급성 림프구성 백혈병 환자에서 발생한 침습성 국균 심내막염 2예

신성철,백경란,정재홍,송봉근,김동희,전경만,채제욱,손준성,정숙인,오원섭,송재훈 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

국균은 호흡기를 통해 유입되며 심한 면역기능저하 환자에서 기회감염을 일으키는 진균이며 주로 혈관을 따라 폐를 침범하고 심장과 골침범은 매우 드문 것으로 알려져 있다. 저자들은 급성 림프구성 백혈병 환자에서 발생한 침습성 국균 심내막염을 2예을 경험하였다. 19세 남자환자로 동종 조혈모세포이식 후 발생한 고열과 요통의 원인으로 감염성 심내막염 진단하에 수술결과 국균에 의한 감염으로 확증되어 수술적 절제술과 liposomal amphotericin B로 치료하였으나 국균 심내막염의 재발과 국균 척추염의 악화, 뇌 출혈로 사망하였다. 23세 남자환자로 관해요법 후 발생한 고열과 요통의 원인으로 국균 심내막염과 국균 척추염 진단하에 수술적 절제술과 amphotericin B로 치료하여 1년 2개월 동안 국균 심내막염의 재발은 없었으나 지속적인 백혈병의 재발과 국균 척추염의 악화, 침습성 폐 국균증으로 사망하였다. Although Aspergillus endocarditis has rarely been reported, it can cause fatal complications in hematologic malignancy patients and allogeneic stem cell transplant recipients. We experienced two cases of aspergillus endocarditis developed in acute lymphoblastic leukemia patients. Case; A 19-year-old patient developed Aspergillus endocarditis after allogenic hemopoietic stem cell transplantation. He was treated with surgical intervention and liposomal amphotericin B. He died of recurred Aspergillus endocarditis and cerebral hemorrhage probably related with aspergillosis of central nervous system. Case 2; A 23-year-old patient developed invasive Aspergillus endocarditis after induction chemotherapy. Aspergillus endocarditis was successfully treated by surgical intervention and amphotericin B. He died of refractory neutropenic fever and sepsis after the third relapse of leukemia and repetitive chemotherapy. He probably had invasive pulmonary aspergillosis without evidence of endocarditis recurrence. Because the mortality of Aspergillus endocarditis is very high, early diagnosis and surgical intervention are very important for better outcome.

9-12%Cr강의 첨가원소 및 열처리에 따른 미세조직거동과 경도변화

주성욱,유정훈,신기삼,허성강,이재현,석진익,김병훈,김정태 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

9-12%Cr steel are getting increasing attention for expanded application as high temperature materials applicable for gas turbine compressors, steam turbine rotors, blade and casing. For efficient and extensive application of 9-12%Cr steel, the data in addition to the improvement of mechanical properties on the correlation of microstructural evolution and mechanical properties are inevitable and thus the investigation in this study is performed for the determination for the specimens heat-treated at 600, 650 and 700℃ for 1000, 3000 and 5000hrs. The microstructure of as-received specimen was tempered martensite, with a high dislocation density and secondary phases. Upon high temperature heat-treatment, the martensite lath got larger and dislocation density decreased resulting the reduction of the strength. In addition, sharp growth of secondary phases was observed in the specimen heat-treated at 700℃ for 5000hrs. A specimen aged at 600℃ and 650℃ Laves phase was observed. The hardness showed close relationship with the secondary phase particle and dislocation density.

Differences in the survival rates of older patients with colorectal cancers in 2003 and 2009

Je-Wook Shin,Byung Kwan Park,Min Jung Kim,Bun Kim,Byung Chang Kim,Sung Chan Park,Kyung Su Han,Dae Kyung Sohn,Jae Hwan Oh 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.4

Purpose: The aim of this study was to investigate survival in patients aged ≥70 years who underwent colorectal cancer surgery in 2003 and 2009. In addition, we aimed to identify the factors that could affect survival in these patients. Methods: In a cross-sectional study, a retrospective review of the data for 878 patients ho underwent colorectal cancer surgery with curative intent in the years 2003 and 2009 was performed. The primary outcome was the 5-year overall survival rate (5-OSR), and he clinicopathologic factors that could affect overall survival were analyzed. Results: The 5-OSR was 77.8% and 84.9% in 2003 and 2009, respectively (P = 0.013). Age, American Society of Anesthesiologists physical status classification, stage, type of surgery, and length of hospital stay possibly affected survival per the univariate and multivariate analyses. In patients aged ≥70 years, the 5-OSR in 2009 was 75.9%, which showed improvement compared to 53.7% in 2003 (P = 0.027). The stage, type of surgery, and hospital stay were the variables that possibly affected survival in patients aged ≥70 years per the univariate analysis, whereas the stage (III; hazard ratio [HR], 2.188; P = 0.005) and length of hospital stay (>12 days; HR, 2.307; P = 0.004), were the variables that showed statistical significance on the multivariate analysis. Conclusion: We found that early stage and shortening the length of hospital stay could affect survival in older patients with colorectal cancers. Because of limited evidence on the influence of shortening the length of hospital stay on survival in older patients, further investigations are warranted.

The impact of old age on surgical outcomes after pancreaticoduodenectomy for distal bile duct cancer

Je-Wook Shin,Keun Soo Ahn,Yong Hoon Kim,Koo Jeong Kang,Tae Jin Lim 한국간담췌외과학회 2011 한국간담췌외과학회지 Vol.15 No.4

Backgrounds/Aims: To compare surgical results and survival of two groups of patients, age ≥70 vs. age <70, who underwent pancreaticoduodenectomy and to identify the safety of this procedure for elderly patients for the treatment of distal common bile duct (CBD) cancer. Methods: Between January 2003 and December 2009, 55 patients who underwent pancreaticoduodenectomy for the treatment of distal CBD cancer at Keimyung University Dong San Medical Center were enrolled in our study. Results: Of 55 patients, 28 were male and 27 female. Nineteen were over 70 years old (older group) and 36 were below 70 years (younger group). The mean ages of the two groups of patients were 73.5 years and 60.5 years respectively. Although patients of the older group had significantly more comorbid diseases, perioperative results including operation time, amount of intraoperative bleeding, duration of postoperative hospital stay and postoperative complications were not significantly different. A higher level (more than 5 mg/dl) of preoperative initial bilirubin showed significant correlations with operative morbidity by univariate analysis, and age was not an independent risk factor of operative morbidity. Overall 5 year survival of older and younger groups were 45.9% and 39.5% respectively (p=0.671) and disease-free 5-year survival were 31.7% and 31.1%, respectively (p=0.942). Conclusions: Surgical outcomes of elderly patients were similar to those of younger patients, despite a higher incidence of comorbid disease. This results shows that pancreaticoduodenectomy can be applied safely to elderly patients. (Korean J Hepatobiliary Pancreat Surg 2011;15:248-253)

Differences in the survival rates of older patients with colorectal cancers in 2003 and 2009

Shin, Je-Wook,Park, Byung Kwan,Kim, Min Jung,Kim, Bun,Kim, Byung Chang,Park, Sung Chan,Han, Kyung Su,Sohn, Dae Kyung,Oh, Jae Hwan The Korean Surgical Society 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.4

<P><B>Purpose</B></P><P>The aim of this study was to investigate survival in patients aged ≥70 years who underwent colorectal cancer surgery in 2003 and 2009. In addition, we aimed to identify the factors that could affect survival in these patients.</P><P><B>Methods</B></P><P>In a cross-sectional study, a retrospective review of the data for 878 patients who underwent colorectal cancer surgery with curative intent in the years 2003 and 2009 was performed. The primary outcome was the 5-year overall survival rate (5-OSR), and the clinicopathologic factors that could affect overall survival were analyzed.</P><P><B>Results</B></P><P>The 5-OSR was 77.8% and 84.9% in 2003 and 2009, respectively (P = 0.013). Age, American Society of Anesthesiologists physical status classification, stage, type of surgery, and length of hospital stay possibly affected survival per the univariate and multivariate analyses. In patients aged ≥70 years, the 5-OSR in 2009 was 75.9%, which showed improvement compared to 53.7% in 2003 (P = 0.027). The stage, type of surgery, and hospital stay were the variables that possibly affected survival in patients aged ≥70 years per the univariate analysis, whereas the stage (III; hazard ratio [HR], 2.188; P = 0.005) and length of hospital stay (>12 days; HR, 2.307; P = 0.004), were the variables that showed statistical significance on the multivariate analysis.</P><P><B>Conclusion</B></P><P>We found that early stage and shortening the length of hospital stay could affect survival in older patients with colorectal cancers. Because of limited evidence on the influence of shortening the length of hospital stay on survival in older patients, further investigations are warranted.</P>

주의력결핍 과잉행동장애에서 파탄적 행동장애의 공존과 약물치료

강제욱(Je Wook Kang),박은진(Eun Jin Park),김성찬(Seong Chan Kim),신의진(Yee-Jin Shin),신윤미(Yun-Mi Shin),정재석(Jaesuk Jung),천근아(Keun-Ah Cheon),육기환(Ki-Hwan Yook) 대한소아청소년정신의학회 2012 소아청소년정신의학 Vol.23 No.S

Disruptive behavioral disorders [oppositional defiant disorder (ODD) and conduct disorder (CD)] are common comorbid disorders in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). ODD/CD may be comorbid up to 60% of children and adolescents with ADHD. Comorbid ODD and CD symptoms can have a significant impact on the course and prognosis o f patients with ADHD. Stimulant medications have shown effectiveness in treating both core ADHD symptoms and oppositional symptoms. Assessment and management of comorbid disruptive behavioral symptoms is an essential part in evaluation and treatment of ADHD patients. Further research is needed to investigate the efficacy and safety of various behavioral and medication regimens for ADHD, comorbid ODD and CD and to examine the relationships between ADHD, comorbid ODD and CD.

허밍 대수를 이용한 허밍 질의처리 시스템

신제용(Je-Yong Shin),한욱신(Wook-Shin Han),이종학(Jonghak Lee) 한국정보과학회 2009 정보과학회 컴퓨팅의 실제 논문지 Vol.15 No.8

허밍 질의는 사용자가 가사를 모를 때, 유용하고 직관적으로 사용할 수 있는 질의 방법이다. 허밍 질의 시스템은 사용자 멜로디를 입력으로 받고, 이 멜로디를 음악 데이터베이스의 모든 멜로디와 비교하며, 가장 유사한 k개의 멜로디를 반환한다. 본 논문에서는 허밍 질의 시스템을 위한 허밍 대수를 제안하고, 허밍 대수를 이용하여 실제 허밍 질의처리 시스템인 HummingBase를 설계하고 구현하였다. 기존 유사 검색 방법들을 분석함으로써 10개의 기본 연산자로 구성된 대수를 유도하였다. 제안한 허밍 대수는 허밍 질의 시스템이 확장이 가능하고 모듈화가 되게끔 구현하는데 사용될 수 있다. 본 논문에서는 두 가지 사례 연구를 통해, 제안한 허밍 대수를 이용하면 기존의 허밍 질의처리 시스템을 쉽고 편리하게 표현할 수 있음을 보인다. Query by humming is an effective and intuitive querying mechanism when a user wants to find a song without knowing lyrics. The query by humming system takes a user-hummed melody as input, compares it with melodies in a music database, and returns top-k similar melodies to the input. In this paper, we propose a novel algebra for query by humming, and design and implement a real query by humming system called HummingBase by exploiting the algebra. By analyzing existing similarity search techniques, we derive 10 core operators for the algebra. By using the well-defined algebra, we can easily implement such a system in a extensible and modular way. With two case studies, we show that the proposed algebra can easily represent the query processing processes of existing query-by-humming systems.

Modeling and Numerical Investigation of the Biomechanical Interaction for Human-Rifle System

Je-Wook Chae,Young-Shin Lee 대한기계학회 2004 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.18 No.12

This paper represents the description of a complex mathematical model of biomechanical interaction for human-rifle system during shooting. The model is developed by finite element method using bar elements. And three typical shooting positions, i.e. standing, kneeling and prone are used. Characteristics of interior/exterior ballistics and behaviors of human-rifle system are evaluated by this model, which takes into account the influence of environment, bullet, powder, barrel geometry parameters and anthropological parameters. The results of this study can be applied to anthropology, biomechanics, medical science, gait analysis, interior ballistics and exterior ballistics.<br/>

성숙한 흰쥐의 방광 및 근위부 요도 기능에 Nitric Oxide Synthase 억제제가 미치는 영향: 암수간의 차이에 대한 연구

김제욱,정희창,신현진,문기학,박동춘 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.9

지연성 방사선 뇌괴사 -1예 보고-

강신광,송준호,이규호,주인욱,지제근 대한병리학회 1988 Journal of Pathology and Translational Medicine Vol.22 No.3