigate the effects of curcumin and EF-24 on cell growth and induction of apoptosis in human salivary gland epidermoid carcinoma cells. Our studies showed that curcumin and EF-24 inhibited the growth of HTB-41 cells in a dose- and time-dependent manner, and the potency of EF-24 was > 34-fold that of curcumin. Treatment with curcumin or EF-24 resulted in nuclear condensation and fragmentation in HTB-41 cells, whereas the control HTB-41 cell nuclei retained their normal regular and oval shape. Curcumin and EF-24 promoted proteolytic cleavages of procaspase-3/-7/-9, resulting in an increase in the amount of cleaved caspase-3/-7/-9 in the HTB-41 cells. Caspase-3 and -7 activities were detected in viable HTB-41 cells treated with curcumin or EF-24. These results suggest that the curcumin and EF-24 inhibit cell proliferation and induce apoptosis in HTB-41 human salivary gland epidermoid carcinoma cells, and that they may have potential properties as an anti-cancer drug therapy.
위치 기반 서비스를 이용한 학내 정보 인공지능 챗봇 연구
김누리 ( Nuri Kim ),김유나 ( Yuna Kim ),김정선 ( Jeongsun Kim ),석영현 ( Yeonghyeon Suk ),김영종 ( Youngjong Kim ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.1
위치 기반 서비스를 중점으로 교내의 각종 정보들을 제공하는 챗봇시스템을 구축한다. 교내 공지사항, 학사정보와 실시간 전화 연결 서비스 및 자연어 처리를 기반으로한 다양한 정보들을 제공한다.
Designing Neural Network Using Genetic Algorithm
Kim, Jeongryul,Park, Jeongsun,Kim, SungHee,Kim, Yongtae 明知大學校 産業技術硏究所 1998 産業技術硏究所論文集 Vol.17 No.-
본 연구는 보험 회사의 파산 예측을 위하여 신경회로망이 사용되는데 이를 최적화하기 위하여 유전자 알고리즘이 사용된다. 유전자 알고리즘은 최적의 네트워크 구조와 매개변수들을 제시해준다. 유전자 알고리즘에 의해 설계된 신경회로망은 파산 예측을 함에 있어 discriminant analysis, logistic regression, ID3, CART등과 비교되는데 가장 좋은 성능을 보여준다.
Influence of Tyrosol on Cell Growth Inhibition of KB Human Oral Cancer Cells
Ue-Kyung Lee,Su-Gwan Kim,Dae-San Go,Sun-Kyoung Yu,Chun Sung Kim,Jeongsun Kim,Do Kyung Kim 대한구강생물학회 2016 International Journal of Oral Biology Vol.41 No.4
Tyrosol, a phenylethanoid and a derivative of phenethyl alcohol, possesses various biological properties, such as anti-oxidative and cardioprotective activity. Olive oil is the principal source of tyrosol in the human diet. However, so far the anti-cancer activity of tyrosol has not yet been well defined. This study therefore undertakes to examine the cytotoxic activity and the mechanism of cell death exhibited by tyrosol in KB human oral cancer cells. Treatment of KB cells with tyrosol induced the cell growth inhibition in a concentration- and a time-dependent manner. Furthermore, the treatment of tyrosol induced nuclear condensation and fragmentation of KB cells. Tyrosol also promoted proteolytic cleavage of procaspase-3, -7, -8 and –9, increasing the amounts of cleaved caspase-3, -7, -8 and –9. In addition, tyrosol increased the levels of cleaved PARP in KB cells. These results suggest that tyrosol induces the suppression of cell growth and cell apoptosis in KB human oral cancer cells, and is therefore a potential candidate for anti-cancer drug discovery.