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서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)
김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1
Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.
김재균,우종열,윤정배 慶尙大學校生産技術硏究所 1995 生産技術硏究所論文集 Vol.11 No.-
The 8 specimens are tested for vertical joint of PC large panel type. The comparison of the specimens having a different strength between grout concrete and panel is presented and other design parameters such as steel reinforcing ratio and location are varied. Test behaviors are discussed on crack patterns near shear-key, maximum shear and energy absorption capacities. If the relative strength of grout concrete is high, the results show more ductile and rely on the reinforcing loop bar than the case of same relative strength.
서진욱,정재훈,최용의,이학성,신차균 중앙대학교 유전공학연구소 2003 遺傳工學硏究論集 Vol.16 No.1
The enzyme, squalene synthase, represents a branch point in the isoprenoid pathway capable of diverting carbon flow specifically to the biosynthesis of phytosterol and Triterpenoid. Transgenic Eleutherococcus senticosus plants were prepared by introducing the genes for squalene synthase derived from Panax ginseng (PgSS1), hygromycin phosphotransferase (HPT) and green fluorescent protein (GFP) through Agrobacterium-mediated transformation. Establishment of transgenic plantlets were confirmed by the presence of PgSS1 and HPT bands in the genomic DNA preparation using a PCR method and a Southern blotting. In addition, expression of the introduced GFP DNA was confirmed by observing green fluorescence of GFP from the embroyos. In the in vitro analysis of the PgSS1 enzymatic activities the transgenic plants showed to have 1.5 to 3 times higher than wild type plant, indicating that the PgSS1 genes was well over-expressed in the transgenic plants. Especially the PgSS1 acivities of embroyogenic cell was 120 times higher than those of plantlet.
Jeong, Sung-Eun,Park, Jae-Kweon,Kim, Jeong-Dong,Chang, In-Jeong,Hong, Seong-Joo,Kang, Sung-Ho,Lee, Choul-Gyun The Korean Society for Microbiology and Biotechnol 2008 Journal of microbiology and biotechnology Vol.18 No.12
Statistical experimental designs; involving (i) a fractional factorial design (FFD) and (ii) a central composite design (CCD) were applied to optimize the culture medium constituents for production of a unique antifreeze protein by the Antartic micro algae Chaetoceros neogracile. The results of the FFD suggested that NaCl, KCl, $MgCl_2$, and ${Na}_{2}{SiO}_{3}$ were significant variables that highly influenced the growth rate and biomass production. The optimum culture medium for the production of an antifreeze protein from C. neogracile was found to be Kalle's artificial seawater, pH of $7.0{\pm}0.5$, consisting of 28.566 g/l of NaCl, 3.887 g/l of $MgCl_2$, 1.787 g/l of $MgSO_4$, 1.308 g/l of $CaSO_4$, 0.832 g/l of ${K_2}{SO_4}$, 0.124 g/l of $CaCO_3$, 0.103 g/l of KBr, 0.0288 g/l of $SrSO_4$, and 0.0282 g/l of ${H_3}{BO_3}$. The antifreeze activity significantly increased after cells were treated with cold shock (at $-5^{\circ}C$) for 14 h. To the best of our knowledge, this is the first report demonstrating an antifreeze-like protein of C. neogracile.
Gene-Based Therapeutic Cancer Vaccine for Her-2/neu Expressing Cancers
Jae-Gyun Jeong,Hwang-Jae Lee,Sung-Min Oh,Seong-Hyun Ho,Seok Kang,Jin-A Chae,Dong-Sik Kim,Sung-Won Lim,Kyu-Woong Shim,Yeon-Sook Cha,Jong-Mook Kim,Sujeong Kim,Choong-Yong Kim,Hyun-Jeong Ko,Yeon-Jeong Ki 한국생물공학회 2009 한국생물공학회 학술대회 Vol.2009 No.10
( Jae Woo Park ),( Jeong-ju Yoo ),( Sang Gyune Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Boo Sung Kim ),( Jae Myung Lee ),( Jong Joon Shim ),( Young Don Kim ),( 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Plug-assisted retrograde transvenous obliteration (PARTO) is the most currently used procedure in patients with gastric varices with portosystemic shunt. Portal pressure and the rate of complications associated with it are expected to rise after PARTO, but it has not yet identified. The study aims: to see how much hepatic venous pressure gradient (HVPG) will be changed after PARTO, and to see if esophageal varix (EV), ascites, hepatic encephalopathy (HE) and liver function will worsen or improve in follow-up period. Methods: During March 2012 to Feburary 2018, 73 patients who had PARTO were analyzed. We reviewed their HVPG, liver function and episode of cirrhotic complications before and 1 and 6 month after PARTO. Results: Among the patients, CTP score decreased at 1 and 6 month {After 1 month, from 7 (6-8) to 6 (5-7), P<0.001 / After 6 month, from 7 (6-8) to 6 (5-7), P<0.001}. And also, MELD score {After 1 month, from 11 (7.25-14.75) to 9 (8- 12), P=0.005 / After 6 month, from 11 (7.25-14.75) to 9 (8- 11.75), P=0.036}. There was an improvement in HE grade after 1 month (-0.03±0.036, P=0.025) and no deterioration after 6 month (-0.06±0.035, P=0.083). HVPG was measured before and after PARTO in 27 patients and elevated from 11.92±0.7 (before) to 14.96±1.038 (after) (P=0.001). The difference before and after PARTO showed no correlation with changes in liver function (MELD score, P=0.12), ascites (P=0.352), HE grade (P=0.14), and EV grade (P=0.564). Also, it did not correlate with changes in beta-blocker (BB) (P=0.474) and diuretics requirements (P=0.284), which could affect the patient’s clinical index. Conclusions: Artificially blocking the portosystemic shunt evidently leads to an increase in HVPG. However, no significant changes in liver function or cirrhotic complications were observed during the follow-up period of 6 months. Long-term observation is needed in the future.
( Jeong-ju Yoo ),( Hyeon Jeong Goong ),( Sang Gyune Kim ),( Young Seok Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Baek Gyu Jun ),( Young Don Kim ),( Gab Jin Cheon 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The indiscriminate use of sedative drug during endoscopy can pose a risk of minimal hepatic encephalopathy (MHE) in patient with liver cirrhosis, . However, it has not been studied yet which drugs are safest and most inviting on these patients. The aim of this study is to evaluate which one among midazolam, propofol, or combination therapy, was the least likely to cause complications including MHE by using Stroop application in cirrhotic patients. Methods: This randomized prospective study included consecutive 32 patients who underwent upper GI endoscopy at tertiary hospitals in Korea. Patients were randomly assigned to one of three groups, midazolam, propofol, or combination group, and underwent Stroop test before endoscopy, and 2 hours after the completion of endoscopy. The vital signs was checked before and after the drug administration and the patient / physician / nurse satisfaction was scored after endoscopy. Results: Mean age of the patients was 54.0 ± 9.30 years and 81.3% were male. Fifteen patients (46.9%) were child-pugh class A, and 17 (53.1%) were child-pugh class B or C. Alcohol was the most common etiology (21, 65.6%). Patients did not show significant changes in Ontime, Offtime on Stroop test before and after drug administration, and there was no significant difference between the three treatment groups. Also, there was no significant vital sign changes after drug use in all groups. However, with respect to subjective indicators, the satisfaction scores of patient and nursing staff was higher in the combined group than in the other two groups, and time to recovery was shorter in propofol than other groups. Conclusions: In patients with cirrhosis, sedative endoscopy using midazolam, propofol, or combination therapy is relatively safe, and was not associated with increased risk of MHE. However, since there is subjective satisfaction or recovery time difference among sedative agents, it should be considered according to each individual patient.
( Jae Yoon Jeong ),( Dae Won Jun ),( Daiseg Bai ),( Ji Yean Kim ),( Sang Bong Ahn ),( Sang Gyune Kim ),( Hyoung Su Kim ),( Soung Won Jeong ),( Yong Kyun Cho ),( Do Seon Song ),( Hee Yeon Kim ),( Young 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: For multicenter studies, the diagnosis of minimal hepatic encephalopathy (MHE) by consensus should utilize at least two of the current validated testing strategies: paper-pencil test and one computerized test. Recently we developed a ‘Korean paper and pencil test’ (K-PPT) and a mobile base ‘Korean Stroop test’ (K-stroop test) as a ‘copyleft’. The aim of this study is to validate the usefulness for K-PPT and K-stroop test to detect MHE in Korea. Methods: One hundred thirty four patients with hepatitis B virus associated cirrhosis without overt HE underwent K-PPT (number connection test-A, number connection test-B, digit span test-forward, digit span test-backward and symbol digit modality test), psychometric hepatic encephalopathy score (PHES) and mobile based K-Stroop test. MHE was defined as an impaired performance under - 1.5 standard deviations from the mean on more than 2 tests in K-PPT. And we defined MHE as ≤ -5 points in PHES. Results: Prevalence of MHE in enrolled patients was 22.4% using K-PPT and 20.9% using PHES. The agreement of MHE diagnosis between K-PPT and PHES was 86.6% (sensitivity 71.4%, specificity 90.6%, k coefficients=0.605, P<0.0001). ‘Off time’ (P=0.001), ‘On time + Off time’ (P=0.007) and ‘On time - Off time’ (P=0.041) of K-stroop test were significantly different between patients with MHE and those without MHE diagnosed using PHES. The number of impaired performance of variables in K-PPT (r=-0.697, P<0.0001) and off-time of K-stroop test (r=-0.405, P<0.0001) showed linear correlation with conventional PHES test. Conclusions: K-PPT and mobile based K-stroop test have good correlation with conventional PHES to detect MHE in patients with cirrhosis.
Jae Yoon Jeong,Dae Won Jun,Sol Ji Park,Joo Hyun Sohn,Sang Gyune Kim,Se Whan Lee,Soung Won Jeong,Moon Young Kim,Won Kim,심재준,김형수,석기태,Sang Bong Ahn 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.5
Background/Aims: We aimed to assess the role of vitamin D supplementation in the response to pegylated interferon-α (PEG-IFN-α) plus ribavirin (RBV) treatment in patients with chronic hepatitis C (CHC). Methods: Our study was a multi-center, randomized controlled trial in 11 hospitals. CHC patients were randomly assigned (1:1) to two groups namely, PEGIFN-α plus RBV (control group) or PEG-IFN-α plus RBV + vitamin D (800 IU daily) (vitamin D group). The primary end-point was the rate of sustained virologic response (SVR). Results: One hundred forty eight CHC patients were randomly assigned to two groups. Seventy-one patients received the PEG-IFN-α plus RBV and 77 patients received the PEG-IFN-α plus RBV + vitamin D. A total of 105 patients completed the study (control group, 47 vs. vitamin D group, 58). Baseline characteristics were mostly similar in both the groups. There was a modest but non-significant increase in SVR in the vitamin D group compared to the control group with the intention to treat analysis (64.0% vs. 49.3 %, p = 0.071) as well as in the per protocol analysis (control group vs. vitamin D group: 74.5% vs. 84.5%, p = 0.202). Fifty-two patients (73.2%) in the control group and 63 patients (81.8%) in the vitamin D group experienced at least one adverse event. The drop-out rate due to adverse effects was not different between both groups (control group vs. vitamin D group: 19.7% vs. 10.4%, p = 0.111). Conclusions: Vitamin D supplement did not increase SVR in treatment naïve patients with CHC irrespective of genotype.