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瀉白散의 肥滿細胞 嫫介性 炎症性 細胞活性物質 分泌 抑制 效果
이병주,신조영,이시형,홍재의,박병민,이승언 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1
Ocjective : Sabaeksan has been used for the purpose of prevention and treatment of bronchial asthma and allergic asthma in korea. Methods : To investigate the biological effect of Sabaeksan, the author examined cytotoxicity and inflammatory cytokines secretion with human leukemic mast cell line, HMC-1. HMC-1 was stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. Sabaeksan by itself had no effect on viability of HMC-1. Result : The effects of Sabaeksan on the secretion of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 from HMC-1 were evaluated with enzyme-linked immunosorbent assay. Sabaeksan (1 mg/㎖) inhibited PMA plus A23187-stimulated TNF-α and IL-6 secretion, by 43.86 ± 5.26%, 56.39 ± 3.65%, respectively. Sabaeksan also inhibited the NF-κB (p50/p65) expression. Conclusion : Taken together, these results suggest that Sabaeksan inhibit the production of inflammatory cytokines in HMC-1 cells through blockade of NF-κB activation.
김종인,신영기,김태형,오재학 대구대학교 산업기술연구소 2009 産業技術硏究 Vol.20 No.1
In this paper, a typical drilled shaft to cylindrical and step-tapered pile, pulse pile are produced by the experiment and then captured the ground, forming Jumunjin standard sand model tests loading at sat joy bearing capacity analysis, tapered plus pulse pile was suggestions. Soft ground and the ground around the sandy soil casting of pile to skin friction research tapered pile adjusting the angle and shape for a wide range of variation of pulse pile further study is underway, and the most graft-type model is not presented. Therefore, in this study, the test bearing capacity of existing drilled shaft current analysis by the comparative analysis, as well as skin friction through mutual tapered plus pulse pile bering capacity and allow the unit to analyze and compare the suggestions model would be effective.
The micro-current stimulation system for cellular inflammatory modulation study
Jae-Hee Shin(신재희),Min-Ho Hwang(황민호),Hyo-Geun Nam(남효근),Hyeong-Guk Son(손형국),Seung-Min Baek(백승민),Chang-Min Yoo(유창민),Jeong-Hun Park(박정훈),Jin-Su Jeong(정진수),Jae-Won Lee(이재원),Hyuk Choi(최혁) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6
Electric stimulation (ES) is known to affect cell migration, proliferation, inflammation regulation, and physiological activities. However, there exist strong attenuation of electric field (EF) when conventional ES pass through tissue, and need of direct contact of target tissue and electrode has been magnified. In order to overcome these limitations, we have designed and fabricated precise ES device (MCS system), which can support with precise current density and adjustable frequency. Then we applied to degenerative disc disease (DDD) model in vitro. We showed that inflamed annulus fibrosus (AF) cells, which mimicked DDD model, express inflamatory cytokines such as interleukin (IL)-6, and –8 as contrasted with normal AF cells. But inflamed AF cells stimulated with ES and showed decrease in inflammatory cytokines. These results suggests that ES can be a therapeutic tool for inflammatory modulation and MCS is expected to be applied in many cell types and foster diverse applications of ES study fields.
신재욱 ( Jae Uk Shin ),정진태 ( Jin Tae Jung ),유성수 ( Sung Soo You ),권중구 ( Joong Goo Kwon ),김은영 ( Eun Young Kim ),이창형 ( Chang Hyeong Lee ),김호각 ( Ho Gak Kim ),박재복 ( Jae Bok Park ) 대한소화기학회 2006 대한소화기학회지 Vol.48 No.5
Primary adenosquamous carcinoma of the liver is generally considered as an extremely rare subtype of cholangiocarcinoma. It has been reported mostly in a form of case studies. As far as we know, there was only one case report on tumor related with biliary fistula. Recently, we experienced a case of primary adenosquamous carcinoma of liver with a formation of tumor-colonic fistula. A 54-year-old man was transferred to our hospital due to liver mass detected by abdominal ultrasonogram. Dynamic computed tomogram of liver showed a large irregular hypodense mass without rim enhancement in right lobe of liver and also suggested a fistula formation between the tumor and hepatic flexure of right colon. Colonoscopic examination showed a large colonic wall defect in hepatic flexure and a friable, nodular mucosa around the defected colonic wall. Extended right lobectomy and right hemicolectomy were done. Microscopically, the tumor was composed of squamous cell carcinoma mainly with foci of the adenocarcinoma component. (Korean J Gastroenterol 2006;48:360-364)