한국에서 유행한 Cholera균에 대한 Antibiotics sensitivity에 관한 연구

손준용,유재근,김영한,민창홍 國立保健硏究院 1970 국립보건연구원보 Vol.7 No.-

벼 유묘기 저온처리에 의한 Chlorosis의 유전

손재근,권용삼,김경민 慶北大學校農業科學技術硏究所 1997 慶北大農學誌 Vol.15 No.-

벼의 유묘기 저온처리하에 나타나는 chlorosis현상의 유전양식을 규명하기 위하여 실험한 결과를 요약하면 다음과 같다. 벼 21 공시품종 유묘기 저온(18℃)처리에서 chlorosis가 나타나는 품종은 통일형인 "밀양23호"와 인디카형인 "IR 36", "Dular"로 3품종이었고, 모든 자포니카형 품종에서는 chlorosis가 나타나지 않았다. 저온처리하의 엽록소 함량 감소는 품종군과 재배종간에 다양한 차이를 나타내었다. Dular와 Toyohatamochi가 교배된 F₂집단에서 저온처리에 의해 나타나는 제3엽의 chlorosis 현상에 대한 분리비는 정상 개체와 chlorsis 개체가 3:1의 이론적 분리비 적합하였다. 이결과로 벼의 유묘기 chlorosis의 유전은 단순열성 유전자에 의해 지배 되는 것으로 분석되었다. The purpose of this study was to determine the inheritance of chlorosis under low temperature at seedling stage of rice. The expression of chlorosis among 21 rice cultivars treated at 18℃ showed in one Tongil type cultivar. Milyang 23. and two Indica type cultivars. IR 36 and Dular. The sign of chlorosis was not appeared in all of the japonica type cultivars under the same treatment. The reduction of chlorophyll content under the low temperature was differed from varietal group and cultivars. The F₂population from a cross between Toyohatamochi and Dular segregated 3:1 ratio for normal and white phenotypes of third leaf. From the result, it was suggested that the chlorosis was controlled by a single recessive gene. The chlorosis rice detected from this study will be used as a good material for the genetic study related to photosynthetic ability of rice.

벼 자동화 육묘시설에서 적정 파종기와 묘대기간의 선정

鄭錫祚,孫再根 慶北大學校 農業科學技術硏究所 2005 慶北大農學誌 Vol.23 No.-

The purpose of this study was carried out to determine the optimum sowing date and days after sowing (DAS) in automatic facility located at Uiseong of Gyeoungbuk province. The seedling height was rapidly increased with a delay of sowing time from April to May. The 10-day old seedlings with suitable plant height(>10cm) for machine transplanting in the facility were obtained when the seeds sowed after May 20 at Uiseong in Gyeoungbuk province. The dry weight-height ratio of 10-day old seedlings was significantly decreased when the seeds sowed after June 20, and 15-days old seedlings did after May 10. No. of panicles/hill was reduced with increasing of days after seeding. But there were no significant difference among other yield components such as no. of grains/panicle, ratio of ripened grains, and 1,000 grain weight. The highest grain yield, 748kg/10a, was attained from the 10-day old seedlings transplanted at May 27 in comparision with those of 15-day and 20-day old seedlings. The grain yield of 10-day old seedlings transplanted at June 26 was also higher than that of 15-day old seedlings.

벼 상자육묘에서 부직포 두께가 묘소질에 미치는 영향

고준모,손재근 경북대학교 농업과학기술연구소 2006 慶北大農學誌 Vol.24 No.-

Seedling characteristics of rice on nursery covered with different weight of polypropylene spunbonded fabric(PSF) were investigated to determine the optimum thickness of PSF for raising of healthy rice seedlings. Four different thickness of PSF 40, 60, 80 and 100g/m^(2) were used in the seedling nursery with a conventional polyethylene(PE) film. PSF and PE were taken off in 20 days after sowing(DAS) on April and in 10 DAS on June. Plant height of 20- and 30- day old seedlings in PSF covering nursery was slightly taller as the increase of PSF thickness from 40g/m^(2) to 100g/m^(2), but number of leaves and shoot dry-weight of the seedlings was reduced. Root solidity of seedlings grown in lighter PSF (40~60g/m^(2)) covering nursery was more favorable than that in relatively heavier PSF(80~100g/m^(2)). The optimum thickness of PSF for the raising of healthy seedlings was 40~60g/m^(2) PSF at sowing on April 20 and April 30 for single cropping, and 40g/m^(2) PSF on June for double cropping based on the growth characteristics of seedlings investigated at seedling nursery covered with different thickness of PSF.

Carrageenan 유도 관절염에 대한 灸律 藥鍼의 진통작용

구성태,신종근,최윤영,송정방,김재효,김경식,손인철 한국전통의학연구소 2006 한국전통의학지 Vol.15 No.1

Objectives: This study was produced to examine the effects of moxibustion that had been played important role to traditional oriental medical treatment on disease. Recently, it was reported that moxi-tar which is generated in the process of moxibustion as burning combustibles decreased nitric oxide(NO) and inducible NO synthase (iNOS) generation in cellular experiments. Methods: Carrageenan-induced arthritis rat model was used to test the effect of moxi-tar as a chronic pain model. Diluted moxi-tar was single injected in several acupoints or combined with electroacupuncture (1 ms, 2 Hz, and 2 mA) into contralateral ST36 acupoint for 30 min to assess the synergic effects. After the treatment, behavioral tests measuring stepping force were periodically conducted during the next 12 hours. Endogenous NO and iNOS, cyclooxygenase-2 (COX-2), and c-Fos protein expression in the spinal cord were examined on a rat model of carrageenan-induced arthritis. Results : After the induction of arthritis, rats subsequently showed a reduced stepping force of the affected limb for at least the next 4 days. The reduced stepping force of the limb was presumably due to a painful knee, since oral injection of indomethacin produced temporary improvement of weight bearing. Moxi-tar produced significant improvement of stepping force of the hindlimb affected by the arthritis lasting at least 9 hours. The magnitude of this improvement was equivalent to that obtained after an oral injection of 3 mg/kg of indomethacin and this improvement of stepping force was interpreted as an analgesic effect. Moxi-tar produced the improvement of stepping force of the affected hindlimb in a dose-dependent manner. Both NO production and iNOS, COX-2 protein expression increased by arthritis were suppressed by moxi-tar. Moxi-tar on combination with electroacupuncture (EA) produced more powerful and longer lasting improvement of stepping force of the hindlimb affected by the arthritis than either moxi-tar or EA did. Conclusion : The present study suggest that moxi-tar produces a potent analgesic effect on the chronic knee arthritis pain model in the rat and that moxi-tar-induced analgesia modulate endogenous NO through the suppression of iNOS/COX-2 protein expression.

순환기 내과로 자문의뢰된 환자의 임상상

황진용,최지용,손상균,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.4

목적 : 순환기내과 영역은 많은 과로부터 자문의뢰를 받는 영역으로 알려져 있다. 특히 최근 우리나라의 순환기질환의 유형이 변화되고 입원환자가 고령화되면서 동반된 심질환의 유병율도 증가하고있다. 이에 저자들은 타과로 입원하여 순환기내과로 자문의뢰되는 환자의 임상상과 3차병원인 경북대학교병원에서의 순환기내과자문의 유용성 등을 평가하여 향후 순환기질병에 대한 협의진료에 도움을 주고자 본 연구를 시행하였다. 방법 : 1995년 3월부터 순환기내과로 공식자문의뢰된 첫 100명을 대상으로 전향적으로 연령, 의뢰이유, 최종진단명, 수술과의 관련성 여부, 순환기내과의 최종조치, 타과의 순응도 등을 조사하였다. 결과 : 1) 자문을 의뢰한 환자는 평균 58±16(15-89, 중앙치 61)세였고 60세이상의 환자가 57%로 고령의 환자가 많았다. 2) 내과계열 25%, 외과계열 75%로 외과계열의 자문이 많았고 일반외과가 26%로 가장 많았고 내과의 다른 분과가 12%, 신경외과 12%, 정형외과 11%, 흉부외과 11%, 신경과 11% 등의 순이었다. 외과계열중 수술을 시행한 경우는 58례로 이중 응급수술이 13례였다. 술전 위험도 평가를 위한 자문이 38례에서 있었는데 순환기적인 문제로 수술을 받지 못한 경우는 2례(1례는 허혈성 심질환, 1례는 심낭질환)이었다. 이때 응급수술을 제외한 입원일과 술전 자문일파의 간격은 평균 3±7일(입원일-42일)이고 술전 자문일과 수술일과의 간격은 평균 6±4일(1-16일)이었다. 3) 타과의 의뢰이유는 심전도 이상이 36례, 높게 측정된 혈압이 20례, 순환기질환의 과거력 17례, 환자의 증상 때문인 경우가 10례였고 심전도의 이상중에는 부정맥이 18례, 이상 Q파 6례, ST절 이상이 5례, 각차단이 3례의 순이었다. 순환기과거력 중에는 허혈성 심질환이 6례, 현재 혈압은 정상이나 고혈압의 과거력이 있는 경우가 4례 순이었고 환자의 증상은 흉통 6례, 호흡곤란이 3례, 기절이 1례였다. 4) 자문후 최종진단이 가능했던 91례를 진단별(총 97 진단명)로 나누어 보면 고혈압이 28례, 부정맥이 16례, 허혈성 심질환이 14례, 판막질환이 11례, 순환기질환이 아닌경우가 19래였다. 이들중 추적진료가 필요하다고 응답한 경우가 57례였으나 순환기내과 외래에 1번이상 추적진료한 경우는 32례(56%)로 환자의 순응도는 낮았다. 결론 : 순환기내과의 자문의뢰는 고령자에게 많았고 수술과 관련된 경우가 많았으며 심전도의 이상이 의뢰이유로 가장 많았으며 진단별로는 고혈압과 부정맥이 가장 많았다. 그리고 순환기적인문제로 수술을 받지 못한 경우는 드물었고 자문후 지속적인 추적진료를 위해 환자의 교육이 필요하겠다. Objective : Clinical characteristics of the patients with cardiovascular diseases in the general hospital have been changed and prevalance of co-existing cardiovascular disease in the patients who were admitted for non-cardiac diseases has been increased remarkably as the proportion of elderly patients increased rapidly in Korea. We evaluated clinical features of the patients consulted for cardiological evaluation and effectiveness of the consultation in the setting of tertiary general hospital, Kyungpook University Hospital. Method : One hundred patients were studied between January 1995 and January 1996. They were evaluated for the reason of consultation, final diagnosis, final recommendation from cardiologists and its impact on the management of the patients, and compliance of the consulting departments. Results : 1) The ages ranged between 15 and 89 (mean 58±16, median 61) years, 57 patients were male and 43 female. Fifty seven patients were older than 60 years. 2) Consultations from surgical parts were 75 patients. Consultation from general surgery was most frequent (26%), followed by other divisions of internal medicine (12%), neurosurgery (12%) and orthopedic surgery (11%), chest surgery (11%), neurology (11%), obstetrics and gynecology (8%), urology (4%), ophthalmology (2%), dermatology (2%), ENT (1%). Among 75 patients from surgical parts, operation was done on 58 patients, including 13 emergency cases. Preoperative cardiac risk evaluation was the reason of consultation in thirty eight patients, of which operation could not be done in only 2 patients (one had severe ischemic heart disease, the other large pericardial disease). Interval between consultation day and operation day was 6±4 days (1-6 days). 3) Reasons for cardiac consultation were electrocardiographic (ECG) abnormalities in 36 patients, high blood pressure in 20 patients, previous cardiovascular diseases in 17 patients, symptoms of the patients in 10 patients. Among EGG abnormalities, arrhythmias was the reason in 18 patients, abnormal Q waves in 6 patients, ST-T segment abnormalities in 5 patients, bundle branch block in 3 patients. Among previous cardiovascular disease, presence of ischemic heart disease was the reason in 6 patients, previous hypertension in 4 patients. Chest pain was the reason of the consultation in 6 patients, dyspnea in 3 patients, syncope in 1 patient. 4) Definite diagnoses could be made in 91 patients with 96 diagnoses which were hypertension and its complications in 28, arrhythmia with underlying disease in 16, ischemic heart disease in 14. valvular heart disease in 11, non-cardiovascular disease in 19. Cardiological follow up was recommended in 57 patients. However, 25 patients (44%) were lost to follow-up. Conclusion : Cardiological consultation was frequent in the elderly patients. Most frequent reason for consultation was EGG abnormalities. Hypertension or arrhythmia was most common final diagnosis. Inoperability due to cardiovascular problems were rare.

벼 自動化 育苗에서 播種期와 育苗期間이 苗素質에 미치는 영향

成會慶,皮宰承,孫再根 경북대학교 농업과학기술연구소 2000 慶北大農學誌 Vol.18 No.-

Seedling characteristics of rice sowed at different sowing date in an automatic facility were studied at different days after sowing(DAS). The objective was to determine the optimum sowing date and age of rice seedlings at three locations in the Kyongbuk Province of Korea viz, Andong, Euisung and Kyongsan. Height and shoot dry weight of rice seedling increased from 10 to 20 DAS and with a delay in sowing time from April to June. In these intervals shoot dry weight-height ratio decreased. For rice seeded in the last ten days of April, optimum seedling characteristics were attained between 15 to 20 DAS at Andong and Euisung and 15 DAS at Kyongsan. At the three locations, 10-day-seedlings exhibited superior characteristics to 15- and 20-day-seedlings for rice seeded in May and June. Rice seedlings of different ages were transplanted at a paddy field to determine the effect of seedling age on yield potential. The mean yield of 10-day-seedlings was 5% higher than that of 35-day-seedlings raised by the conventional method. The yield of 20-day-seedlings was 9% lower than that of 35-day-seedlings. Varietal differences in seedling characteristics of 13 rice cultivars were evaluated for the seedlings seeded in the automatic facility on June. Ten-day old seedlings ranged in height from 13.3 to 17.5 cm and shoot dry weight from 7.7 to 9.4 mg. Two cultivars, Daesanbyeo and Hwayeongbyeo, exhibited superior seedling traits compared to the remaining 11 cultivars and were ,therefore, better adapted to the automatic seedling-raising facility.

마늘의 珠芽를 利用한 優良種球生産

徐永培,金大圭,孫再根 경북대학교 농업과학기술연구소 1999 慶北大農學誌 Vol.17 No.-

This study was carried out to determine the promising method for the production of mother bulbs using garlic bulbil at the experimental field of Ange high school, Eusung in Korea from 1996 to 1998. The bulbs and bulbils were taken from a local cultivar 'Eusung' garlic. The growth of bulbil and yield potential were compared with different harvesting times and cultivation methods of bulbil. The harvesting time of bulbils which were capable of producing the mother bulbs was ranged from 15 days to 30 days after the emergence of flower stalks. The best results based on the yield and number of bulbs were obtained from the bulbils sampled at the just before garlic harvesting, 30 days after flower-stalk emergence. The mulching with transparent polyethylene(PE) film in bulbil cultivation was more effective for the plant growth and bulb formation than that with black PE film. The PE mulching from 30 days after seeding of bulbils to 30 days (late-April) before bulb harvesting was the most effective for the increase of bulb yield. In the cultivation of garlic bulbils, application of lime (150kg/10a) and compost (3,000 kg/10a) without any chemical fertilizers produced more bulbs in comparison with the standard level of fertilizer (N - P2O5 - K2O - compost -lime = 24.8 - 8.0 - 19.2 -3,000 - 150 kg/10a). It was determined that the involucre seeding and assemble seeding of bulbils was effective and labour-saving methods for the production of mother bulbs from garlic bulbils. Input of labour force for the involucre seeding was decreased up to 61% as compared with the conventional drill seeding of bulbils. Mean yield from the cultivation of bulbil-derived single cloves was remarkably increased up to 95% in comparison with that of the common cloves. The larger size of single clove produced more yields, and the optimum planting density of single clove was 20×10cm. The cloves differentiated directly from bulbil showed to have higher yield potential than that from common cloves.

정신과를 방문하는 환자의 통증호소의 빈도 및 특성

송지영,박진철,박종학,오동재,손형석,정근재 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 정신과 방문 환자에서 통증 호소는 적지 않을 것이라고 알려져 있으나 국내에서 정신과 외래 환자의 통증 관련 연구는 부족한 실정이다. 이에 정신과 외래에 오는 환자들에서 통증의 빈도와 특성을 1,2,3차 의료기관에서 알아보고자 하였다. 대상과 방법: 1차 의료기관(개인정신과의원) 외래환자 298명, 2차 의료기관(종합병원) 정신과 외래환자 99명, 3차 의료기관(대학병원) 정신과 외래환자 446명으로 총 843명의 성인 남녀를 대상으로 이들이 정신과에 방문했을 당시의 통증 여부와 조사 당시의 통증 유무 및 현재 통증의 정도를 평가하였다. 그리고 기질적 원인의 여부, 만성 통증의 여부, 통증의 부위, 통증 악화 요인, 보상문제의 유무, 약물 투여 내용 등을 조사하였다. 결 과: 1) 전체 대상자 843명 중 통증이 동반되었던 환자의 비율은 41.3%였으며, 기관별로 보면 개인의원 44.9%, 종합병원 44.5%, 대학병원 38.1%였다. 2) 조사 당시에 통증을 갖고 있는 경우는 3개 기관에서 평균 24.1%였다. 통증의 정도는 VAS상 평균 46.7㎜였으며 개인의원에서 대학병원에 비해 의미있게 그 정도가 심했다. 또한 `강하다` 이상의 통증 정도를 호소한 경우는 34.0%, `괴롭다` 이상의 불쾌정도를 표현한 경우는 26.2%였다. 3) 통증이 있었던 환자 중 기질성이 뚜렷한 경우는 적었으며(1.5∼5.9%), 통증의 부위는 머리가 50.9%로 가장 많았다. 통증의 지속기간은 6개월 이상인 만성통증의 경우가 68.7%를 차지했다. 4) 주요 약물로는 항불안제가 41.4%로 가장 많이 사용되고 있었으며, 통증과 관련하여 진통제를 처방받는 환자는 3.2%에 불과하였다. 결 론: 정신과 외래를 방문하는 환자들의 통증의 특성은 의료기관에 따라 인구통계학적 차이 뿐만 아니라 진단분포도 다르므로 3기관을 직접 비교하기에는 무리가 있으나, 본 연구 조사 결과 정신과 외래를 방문하는 환자들 중에서 40% 이상이 통증을 경험하고 있으며 2/3이상은 만성 통증이라 할 수 있었다. 이들은 중등도 이상의 통증을 갖고 있으며 당장 통증을 해결해 주어야 할 숫자도 적지 않았다. 따라서 정신과 환자의 통증에 대한 평가와 관리가 앞으로 더욱 강조되어야 할 필요가 있다고 사료된다. Objectives: The purposes of this study were to investigate the frequency and clinical characteristics of pain among the psychiatric out-patients in three clinics. Methods: A Total of 843 psychiatric adult out-patients(298 subjects from a private clinic, 99 subjects from a general hospital, 446 subjects from a university hospital) were assessed for the presence of pain during OPD follow-up and at the time assessed. And, the presence of organic causes, duration and site of pain, aggravating factors, compensation problems, and prescribed drugs were also investigated. Results: 1) The frequency of pain among psychiatric out-patients was overall 41.3%(44.9% in private clinic, 44.5% in general hospital, and 38.1% in university hospital, respectively). 2) The frequency of pain at the time assessed was 24.1%. In severity of pain, the average of VAS was 46.7±18.0㎜. Patients of private clinic showed more severe pain than that of general hospital. Moreover, patients who experienced over `marked` occupied 34.0% and pain as over `distressed` occupied 26.2%. 3) Only a few subjects had the definite organic causes(1.5-5.9%). The most common site of pain was on head. The patients having a pain over 6 months(i.e. chronic pain) occupied 68.7%. 4) The most common drugs prescribed were anxiolytics; 41.4% of patients were prescribed. The analgesics were prescribed only in 3.2% of patients. Conclusion: This result revealed that more than 40% of patients experienced pain in psychiatric OPD and two third of patients were suffered from chronic pain. Therefore, the evaluation and management of pain should be more emphasized.

벼의 callus 培養에서 再分化된 植物體의 主要 形質 變異

Jae Keun Sohn(孫再根),Oh Hee Kwon(權五熙),Sam Taek Cheong(鄭三澤),In Koo Rhee(李麟九) 한국육종학회 1991 한국육종학회지 Vol.23 No.3

Somaclones regenerated from callus culture of a japonica rice cultivar, “Chucheongbyeo”, were evaluated for variation in nine agronomic and morphological characters ; heading date, grain fertility, culm length, panicle length, number of panicles per hill, number of grains per panicle, grain weight, amylose content and leaf color. The R₂ pedigree lines were derived by self-pollination of 196 plants(R₁) regenerated from primary callus. The calli were induced from mature seeds of an anther-derived plant. Only 24% of 196 R₂ lines were normal in all characters observed, 50% of the total lines were uniform within each line although the differences among lines were recognized, and 51 R₂ lines(26%) were segregated in one or more characters investigated. The proportion of R₂ lines carrying one or two mutated characters was 58.6% of total R₂ lines tested. The R₂ populations appeared to have shorter culm and panicle length, less effective tillers, and more grains per panicle as compared with mean values of original cultivar. However, the means of heading date, grain weight and amylose content were nearly the same as their respective checks.