관상동맥질환의 중증도와 혈중지질치 및 아포지단백과의 상관관계

임현주,황종현,류재근,정병천,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

목적 : 관상동맥질환의 위험인자로서 혈청지질 및 혈장 지단백에 대한 관심이 높아지고 있고 또 아포지단백이 관상동맥 질환을 일으키는데 다른 지질보다 더 중요하다는 연구가 많이 발표되고 있으나 우리나라에서는 아포지단백에 대한 연구가 그리 많지 않은 편이다. 이에 저자등은 혈중지질치와 새로운 위험인자로 알려지고 있는 아포지단백치를 측정하고 이들과 관상동맥질환 중증도와의 상관 관계를 알아보았다. 대상 및 방법 : 관상동맥질환이 의심되어 관상동맥조영술을 실시한 69명의 환자를 대상으로 하였으며 12시간 이상 공복후 혈청을 채취하여 총콜레스테롤, 중성지방, HDL-콜레스테롤, 아포지단백 AI (ape AI), 아포지단백 B (ape B)를 측정하였다. 관상동맥조영상 50%이상의 협착이 있는 혈관의 수 (lesion number), 최대협착을 합한 값 (lesion score), 각 분절의 최대협착을 합한 값 (total score), 가장 심한 협착 값 (peak stenosis) 등으로 관상동맥 중증도를 알아본 다음 이들과 혈청지질치, 아포지단백과의 상관 관계를 비교해 보았다. 상관 관계는 Spearman's correlation coefficient를 구하였다. 결과 : 관상동맥질환의 중증도와 각 지질치 간의 상관 관계를 비교해 보았을때 lesion number와 관계있는 것은 연령 (r=0.2789), 중성지방치 (r=0.2829)이며 lesion score와 관계있는 것은 연령(r=0.2911), 중성지방치0 (r=0.3316), 총콜레스테롤과 HDL-콜레스테롤의 비 (r=0.2361), apo B 치(r=0.2759), apo AI과 apo B의 비 (-0.3154)로 나타났다. Total score는 연령 (r=0.3100), 총콜레스테롤치 (r=0.2452), 중성지방치 (r=0.3022), 총콜레스테롤과 HDL-콜레스테롤의 비 (r=0.2770), apo B치 (r=0.2927), apo AI과 apo B의 비 (r=-0.3408)와 연관이 있었고 peak stenosis는 중성지방 치(r=0.3305), ape B 치 (r=0.2968), apo AI과 apo B의 비 (r=-0.3977)와 관계가 있었다. 연령으로 조정하여 partial correlation을 좌면, 관상동맥조영술상 중증도는 중성지방치 (r=0.3408), apo B 치(r=0.2877), apo AI과 apo B의 비 (r=-0.3460)와 유의한 상관 관계가 있었다. 이중 ape AI과 ape B의 비는 lesion score (r=-0.2640), total score (r=-0.3057), peak stenosis (r=-0.3460)와 유의한 상관관계를 보였다. 결론 : 이상의 결과로 보아 apo B치 그리고 apo AI과 apo B의 비가 관상동맥 중증도의 예견인자로 다른 혈중 지질 치보다 더 유용하다는 것을 알 수 있었다. Objectives : Recently, it was reported that the measurements of apolipoprotein levels may be valuable in the clinical assessment of coronary artery disease severity. However there are a few reports regarding to the relationship between coronary artery disease severity and apolipoprotein levels in Korea. Thus, we measured serum lipid and apolipoprotein levels and studied the relationship between coronary artery disease severity and serum lipids and apolipoproteins levels. Subjects and Methods : The 69 patients who underwent coronary angiography to evaluate chest pain were subjected to this study. We measured the levels of serum cholesterol, triglycerides, HDL cholesterol, apolipoprotein AI(apo AI) and apolipoprotein B(Apo B) and measured the severity of coronary artery disease by lesion number, lesion score, total score and peak stenosis. Then, we studied the relationship between coronary artery disease severity and apolipoproteins and calculated the correlation coefficient. Results : The results were as follows. There are significant correlation(r=0.3) between age, triglycerides, apo B levels, apo AI/B ratio and coronary artery disease severity. In controlling for age, tyiglycerides, apo B levels and apo AI/B ratio shows significant correlation(r=0.3) with coronary artery disease severity. Especially, apo AI/B ratio shows significant correlation(r=0.3) with lesion number, total score and peak stenosis. Conclusion : These results suggest that the apo B levels and the ratio of apo AI/B can be used as significant independent predictor for coronary artery disease severity rather than other serum lipid levels.

지역사회에서 형성된 사회적 지지와 근로자의 사회심리적 스트레스간의 관련성

임화영,김형수,최영환,장성훈,이건세,정최경희,오원기,최재욱,정춘화 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

Objective: This study was performed to examine the relationship between community-based social support and psychosocial distress in workers. Methods: The study subjects were 596 workers recruited from 11 companies in Chungju city. A structured questionnaire was used to assess sociodemographics, health-related behaviors, job characteristics, job stress, work-based social support, community-based social support and level of psychosocial distress. Results: Hierarchical multiple regression analysis showed that workers with no chronic disease, exercise and sufficient sleep had a higher score of psychosocial distress than those with chronic disease, no exercise, and not enough sleep. Coworker's work-based social support and community-based social support were negatively associated with psychosocial distress. The R square value of total independent variables on psychosocial distress was 0.409, and that of community-based social support on psychosocial distress was 0.052. Conclusion: This study showed that community-based social support served as a protective factor against psychosocial distress in some workers. We recommend the establishment of a worksite stress reduction program in occupational level as well as community-based social support.

李箱文學의 文體 考察

林鐘秀,李在天 三陟大學校 2001 論文集 Vol.34 No.3

The purpose of this thesis is to understanding wholly such stylistic of Lee Sang's works thought analyzing style. The difficultly in understanding Lee Sang's world of literature is not in his queer life, but in the peculiar uses of words in his works. It may be reasonable in these on hin that everyone should search for the secrecy of writing hinted by his literary style. But there few theses that have dealt with the style of Lee Sang as a leading topic. And most of theses on him have had a tendency to remain within the line of superficial observation till now.

우관상동맥 개구부 완전 폐쇄가 동반된 대동맥 판상부 협착증 1례

임상현,김종진,김희열,진승원,전희경,노태호,채장성,김재형,홍순조,최규보,윤정섭,김치경 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

Sport Dance 에 關한 大學生들의 意識觀

천영일,임재숙 중앙대학교 스포츠과학연구소 2000 體育硏究 Vol.- No.13

Purpose ; This study is to present data for understanding and development of Sport Dance, an exhibition event of Sydney Olympic Game 2000 years, by examining university students' view consciousness on the Sport Dance. Method ; To investigate and analysis in conformity with questionnaire method on 300(150 male, 150 female) students attending three universities in Seoul. Result ; 1. The practical sense on the Sport Dance showed 41.37% of the university time, 53.44% of social dance on the contents, 55.86% of nothing on the concern. 2. The acknowledge of events on the Sport Dance showed 66.89% of know, 43.79% of adult social intercourse on the point of ours social view, 55.5% of lack of the understanding and the sense of value. 3. The necessity of modern society showed 55.86% of affirming, that reason showed 46.91% of moral health, 37.03% of personal relation, etc. 4. The opinion for healthy popularization showed 30.68% of the reform of consciousness and the establishment of value system, 47.93% of the course of university physical education, etc.

초임계유체와 염을 이용한 에탄올농축에 관한 연구(1) : CO2 - C2H5OH 계와 CO2 - H2O 계의 고압기액평형 High Pressure Vapor - Liquid Equilibria for Co2 - C2H5OH and CO2 - H2O Systems

전해수,이윤용,김재덕,임종성,조정식,박선근 한국화학공학회 1991 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.29 No.1

기상과 액상 모두를 계속해서 순환시키는 상평형실험장치(circulation type)를 이용하여, CO₂-C₂H_5OH계에 대한 고압기액상평형실험을 313.2 K, 323.2 K, 333.2 K에서 압력 (약 5 ㎫-혼합물의 임계압력부근)을 변화시키면서 수행하였다. 각각의 온도에 대한 혼합물의 임계압력은 8.1㎫, 9.3㎫, 10.6㎫ 정도로서 온도가 증가할수록 혼합물의 임계압력이 증가하는 것을 알 수 있었다. 또 CO₂-C₂H_5OH 및 CO₂-H₂O계의 고압상평형자료를 Adachi와 Sugie의 혼합법칙을 사용한 Patel-Teja의 3차상태방정식에 적용하여 상관시켜 본 결과 만족할 만한 상관결과를 얻었다. High pressure vapor-liquid equilibria for CO₂-C₂H_5OH system were measured at three temperatures of 313.2 K, 323.2 K and 333.2 K using a circulation type of apparatus in which both vapor and liquid phase were continuously recirculated over a pressure range from ca. 5 ㎫ up to near mixture critical point. The critical pressures of the mixtures were about 8.1 ㎫, 9.3 ㎫ and 10.6 ㎫ at the three temperatures, respectively. This result shows that the temperature increases with the critical pressure of the mixture. The high pressure vapor-liquid equilibrium data for CO₂-C₂H_5OH and CO₂-H₂O systems were satisfactorily correlated by applying the Patel-Teja equation of state with the Adachi-Sugie mixing rule.

數學敎育의 現況 分析과 改善 方案(Ⅰ) : 圖形의 變換의 指導內容 分析 The Analysis of Contents about Transformation of Figure

林在圭,奇宇恒,鄭長春,金海龍 경북대학교 과학교육연구소 1980 科學敎育硏究誌 Vol.4 No.-

Some concepts of modern mathematics give rise to the new contents of school mathematics in accordance with the modernization movement of mathematics education. The trasformation of the figures is one of contents. In the present paper, to find out the effective teaching methods for the transformations of figures, we study the followings; (1) the structures of various transformations (2) analizing the curriculum and the mathematics textbooks (3) organizing the development of contents by logical arguments (4) pointing out difficult aspects of contents which can be found in the educating place.

기무라씨병의 치험례 -2례 증례보고-

임재호,최재원,김우경,정전은 大韓成形外科學會 1990 Archives of Plastic Surgery Vol.17 No.5

Kimura's diseas is a distinct clinico-pathologic entity characterized by proliferation of vascular endothelial cells and lymphoid hyperplasia with florid germinal centers associated with lymphocytic, histiocytic and eosinopholic infiltration. Two cases of Kimura's disease are presented. The first was 53 year-old female patient who had a slow growing mass on right parotid area. The second case was a 25 year-old female patient with two irregular growing masses on both submandibular region. Both cases had markedly increased peripheral eosinophilia with 34% in first case and 31% in second case. The first was treated by superficial parotidectomy and the second by direct surgical excision of masses. The specimens were confirmed ad Kimura's disease on histopathologic examination and the two cases are presented with the review of literature.

급성하벽심근경색에서 전흉부유도 ST절 하강의 의의

정병천,배호상,곽동훈,김영태,배용학,황종현,임현주,류재근,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 급성하벽심근경색증 환자에서 심전도상 흔히 동반되는 전흉부유도 ST절 하강의 의의를 알아보았다. 방법 : 심근경색후 24시간에서 48시간에 얻은 심전도를 기준으로 52명의 급성하벽심근경색증 환자를 전흉부유도에서 ST절의 하강이 있는 군과 없는 군으로 나누었으며 심도자, 관상동맥조영술, 심초음파도 및 방사성 핵종을 이용한 좌심구혈율 측정 등을 시행하였다. 결과 : 1) 좌심실확장기말압은 전흉부유도에서 ST절의 하강이 있는 경우에서 16.9±5.33mmHg로 없는 경우의 11.0±4.02mmHg보다 유의하게 높았다(p<0.05). 그러나 운동량 및 좌심구혈을은 흥부 유도상 ST절의 하강이 있는 경우 7.6±3.0 METs 및 53.9±9.1%로 없는 경우의 9.1±2.7 METs 및 54.6±9.5%보다 낮았으나 통계적 유의성은 없었다(p=0.180, p=0.823). 2) 관상동맥조영술상 전흉부 ST절의 하강이 동반된 군에서는 유의한 좌전하행지나 좌회선지의 협착이 있는 경우가 60.9% 및 57.9%로 ST절의 하강이 없는 군에서의 34.5% 및 7.7%와 비교해 좌관상동맥에 협착이 동반된 경우가 많았다(p=0.050, p=0.001). 3) 관상동맥조영술상 세 혈관질환의 빈도는 흉부유도상 ST절의 하강을 보인 23예에서 10예로 ST절 하강이 없었던 29예중 2예에 비하여 유의하게 많았고(P=0.007), 단 혈관질환의 빈도는 ST절의 하강을 보인 군에서 23예중 5예로 ST절 하강이 없었던 29예중 17예에 비하여 유의하게 적었다(P=0.002). 두 혈관질환의 경우에는 각각 8예와 10예로 양군간에 유의한 차이가 없었다. 4) 흉부유도상 ST절 하강의 빈도는 단 혈관질환 22예 중 5예에서, 두 혈관질환 18예중 8예, 세 혈관질환 12예 중 10예에서 관찰되어 협착이 있는 관상동맥의 수가 많을수록 ST절의 하강이 나타나는 빈도가 많음을 보였다(p=0.00308). 그러나 흉부유도상 나타난 ST절의 하강을 모두 합하여 구한 ST절 하강의 합은 협착이 있는 관상동맥의 수와 통계적인 유의성이 없었다. 5) 심초음파도상 좌심실 하벽의 벽운동은 ST절 하강을 보인 군에서는 akinesia가 83.3%, hypokinesia가 11.1%, 정상 벽운동이 5.6%로, ST절 하강이 없었던 군에서의 dyskinesia가 3.6%, akinesia가 39.3%, hypokinesia가 25.0%, 정상 벽운동이 32.1%와 비교하여 ST절의 하강이 있는 군에서 유의하게 벽운동의 장애가 빈번함을 보였다(p=0.03891). 그러나 좌심실전벽, 측벽 및 중격부위에서는 유의한 벽운동의 차이가 없었다. 결론 : 급성하벽심근경색증 환자의 전흉부유도에서 ST절의 하강이 동반되는 경우 다혈관 질환의 가능성이 높으며 좌심실확장기말압이 상승되었고 운동능력은 감소되어 있었다. 또한 심초음파도상 좌심실하벽의 벽운동장애도 심하였다. 따라서 전흉부 ST절의 하강을 동반한 급성하벽심근경색증 환자는 전흉부유도에 ST절 하강이 없는 경우보다 예후가 불량할 것으로 생각되며, 보다 적극적인 치료가 필요할 것으로 생각된다. The purpose of this study was to determine the significance of precordial ST segment depression appearing during acute inferior myocardial infarction and to assess the correlation of that with angiographic finding. 52 patients were allocated into two groups based on the existence of precordial ST segment depression : 23 patients with ST segment depression and 29 patients without ST segment depression. The extent of coronary artery disease as well as the prevalence of significant stenosis (≥70%) in left anterior descending artery were more frequent in patients showing precordial ST segment depression than in patients not showing them (p=0.050) and the result were similar in cases of left circumplex artery (p=0.001). On echocrdiographic examination of left ventricular (LV) wall motion, it showed more severely decreased inferior LV wall motion in patients showing precordial ST segment depression than in patients not showing them (p=0.03891) even though the other segment of LV wall motion didn't show the statistical difference between both groups. The other cardiac parameters such as LVEDP, exercise amount (METs) and ejection fraction were tend to showing bad profile in patients with precordial ST segment depression. From the above results, we could deduce that patients with precordial ST segment depression have relatively large infarction or concomitant left coronary artery disease, so they need more caution and intensive theraphy.

일부 산모에서 산모혈, 제대혈, 모유 및 태반에서의 환경 에스토레겐성 화합물(PCBs) : Environmental estromgen compounds(PCBs) in Maternal Blood, Cord Blood, Human Milk and Placenta of Korea women

이강숙,임현우,노영만,구정완,조재천,박정일,김진홍 가톨릭대학산업의학센타 산업의학연구소 2003 韓國의 産業醫學 Vol.42 No.2

The production and intensive use of organochlorine chemicals, both in agriculture and industry, have led to wide spread contamination of the environment. There may be biological effects of organochlorine contaminated breast milk even when levels are below those concentrations that are currently regarded as tolerable. To evaluate the exposure of to fetus PCBs, we measured the sum of 13 congeners of PCBs in maternal blood, cord blood, breast milk and placenta of 30 Korean women by gas chromatograpy/electron capture detector. The concentration of total PCBs of maternal blood, cord blood and breast milk were 7.16±4.29 ㎍/ℓ, 5.16±3.12 ㎍/ℓ, 1.77±2.87 ㎍/ℓ respectively and they have no significant correlation. PCBs in placenta was not defected. However there were no significant differences of PCBs according to age, education, body mass index, parity, breastfeeding, smoking and drinking.