인조 합성 테니스 바닥재의 지면 반력 분석

조승제,정미라,서국웅,박승범,윤양진,이훈식,강영택 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

Some authors suggest that certain types of surfaces are the origin of such injuries. A few years after the first medical concerns about surfaces were voiced, publications of biomechanical measurements apperared, describing accleration, force, and impact measurement on different types of surfaces. In many sport activities, surfaces can be under very high dynamic load. This was the reason for the development of various methods for impact simulation, like the development of various methods for impact simulation, like the artificial athlete. Furthermore, it is important to collect information about the hardness of new and already existing surfaces in sport arenas. The idea on which this measuring system is based Is as follows: The stiffness of the material can be computed from the kinematics measurd at touch down of a rigid body onto a material sample. The results show the following The result for the artifical surfaces(Synpave ace) is surprising. It is known that these surfaces are much harder than synpave rebound classic, synpave spring. This finding suggests that it may be possible that the subjective impression is used as one criterion in the selection of landing(or style) strategies. The number of subjects in this experiment is too small to make statistically significant conclusions. It is shown analytically that when an object a deformable surface, the acceleration it experiences is inversely propotional to its mass. In future, it need to stress that the interaction between shoe and surface is important, and this aspect has now become well accepted. Considering biomechanical aspect in player's injury, it request Korean Standards for synthetic playing surfaces in sport like ASTM(America Society for Testing & Materials) standards of America, DIN 18035 standards of Germany, BSI standards of U.K.

발열을 동반한 호중구감소증에서 Cefepime 단독투여와 Ceftazidime 및 Tobramycin 병합투여의 효능비교

정현욱,채제욱,강미라,양정채,문치숙,기현균,장현하,오원섭,김기현,백경란,이남용,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내에서 발열을 동반한 호중구감소증이 있는 악성 종양환자에게 경험적 항생제로 베타락탐계 항생제와 아미노배당체의 병합요법의 사용이 일반적이다. Cefepime은 광범위 항균 작용을 가지고 있어, 그람 음성균 뿐만 아니라 그람 양성균에 대해서도 우수한 효과를 나타낸다. 재료 및 방법: 발열을 동반한 호중구감소증이 있는 악성 종양환자를 대상으로 무작위, 공개, 비교 연구를 시행하였다. 대상 환자를 무작위로 cefepime 단독요법군과 ceftazidime 및 tobramycin 병합요법군으로 나누어 투여하고 각각의 임상적 효능과 안전성을 비교하였다. 구강및 인후 점막염이 있는 환자에서 분리된 녹색 연쇄알 구균에 대한 항생제 내성 정도를 조사하였다. 결과 : 대상환자 89명 중 CA 투여군이 48예(53.9%), CT 투여군이 41예(46.1%)이었다. 발열의 유형별로 MDI는 18예(20.2%), CDI는 9예(10.1%), UF는 62예(69.7%)로 두 군 간에 차이가 없었다. CA 투여군과 CT 투여군의 임상적 호전률은 시험약 투여 후 2-4일째 각각 91.7%, 85.4% (P=0.31), 치료 종료 시 각각 91.7%, 100% (P=0.15)로 두 군간에 유의한 차이가 없었다. 치료 종료 시 CA 투여군과 CT 투여군의 세균학적 소실률은 모두 100%로 두 군간의 유의한 차이가 없었다(P=0.78). 점막염이 있는 환자로부터 녹색 연쇄알 구균이 분리된 경우는 25예(28.1%)이었으며, 분리된 녹색 연쇄알 구균은 penicillin, ceftriaxone, cefepime, vancomycin에 모두 감수성을 보였다. 약제 관련 이상 반응의 발생 빈도도 두 군간에 유의한 차이가 없었다. 결론 : 발열을 동반한 호중구감소증이 있는 악성 종양환자의 경험적 항생제로서 cefepime 단독요법은 ceftazidime 및 아미노배당체의 병합요법만큼 효과적이고 안전하였다. Background : Broad-spectrum antibiotic therapy has been recommended as an empirical regimen in cancer patients with febrile neutropenia. Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and gram-negative bacilli. Materials and Methods : To compare the efficacy and safety of cefepime alone with ceftazidime plus tobramycin as empirical regimen for adult cancer patients with febrile neutropenia, a randomized, open label, comparative trial was performed. If the patient showed clinical improvent 72 hours, antibiotic could be changed to oral ciprofloxacin. Clinical and microbiological responses were determined at 72 hours and at the end of therapy. To investigate the antimicrobial resistance of viridans streptococci, swab cultures were obtained from throat in all enrolled patients and antimicrobial susceptibility tests were performed by using microdilution method according to the NCCLS. Results : A total of 89 patients were enrolled. Forty-eight patients received cefepime alone (CA), and 41 patients received ceftazidime plus tobramycin (CT). Demographic and baseline clinical characteristics were similar in both groups (P>0.05). The initial clinical success rate at day 2-4 in group CA (91.7%) was similar with that in CT group (85.4%) (P=0.31). At the end of therapy, the final clinical success rate in CA group (91.7%) was similar to that in CT group (100%) (P=0.15). In 18 patients, with microbiologically defined infections, the eradication rate was 100% in both groups. Adverse events including liver dysfunction (21.3%) and renal dysfunction (2.2%), were similar in both groups (P=0.87). Viridans streptococci were isolated from the throat cultures in 25 cases, and all of these strains were susceptible to penicillin (MIC_(90) 0.12 ㎍/mL), cefepime (1 ㎍/mL), and vancomycin (0.12 ㎍/mL). Conclusion : Efficacy and safety of cefepime monotherapy was comparable to the combination of ceftazidime and tobramycin. It could be used as an alternative empirical regimen for treating cancer patients with febrile neutropenia.

급성기 주요우울장애 환자에서 Natural Killer T 세포

박이진,이제훈,이권행,한상익,전양환 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3

Objectives : To evaluate an association between depression and altered immunity, we examined peripheral T lymphocyte or natural killer (NK) cell measures plasma ACTH and cortisol using the flow cytometry in acute and unmedicated patients with major depressive disorder (MDD). Methods : Forty-two patients with MDD from the outpatient clinic and forty normal controls from the hospital staff were recruited. We applied Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) for depressed subjects. Peripheral T lymphocyte or NK cell measures (CD3, CD4, CD8, or CD56) and plasma hormones (ACTH and cortisol) were obtained from all subjects. Results : There were no statistical differences in CD3, CD4, CD8, or CD56 between the two subjects. The number of CD56 cells negatively correlated with HAM-D scores (r= -0.42, P<0.01), but did not correlate with HAM-A scores in patients with MDD. The number of CD56 cells showed strong negative correlation with CD4/CD8 (r= -0.47, P<0.01) in the control group, but not in the depressed group. Patients with MDD had higher cortisol level than controls within the normal range. Conclusion : The trait of immunological imbalance and HPA axis abnormality were shown in patients with MDD. Especially, the severity of depression, but not the anxiety, could be reflected as decreased number of CD56 (NK T) cells in acute and Unmedicated state.

The Effects of Cyclophosphamide on Apoptosis in Murine Lymphoma

Yang, Je-Hoon,Bae, Hyung-Joon,Seo, Deuk-Rok,Koh, Phil-Ok,Kwak, Soo-Dong 대한의생명과학회 2001 Journal of biomedical laboratory sciences Vol.7 No.4

Whereas apoptosis is a critical mode of cell deletion in normal organism development, apoptotic cells are also observed in tumor therapy. We therefore investigated the expression of apoptotic cells induced as a function of time and dose in murine A-20 lymphoma treated with cyclophosphamide in vivo, by H&E and TUNEL method. The percent of apoptotic cells were scored from tumor section using TUNEL method. The expression of apoptotic positive cell was determined over a 10-day period following treatment of the mice with 200 mg/kg. Apoptosis increased further with time, reaching a peak value between 12~24 hr (scored 6.7$\pm$1.0%~6.1$\pm$0.7%), and then slowly declined to background levels by 10 days after treatment. The dependence of induction of apoptosis on the dose of cyctophosphamide was determined by treatment with 50, 100, or 200 mg/kg at 12 hr after treatment. Apoptosis was dose dependent in that as the dose was increased the percentage of apoptosis increased. However, the increase in apoptosis at the lower dose used (50 mg/kg) was higher on a per unit dose basis than that at the higher dose used (200 mg/kg). This result show that the alkylating agent cyclophosphamide strongly induces apoptosis in murine lymphoma.

제Ⅱa형 다발성 내분비선종증(MEN type Ⅱa) 3예

박제훈(Je Hoon Park),이해경(Hae Kyung Lee),남석진(Seok Jin Nam),정재훈(Jae Hoon Jung),이명식(Myung Shick Lee),양정현(Jung-Hyun Yang) 대한외과학회 2000 Annals of Surgical Treatment and Research Vol.59 No.1

Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation Targeting Restitution Parameter-Guided Catheter Ablation: CUVIA-REGAB Prospective Randomized Study

Young Choi,Byounghyun Lim,Song Yi Yang,So-Hyun Yang,Oh-Seok Kwon,Daehoon Kim,Yun Gi Kim,Je-Wook Park,유희태,김태훈,Pil-Sung Yang,엄재선,Jamin Shim,Sung Hwan Kim,Jung-Hoon Sung,Jong-il Choi,정보영,이문형,Young-Hoon K 대한심장학회 2022 Korean Circulation Journal Vol.52 No.9

Background and Objectives: We investigated whether extra-pulmonary vein (PV) ablation targeting a high maximal slope of the action potential duration restitution curve (Smax) improves the rhythm outcome of persistent atrial fibrillation (PeAF) ablation. Methods: In this open-label, multi-center, randomized, and controlled trial, 178 PeAF patients were randomized with 1:1 ratio to computational modeling-guided virtual Smax ablation (V-Smax) or empirical ablation (E-ABL) groups. Smax maps were generated by computational modeling based on atrial substrate maps acquired during clinical procedures in sinus rhythm. Smax maps were generated during the clinical PV isolation (PVI). The V-Smax group underwent an additional extra-PV ablation after PVI targeting the virtual high Smax sites. Results: After a mean follow-up period of 12.3±5.2 months, the clinical recurrence rates (25.6% vs. 23.9% in the V-Smax and the E-ABL group, p=0.880) or recurrence appearing as atrial tachycardia (11.1% vs. 5.7%, p=0.169) did not differ between the 2 groups. The post-ablation cardioversion rate was higher in the V-Smax group than E-ABL group (14.4% vs. 5.7%, p=0.027). Among antiarrhythmic drug-free patients (n=129), the AF freedom rate was 78.7% in the V-Smax group and 80.9% in the E-ABL group (p=0.776). The total procedure time was longer in the V-Smax group (p=0.008), but no significant difference was found in the major complication rates (p=0.497) between the groups. Conclusions: Unlike a dominant frequency ablation, the computational modeling-guided V-Smax ablation did not improve the rhythm outcome of the PeAF ablation and had a longer procedure time.

Daclatasvir plus Asunaprevir for Chronic Hepatitis C Virus Genotype 1b Infection: Real Life Data in Korea

( Yang Jae Yoo ),( Ji Hoon Kim ),( Young-sun Lee ),( Jihye Je ),( Sang Jun Suh ),( Young Kul Jung ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: We conducted an interim analysis of real life data in Korean patients with genotype 1b HCV infection who were treated with daclatasvir plus asunaprevir. Methods: One hundred eight patients with chronic HCV genotype 1b infection who were treated with daclatasvir plus asunaprevir in multicenters from July, 2015 were analyzed. HCV RNA at baseline, 4, 12, 24 weeks were assayed with laboratory tests. Resistant associated variant (RAV) were evaluated at baseline. Lower limit of HCV RNA quantification was 20 IU/ml. Significant adverse events were defined as more than grade 3 according to CTCAE v4.0. Results: Mean age was 60 years, 76 patients were treatment naive (67%), and thirty patients had liver cirrhosis. RAV was observed in 3 patients (all Y93 positive). Median treatment duration was 16 weeks. 29 patients completed 24 week therapy (1 virologic breakthrough (VT)), while 9 patients stopped during therapy (3 VT, 2 adverse events, 4 economic burden), and 70 patients were on treatment. HCV RNA was not detected in 99/101 patients at 4 weeks (98.0%), 87/90 patients at 12 weeks (96.7%), and 31/34 patients at 24 weeks (91.2%). All four patients with VT had undetectable HCV RNA at 4 weeks. Two patients experienced VT at 12 weeks and other two at 16 and 24 weeks. All three patients with RAV completed 24 week therapy, and HCV RNA were not detected throughout 4,12, 24 weeks. Adverse event was observed in 39 patients (36%), including 2 significant adverse events (1 aminotransferase > 5 times UNL, 1 myalgia). SVR rate will be analyzed after further follow up. Conclusions: In our patients, daclatasvir plus asunaprevir showed comparable efficacy and safety with previous clinical studies. More data in large population are needed including SVR results

Study of the Efficiency Droop Phenomena in GaN based LEDs with Different Substrate

Yang-Seok Yoo,Song-Mei Li,Je-Hyung Kim,Su-Hyun Gong,Jong-Ho Na,Yong-Hoon Cho 한국진공학회 2012 한국진공학회 학술발표회초록집 Vol.2012 No.8

Biosynthesis of poly(2‐hydroxyisovalerate‐co‐lactate) by metabolically engineered <i>Escherichia coli</i>

Yang, Jung Eun,Kim, Je Woong,Oh, Young Hoon,Choi, So Young,Lee, Hyuk,Park, A‐,Reum,Shin, Jihoon,Park, Si Jae,Lee, Sang Yup WILEY 2016 BIOTECHNOLOGY JOURNAL Vol.11 No.12

<P><B>Abstract</B></P><P>Polyhydroxyalkanoates (PHAs) containing 2‐hydroxyacids such as lactate (LA) and 2‐hydroxybutyrate (2HB) have recently been produced by metabolically engineered microorganisms. Here, we further expanded 2‐hydroxyacid monomer spectrum of PHAs by engineering <I>Escherichia coli</I> to produce PHAs containing 2‐hydroxyisovalerate (2HIV). To generate 2HIV in vivo, feedback resistant <I>ilvBN</I>mut genes encoding acetohydroxyacid synthase and <I>ilvCD</I> genes encoding ketol‐acid reductoisomerase and dihydroxyacid dehydratase, respectively, and <I>panE</I> gene encoding <SMALL>d</SMALL>‐2‐hydroxyacid dehydrogenase are overexpressed. Also, <I>pct540</I> gene encoding evolved propionyl‐CoA transferase and <I>phaC1437</I> gene encoding evolved PHA synthase are overexpressed along with <I>ilvBN</I>mut, <I>ilvCD</I>, and <I>panE</I> genes in <I>E. coli</I> strain for in vivo synthesis of 2HIV containing PHAs. <I>E. coli</I> strain expressing all of these genes can produce poly(13.2 mol% 2HIV‐<I>co</I>‐7.5 mol% 2HB‐<I>co</I>‐42.5 mol% 3HB‐<I>co</I>‐36.8 mol% LA) when it is cultured in a chemically defined medium containing 20 g/L of glucose and 2 g/L of sodium 3‐hydroxybutyrate (3HB). To produce PHA containing only 2HIV and LA monomers, <I>poxB</I>, <I>pflB</I>, <I>adhE</I> and <I>frdB</I> genes encoding enzymes involved in competing pathways for pyruvate are deleted so that cells can generate more 2HIV and LA. When this engineered <I>E. coli</I> strain expressing <I>ilvBN</I>mut, <I>ilvCD</I>, <I>panE</I>, <I>pct540</I> and <I>phaC1437</I> genes is cultured in the medium containing 20 g/L of glucose and 2 mM <SMALL>l</SMALL>‐isoleucine, which can inhibit <SMALL>l</SMALL>‐threonine dehydratase responsible for in vivo 2HB generation, poly(20 mol% 2HIV‐<I>co</I>‐80 mol% LA) can be produced to the polymer content of 9.6% w/w. These results suggest that novel PHAs containing 2HIV can be produced by engineering branched‐chain amino acid metabolism.</P>

Secondary neurulation of human embryos: morphological changes and the expression of neuronal antigens

Yang, Hee-Jin,Lee, Do-Hun,Lee, Yun-Jin,Chi, Je G.,Lee, Ji Yeoun,Phi, Ji Hoon,Kim, Seung-Ki,Cho, Byung-Kyu,Wang, Kyu-Chang Springer-Verlag 2014 Child's nervous system Vol.30 No.1