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Jeeyeon Kim,김현건,김경옥,김형욱,Jongha Park,Jeong-Sik Byeon,Sung-Wook Hwang,Hyun Deok Shin,Jeong Eun Shin,Hyo-Joon Yang,이현석,정윤호,조영석,주영은,Dae-Seong Myung,Kyu Chan Huh,Eu Mi Ahn 대한장연구학회 2019 Intestinal Research Vol.17 No.3
Background/Aims: This study compared the efficacy, compliance, and safety of bowel preparation between sodium picosulfate with magnesium citrate (SPMC) and oral sulfate solution (OSS). Methods: A prospective randomized multicenter study was performed. Split preparation methods were performed in both groups; the SPMC group, 2 sachets on the day before, and 1 sachet on the day of the procedure, the OSS group, half of the OSS with 1 L of water on both the day before and the day of the procedure. The adenoma detection rate (ADR), adequacy of bowel preparation using the Boston Bowel Preparation Scale (BBPS) score, patient satisfaction on a visual analog scale (VAS), and safety were compared between the 2 groups. Results: This study analyzed 229 patients (121 in the SPMC group and 108 in the OSS group). ADR showed no differences between 2 groups (51.7% vs. 41.7%, P>0.05). The mean total BBPS score (7.95 vs. 8.11, P>0.05) and adequate bowel preparation rate (94.9% vs. 96.3%, P>0.05) were similar between the 2 groups. The mean VAS score for taste (7.62 vs. 6.87, P=0.006) was significantly higher in the SPMC group than in the OSS group. There were no significant differences in any other safety variables between the 2 groups except nausea symptom (36.1% vs. 20.3%, P=0.008). Conclusions: Bowel preparation for colonoscopy using low volume OSS and SPMC yielded similar ADRs and levels of efficacy. SPMC had higher levels of satisfaction for taste and feeling than did OSS.
Jeong, Jiyeon,Lee, Jeeyeon,Lee, Heeyoung,Lee, Soomin,Kim, Sejeong,Ha, Jimyeong,Yoon, Ki-Sun,Yoon, Yohan ational Association for Food Protection 2017 Journal of food protection Vol.80 No.4
<B>ABSTRACT</B><P>This study evaluated the risk of Campylobacter foodborne illness caused by the intake of raw beef offal in South Korea. The prevalence of Campylobacter spp. in raw beef offal (liver and tripe) was investigated by plating samples on modified charcoal-cefoperazone-deoxycholate agar with Preston enrichment broth. Data were collected about storage temperature and length of storage of raw beef offal, and probabilistic distributions for the data were determined, using @RISK software. Predictive models were developed to describe the fate of Campylobacter in raw beef offal, and the amount and frequency of consumption and dose-response model were surveyed. Subsequently, these data were used to estimate the risk of Campylobacter foodborne illness caused by the intake of raw beef offal. Of 80 beef offal samples, 1 (1.25%) was contaminated with Campylobacter jejuni. Predictive models were used for exposure assessment. An exponential distribution was selected to represent beef offal consumption by people who eat this occasionally, with a mean of 60.2 g and 3.6% monthly consumption frequency. Simulations using @RISK predicted that the probability of Campylobacter foodborne illness per person per month is 1.56 × 10−5 for home consumption and 1.74 × 10−5 for restaurant consumption in South Korea, which indicates the risk of Campylobacter foodborne illness by intake of raw beef offal in South Korea.</P>
정지연,이광용,이나루,전홍진,김성진,이인섭,김광종 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1
Although in the U.S perchloroethylene is the most commonly used in commercial dry cleaning shops, petroleum based dry cleaning solvent is the most frequently used in Korea. The solvent is a mixture of hydrocarbons, straight or branched chain aprraffins, naphthenes, and aromatic hydrocarbons. Exposure assessment at the cleaning shop was mainly focused on highly toxic substances, especially benzene, toluene, xylene, ethylbenzene, and 2-butoxyethanol in the solvents. However the contents of the toxic substances in the solvents are very small. Not only the exposure assessment for highly toxic substances is important, but also exposure for the petroleum based solvent itself is more important in dry cleaning shop. The specific aim of the present study was to identify the physical and the chemical properties of petroleum based dry cleaning solvents and to investigate the possivility of using occupational exposure standard of stoddard solvent for overall expostreassessment of petroleum based solvent. Four different petroleum based solvent(solvent A~solvent D). commonly used in Korda were analyzed and investigated for identifying the phtsical and chemical properties of those solvents. Molecula species of those solvents were C8~C12, and predominant molecular species were C10~C11 for solvent A, solvent C, solvent D. C9~C10 for solvent B. The proportion of paraffin, aromatic, naphthenic,and olefin compounds in dry cleaning solvents was 45.5~54.5%, 16.0~21.4%, 7.9%~15.8%, and 0.8%~1.0%, respectively. The range of boiling point, specific grabity, flash point found in material safety and data sheet made by the solvent manufacturing company was 150 ~210˚C. 0.76~0.79, and 30~44˚C., respectively. We conclude that petroleum based solvents used in dry cleaning shop is almost similar to stoddard solvent defined by ACGIH and NIOSH, and the occupational exposure standard of stoddrd solvent could be used in total exposure assessment of those solvents.
Role of Ultrasound for the Detection of Supraclavicular Lymph Node in Patients with Breast Cancer
Jeeyeon Lee,Jin Hyang Jung,Wan Wook Kim,Ryu Kyung Lee,Hye Jung Kim,Won Hwa Kim,Yee Soo Chae,Soo Jung Lee,Ji-Young Park,Sang-Woo Lee,Shin Young Jeong,Ho Yong Park 대한외과학회 2018 대한외과학회 학술대회 초록집 Vol.2018 No.11
Lee Jeeyeon,Park Ho Yong,Kim Wan Wook,Park Chan Sub,Jeong Minhye,Jung Jin Hyang 대한외과초음파학회 2020 대한외과초음파학회지 Vol.7 No.2
Purpose: Axillary lymph node status is an important prognostic factor in breast cancer. Axillary lymph nodes can be evaluated using fine-needle aspiration cytology (FNAC) or core needle biopsy (CNB) before surgery. This study compared the accuracy and false-negative rates between FNAC and CNB in patients with breast cancer who either did or did not receive neoadjuvant chemotherapy (NAC). Methods: The clinicopathological factors of the patients were analyzed retrospectively, and the sensitivity, specificity, positive and negative predictive values, false-positive and false-negative rates, and accuracy of FNAC (n = 27) and CNB (n = 23) were compared. Results: Regardless of whether or not NAC was performed, the CNB evaluation of the metastatic axillary lymph nodes had a 100.0% sensitivity, specificity, negative predictive value, and accuracy, except for one case with an inadequate sample. In the FNAC group, the false-negative rate was higher in patients with breast cancer who received NAC before evaluating the lymph nodes (9.1% vs. 7.7%). Moreover, ultrasound imaging was the most sensitive imaging modality that can detect the suspicious axillary lymph node. Conclusion: CNB was more effective in evaluating the axillary lymph nodes in breast cancer than FNAC and was performed without major complications.
LEE, JEEYEON,JUNG, JIN HYANG,CHAE, YEE SOO,PARK, HO YONG,KIM, WAN WOOK,LEE, SOO JUNG,JEONG, JAE-HWAN,KANG, SEUNG HEE Potamitis Press 2016 Anticancer research Vol.36 No.12
<P>Aim: We evaluated the role of long noncoding ribonucleic acid (lncRNA) in breast cancer cell lines by quantitative reverse transcription-polymerase change reaction. Materials and Methods: The effects of small NF90-associated RNA (snaR) with RNA interference on proliferation, migration and invasion of MDA-MB-231 cells were observed by 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide, wound healing and transwell assay. Results: Among 90 lncRNAs, E2F transcription factor 4, p107/p130-binding (E2F4) antisense, insulin-like growth factor 2 antisense (IGF2AS), snaR, and small nucleolar RNA host gene 5 (SNHG5) were up-regulated in MDA-MB-231 and 7SK, antisense noncoding RNA in the INK4 locus (ANRIL), IGF2AS, Nespas, p53 mRNA, and snaR were up-regulated in MCF-7 cells. Down-regulation of snaR inhibited the proliferation, migration, and invasion of MDA-MD-231 breast cancer cells. Conclusion: LncRNA snaR was found to be up-regulated in breast cancer cells, and the cancer progression of MDA-MB-231 cells was significantly suppressed by down-regulation of snaR. Therefore, snaR knockdown has potential as a treatment modality for triple-negative breast cancer.</P>
Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
Cho Yongsik,Jeong Sumin,Kim Hyeonkyeong,Kang Donghyun,Lee Jeeyeon,강승백,Kim Jin-Hong 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive destruction of articular cartilage and the development of chronic pain and constitutes a considerable socioeconomic burden. Currently, pharmacological treatments mostly aim to relieve the OA symptoms associated with inflammation and pain. However, with increasing understanding of OA pathology, several potential therapeutic targets have been identified, enabling the development of disease-modifying OA drugs (DMOADs). By targeting inflammatory cytokines, matrix-degrading enzymes, the Wnt pathway, and OA-associated pain, DMOADs successfully modulate the degenerative changes in osteoarthritic cartilage. Moreover, regenerative approaches aim to counterbalance the loss of cartilage matrix by stimulating chondrogenesis in endogenous stem cells and matrix anabolism in chondrocytes. Emerging strategies include the development of senolytic drugs or RNA therapeutics to eliminate the cellular or molecular sources of factors driving OA. This review describes the current developmental status of DMOADs and the corresponding results from preclinical and clinical trials and discusses the potential of emerging therapeutic approaches to treat OA.