Clinical efficacy of multiple biomarker in detection of ovarian cancer

( Min Sun Kyung ),( Ji Eun Sung ),( Yong Cho ),( Eu Sun Ro ),( Sung Ho Park ),( Hong Bae Kim ),( Young Han Park ),( Hey Jeong Song ) 대한산부인과학회 2011 대한산부인과학회 학술대회 Vol.97 No.-

Association between dyslipidemia and asthma in children: a systematic review and multicenter cohort study using a common data model

Hey-Sung Baek,Ji Eun Lim,Hye Min Kim,Ju Hee Kim,Man Yong Han 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.8

Background: The association between dyslipidemia and asthma in children remains unclear. Purpose: This study investigated the association between dyslipidemia and cholesterol levels in children. Methods: A systematic literature review was performed to identify studies investigating the association between dyslipidemia and asthma in children. The PubMed database was searched for articles published from January 2000–March 2022. Data from a cohort study using electronic health records from 5 hospitals, converted to the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM), were used to identify the association between total cholesterol (TC) levels and asthma in children. This cohort study used the Cox proportional hazards model to examine hazard ratio (HR) of asthma after propensity score matching, and included an aggregate meta-analysis of HR. Results: We examined 11 studies reporting an association between dyslipidemia and asthma in children. Most were cross-sectional; however, their results were inconsistent. In OMOP-CDM multicenter analysis, the high TC (>170 mg/dL) group included 29,038 children, while the normal TC (≤170 mg/dL) group included 88,823 children including all hospital datasets. In a meta-analysis of this multicenter cohort, a significant association was found between high TC levels and later development of asthma in children <15 years of age (pooled HR, 1.30; 95% confidence interval, 1.12–1.52). Conclusion: Elevated TC levels in children may be associated with asthma.

Actual situation and prescribing patterns of opioids by pain physicians in South Korea

Min Jung Kim,Ji Yeon Kim,Yun Hee Lim,Sung Jun Hong,Jae Hun Jeong,Hey Ran Choi,Sun Kyung Park,김정은,Min Ki Lee,Jae Hun Kim 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.4

Background: Use of opioids for chronic intractable pain is increasing globally, and their proper use can improve patients’ quality of life. In contrast, opioid use disorders, such as abuse or addiction, caused by prescribing opioids, are a worldwide issue. This study aimed to understand current opioid prescribing patterns and pain physicians’ experiences with opioid use in South Korea. Methods: Pain physicians in 42 university hospitals in South Korea were asked to complete anonymous questionnaires regarding opioid prescriptions. Results: A total of 69 surveys were completed. Most pain physicians started prescribing opioids at a pain score of 7/10 and aimed to reduce pain by 50%. Most physicians (73.1%) actively explained the prescribed medications and possible side effects, and 61.2% of physicians preferred the prescription interval of 4 weeks. Immediate-release opioids were the most popular treatment for breakthrough pain (92.6%). The most common side effect encountered by physicians was constipation (43.3%), followed by nausea/vomiting (34.3%). Of the physicians, 56.5% replied that addiction and misuse prevalences were less than 5%. However, the most concerning side effect was addiction (33.0%). Conclusions: The survey results showed that the prescribing patterns of pain physicians generally followed Korean guidelines. Physicians were most interested in the safety and effectiveness of opioid prescriptions. They were most concerned about respiratory depression and abuse or addiction. A significant number of physicians agreed that the NHIS regulations needed improvement for patient convenience and safe and effective treatment, though there were pros and cons of the NHIS restrictions on prescription conditions.

Poster Session : PS 0821 ; Upper GI Tract : Primary Malignant Melanoma of the Esophagus: A Case Report

( Ji Hyun Lee ),( Ki Nam Shim ),( Min Sun Ryu ),( Kwang Jin Woo ),( Jeon Mi Lee ),( Hey Won Yoon ),( Chung Hyun Tae ),( Chang Mo Moon ),( Seoung Eun Kim ),( Hye Kyung Jung ),( Sung Ae Jung ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Primary malignant melanoma of the esophagus is an extremely rare disease which counts for approximately 0.1-0.2% of all esophageal malignancies. It is also a very aggressive disease with a poor prognosis, with its 5yr survival rate ranging from 2.2% - 37.5%. Here we report a case of primary malignant melanoma of the esophagus in a patient whose diagnosis was made relatively early and thus total resection by an Ivor Lewis procedure was possible. A 51 year old Asian woman visited our hospital with epigastric discomfort. The patient had no noticeable medical history. She complained of mild nausea and dyspepsia, but there was no vomiting or weight loss. Physical examination showed no palpable lymph nodes in the head and neck region. There was no tenderness or rebound tenderness on the abdomen. For evaluation of her upper gastrointestinal symptoms, she had the upper endoscopy done. Endoscopy identifi ed a few dark pigmented, polypoid lesions scattered from 22cm to 30cm from the incisor tooth. The lesions were various in size, ranging from 0.2cm to 4-5cm and were fl at, slightly elevated with a irregular base. Biopsy done from two spots showed a well demarcated, slightly elevated and black pigmented tumor. For stage work-up, additional examinations were performed. The chest CT showed no abnormal thickening of the esophagus or any enlarged lymph nodes in the mediastinum. The PET-CT showed a mild focal abnormal uptake in the upper thoracic esophagus. The patient underwent an Ivor-Lewis procedure in June, 2013. Pathologic examination revealed spindle shaped malignant melanocytes with hyperchromated nucleis and black pigmentation. The lesion had invaded the submucosal layer. Thus the patient was diagnosed as esophageal malignant melanoma, stage T2N0M0. She is now under close observation at the out-patient department and has been disease free for 13 months.e

Resident microglia die and infiltrated neutrophils and monocytes become major inflammatory cells in lipopolysaccharide-injected brain

Ji, Kyung-Ae,Yang, Myung-Soon,Jeong, Hey-Kyeong,Min, Kyoung-Jin,Kang, Seung-Hee,Jou, Ilo,Joe, Eun-Hye John Wiley & Sons, Inc. 2007 Glia Vol.55 No.15

<P>Generally, it has been accepted that microglia play important roles in brain inflammation. However, recently several studies suggested possible infiltration of blood neutrophils and monocytes into the brain. To understand contribution of microglia and blood inflammatory cells to brain inflammation, the behavior of microglia, neutrophils, and monocytes was investigated in LPS (lipopolysaccharide)-injected substantia nigra pars compacta, cortex, and hippocampus of normal and/or leukopenic rats using specific markers of neutrophils (myeloperoxidase, MPO), and microglia and monocytes (ionized calcium binding adaptor molecule-1, Iba-1), as well as a general marker for these inflammatory cells (CD11b). CD11b-immunopositive (CD11b<SUP>+</SUP>) cells and Iba-1<SUP>+</SUP> cells displayed similar behavior in intact and LPS-injected brain at 6 h after the injection. Interestingly, however, CD11b<SUP>+</SUP> cells and Iba-1<SUP>+</SUP> cells displayed significantly different behavior at 12 h: Iba-1<SUP>+</SUP> cells disappeared while CD11b<SUP>+</SUP> cells became round in shape. We found that CD11b/Iba-1-double positive (CD11b<SUP>+</SUP>/Iba-1<SUP>+</SUP>) ramified microglia died within 6 h after LPS injection. The round CD11b<SUP>+</SUP> cells detected at 12 h were MPO<SUP>+</SUP>. These CD11b<SUP>+</SUP>/MPO<SUP>+</SUP> cells were not found in leukopenic rats, suggestive of neutrophil infiltration. MPO<SUP>+</SUP> neutrophils expressed inducible nitric oxide synthase, interleukin-1β, cyclooxygenase-2, and monocyte chemoattractant protein-1, but died within 18 h. CD11b<SUP>+</SUP> cells detected at 24 h appeared to be infiltrated monocytes, since these cells were once labeled with Iba-1 and were not found in leukopenic rats. Furthermore, transplanted monocytes were detectable in LPS-injected brain. These results suggest that at least a part of neutrophils and monocytes could have been misinterpreted as activated microglia in inflamed brain. © 2007 Wiley-Liss, Inc.</P>

Development and Assessment of an ICT-Based Non-Face-to-Face Lifestyle Program to Improve the Mental Health of Older Adults: A Pilot Study

이혜식 (Hey Sig Lee),박혜연(Hae Yean Park),정민예(Min-Ye Jung),박지혁(Ji-Hyuk Park),홍익표(Ickpyo Hong),김정란(Jung-Ran Kim) 대한신경계작업치료학회 2024 재활치료과학 Vol.13 No.1

목적 : 본 연구에서는 정보통신기술(information and communication technology, ICT) 기반의 고령자를위한 비대면 라이프스타일 프로그램을 개발하고 그 적용 가능성을 평가하였다. 연구방법 : 본 프로그램은 분석, 설계, 개발, 구현 및 평가 5단계로 구성된 ADDIE 모델을 기반으로 개발되었다. 5단계의 연구과정 동안 8단계를 거쳐 최종적으로 지역사회 고령자들을 대상으로 비대면 라이프스타일 프로그램이 수행되었다. 결과 : 프로그램 분석 결과, 대상자들의 우울 증상과 외로움이 유의하게 감소한 것으로 나타났고 삶의질 점수가 증가함을 확인할 수 있었다. 결론 : 본 연구를 통해 개발된 ICT 기반의 비대면 라이프스타일 프로그램은 고령자들이 성공적인 노화를위한 생활 방식을 더 잘 이해하도록 동기부여하는 데 도움이 되었다. Objective : This study aimed to develop an information and communication technology (ICT)-based, non-face-to-face lifestyle program for older adults and assess its applicability. Methods : The program was developed on the basis of the ADDIE model which comprises 5 stages: analysis, design, development, implementation, and evaluation. In this study, a step-by-step identification was performed in 8 stages. Results : The results of the program analysis showed a significant decrease in depressive symptoms and loneliness scores, and an increased quality of life scores. Conclusion : The findings suggest that the ICT-based non-face-to-face lifestyle program developed in this study can motivate older adults to better understand their lifestyles for successful aging, while helping senior citizen centers resume stagnant projects.

복합부위통증증후군 환자의 이환 부위 수술 전후의 통증관리

조지연 ( Ji Yon Jo ),이미금 ( Mi Geum Lee ),이효민 ( Hyo Min Lee ),최윤숙 ( Yun Suk Choi ),윤혜정 ( Hey Jeong Yun ),이철중 ( Chul Joong Lee ),이상철 ( Sang Chul Lee ),김용철 ( Yong Chul Kim ) 대한통증학회 2006 The Korean Journal of Pain Vol.19 No.2

Anti-Inflammatory Effect of Procyanidins from Wild Grape ( <i>Vitis amurensis</i> ) Seeds in LPS-Induced RAW 264.7 Cells

Bak, Min-Ji,Truong, Van Long,Kang, Hey-Sook,Jun, Mira,Jeong, Woo-Sik Hindawi Publishing Corporation 2013 Oxidative medicine and cellular longevity Vol.2013 No.-

<P>In the present study, the anti-inflammatory effect and underlying mechanisms of wild grape seeds procyanidins (WGP) were examined using lipopolysaccharide- (LPS-) stimulated RAW 264.7 cells. We used nitric oxide (NO) and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and reactive oxygen species (ROS) assays to examine inhibitory effect of WGP and further investigated the mechanisms of WGP suppressed LPS-mediated genes and upstream expression by Western blot and confocal microscopy analysis. Our data indicate that WGP significantly reduced NO, PGE<SUB>2</SUB>, and ROS production and also inhibited the expression of proinflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions. Consistently, WGP significantly reduced LPS-stimulated expression of proinflammatory cytokines such as tumor necrosis factor <I><I>α</I></I> (TNF-<I><I>α</I></I>) and interleukin- (IL-) 1<I><I>β</I></I>. Moreover, WGP prevented nuclear translocation of nuclear factor-<I><I>κ</I></I>B (NF<I><I>κ</I></I>B) p65 subunit by reducing inhibitory <I><I>κ</I></I>B-<I><I>α</I></I> (I<I><I>κ</I></I>B<I><I>α</I></I>) and NF<I><I>κ</I></I>B phosphorylation. Furthermore, we found that WGP inhibited LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK). Taken together, our results demonstrated that WGP exerts potent anti-inflammatory activity through the inhibition of iNOS and COX-2 by regulating NF<I><I>κ</I></I>B and p38 MAPK pathway.</P>

Anti‐fibrotic effect of chorionic plate‐derived mesenchymal stem cells isolated from human placenta in a rat model of CCl₄‐injured liver: Potential application to the treatment of hepatic diseases

Lee, Min‐,Jae,Jung, Jieun,Na, Kyu‐,Hwan,Moon, Ji Suk,Lee, Hey‐,Jin,Kim, Jae‐,Hwan,Kim, Gwang Il,Kwon, Sung‐,Won,Hwang, Seong‐,Gyu,Kim, Gi Jin Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of cellular biochemistry Vol.111 No.6

<P><B>Abstract</B></P><P>Translational studies have explored the therapeutic effects of stem cells, raising hopes for the treatment of numerous diseases. Here, we evaluated the therapeutic effect of chorionic plate‐derived mesenchymal stem cells (CP‐MSCs) isolated from human placenta and transplanted into rats with carbon tetrachloride (CCl<SUB>4</SUB>)‐injured livers. CP‐MSCs were analyzed for hepatocyte‐specific gene expression, indocyanine green (ICG) uptake, glycogen storage, and urea production following hepatogenic differentiation. PKH26‐labeled CP‐MSCs were directly transplanted into the livers of rats that had been exposed to CCl<SUB>4</SUB> (1.6 g/kg, twice per week for 9 weeks). Blood and liver tissue were analyzed at 1, 2, and 3 weeks post‐transplantation. The expression of type I collagen (Col I) and matrix metalloproteinases (MMPs) was analyzed in rat T‐HSC/Cl‐6 hepatic stellate cells co‐cultured with CP‐MSCs following exposure to TGF‐β. The expression levels of α‐smooth muscle actin (α‐SMA) and Col I were lower in transplanted (TP) rats than in non‐transplanted (Non‐TP) animals (<I>P</I> < 0.05), whereas the expression levels of albumin and MMP‐9 were increased. TP rats exhibited significantly higher uptake/excretion of ICG than non‐TP rats (<I>P</I> < 0.005). In addition, collagen synthesis in T‐HSC/Cl‐6 cells exposed to TGF‐β was decreased by co‐culture with CP‐MSCs, which triggered the activation of MMP‐2 and MMP‐9. These results contribute to our understanding of the potential pathophysiological roles of CP‐MSCs, including anti‐fibrotic effects in liver disease, and provide a foundation for the development of new cell therapy‐based strategies for the treatment of difficult‐to‐treat liver diseases. J. Cell. Biochem. 111: 1453–1463, 2010. © 2010 Wiley‐Liss, Inc.</P>

치어리딩이 여중생의 체력과 골밀도에 미치는 영향

박지혜 ( Ji-hey Park ),김경래 ( Kyeong-lae Kim ),서영민 ( Yung-min Seo ) 한국리듬운동학회 2021 한국리듬운동학회지 Vol.14 No.2

The purpose of this study is to confirm the effect of 12-week cheerleading on the physical fitness and bone mineral density in middle school girls. In order to achieve the purpose of this study, 42 female students from H middle school were selected and 21 students were randomly assigned to each of the exercise group and the control group, measured the physical fitness, body composition and bone mineral density before and after conducted cheerleading activity of 45 minutes 3 times a week for 12 weeks. The data obtained in this study were analyzed using the SPSS 21.0 statistical program, and paired sample t-test was performed to confirm the within-group difference, and independent sample t-test was performed to confirm the difference between groups after the experiment. The results were as follows; First, the change in physical strength within the group showed significant differences in strength, muscular endurance, cardiorespiratory endurance, flexibility, and agility only in the exercise group, muscular endurance, cardiorespiratory endurance, flexibility, quickness, agility, and coordination were significantly different between groups. Second, the body composition showed a difference in body fat percentage in the exercise group, no significant difference between groups. Third, the bone mineral density showed the significant difference due to the improved average bone mineral density, showed no difference between groups.