두 가족의 가족성 모야모야병 환자 4례

구자성,노재규,박성호,이한보,이용석,윤창호,송치성,송재우 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

ERK1/2 activation in quercetin-treated BEAS-2B cell plays a role in Nrf2-driven HO-1 expression

이윤진,Jun-Hwan Song,Myung-Ho Oh,Yong-Jin Lee,김용배,Jae-Hyuk Im,이상한 대한독성 유전단백체 학회 2011 Molecular & cellular toxicology Vol.7 No.4

Quercetin, a member of the flavonoids,has been heralded as chemopreventive agent, generally because of its free radical-scavenging and antiproliferative activities. In this process, NF-E2-related factor-2 (Nrf2) plays a role in protecting cells from oxidative damage; however, the exact mechanisms in which bronchial epithelial cells respond to quercetin by activating Nrf2 are not fully understood. Here, we report the role of extracellular signal-regulated kinase (ERK) activation in response to quercetin. Quercetin treatment decreased the viability of human bronchial epithelial BEAS-2B cells in a dose- and time-dependent manner. ERK1/2 was activated within 10 min of quercetin addition and then remained increased above control level throughout 48 h, whereas AKT phosphorylation was suppressed from the first 1 h of quercetin treatment. Inhibition of Erk1/2 phosphorylation attenuated quercetin-induced loss of cell viability. Nrf2levels in both nuclear and whole cell lysates increased after quercetin treatment and was accompanied by the increase of heme oxygenase-1 (HO-1) protein level,indicating that increased HO-1 expression is Nrf2-mediated. Activation of the Nrf2/HO-1 system after quercetin treatment was suppressed by the pretreatment with MEK inhibitor, PD98059. Also, silencing Nrf2 with siRNA decreased cell viability and augmented cytotoxic effect of anticancer drug LBH589. Overall, our results indicate that quercetin induces the up-regulation of Nrf2-mediated HO-1 expression, at least in part, via MEK/ERK1/2 signaling, as an adaptive mechanism which may provide advantages for cell proliferation and enhance survival despite endogenous and/or exogenous oxidative insults.

Morin exerts cytoprotective effects against oxidative stress in C2C12 myoblasts via the upregulation of Nrf2-dependent HO-1 expression and the activation of the ERK pathway

Lee, Moon Hee,Han, Min Ho,Lee, Dae-Sung,Park, Cheol,Hong, Su-Hyun,Kim, Gi-Young,Hong, Sang Hoon,Song, Kyoung Seob,Choi, Il-Whan,Cha, Hee-Jae,Choi, Yung Hyun UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.39 No.2

<P>In the present study, we investigated the cytoprotective efficacy of morin, a natural flavonoid, against oxidative stress and elucidated the underlying mechanisms in C2C12 myoblasts. Our results indicated that morin treatment prior to hydrogen peroxide (H2O2) exposure significantly increased cell viability and prevented the generation of reactive oxygen species. H2O2-induced comet-like DNA formation and gamma H2AX phosphorylation were also markedly suppressed by morin with a parallel inhibition of apoptosis in C2C12 myoblasts, suggesting that morin prevented H2O2-induced cellular DNA damage. Furthermore, morin markedly enhanced the expression of heme oxygenase-1 (HO-1) associated with the induction and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the inhibition of Kelch-like ECH-associated protein 1 (Keapl) expression. Notably, these events were eliminated by transient transfection with Nrf2-specific small interfering RNA. Additional experiments demonstrated that the activation of the Nrf2/HO-1 pathway by morin was mediated by the extracellular signal-regulated kinase (ERK) signaling cascade. This phenomenon was confirmed with suppressed Nrf2 phosphorylation and consequently diminished HO-1 expression in cells treated with a pharmacological inhibitor of ERK. Collectively, these results demonstrated that morin augments the cellular antioxidant defense capacity through the activation of Nrf2/HO-1 signaling, which involves the activation of the ERK pathway, thereby protecting C2C12 myoblasts from H2O2,-induced oxidative cytotoxicity.</P>

시계열을 활용한 제주지역 관광객 수요 예측 : 예측모델간 비교와 유치목표치 설정

송재호,허향진 제주대학교 관광산업연구소 2001 産經論集 Vol.15 No.1

유한요서법을 이용한 하중분배계수에 관한 연구

송재호,장일영,한상묵 金烏工科大學校 産業技術開發硏究院 1999 産業技術開發硏究 Vol.15 No.-

AASHTO specification has been found to be approximate value because these methods are based on equivalent orthogonal plate theory and semicontinuum theory. This study compared the results of field tests to confirm validity of the proposed formulas which is developed rational finite element model and carried out finite element analysis and statistic techniques. Parametric studies of load distribution on box-girder bridges are performed. The parameters affecting load distribution factors include girder spacing, span length, bridge width, and number of girders. Results of proposed formula are compared with those of AASHTO specification, AASHTO-LRFD specification.

치과기공사의 성격 및 직무 부합도에 관한 연구

송재상, 정인호 김천대학교 2006 김천대학교 논문집 Vol.27 No.-

This study was designed to examine the fit between an individual and his similar personalities were defined as person-person fit (P-P fit), and one s cur-leader's personality and one's current job features. The individual and leader's rent job features and his ideal job features were defined as person-job fit (P-J fit). This study also examined the difference of P-P fit and P-J fit on person's employee engagement, self-esteem, job satisfaction. The analysis of variance (ANOVA) was used to examine the difference between P-P fit group. And t-test was used to examine the difference between P-J fit group. This result implies that when one's personality was respected, one adjusts well to his work environment and as one gets ideal work, he engage more to improve his outcome. Finally, some suggestions for the increase of the level of job satisfaction of den-tal technicians are introduced and discussed.

열처리에 따른 Cd₁-xZnxS/In 박막의 광학적 및 전기적 특성 분석

송우창,이경호,심상흥,이상교,심재선,박종국 三陟大學校 2002 論文集 Vol.35 No.-

In this thesis, effects of the thickness of indium films and the annealing temperature on optical and electrical properties of chemically deposited CdZnS films for the efficiency of the Cd1-xZnxS/CdTesolar cells were investigated. To improve the electrical conductivity of Cd1-xZnxs films, thin indium films(10-4Onm thickness)were evaporated on the suface of Cd1-rZnxs films. Experimental parameters such as indium film thickness, Zn mole fraction, and the annealing temperature in terms of structural and electrical properties of Cd1-xZnxs films were investigated. The diffusion process was carried out by heating the sample in air at 150-550℃ for 20 minute As the indium film thickness is increased, the resistivity decreases and the lowest value(0.3 O -cm)is obtained for Cd1-xZnxs films annealed at 450℃ with 40nm of the thickness.

觀光計劃과 環境에 관한 考察 : 人間-觀光志向 戰略的 觀光計劃의 틀 The Framewwork of Human-Environment Oriented Tourism Planning

송재호 서강전문대학 1994 論文集 Vol.13 No.-

Environment should be protected both for tourism and from tourism. Careful tourism planning is essential to the preservatiom of environment. The relation of tourism planning to environment is considerably deep and broad. Tourism planning So long as tourism planning is defined as the process which realizes the balance of tourism demand & supply by way of linking the available resources with the potential tourist market within the limits of environmental conservation, its goals can be summarized as the optimalization of the interaction between human(tourists & residents) and environment(phisical & socio-cultural) through the rational distribution of resources. Interaction between tourism and environment - 1) environmental resources provide a critica production) factor for the oroduction of the tourist product, 2) tourism produces a variety of unwanted byproducts, maninly negative, which may modify the environment - should be emphasized and reflected on the tourism planning process. This study began so as to research a new tourism planning method which puts an emphasis on human/environmental interaction. This new tourism planning model is named and conceptualized as the human-environment oriented stratrgic tourism planning, and then its reference standards, its basic directions, and its processing framework are discussed. The contents of this article are as follows Ⅰ. For the description of discussion Ⅱ. Tourism and environment Ⅲ. Previous environment-oriented approaches to tourism planning Ⅳ. Human-environment oriented strategic tourism planning model building Ⅴ. Discussion

전자상거래에서의 번들링 상품으로서의 택배서비스에 관한 분석

송재도,천세학,주지호,김재철 한국경영과학회 2004 經營 科學 Vol.21 No.3

We discuss that the proliferation of new types of retailers such as Internet shopping mails, home shopping systems, which use telecommunication media as means of providing information of products, makes delivery service generally available. Then, we show that the delivery service can be used strategically for profit maximization by intentionally homogenizing consumers and, furthermore, social welfare generally increases by this delivery service unless the cost of delivery service is higher than that of ail consumer groups.

補中益氣湯 투여가 장거리 달리기 선수의 에너지 및 전해질 대사에 미치는 영향 : changes in the energy and electrolyte metabolism among long distance runners

송순기,금동호,오재근,이명종 동국대학교 한의학연구소 1998 東國韓醫學硏究所論文集 Vol.7 No.1

스포츠 과학 분야에서는 운동 선수들의 경기력 향상과 운동 피로의 신속한 회복을 도모하기 위하여 한약을 복용하고 그 효과와 유의성에 대하여 연구가 활발히 이루어지고 있다. 격심한 운동을 수행할 때 나타나는 Glucose 등 에너지원의 고갈, Lactate 등 대사 산물의 축적, 전해질의 불균형 등의 여러 제반 증상이 氣虛로 인하여 나타나는 전신의 증후와 유사하다고 생각하여 補中益氣湯을 투여한 후 인체의 대사 변화를 관찰함으로서 운동수행능력에 미치는 영향과 유의성을 평가하고자 하였다. 본 연구는 장거리 달리기 선수를 대상으로 2주간의 補中益氣湯의 투여가 에너지 대사 및 전해질대사에 미치는 영향을 규명하기 위하여 최대심박수의 70% 강도의 운동을 실시한 후 운동전 안정시, 운동 직후, 휴식 후 10분, 휴식 후 30분, 휴식 후 1시간으로 나누어 혈액검사를 하였을 때 나타나는 각종 변인의 반응 양상을 비교 분석하여 유의한 결과를 얻었다. 혈중 에너지 대사에서는 free fatty acid와 Lactate 반응에서 유의성 있는 차이가 나타났고, 전해질대사에서도 Na^(+), Cl-와 K^(+) 반응에서 모누 유의성 있는 차이를 나타냈다. 그러므로 補中益氣湯은 에너지 및 전해질 대사에서 유의성있는 변화를 나타내었으며 운동수행능력의 향상에 유효하였다. Objective This experimental study was designed to investigate effects of Bo-joong-ik-gi-tang administration among long distance runners on changes of the energy and electrolyte metabolism. Materials and Methods All subjects were divided randomly with two groups, Bo-joong-ik-gi-tang Group (N=4) and control group (N=4) and performed to run the 400m track with 70% of HR max about 1 hour. The blood samples were collected from antecubital vein by 5㎖ syringes at before exercise, immediateIy after exercise, recovering- 10 min, recovering-30 min, recovering-1 hour. These sampie were used to analyze for the factors of the changes on metabolic responses. Firest, the primary factors on the changes of the energy metabolism were checked ; Glucose, Free fatty acid, Lactate, LDH. Second, the primary factors on the changes of the electroIyte metabolisrn were checked ; Na^(+), Cl^(-), K^(+). Results 1. The change of the energy metabolism 1) Glucose response was not shown significant difference between two groups. 2) Free fatty acid response in Bo-joong-ik-gi-tang group was significantly increased at recover-10 min. 3) Lactate response in Bo-joong-ik-gi-tang group was significantly decreased at immediately after exercise, recover-10 min, recover-30 min. 4) LDH response was not shown significant difference between two groups. 2. The change of the electrolyte metabolism 1) Na^(+) response in Bo-joong-ik-gi-tang group was shown significant difference between two groups at before exercise. 2) C^(-) response in Bo-joong-ik-gi-tang group was significantly increased at before exercise, immediately after exercise. 3) K^(+) response in Bo-joong-ik-gi-tang group was significantly increased at recover-10 min. Conclusion According to the above results, it was shown that Bo-joong-ik-gi-tang had the positive effects on changes of the energy and electrolyte metabolism for the long distance runners.