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A Method for Comparing Multiple Bacterial Community Structures from 16S rDNA Clone Library Sequences
Inae Hur,천종식 한국미생물학회 2004 The journal of microbiology Vol.42 No.1
Culture-independent approaches, based on 16S rDNA sequences, are extensively used in modern microbial ecology. Sequencing of the clone library generated from environmental DNA has advantages over fingerprint-based methods, such as denaturing gradient gel electrophoresis, as it provides precise identification and quantification of the phylotypes present in samples. However, to date, no method exists for comparing multiple bacterial community structures using clone library sequences. In this study, an automated method to achieve this has been developed, by applying pair wise alignment, hierarchical clustering and principle component analysis. The method has been demonstrated to be successful in comparing samples from various environments. The program, named CommCluster, was written in JAVA, and is now freely available, at http://chunlab.snu.ac.kr/commcluster/.
Development of a Public Service based on Service Design Process
Inae Jung,Joo-Seoung Lee 대한인간공학회 2013 대한인간공학회 학술대회논문집 Vol.2013 No.5
Objective: This research is a case study of a consumer oriented public service with the service design process. The research has utilized the case of “Eye Tracking Mouse for People with Disabilities” which is a public welfare project from the KODDI (Korea Disabled People’s Development Institute) to distribute the mouse to the consumers to use. The research develops a new process for the eye-tracking mouse distribution service from the service design perspective and the goal is to develop and apply the new public service process concept from the outcome analysis. Method: DesignDIVE which is a crowd sourced Service Design Workshop that gather people from various fields and through collaboration with stakeholders has developed a new product and service model concept. In order for the participants of the workshop to spend the time efficiently, the core people on this project pre-researched the stakeholders to develop a framework for the workshop and this framework is utilized within each team to co-create Service design output. Conclusion: In conclusion, this new public service process, includes the service users’ experiences early on, so that the comprehensive requirements can be defined; thus, the service concepts have taken not only the product upgrade but to include delivery system, education, and the stakeholder’s circumstances into account. Therefore, this public service process definitely needs to include the service design, which is user-centric and includes all stakeholders and collaborates with people to come up with the creative solutions. Application: In this case, the project is showcased by Service design Workshop, if the same process can be applied to the public service or the legislation process more formally, it seems that professional establishment of public service process can be developed in depth. We hope this can become an important methodology for improving the quality of life for all stakeholders including the consumers and providers.
Inae Jeong,송자영,Song Yi Bae,Sang Kook Lee 대한암예방학회 2019 Journal of cancer prevention Vol.24 No.4
Background: Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, is a limited factor in the treatment of non-small-cell lung cancer (NSCLC) patients. Therefore, ongoing studies are trying to identify EGFR-TKIs-resistant mechanisms and to discover novel therapeutic strategies and targets for NSCLC treatment. Methods: In the present study, the possibility of overcoming intrinsic gefitinib-resistance was examined by regulating the expression of AXL. A natural product-derived antitumor agent, yuanhuadine (YD) was employed to modulate the expression of AXL in the cells. Results: Treatment with YD effectively downregulated AXL expression in AXL-overexpressed gefitinib-resistant H1299 cells. The combination of gefitinib and YD exhibited a synergistic grwoth-inhibitory activity in H1299 cells by downregulation of AXL expression. Conclusions: Based on these findings, AXL was found to be a promising therapeutic target to overcome the intrinsic resistance to gefitinib in NSCLC. Furthermore, YD is able to effectively regulate the expression of AXL and thus it may be applicable as a potential lead compound for the treatment of gefitinib-resistant NSCLC. (J Cancer Prev 2019;24:217-223)
Adipose Tissue-Derived Exosomes Regulate Proliferation of Pancreatic Cancer Cells during Obesity
Inae Jeong,Ok-Kyung Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
It is well known that the risk of pancreatic cancer is increased among those who are obese or have a high body mass index. However, the complex molecular mechanisms underlying the pancreatic cancer-obesity link are not fully understood. Recent accumulating evidence has demonstrated the role of exosomes in promoting tumor progression and survival. Here, we investigated the function of adipose tissue-derived exosome from obese mice in pancreatic cancer cells. Level of HB-EGF, ligand of epidermal growth factor receptor, was increased in the adipose tissue-derived exosome from the high fat diet-induced obese mice compared to the normal mice. The adipose tissue-derived exosome from the high fat diet-induced obese mice stimulated ERK and cell proliferation in Panc02 cells. In addition, it suppressed the activation of splenocytes on pancreatic cancer cells. Here, we suggest that exosomes-derived from adipose tissue affects the molecular mechanisms underlying the pancreatic cancer-obesity link.
Building a Co-participatory Partnership Framework for School-visit STEAM Outreach Program
( Inae Kang ),( Jungwon Hwang ),( Jin Hye Jang ),( Eunsung Kang ) 한국교육공학회 2016 한국교육공학회 학술대회발표자료집 Vol.2016 No.1
This study aimed to provide a co-participatory partnership framework for a school-visit STEAM outreach program. The framework has been created through a STEAM outreach program practiced between an elementary school and an University hospital, in which 76 students with two teachers, and three medical doctors have participated during the fall semester of 2015. Data analysis collected from interviews and surveys with the participants showed highly positive responses to the program, which, in turn, reflects the usefulness of the framework. The STEAM outreach framework is basically a model of school visit which seems to ensure more possibility of sustaining the outreach program, compared to the models of organization visit more often experienced in most STEAM outreach programs. The framework, on one hand, assumes three pedagogical principles of STEAM (context-based, creative design, affective experience) in developing the STEAM outreach program, and the other hand, suggests three stages of management (planning, designing, and implementing), each of which describes specific roles of the participants, and things to consider for the outreach program management.