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Jaehyun Kim(김제현),Taehyoung Kim(김태형),Youngsu Park(박영수),Kyung Sun Ham(함경선) 한국컴퓨터정보학회 2019 韓國컴퓨터情報學會論文誌 Vol.24 No.3
In this study, we introduce a model that satisfies energy efficiency and economical efficiency by introducing and demonstrating cogeneration generators in industrial complexes using various actual data collected at the site. The proposed model is composed of three scenarios, ie, full - time operation, scenario operated according to demand, and a fusion type. In this study, the power generation profit and surplus thermal energy are measured according to the operation of the generator, and the thermal energy is traded according to the demand of the customer to calculate the profit and loss including the heat and evaluate the economic efficiency. As a result of the study, it is relatively profitable to reduce the generation of the generator under the condition that the electricity rate is low and the gas rate is high, while the basic charge is not increased. On the contrary, if the electricity rate is high and the gas rate is low, The more you start up, the more profit you can see. These results show that even a cogeneration power plant with a low economic efficiency due to a low "spark spread" has sufficient economic value if it can sell more than a certain amount of heat energy from a nearby customer and adjust the applied power through peak management.
Taesu Ham,Hyeungsik Lee,Jaehyun Lee,Saekwang Ku 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3
The changes on the regional distribution and frequency of chromogranin-immunoreactive (CG-IR) cells in gastrointestinal (GI) tract of BALB/c mouse after implantation of murine carcinoma cells, colon-26 were studied by immunohistochemical methods. The experimental animals were divided into two groups; non¬implanted (Sham) and colon-26 (CT-26) cell implanted (Colon-26) groups. Samples were collected from each part of GI tract (fundus, pylorus, duodenum, jejunum, ileum, cecum, colon and rectum) at 28th days after subcutaneously implantation of CT-26 cells (1×10⁵ cell/mouse). CG-IR cells were distributed throughout the whole GI tract except for the rectum in Sham with various frequencies. However, they were restricted to the fundus, pylorus, duodenum and jejunum of Colon-26. A significantly (p<0.01) decrease of CG-IR cells was detected in Colon-26 compared to that of Sham in both fundus and pylorus, but similar cell frequencies were detected in the duodenum and jejunum, respectively. In conclusion, the CG is generally known that it is one of the endocrine markers. Therefore, the abnormality in density of GI endocrine cells detected in the mouse implanted with CT-26 cells may contribute to the development of GI symptoms such as anorexia and indigestion, frequently encountered in patients with cancer.
Kim Min-Kyung,Lee Kyung-Shin,Ham Sin Young,Choi Youn Young,Lee Eunyoung,Lee Seungjae,Lee Bora,Jeon Jaehyun,Chin BumSik,Kim Yeonjae,Kim Gayeon,Jang Hee-Chang,Choi Jae-Phil,Park Sang-Won 대한의학회 2023 Journal of Korean medical science Vol.38 No.35
Background: Nirmatrelvir-ritonavir is highly effective in preventing severe coronavirus disease 2019 (COVID-19) in high-risk patients with mild-to-moderate severity. However, real-world performance data are limited, and the drug is not so acceptable to the COVID-19 patients at high risk who need it in Korea. Methods: To evaluate the effectiveness of nirmatrelvir-ritonavir, we conducted a propensity score-matched retrospective cohort study on patients with mild-to-moderate COVID-19 at high risk for a severe disease who were hospitalized at four hospitals in South Korea from February 2022 to April 2022. A total of 236 patients in the treatment group (administered nirmatrelvir-ritonavir) and 236 in the matched control group (supportive care only) were analyzed for the primary outcome, i.e., the time to oxygen support-free survival. The secondary outcome was a composite result of disease progression. The reason for not prescribing nirmatrelvir-ritonavir to the indicated patients was also investigated. Results: The treatment group showed significantly longer oxygen support-free survival than the matched control group (adjusted hazard ratio [aHR], 0.07; 95% confidence interval [CI], 0.01–0.31; P < 0.001). Multivariate Cox regression analysis showed that age (aHR, 1.03; 95% CI, 1.00–1.07), National Early Warning Score-2 at admission (aHR, 1.36; 95% CI, 1.08–1.71), nirmatrelvir-ritonavir treatment, female sex (aHR, 0.37; 95% CI, 0.15–0.88), and time from symptom onset to admission (aHR, 0.67; 95% CI, 0.48–0.95) were significantly associated with oxygen therapy. However, none of the factors were related to the composite outcome. In the unmatched control group, 19.9% of 376 patients had documented explanations for nirmatrelvirritonavir non-prescription, and 44.0% of these were due to contraindication criteria. In the treatment group, 10.9% of patients discontinued the medication primarily because of adverse events (71.4%), with gastrointestinal symptoms being the most common (50.0%). Conclusion: Nirmatrelvir-ritonavir treatment significantly reduced oxygen therapy requirements in high-risk patients with COVID-19 during the omicron variant surge in South Korea. Physicians are encouraged to consider the active use of nirmatrelvir-ritonavir and to be watchful for gastrointestinal symptoms during medication.
A software tool for integrated risk assessment of spent fuel transportation and storage
Mirae Yun,Robby Christian,김보경,Belal Almomani,Jaehyun Ham,이상훈,강현국 한국원자력학회 2017 Nuclear Engineering and Technology Vol.49 No.4
When temporary spent fuel storage pools at nuclear power plants reach their capacity limit, the spentfuel must be moved to an alternative storage facility. However, radioactive materials must be handledand stored carefully to avoid severe consequences to the environment. In this study, the risks of threepotential accident scenarios (i.e., maritime transportation, an aircraft crashing into an interim storagefacility, and on-site transportation) associated with the spent fuel transportation process were analyzedusing a probabilistic approach. For each scenario, the probabilities and the consequences were calculatedseparately to assess the risks: the probabilities were calculated using existing data and statistical models,and the consequences were calculated using computation models. Risk assessment software wasdeveloped to conveniently integrate the three scenarios. The risks were analyzed using the developedsoftware according to the shipment route, building characteristics, and spent fuel handling environment. As a result of the risk analysis with varying accident conditions, transportation and storage strategieswith relatively low risk were developed for regulators and licensees. The focus of this study was the riskassessment methodology; however, the applied model and input data have some uncertainties. Furtherresearch to reduce these uncertainties will improve the accuracy of this model.