분변 감입을 동반한 무증상의 심한 소아변비 치험례

정지은,장인수,정민정,Jeong, Ji Eun,Jang, In Soo,Jeong, Min Jeong 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.4

Objectives The purpose of this study is to report the case of fecal impaction in a child without any abdominal symptoms treated by taking herbal medicine. Methods We examined a 7-year-old girl who had normal bowel movement and defecation per day, and had no particular abdominal symptoms. Abdominal radiography was taken, and unexpected severe fecal impaction was observed throughout the abdominal cavity, filled with intestinal gas and feces. According to the subject's parents, she had no generalized symptoms, such as abdominal pain or distension, and had on a regular diet and normal bowel movement daily. She was treated with herbal medicine (Daeseunggi-tang) for 23 days. While she was on the therapy, numbers, doses, bowel movements, and radiography were checked and recorded. Results During the treatment, her stool was softened, and fecal impaction was relieved as showed by abdominal radiography. Conclusions We have identified that there are cases where subjects have no symptoms of abdominal pain, despite presence of severe fecal impaction. In addition, it was found that Daeseunggi-tang is effective in fecal impaction in childhood.

위 내 이물로 오인한 석회화 섬유 종양 1예

정지은,이경훈,성현정,조창호,Jeong, Ji-Eun,Lee, Kyung-Hun,Sung, Hyun-Jung,Cho, Chang-Ho 대한소아소화기영양학회 2009 Pediatric gastroenterology, hepatology & nutrition Vol.12 No.1

평소 복부 팽만을 보인 2세 남아가 내원 3일 전부터 간헐적인 구토를 동반하여 시행한 복부 방사선 사진에서 좌상복부에서 석회화 소견을 관찰하여 상부 위장관내시경과 복부 전산화 단층 사진을 시행하였다. 술 후 병리 검사에서 상당히 빈도가 드문 석회화 섬유 종양을 발견하였기에 보고하는 바이다. Calcifying fibrous tumors (CFTs) are unusual benign tumors of childhood, located primarily in soft tissues, pleura, and peritoneum. The cause and pathogenesis are unclear. We report a rare case of a CFT in a 2-year-old boy who presented with vomiting and abdominal distension. An abdominal X-ray showed an elliptical, calcific shadow in the LUQ area mimicking a foreign body. An internally protruding mass along the lesser curvature of the gastric body was an incidental finding during upper endoscopy, biopsies of which were negative. Abdominal CT showed a 4.5${\times}$3.2 cm soft tissue mass of the gastric wall with calcifications. A diagnosis of gastric submucosal mass was suspected and a wedge resection of the stomach was performed. On microscopic examination, the tumor was composed of whorls of dense hyalinized collagen bundles with a few fibroblasts. There were also amorphous dystrophic calcifications and nodular aggregates of mononuclear inflammatory cells. Immunohistochemically, spindle cells did not stain for anaplastic lymphoma kinase-1 (ALK-1), CK, smooth muscle actin (SMA), or desmin. Taken together, the mass was compatible with a CFT of the gastric wall. This is the first reported case of CFT in a Korean child.

신생아 선별검사를 통해 진단된 1형 타이로신혈증의 NTBC 치료 사례 보고

정지은,김화영,고정민,Ji Eun Jeong,Hwa Young Kim,Jung Min Ko 대한유전성대사질환학회 2023 대한유전성대사질환학회지 Vol.23 No.2

Hereditary tyrosinemia type 1 (HT-1) is a metabolic disorder caused by biallelic pathogenic variants in the fumarylacetoacetate hydrolase (FAH) gene, which impairs the function of the FAH enzyme, resulting in the accumulation of tyrosine's toxic metabolites in hepatocytes and renal tubular cells. As a consequence, individuals with HT-1 exhibit symptomatic manifestations. Rapid diagnosis and treatment of HT-1 can prevent short-term death and long-term complications. A 15-day-old boy presented to the outpatient department with elevated levels of tyrosine on his newborn screening tests conducted at the age of 3 and 10 days, respectively. Further blood tests revealed increased levels of alpha-fetoprotein and amino acids including tyrosine and threonine. Urine organic acid tests indicated a significant elevation in tyrosine metabolites, as well as the presence of succinylacetone (SA), which led to the diagnosis of HT-1. Two pathogenic and likely pathogenic variants of FAH compatible with HT-1 were also detected. He began a tyrosine-restricted diet at one month old and received nitisinone (NTBC) at two months old. With continued treatment, the patient's initially elevated AFP level, detection of SA in the urine, and mild hepatomegaly showed improvement. During four years and seven months of treatment, there were no exceptional complications apart from an increase in tyrosine levels and a delay in speech. We report a case of tyrosinemia type 1 detected through newborn screening, treated with dietary restriction and NTBC, with a good prognosis.

반복되는 쌕쌕거림이 있는 소아에서 IgG 아형 결핍의 진단과 치료 1예

정지은 ( Ji Eun Jeong ),장윤영 ( Yoon Young Jang ) 대한천식알레르기학회 2022 Allergy Asthma & Respiratory Disease Vol.10 No.1

Differential diagnosis of recurrent wheezing in school-age children includes not only asthma but also immunodeficiency. Immunoglobulin G (IgG) subclass deficiency is deficiency of 1 or more IgG subclasses (<2 standard deviations below the mean for age). IgG subclass deficiency in children may be associated with frequent respiratory tract infection and wheezing. An 8-year-old female patient had recurrent respiratory tract infection and wheezing despite the use of inhaled corticosteroids after the first wheezing around 100 days of age. The results of chest radiography, high resolution computed tomography of the chest, and spirometry were normal. In methacholine challenge test, provocation concentration causing a 20% fall in forced expiratory volume in 1 second was 18.29 mg/mL. Her total IgG was within the normal limit on the immunologic evaluation, but the IgG3 and IgG4 levels were decreased. She was diagnosed with IgG3 and IgG4 subclass deficiency. After intravenous immunoglobulin G (IVIG) infusion every 4-6 weeks, the number of respiratory tract infection and wheezing, the doses of systemic corticosteroids, and duration of antibiotic therapy were reduced. This case suggests that even in pediatric patients, if there are frequent respiratory tract infection and poorly controlled asthma, IgG subclass deficiency is suspected and clinical symptoms can be alleviated through IVIG treatment. (Allergy Asthma Respir Dis 2022;10:55-59)

공액고분자전해질-바이오분자 기반의 고감도, 고선택도 화학/바이오 센서

정지은(Ji-Eun Jeong),우한영(Han Young Woo) 한국고분자학회 2015 고분자 과학과 기술 Vol.26 No.2

NO, CO, VOC 동시 제거를 위한 MnFeOₓ/Al₂O₃ 촉매의 활성평가

정지은(Ji Eun Jeong),조연정(Yeon Jeong Jo),이창용(Chang Yong Lee) 한국환경에너지공학회 2022 한국열환경공학회 학술대회지 Vol.2022 No.1

산성비, 광화학적 스모그와 같은 대기오염문제를 해결하기 위해 정부는 대기오염물질 배출규제를 강화시켰으며, 배출할당량을 지정하는 등 점진적인 감량을 유도하고 있다. 암모니아(NH3-SCR)를 사용한 선택적 촉매 환원법은 발전소, 자동차, 선박 등에서 질소산화물을 제거하는데 사용되는 가장 오래된 상업용 촉매 기술이다. 배기가스의 NOx는 대부분 NO로 존재하는데(약 95 %), NO 일부를 N아로 전환시켜 NO/NO₂ 농도비가 1 이 된다면 SCR 반웅 속도를 상당히 증가시키는 Fast-SCR 반응이 일어날 수 있다. 따라서 Fast-SCR 반응을 위해서는 NH3-SCR공정 전에 NO를 NO₂로 산화시키는 산화 반응 단계가 필요하다. 이때 배기가스에 존재하는 CO 및 미연탄화수소를 NO와 동시에 산화시켜 제거할 수 있다면 대기오염물질 배출허용 기준에 만족시킬 수 있다. 따라서 본 연구에서는 NO, CO, VOC 동시 제거를 위한 MnFeOₓ/Al₂O₃ 산화 촉매를 제조하여 특성 평가를 수행하고, 활성물질의 담지량, 가스농도, 반응온도에 따른 촉매의 산화특성을 고찰하였다.

시판중인 우유 및 발효유제품의 이화학적 및 기능적 특성

정지은(Ji-Eun Jeong),홍윤호(Youn-Ho Hong) 전남대학교 생활과학연구소 2007 生活科學硏究 Vol.17 No.-

The present study was performed to assess the intake, consumption pattern, and functional protein components of milk and fermented dairy products. Total 8 commercial processed dairy products from supermarkets were surveyed. The fermented dairy products were classified according to the health-promoting effects on stomach, intestine, and Liver. In main nutrition sources of information about fermented dairy products have the property of containing living microorganisms such as Bifidobacterium, Lactobacillus and Streptococcus featuring sensory and nutritional qualities. The pH values of the products for stomach protection were 4.30~4.52, for intestinal improvement were 4.26~4.27, and for liver protection were 4.20~4.26. The SDS-PAGE results indicated that main bands of fermented dairy products had Ig heavy chain, lactoferrin, BSA, caseins and whey proteins, immunoglobulin (Ig) and bovine serum albumin (BSA). There were no remarkable differences of protein fractions and peptides between products.

올레산과 미생물 유래 트랜스글루타미나제를 첨가한 우유 알파-락트알부민의 암세포사멸 효과

정지은(Ji-Eun Jeong),홍윤호(Youn-Ho Hong) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.3

본 연구에서는 기능적 특성이 우수한 우유 단백질 소재를 개발하여 식품산업에 응용하고자 우유 α-La의 영양생리학적 특성에 대하여 분석하였다. 우유 α-La의 기능성을 향상시키려는 시도로써 MTGase의 첨가가 이 단백질의 이화학적 및 면역학적 특성에 미치는 영향을 조사하고, 수종의 암세포주의 생육에 대한 억제 효과를 탐색하였으며, α-La의 구조적 상태에 따라 항암활성의 관련성을 검토하였다. α-La에 반응한 MTGase에 의해 생성된 중합체는 인체 내 가수분해효소에 의해 분해가 용이한 것으로 확인되었다. 위암 세포주에 α-La을 10 ㎎/mL 농도로 처리한 경우 높은 세포독성을 나타냈다. α-La과 올레산의 복합체인 BAMLET은 간암 세포주에서 α-La에 비해 더 강한 활성을 보였다. BAMLET은 apo 상태로 상당량의 이차구조를 지니고 있지만, 소수성 중심부는 느슨하게 형성된 MG와 같은 형태를 지니고 있을 것으로 추정되었다. NMR 분석 결과, BAMLET은 1.2 ppm과 0.8 ppm에서 지방산 보조인자인 올레산과 상호 작용하는 것으로 분석되었다. In order to investigate the biological effects of conformational changes in the folding state of bovine α-lactalbumin (α-La), the protein was prepared and classified as apo form, microbial transglutaminase (MTGase) added form, or bovine α-La made lethal to tumor cell (BAMLET) form. Apo α-La form showed weaker cancer cell inhibitory activity (apoptosis) than native α-La, which suggests that the metal ion-like Ca<SUP>2+</SUP> had a positive effect, whereas BAMLET form showed strong cancer cell apoptotic activity. The BAMLET form seemed to be a molten globule structure that increased hydrophobicity. MTGase added to apo α-La polymer showed similar anti-cancer activity as native α-La, and it was well hydrolyzed by digestive enzymes. NMR results showed that BAMLET interacted with oleic acid and produced a complex.

NIR-triggered Structural and Functional Recovery of Polymer Networks

Ji-Eun Jeong(정지은),이상호,정효철,정유진,박영일,김진철 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.2

오이고추 피클의 저장기간 중의 성분 및 기호도의 변화

정지은 ( Ji Eun Jeong ),신지은 ( Ji Eun Shin ),황경준 ( Kyung Jun Hwang ),이재욱 ( Jae Wook Lee ),김선일 ( Sun Il Kim ) 한국식품조리과학회 2009 한국식품조리과학회지 Vol.25 No.3