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Cho, Kie Yong,An, Heseong,Do, Xuan Huy,Choi, Keunsu,Yoon, Ho Gyu,Jeong, Hae-Kwon,Lee, Jong Suk,Baek, Kyung-Youl The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.39
<P>The facile tuning of the gate size and the chemical functionalization of zeolitic imidazolate frameworks (ZIFs) have been considered efficient strategies for various potential applications including gas membranes, sensors, and catalysts. Herein, we demonstrate the synthesis of amine-functionalized ZIF-8 (ZIF8-A) with 3-amino-1,2,4-triazole (Atz) by postsynthetic modification (PSM) towards two objectives: (1) CO2 selective adsorption by a combination of chemical interactions and controlled gate sizes and (2) potential for further chemical modifications. The acquired ZIF8-A substantially enhanced CO2/N2 and CO2/CH4 selectivity at 35 °C compared to ZIF-8 since the Atz conversion enhanced chemical interactions with CO2 due to the introduction of amine moieties while reducing both the surface area and pore volume. The gate size control of ZIF-8 by the replacement of Atz was thoroughly investigated by extensive transport experiments and density functional theory (DFT)-based computational simulations. In addition, the vinyl-functionalized ZIF-8, another versatile starting material, was successfully prepared by further chemical modifications of ZIF8-A with either methacrylic anhydride or glycidyl methacrylate through nucleophilic substitution reactions. As such, we believe that our current work can provide promising platforms for designing ZIF-based materials with versatile properties including precise control of the gate size and the incorporation of various functional groups.</P>
A Case of Polymyositis Associated with Immunoglobulin A Nephropathy
( Yoon-jeong Oh ),( Eun Sung Park ),( Mi Jang ),( Ea Wha Kang ),( Jeong-hae Kie ),( Sang-won Lee ),( Jason Jungsik Song ),( Yong-beom Park ),( Chan-hee Lee ),( Jin-su Park ) 대한류마티스학회 2017 대한류마티스학회지 Vol.24 No.4
Polymyositis (PM) is a chronic inflammatory disease that predominantly affects muscles. Systemic organ involvement, including the respiratory and gastrointestinal tracts, is frequently observed in PM, but renal involvement is rare. Herein, we report the case of a 56-year-old woman presenting with weight gain, edema, and generalized myalgia. Laboratory tests revealed elevated creatinine kinase level, hypoalbuminemia, and proteinuria. Histopathological examination of muscle biopsy revealed inflammatory myositis, and a renal biopsy confirmed immunoglobulin A (IgA) nephropathy. Based on the clinico-pathological results, the patient was diagnosed with PM with IgA nephropathy. This is a report of a rare occurrence of IgA nephropathy in a patient with PM presenting with chronic glomerulonephritis. (J Rheum Dis 2017;24:241-245)
IgA 신병증에 합병된 신증후군의 자연관해를 보인 증례보고
김정호 ( Jeong Ho Kim ),김하나 ( Ha Na Kim ),홍석민 ( Seok Min Hong ),기정혜 ( Jeong Hae Kie ),강이화 ( Ea Wha Kang ),신석균 ( Suk Kyun Shin ),한승혁 ( Seung Hyeok Han ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.3
Although a moderate degree of proteinuria is common in patients with IgA nephropathy (IgAN), nephrotic syndrome combined with IgAN is rare. It has been reported that approximately 5% of all patients with IgAN are complicated by minimal change disease and these patients respond well to corticosteroid therapy. However, spontaneous remission is uncommon in heavy proteinuric patients with IgAN. Recently, we experienced two cases of spontaneous remission of nephrotic syndrome combined with IgAN without use of corticosteroid. In these patients, heavy proteinuria disappeared in 1 month after the onset and no recurrence occurred during follow-up. With such limited number of cases, factors associated with spontaneous remission in these patients could not be explored. Further study with a larger number of patients is required and careful attention should be paid to these complicated cases.
( Young Eun Kwon ),( Jeong Hae Kie ),( Seong Yeong An ),( Yung Ly Kim ),( Kyoung Sook Park ),( Ki Heon Nam ),( Ah Young Leem ),( Hyung Jung Oh ),( Jung Tak Park ),( Tae Ik Chang ),( Ea Wha Kang ),( Se 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Background: Many studies have shown that clinical characteristics and outcomes differ depending on pathologic variants of focal segmental glomerulosclerosis (FSGS). However, these are not well defined in Asian populations. Methods: This retrospective study evaluated clinical features and outcomes of pathologic FSGS variants in 111 adult patients between January 2004 and December 2012. Primary outcome was the composite of doubling of baseline serum creatinine concentrations (D-SCr) or onset of end-stage renal disease (ESRD). Secondary outcome included complete (CR) or partial remission (PR). Results: There were 70 (63.1%), 20 (18.0%), 17 (15.3%), 3 (2.7%), and 1 (0.9%) patients with not-otherwise specified (NOS), tip, perihilar, cellular, and collapsing variants, respectively. Nephrotic syndrome occurred more commonly in tip lesion than in other variants. The overall 5- and 8-year renal survival rates were 76.8% and 56.3%, respectively. During a median follow-up of 34.5 months, only 1 (5.0%) patient reached the composite outcome compared to 2 (11.8%) and 12 (17.1%) patients in perihilar and NOS variants, but this difference was not statistically significant in an adjusted Cox model. However, tip lesion was associated with a significantly increased probability of achieving CR (p=0.044). Conclusions: Similar to other populations, Korean adult patients with FSGS have distinct clinical features with the exception of a rare frequency of cellular and collapsing variants. Although pathologic variants were not associated with overall outcome, the tip variant exhibited favorable outcome in terms of achieving remission. Further studies are required to delineate long-term outcome and response to treatment of the pathologic variants.
이규인(Kyuin Lee),기정혜(Jeong Hae Kie),신향애(Hyang-Ae Shin),김지훈(Ji-Hoon Kim) 대한두경부종양학회 2021 대한두경부 종양학회지 Vol.37 No.2
Liposarcoma is a very rare malignant tumor affecting the head and neck area. Since it is an invasive and lifethreatening disease, active treatments is necessary. However, differential it from lipoma, its corresponding benign counterpart, may be difficult. Herein, we report a rare case of posterior neck myxoid liposarcoma in a 72-year-old man who was initially misdiagnosed with lipoma, including a literature review of differential diagnosis between lipoma and liposarcoma.
이해석,정진기,김태영,남기대 ( Hae Suck Lee,Jin Kie Jeong,Tae Young Kim,Kie Dae Nam ) 충북대학교 산업과학기술연구소 1995 산업과학기술연구 논문집 Vol.9 No.2
Abstract_Roman New six aldehyde polyoxyethylene glycol acetals were synthesized through the reaction of aliphatic aldehydes such as dodecyl aldehyde, hexadecyl aldehyde with excess diethylene glycol, triethylene glycol and tetraethyene glycol respectivel
정세원(Se Won Jeong),남재성(Jae Sung Nam),기정혜(Jeong Hae Kie),신향애(Hyang Ae Shin) 대한두경부종양학회 2015 대한두경부 종양학회지 Vol.31 No.2
Benign symmetric lipomatosis, also known as Madelung’s disease, Launois–Bensaude syndrome and multiple sym-metric lipomatosis is a cutaneous condition characterized by extensive symmetric fat deposits in the neck, shoulders, and upper trunk. But symmetrical lipomatosis of the tongue is very rare and characterized by involvement exclusively of the tongue, invasiveness, and absence of encapsulation of the adipose tissue. A 75-year-old man presented with about a year history of painless tongue masses on both lateral border. Bilateral partial glossectomy was performed and subsequently was confirmed as symmetrical lipomatosis pathologically. We report this case with a review of the literatures.
S-365 : Comparison of the Haas and the Oxford Classifications for Prediction in IgA Nephropathy
( Kyoung Sook Park ),( Jeong Hae Kie ),( Ki Heon Nam ),( Mi Jung Lee ),( Beom Jin Lim ),( Young Eun Kwon ),( Yung Ly Kim ),( Seong Yeong An ),( Ah Young Ji ),( Min Hwan Kim ),( Hyung Jung Oh ),( Seung 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Background: Pathologic features can provide valuable information for determinining prognosis in IgA nephropathy (IgAN). However, it is uncertain whether the Oxford classification, a new classification of IgAN, can predict renal outcome better than previous ones. Method: We conducted a retrospective cohort study in 500 patients with biopsy-proven IgAN between January 2002 and December 2010 to compare the ability of the Haas and the Oxford classifications to predict renal outcome. Primary outcome was a doubling of the baseline serum creatinine concentration (D-SCr). Results: During a mean follow-up of 68 months, 52 (10.4%) and 35 (7.0%) developed D-SCr and ESRD, respectively. There were graded increases in the development of D-SCr in the higher Haas classes. In addition, the primary endpoint of D-SCr occurred more in patients with the Oxford M and T lesions than those without such lesions. In multivariable Cox regression analyses, the Haas class V (HR, 12.19; p=0.002) and the Oxford T1 (HR, 6.68; p<0.001) and T2 (HR, 12.16; p<0.001) lesions were independently associated with an increased risk of reaching D-SCr. Harrell`s C index of each multivariable model with the Haas and the Oxford classification was 0.867 (p=0.015) and 0.881 (p=0.004), respectively. This was significantly higher than that of model with clinical factors only (c-statistic=0.819). However, there was no difference in c-statistics between the two models with the Haas and the Oxford classifications (p=0.348). Conclusion: This study suggests that the Hass and the Oxford classifications are comparable in predicting progression of IgAN.
정재헌 ( Jae Heon Jeong ),신상윤 ( Sang Yun Shin ),손명균 ( Myoung Kyun Son ),이영주 ( Young Joo Lee ),김세현 ( Se Hyun Kim ),기정혜 ( Jeong Hae Kie ),최윤정 ( Yoon Jung Choi ),홍용국 ( Yong Kook Hong ),한창훈 ( Chang Hoon Hahn 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.2
악성 흉수의 원인은 폐암, 유방암, 및 악성 림프종, 백혈병이 그 대부분을 차지하며 내분비 종양에 의한 악성 흉수는 매우 드물며 특히 유두상 갑상선 암에 의한 흉수는 거의 없다. 저자들은 유두상 갑상선 암이 폐 전이를 거치지 않고 유방 전이를 거쳐 흉막 전이 일으킨 것으로 보이는 1예를 경험하였기에 보고하는 바이다. 아울러 원인이 명확하지 않은 악성 흉수의 원인 감별에 유두상 갑상선 암도 고려 대상으로 할 필요가 있다고 생각한다. Lung cancer, breast cancer and lymphoma are the common oncologic causes of malignant pleural effusion, comprising more than the half of the causes. However, an endocrinologic carcinoma associated malignant effusion is very rare. Recently, we encountered a case of papillary thyroid carcinoma causing malignant effusion. An 83-year-old female patient presented with dyspnea due to massive pleural effusion in her left side. The pleural biopsy, pleural fluid cytology and breast needle aspiration biopsy results were consistent with a metastatic papillary thyroid carcinoma. Thyroid ultrasonography showed two thyroid masses, but the patient refused a thyroid biopsy. This case highlights the need for considering the possibility of papillary thyroid carcinoma when the cause of malignant pleural effusion cannot be found because one of the rare clinical manifestations of a papillary thyroid carcinoma can be dyspnea due to malignant effusion. (Tuberc Respir Dis 2007; 63: 188-193)