Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

Schiff Base에 의한 구리 부식 억제

정병구,이현석,장영학,문채주 木浦大學校 應用科學硏究院 2001 應用科學硏究誌 Vol.1 No.-

The inhibiting action of copper in 5% hydrochloric acid(HCI) solutions with or without Schiff base, 1,2-bis(naphthylideneimine)ethane(NET), 1,3-bis(naphthylideneimine) propane(NPR), 1,4-bis(naphthylideneimine)butane(NBU), and 1,5-bis(naphthylideneimine) pentane(NPE), has been studied by the Tafel method and AC impedance technique. The corrosion parameters were obtained at different inhibitor concentrations and the temperature effect was also investigated. The inhibiting efficiency increases with a decrease in temperature or increase in concentration of the Schiff base. NPE is the best inhibitor in this series and the maximum inhibition efficiency at a concentration of 5×10^-4 M at 298 K approached 90.07%. Schiff base with longer-chain are superior to shorter-chained analogues in inhibition efficiency.

Rotary type과 linear type 자동흡연 장치에 따른 담배연기 중 타르, 니코틴 및 일산화탄소의 함량 비교

정재훈,김영신,임흥빈,석영선,신주식,이학수 충북대학교 연초연구소 2004 煙草硏究 Vol.19 No.-

본 실험은 type별 흡연 장치의 담배 주류연 포집에 대한 차이를 비교하고자 주류연 중 일반적인 다량의 성분을 측정하였다. 1. 니코틴 함량은 대체로 linear-type 흡연 장치에서 높은 경향 이였으나 유의한 차이는 없었다. 2. 수분 함량은 두 가지 type 간에 유의한 차이는 없었다. 3. tar 함량은 저 농도에서 linear-type 보다 otary-type 흡연 장치가 높은 경향 이였으나 유의한 차이는 없었다. 4. 일산화탄소는 rotary-type과 linear-type 모두 유의한 차이는 없었다. 본 실험결과 ISO 표준 흡연 조건에서 담배 주류연의 tar, 니코틴, 일산화탄소 함량의 측정은 흡연 장치의 type별 통계적으로 유의한 차이는 없는 것으로 판단된다. This study was conducted to compare rotary-type with linear-type automatic smoking machine referred to ISO 3308 in the determination of tar, nicotine and CO in cigarette smoke. Sample were used with 4 kinds of domestic branded cigarettes(tar ; 1, 3, 6, 10 mg/cig) and CORESTA Monitor 4 cigarettes(tar ; 14 mg/cig). Tar and nicotine contents were analysed by gas-chromatograph methods in accordance with ISO 4387 and 10315-1. Determination of carbon monoxide in the vapour phase of cigarette smoke was meaured by NDIR method in ISO 8454. Sample preparation were performed in conditioning room at 22℃, 60 % for 48 hours according to ISO 3402. There was no significant difference between two smoking machine from 1 mg/cig to 14 mg/cig tar cigarettes, but, the contents of three components measured by rotary type showed higher tendency than those by linear type in the case of hight tar cigarettes. The results were the opposite in low tar cigarettes.

융모성림프구를 보이는 비장변연부 림프종 1예

진한영,손창학,주영돈,박정하,이재익,조영완,이원식 인제대학교 2006 仁濟醫學 Vol.27 No.-

Splenic marginal zone lymphoma is very rare B-cell lymphoma, characterized by an indolent clinical course. Clinical features are moderate-to severe splenomegaly, absolute lymphocytosis, and bone marrow intrasinusoidal infiltration of lymphocyte. We report the case of a 37-year-old male with SMZL. He complained of LUQ pain, who had a massive splenomegaly and moderate lymphocytosis in peripheral blood. Immunophenotyping findings and morphologic findings were consistent with SMZL. He underwent splenectomy and received chemotherapy with cyclophosphamide for eight months. Now, one year later after surgery he has a nearly normal blood count with no treatment.

종골 골절 치료에 있어서의 전산화 단층 촬영의 유용성

김학준,하권익,윤정로,심재익,김택선,김영배,이우승,최재혁 대한골절학회 2003 대한골절학회지 Vol.16 No.4

잡음환경에서 구름 볼 베이링의 결함검출을 위한 ALE의 적용

김영태,최만용,김기복,박해원,박정학,김종억,류준 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

It is very important to detect the bearing defects in rotating machinery since the critical failure of bearing cause a machinery shutdown. However it is difficult to detect the vibration signal resulting from the initial defects of bearing because of the high level of broadband noise. A signal processing technique, called the adaptive line enhancer(ALE) as one of adaptive filter, is studied in this work. This technique is to eliminate broadband noise without a prior knowledge of the noise and signal characteristics. Also we propose the optimal methods for selecting the three main ALE parameters such as correlation length, filter order and adaptation constant used in the adaptative process. Vibration signals for three abnormal bearings, including inner and outer raceways and ball defects, were acquired from Anderon(angular derivative of radius on)meter. The experimental results showed that the proposed technique can reliably detect the bearing defective signals masked by broadband noise.

제조공장에서의 극저주파 자기장의 측정 및 분석(Ⅰ) : 작업장의 지역별 구분에 의한 자기장을 중심으로

임영철,양승학,정익모 호남대학교 1998 호남대학교 학술논문집 Vol.19 No.2

This proper deals with the recent allegation that the electro-magnetic fields may have a bad influence on the human health. The two manufacturing plants are examined, which leave the same manufacturing processes but different environments of the electrical equipment and voltages in use. This study analyzes the characteristics of the magnetic fields occurred in the two plants by measuring the distribution of the magnetic fields of the extremely low frequency band at constant points.' The average values of the magnetic field strengths are 2.96mG at "A"plant, and 1.57mG at "B"plant. respectively, By comparing those two values, it is found that the magnetic field strength in "B"plant turns out to be half of that in "A"plant. The characteristics of "B"plant are: "B"plant uses the voltage twice as high as "A"plant; (2)the buildings of "B"plant are higher than those of "A"plant; and (3)"B"plant has wider spaces for the electrical equipment.

흔적이론과 의미해석

이영헌,조학행,이흥수,허정 조선대학교 외국문화연구소 1980 外國文化硏究 Vol.3 No.1

표준이론(Standard Theory)에 있어서 한 문장의 의미해석은 오직 심층구조에 의해서만 가능하였다. 그러나 어떤 문장에 있어서는 심층구조의 정보만으로는 그 문장이 지니고 있는 모든 의미를 나타내주지 못하는 경우가 있기 때문에 표층구조에서도 의미해석을 하여야 할 경우가 생긴다. 이와 같은 문법기술의 궁극적 목표인 의미해석에 밝은 전망을 주지 못하는 표준이론은 확대표준이론으로 발전되었다. 확대표준이론(Extended Standard Theory)에 의하면 한 문장의 의미해석은 심층구조와 표층구조를 모두 다 들여다 보아야 가능하다. 그러므로 의미해석의 정보를 심층구조에서 뿐만 아니라 표층구조에서도 택하여야 한다면, 어떤 정보는 심층구조에서 얻어야 하고, 또 어떤 정보는 표층구조에서 얻어야 할 것이냐 하는 문제가 생긴다. 다시 말하면 심층조와 표층구조가 제공하는 정보의 구별에 따르는 문제가 생기는 의미해석의 문제도 그만큼 복잡해진다. 뿐만 아니라 두 구조가 제공하는 정보에 의한 의미해석이 복잡해짐에 따라 의미가 동일한 두 문장과 한 문장이 두개 이상의 의미를 지녔을 경우의 의미해석은 더욱 어려운 문제가 된다.

볼 베어링의 결함검출을 위한 Adaptive Line Enhancer의 적용

김영태,최만용,김기복,박해원,박정학,김종억,류준 한국공작기계학회 2005 한국생산제조학회지 Vol.14 No.2

The early detection of the bearing defects in rotating machinery is very important since the critical failure of bearing causes a machinery shutdown. However it is not easy to detect the vibration signal caused by the initial defects of bearing because of the high level of random noise. A signal processing technique, called the adaptive line enhancer(ALE) as one of adaptive filter, is used in this study. This technique is to eliminate random noise with little a prior knowledge of the noise and signal characteristics. Also we propose the optimal methods for selecting the three main ALE parameters such as correlation length, filter order and adaptation constant. Vibration signals for three abnormal bearings, including inner and outer raceways and ball defects, were acquired by Anderon(angular derivative of radius on) meter. The experimental results showed that ALE is very useful for detecting the bearing defective signals masked by random noise.

담배연기성분 중 니코틴함량 측정결과에 대한 불확도 산정

김영신,정재훈,임흥빈,이학수,석영선,신주식 충북대학교 연초연구소 2004 煙草硏究 Vol.19 No.-

담배성분에 대하여 정량분석을 하여 구하는 값은 측정하고자 하는 대상의 참값에 대한 추정값이며, 이는 이상적인 참값으로부터 여러 가지 원인에 의해 벗어나게 된다. 실험 분석 결과는 실험대상에 대한 여러 가지 판단 근거를 제공하는 것이며, 이에 대한 신뢰성의 척도로 불확도가 사용되고 있다. 따라서, 본 연구는 담배연기성분 중 니코틴함량 측정결과에 대하여 신뢰성을 부가시키고, 더욱이 실험과정에서 중요한 불확도의 원인을 찾아내어 해당부분의 불확도를 줄임으로써 보다 정확한 분석결과를 얻고자 이루어졌으며 이 방법으로 추정된 CM4의 측정값과 불확도 표현은 다음과 같다. Nicotine : 1.28 ± 0.01 mg/cig. (신뢰 구간 95.45%, k=2) Measurements by quantitative analysis of tobacco components were the presumed value of a true value. But this measurement was out of ideal true value by various reasons. The aim of this study was to invest with confidence to measurement of nicotine content in tobacco smoke components and to reduce uncertainty by searching uncertainty reasons. Uncertainty of nicotine contents of CORESTA monitor 4 by this method was as follows.