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양식장 배출물 발효물의 어류 사료 첨가에 따른 넙치, Paralichthys olivaceus의 혈액학적 변동에 미치는 영향
강주찬,지정훈,송승엽,문상욱,강지웅,이영돈,김세재 한국어병학회 2004 한국어병학회지 Vol.17 No.1
본 연구는 우리나라 주요 양식어류인 넙치, Paralichthys olivaceus를 대상으로 육상수조식양식장 배출물 발효물의 어류 사료 첨가에 따른 혈액학적 변동에 미치는 영향을 검토하였다. 젖산균 및 효모를 사용하여 발효한 양식장 배출물의 이화학적 분석을 실시하였고, 발효물을 0.1, 0.5, 1.0 및 5.0% 농도로 8주간 투여하였다. 투여 4주째 및 8주째에 각 투여 구간별로 혈액학적 항목을 중심으로 그 차이를 확인하였다. 배출물 발효농도별 유의한 차이는 나타나지 않았지만, 분석시기에 따른 적혈구수, 혈색소 농도 및 혈색소 지수가 증가하는 경향을 나타내었으나, 주요 혈청 무기 및 유기성분은 배출 발효물 농도별로 유의한 차이는 나타나지 않았다. 또한 혈청 효소학적 조사에서는 조사시기별로 변동은 나타났지만, 동일 조시시기에서 각 구간별 유의한 차이는 나타나지 않았다. 따라서 이러한 육상 약식장 유래의 배출물 발효산물에 대한 다양한 방면의 연구가 진행되어야겠다. Effects of oral administration with fermented product from sewage in land-based seawater fish farm on haematological disturbance in the olive flounder, Paralichthys olivaceus was investigated. After 4 weeks of conditioning with a basal diet, fish were divided into 4 groups and provided experimental diet (0.1,0.5, 1.0 and 2.0%) supplement of fermented sewage for 80 days. Proximal analysis was performed for the product of sewage which was fermented by lactic acid and yeast. RBC count, hemoglobin concentration and hematocrit value were increased according to the treated periods, however, no statistical difference was observed between control and treatment groups. There were no significant difference in serum organic, inorganic compounds and enzyme activities between control and treatment groups. This study hypothesized that the supplement of fermented product from sewage in land-based seawater fish farm might be an additive sup plement for source of fish diet in view of haematological examination. Recycling of the sewage may be an economic artificial sources of diet for fish aquaculture practices.
박순식,최지웅,윤관섭,나정열 한양대학교 이학기술연구소 2002 이학기술연구지 Vol.5 No.-
During the last several decades, although there have been lots of efforts to develope the high-frequency bottom reflection loss model, the frequency dependence of bottom loss was not considered in most cases because the sea bottom was assumed to be generally much smoother and lower gradient than the sea surface. However, if the sea bottom is rougher than acoustic wavelength, the scattered field will be increased and the reflected field will be decreased. In this paper, the high-frequency bottom reflection losses were obtained through the measurement of reflected waves from the artificially-made-flat sandy bottom. The experimental data were compared with the values calculated by the forward loss model of Mourad & Jackson. Conseouently, we suggest the frequency dependence of bottom reflection loss. 기존 해저면 반사손실 모델들은 해저면을 해수면에 비해 거칠기와 경사도가 매우 평탄하거나 완만한 경계면으로 가정하므로 주파수에 따른변화를 고려하지 않거나 미약하다고 가정하였다. 그러나 고주파를 사용하는 소오나 시스템의 경우, 음파의 파장에 비해 해저면이 거칠다면 음파는 산란 영향이 증가하게 되므로 상대적으로 반사손실 또한 증가하게 된다. 따라서 본 논문에서는 임의로 모의된 사질 성분의 해저면에서 수십 ㎑ 이상의 고주파들을 사용하여 주파수별 반사손실을 계산하고, 이를 기존의 해저면 반사손실 모델과 비교하였으며, 해저면 반사손실의 주파수 종속성을 제시하고자 한다.
Choroidal Ischemia and Serous Macular Detachment Associated with Severe Postoperative Pain
( Jee Woong Jung ),( Dae Young Lee ),( Dong Heun Nam ) 대한안과학회 2008 Korean Journal of Ophthalmology Vol.22 No.2
To report the association of a unilateral serous macular detachment with severe postoperative pain. A 71-year-old woman presented with a sudden decrease in vision in the right eye, seven days after a total knee replacement arthroplasty. The patient`s history was unremarkable except for a severe pain greater than the visual analog scale of 8 points for about 2 days after surgery. Retinal examination showed a well differentiated serous detachment that was about 3.5 disc diameter in size and located in the macular area. Fluorecein angiography and indocyanine green angiography showed delayed perfusion of the choriocapillaris without leakage points in the early phase and persistent hypofluorescence with pooling of dye in the subretinal space in the late phase. There was a spontaneous resolution of the serous detachment and the choroidal changes with residual pigment epithelial changes. Severe postoperative pain may influence the sympathetic activity and introduce an ischemic injury with a focal, choroidal vascular compromise and secondary dysfunction of overlying RPE cells in select patients.
The double-barrier technique using platelet-rich fibrin for closure of oroantral fistulas
Jae-Woong Jung,Sung ok Hong,Eun-Jee Lee,Ra-Yeon Kim,Yu-Jin Jee 대한구강악안면외과학회 2023 대한구강악안면외과학회지 Vol.49 No.3
An oroantral fistula (OAF) or oroantral communication (OAC) is an opening between the oral cavity and the maxillary sinus. If left untreated, these openings may cause chronic maxillary sinusitis. Although small defects (diameter <5 mm) may close spontaneously, larger communications require surgical intervention. Various studies have been conducted on OAC closure using a platelet-rich fibrin (PRF) membrane; most of these prior studies have involved simple direct application of PRF clots. This study introduces a new “double-barrier technique” using PRF for closure of an OAF involving sinus mucosal lifting and closure. The PRF material is inserted into the prepared maxillary sinus space, and the buccal advancement flap covers the oral side. This technique was successfully used to treat two patients with chronic OAF in the posterior maxillary region after implant removal or tooth extraction. The use of a PRF membrane in a double-barrier technique may have advantages in soft-tissue healing and could enable easy closure of chronic OAF with minimal trauma.
Gold nanostar-mediated neural activity control using plasmonic photothermal effects
Lee, Jee Woong,Jung, Hyunjun,Cho, Hui Hun,Lee, Jung Heon,Nam, Yoonkey Elsevier 2018 Biomaterials Vol.153 No.-
<P><B>Abstract</B></P> <P>Nanomaterials have emerged as an essential tool for the understanding of cellular level mechanism in the fields of biology and medical science. Recently, researchers have been studying the regulation of neuronal activity using plasmonic nanoparticles and light, and it has been reported that photothermal effects could lead to both excitation and inhibition of neuronal cells. So far, only a few photothermal transducers have been applied to modulate neural activity. In this paper, we synthesized biocompatible gold nanostars (AuNSs) which generate heat by absorbing near-infrared (NIR) light. And we used the AuNS to inhibit the activity of neurons through light stimulation. We have demonstrated that AuNS inhibits the neural activity by NIR laser in both chip-attached mode and cell-attached mode. We also confirmed the suppression of single neuron signal by using digital micromirror device (DMD) set up. This approach is possible to inhibit the neural firing by controlling the intensity of light, and overcome the disadvantages of conventional electrochemical stimulation methods. This method of NIR-mediated stimulating neurons using light sensitive AuNS will be a powerful tool for neuromodulation researches and neuroscience studies.</P>
정상적인 부모에서 산전초음파로 진단된 Holt-Oram 증후군 1 예
이용희,이정건,이정노,이숙환,최안나,지은경,권태희,조주연,정창조,계정웅 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.11
Holt-Oram Syndrome is an autosomal dominant disorder characterized by the association of upper-limb abnormalities and congenital heart disease. A woman with no family history of genetic disease underwent antenatal sonography at 27 weeks' menstrual age to screen for fetal anomalies. Ultrasonography revealed abnormalities in the upper limbs. The limb abnormalities included abscence of bilateral thumbs and radius: the left humus was short. Pregnancy termination was performed. The postnatal chromosomal analysis revealed a normal 46XX karyotype and the autopsy finding confirmed the Holt-Oram syndrome. We report a case of Holt-Oram Syndrome in fetus with unaffected parents with brief of the literatures.
Adiponectin Concentrations: A Genome-wide Association Study
Jee, Sun Ha,Sull, Jae Woong,Lee, Jong-Eun,Shin, Chol,Park, Jongkeun,Kimm, Heejin,Cho, Eun-Young,Shin, Eun-Soon,Yun, Ji Eun,Park, Ji Wan,Kim, Sang Yeun,Lee, Sun Ju,Jee, Eun Jung,Baik, Inkyung,Kao, Lind Elsevier 2010 American journal of human genetics Vol.87 No.4
<P>Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in <I>CDH13</I> on chromosome 16 (p = 1.69 × 10<SUP>−15</SUP> in the initial sample, p = 6.58 × 10<SUP>−39</SUP> in the second genome-wide sample, and p = 2.12 × 10<SUP>−32</SUP> in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10<SUP>−83</SUP>. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10<SUP>−58</SUP>) was even stronger in the third sample. A reporter assay that evaluated the effects of a <I>CDH13</I> promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in <I>CDH13</I> influence adiponectin levels in Korean adults.</P>