DMBA 유도 햄스터 협낭암 발생과정에서 방사선 조사가 증식세포핵항원(PCNA)의 발현과 apoptosis 유발에 미치는 영향

전인성,허민석,최항문,이삼선,최순철 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.3

Purpose : This study was carried out to investigate the effect of irradiation on the expression of proliferating cell nuclear antigen (PCNA) and apoptosis induction during the carcinogenesis in hamster buccal pouch. Materials and methods : Three months old Syrian golden hamsters were divided into control and 2 experimental groups, Hamsters in control group were left untreated on buccal pouchs. Twenty four hamsters were treated with 0.5% DMBA tri-weekly on the right buccal pouch. Forty eight hamsters were treated with 0.5% DMBA tri-weekly and irradiated with the dose of 5 Gy and 10 Gy at 6,9, 12, 15 weeks after DMBA application. Resected buccal pouches were sectioned and examined for potential expression pattern of PCNA and apoptosis. Results : The PCNA index was increased with the stages of buccal pouch epithelium carcinogenesis except the hyperplasia stage in control group (p< 0.05). The irradiation did not effect on the PCNA index in the dysplasia and the carcinoma in situ stage, but in the hyperplasia stage, the PCNA index was increased with 10 Gy radiation and decreased in the carcinoma stage (p< 0.05). The apoptotic index was significantly decreased from the carcinoma in situ stage and the lowest in the carcinoma stage, The apoptotic index was significantly decreased in the hyperplasia and dysplasia stage with the 5 Gy irradiation and significantly increased only in the carcinoma stage with the 10 Gy irradiation (p< 0.05). Conclusion : The PCNA and apoptotic index were varied according to the irradiation period and dosage in each carcinogenesis stage. (Korean J Oral Maxillofac Radiol 2000; 30: 207-216)

Adult invasive pneumococcal disease in the Republic of Korea: Risk medical conditions and mortality stratified by age group

Kim, Jong Hun,Baik, Seung Hee,Chun, Byung Chul,Song, Joon Young,Bae, In-Gyu,Kim, Hyo Youl,Kim, Dong-Min,Choi, Young Hwa,Choi, Won Suk,Jo, Yu Mi,Kwon, Hyun Hee,Jeong, Hye Won,Kim, Yeon-Sook,Kim, Jeong Elsevier 2018 INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES Vol.74 No.-

<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>This study aimed to characterize the risk factors for mortality in adult patients with invasive pneumococcal disease (IPD) stratified by age groups, after implementation of the national immunization program of 23-valent polysaccharide vaccine (PPSV23) for those aged ≥65 years in the Republic of Korea (ROK).</P> <P><B>Methods</B></P> <P>Clinical data and pneumococcal isolates from adult patients with IPD (≥18 years of age) were collected prospectively from 20 hospitals through the nationwide surveillance program from March 2013 to October 2015.</P> <P><B>Results</B></P> <P>A total of 319 patients with IPD were enrolled. Median age was 69 years. Overall in-hospital mortality was 34.2%: 17.1% in those aged 18–49 years, 23.7% in those aged 50–64 years, 33.0% in those aged 65–74 years, and 51.0% in those aged ≥75 years (<I>p<</I> 0.001). In particular, early death within 7days of hospitalization accounted for 60.6% (66/109). While old age (≥65 years), higher Pitt bacteremia score (≥4), and bacteremic pneumonia were independently associated with IPD mortality in all age groups, an additional mortality risk factor of immunocompromised status was identified for patients aged 50–64 years. PPSV23 serotypes accounted for 64.4% (122/189) of the pneumococcal isolates serotyped.</P> <P><B>Conclusions</B></P> <P>This study suggests that vaccine-type IPD continues to place a substantial burden on older adults in the ROK, necessitating an effective vaccination strategy for those at higher risk.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization of the elderly with the 23-valent polysaccharide vaccine (PPSV23) was implemented in Korea in 2013. </LI> <LI> Overall in-hospital mortality was 34.2% for adult invasive pneumococcal disease (IPD) and 51.0% for patients ≥75 years of age. </LI> <LI> Mortality risks were older age, higher bacteremia score, and immunocompromised status. </LI> <LI> An effective vaccination strategy for those at higher risk of IPD is needed. </LI> </UL> </P>

가곡 스카른 광상 월곡-선곡 광체의 광물.지구화학적 특성: 성인적 의미

최부갑,최선규,서지은,유인걸,강흥석,구민호,Choi, Bu-Kap,Choi, Seou-Gyu,Seo, Ji-Eun,Yoo, In-Kol,Kang, Heung-Suk,Koo, Min-Ho 대한자원환경지질학회 2010 자원환경지질 Vol.43 No.5

가곡 스카른 광상은 고생대 조선누층군 석회질암을 관입한 백악기 화강암체의 접촉부를 따라 층상으로 교대된 광상으로 구성되어 있다. 관계화성암인 반심성암체는 석영몬조암~화강반암 조성과 함께 I형, 칼크-알카리 계열, 고알루미나질 지화학적 특정을 보이며, 가곡 Zn-Pb 광상에서는 내성스카른과 비하여 외성스카른이 광범위하게 배태되어 있다. 선곡과 월곡 지역의 광체에서 지화학적/광물학적 특성은 관계화성암으로부터 근접성에 의하여 좌우되고 있다. 가곡 광산의 섬아연석에는 Mn, Cd, Cu, In 성분이 미량 함유되어 있고, 정출온도 차이 및 분화과정을 통하여 차별화된 농집 과정이 유도됨으로서 광체에 따라 미량원소의 차이를 보이고 있다. 광석 중 높은 In/Zn비와 Cd/Zn비 그리고 섬아연석 중 낮은 Mn/Zn비는 마그마로부터 공급된 근원물질의 근접성과 밀접한 연관성을 보이고 있다. 따라서, 광석과 섬아연석에 함유된 미량원소의 농집 양상은 정출온도와 광화유체의 근원물질과 관련된 광체의 지화학적/광물학적 차별성을 인지할 수 있는 중요한 지시자로 이용될 수 있다. The Gagok stratabound skarn deposit is the result of the intrusion of the Cretaceous granitic pluton into the Paleozoic calcareous rocks. The subvolcanic intrusion ranges in composition from quartz monzonite to granite porphyry with I-type, calc-alkaline and weakly peraluminous characteristics. Both endoskarn and exoskarn are developed at the Gagok Zn-(Pb) deposit, with more exoskarn than endoskarn. Geochemical and mineralogical characteristics in the Seongok and Wolgok orebodies can be treated in terms of self-organization. Sphalerites in the Gagok ore can also incorporate minor amounts of Mn, Cd, Cu and In. Trace element concentrations in different orebodies vary because fractionation of a given element into sphalerite is influenced by formation temperature and the amount of sphalerite in the ore. A group of high In/Zn and Cd/Zn ratios in ores, and low Mn/Fe ratios in sphalerites are correlated with proximal processes of a magmatic source. The pattern of minor/trace element variations in ores and sphalcrites can be used for petrogenetic interprctation, e.g., orebody zonation related to crystallization temperature and fluid d sources.

忠州市 主幹線 道路邊 建築外部色彩에 關한 硏究

崔生吉,孫泰鎭,柳顯紀,辛同寅,梁富弘,尹勝照,朴碩鉉 忠州大學校 1998 한국교통대학교 논문집 Vol.33 No.2

In order to understand the influence of colours on the urban design of a city, a portion of the central Chung-Ju was chosen as the study area, and three cases were researched as colours. These surveyed colours are analysed in their hue, value and chroma. It was necessary to determine the colours of 272 buildings exterior in all in order formulate the findings presented in this study. The result of this study can be briefly summerised as the following ; 1) The trends in the use of colour turn out like this ; 55.3% of the building were Y(yellow), YR(yellow-green), R(red) Family in Hue, abour 33.9% of them were within 8.0-8.9 and 26.6% were within 7.0-7.9 on the value scale, and about 48.5% of them were within 1.0-1.9, 2.0-2.9 and 3.0-3.9 on the chroma scale. 1) For case 1 on the exterior colours of buildings, about 57.8% were Y and YR family in Hue, about 53.7% were 8.0-8.9 and 7.0-7.9 in Value, and about 49.6% of them were within 1.0-3.9 in chroma. 2) For case 2 on the exterior colours of buildings, about 52.4% were Y and R family in Hue, about 65.1% were 7.0-8.9 in Value, and about 46% were 1.0-2.9 in Chroma. 3) For case 3 on the exterior colours of buildings, about 55.7% were Y and YR Family in Hue, about 72.1% were 7.0-8.9 in Value, and about 31.1% were 2.0-2.9 in Chroma. In summary, the colours of the building surveyed in central Chung-Ju can be characerized as Y, YR, R, N family in Hue, 7.0-7.9, 8.0-8.9 in Value registered in 1.0-1.9, 2.0-2.9, 3.0-3.9 in Chroma. The observed exterior colours show a tendency toward Yellow in Hue, High in Value and low in Chroma. Generally, the majority of the colours is light rather than strong in tone.

Economical Gas Chamber for In-situ Gas Measurement and Analysis of Gas Response Characteristics according to Sensor Voltage

Yun-Suk Choi(최연석),In Hwan Lee(이인환) 한국기계가공학회 2019 한국기계가공학회지 Vol.18 No.5

Breath analysis using a portable device is better than the classical breath analysis system in terms of installation and operation. There is an increasing need to develop cost-effective equipment for testing gas sensors from the viewpoint of functionalities that can be applied applicable to portable devices. In the present study, an economical gas chamber for in-situ gas measurement is implemented with a single gas chamber without using expensive gas storage and control equipment; the gas response characteristics are analyzed using the above-described chamber. The main features of the implemented gas chamber are simple injection procedure, improved gas diffusion, easy measurement and cleaning, support for low-power mode measurement function for portable devices, and open source platform. Moreover, an analysis of gas response characteristics based on changes in sensor voltage show that the sensitivity and 90% response time are affected by the sensor voltage. Furthermore, the sensitivity graph has an inflection point in a specific range. The gas sensor applied in this study showed fast response speed and high sensitivity for sensor voltages of 3.0-3.5 V, regardless of the concentration of acetone gas, the target gas used in this study.

전산화 신경인지기능 검사를 이용한 외상성 두뇌손상환자의 신경인지기능평가

정인원,최인석,김재진 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.2

뇌영상검사상 국소적인 병변을 보이지 않는 경도 외상성 두뇌손상환자를 대상으로 한 신경인지기능검시에서 인지기능결함이 보고되고 있으며 이에 대하여 객관적인 인지기능장애 평가도구가 요구돼 왔다. 본 연구에서는 외상성 두뇌손상환자들을 대상으로 뇌 영상검사를 시행하여 국소적인 병변의 유무에 따라 병변군과 비병변군으로 분류하였으며, 이와 동시에 신경인지기능검사를 시행하여 병변의 유무에 따른 Bender-Gestalt Test, 표준도형검사, 인식력검사. 신호탐지검사 결과를 비교해 보았다. 또한 KWIS 지능지수와 표준도형검사 지능지수간의 상관관계를 조사하여 지능검사도구로 표준도형검사의 유용성을 알아보고자 하였다. 외상성 두뇌손상환자집단의 신경인지기능검사 결과는 다음과 같았다. 1) 신경정신과적 주요 증상 비교에서 병변군은 인지장애 호소가 맡았으며. 비병변군은 신체장애 호소가 많았다. 2) BGT 전체수행오류는 병변군이 비병변군보다 많았다. 3) KWIS 지능검사상 병변군과 비병변군간의 차이는 없었다. 4) 표준도형검사 소항목 검사결과 병변군은 정상대조군이나 비병변군에 비하여 난이도가 높을수록 수행이 낮았다. 5) 인식력검사 결과 병변군은 정상대조군보다 수행이 낮았다. 6) 외상성 두뇌손상환자집단에서 표준도형검사 지능지수는 KWIS 지능지수와 r=0.67의 높은 상관관계를 보였다. . 이와 같은 결과로 외상성 두뇌손상환자 중 병변군은 공간구성능력, 미세운동협응능력. 형태기억능력, 반응속도에서 장애를 보임을 알 수 있었다. 통계적인 의미는 없었으나 인식력검사결과에서 비병변군은 정상대조군과는 다른 반응 경향을 나타내고 있었다. 인식력검사상 비병변군의 이러한 차이는 비병변군이 신체장애를 주로 호소하였고. 경도 외상성 두뇌손상에서 보상과 같은 심리적 요인들이 증상의 유지에 기여할 수 있다는 보고를 고려할 때. 신경인지기능검사의 임상적,인 해석에 주의를 요하고 있다. 그리고 외상성 두뇌손상환자에서 표준도형검사 지능지수와 KWIS 지능지수는 정상대조군보다 높은 상관관계를 보여 표준도형검사는 두뇌손상환자와 같이 지적능력이 저하된 진단에서 KWIS 지능검사를 보완할 수 있는 유용한 지능검사로 임상상황에서 경제적이고 객관적인 지능검사 도구가 될 수 있음을 알 수 있었다. Irrespective of focal lesion in brain imaging study, the deficits in cognitive function have been reported in mild traumatic brain injury patients. Therefore, they have been asked sensitive and objective assessment tools measuring cognitive deficits. In this study, traumatic brain injury patients were classified into lesion group and non-lesion group by presence of focal lesion in brain imaging study At the same time, Results of Bender-Gestalt test, Standard Progressive Matrices, Cognitrone, and Signal Detection were analyzed among the groups. We assessed usefulness of Standard Progressive Matrices as assessment tool of intelligence in traumatic brain injury patients by correlation coefficients between KWIS and Standard Professive Matrices intelligence quotients. 1) Most lesion group showed severe deficits in cognitive function, and most non-lesion group showed severe somatic symptoms. 2) The lesion group showed higher Bender-Gestalt test total error score than non-lesion group. 3) There was no difference in KWIS intelligence quotients between lesion and non-lesion group. 4) The lesion group showed lower performance than normal control and non-lesion group as increasing complexity of Standard Progressive Matrices subset. 5) The lesion group showed poor performance than normal control group in Cognitrone. 6) There were higher correlation coefficients than normal control group between Standard Progressive Matrices intelligence quotients and KWIS intelligence quotients in traumatic brain injury patients. According to the above results, lesion group showed deficits in space-construction ability, fine-motor coordination ability, form-memory ability, and delayed response-time. Although there are no statistical significance, comparing with normal control group, non-lesion group showed different response-trend in Cognitrone. Considering somatic symptoms in most nonlesion group and contribution of psychological factors in maintenance of symptoms in mild traumatic brain injury patients, the differences in Cognitrone must be interpreted carefully. These result suggest than Standard Professive Matrices can be a useful tool for assessment of intelligence in traumatic brain injury patients who showed deficits in cognitive function.

嶺湖南地方의 蒸發量分布에 關한 調査硏究

金仁湖,崔文錫,徐承德 慶尙大學校 1972 論文集 Vol.11 No.-

This report is statistically carried out the research on the distribution of evaporation from 1931 to 1970 in Yeungnam and Honam provinces in Korea. For this work, several data of evaporation were derived from Climatic table(for 1931∼'60) and monthly reports(for 1961∼'70) by thirty eight meteorological stations or observations which were instituted in Yeungnam and honam. Previously, the results and those distribution charts of evaporation from 1961 to 1970 are shown Table-2 and Fig. 1∼l4. Since mostly meteorological stations or observations in Yeungnam and Honam were hardly to retain all data of evaporation from 1931 to 1970, ten places(*marked places in Table-2) where they didn't comparatively occur to the lacks of measured evaporation for forty years(l931∼'70) were selected in the representatives in Yeungnam and Honam. Table 3 shows the distribution of evaporation in the representatives for forty years. Some differences are happend to numerical values of mean evaporation per year in the results between Table-2 and Table-3. However, if all of data are treated of reasonably statistical process, Table-2 and those charts(Fig. 1∼14) are presented obtaining considerations as a distributive tendency of evaporation there. From the conclusion of Table-2, mean value of evaporation per year in Yeungnam and Honam is proposed about 1,200mm

체외순환 없이 시행한 관상동맥우회술의 조기성적

원태희,최세용,양인숙 이화여자대학교 의과대학 2005 EMJ (Ewha medical journal) Vol.28 No.1

Background : The advances in surgical techniques and stabilizing devices have made the off-pump coronary artery bypass (OPCAB) popular, and good results have been published. We analyzed the early results of OPCAB performed in our hospital. Materials and Methods : Between January 2004 and December 2004, 23 patients underwent OPCAB. There were 14males and 9 females with mean age of 62.6± 10.3years. Preoperative diagnoses were unstable angina in 13(57%), acute myocardial infarction in 9(39%), and stable angina in 1(4%). Preoperative angiographic diagnoses were three-vessel disease in 12 (52%), two-vessel disease in 8(35%), one-vessel disease in 1(4%), and left main disease in 2(9%). Results : The mean number of grafts was 2.6 ±0.9 per patient. Vessels accessed were left anterior descending artery in 23, diagonal branch in 14, obtuse marginal branch in 9, right coronary artery in 12, and posterior descending artery in 1. Left internal mammary artery were used in 22 patients and bilateral internal mammary arteries were used in 1 patient. There was no operative mortality. Postoperative complications were cerebral vascular accident in 1, postoperative bleeding which required operative management in 2, arrhythmia including atrial fibrillation in 5, and minor operative wound problem in 1. Pre-discharge graft patency was evaluated in 11 patients. One internal mammary artery graft was occluded in 11 internal mammary artery graft evaluated. The patency rate was 91%. Seventeen saphenous vein grafts were patent in 19 saphenous vein grafts and the patency rate was 89%. Conclusion : Our result of OPCAB is promising and OPCAB is suggested to be the ideal technique with less morbidity and mortality.

성장호르몬 결핍증과 특발성 저신장증 환아에서 성장호르몬의 치료 효과

강정철,최윤석,최인경,김호성,김덕희 대한소아과학회 2004 小兒科 Vol.47 No.3

Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid

( Kicheol Yoo ),( Kang Yeol Suh ),( Gi Hun Choi ),( In-suk Kwak ),( Dong Kook Seo ),( Dohern Kym ),( Hyeon Yoon ),( Yong Se Cho ),( Hye One Kim ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.2

Background: It has been reported that heat shock protein 70 (HSP70) and interleukin-8 (IL-8) play an important role in cells during the wound healing process. However, there has been no report on the effect of HSP70 and IL-8 on the blisters of burn patients. Objective: This study aimed to evaluate the serial quantitative changes of HSP70 and IL-8 in burn blisters. Methods: Twenty-five burn patients were included, for a total of 36 cases: twenty cases on the first day, six cases on the sec-ond, five cases on the third, three cases on the fourth, and two cases on the fifth. A correlation analysis was performed to de-termine the relationship between the concentration of HSP70 and IL-8 and the length of the treatment period. Results: The HSP70 concentration was the highest on the first day, after which it decreased down to near zero. Most HSP70 was generated during the first 12 hours after the burn accident. There was no correlation between the concen-tration of HSP70 on the first day and the length of the treat-ment period. No measurable concentration of IL-8 was de-tected before 5 hours, but the concentration started to in-crease after 11 hours. The peak value was measured on the fourth day. Conclusion: While HSP70 increased in the first few hours and decreased afterwards, IL-8 was produced after 11 hours and increased afterward in burn blister fluid. These findings provide new evidence on serial changes of in-flammatory mediators in burn blister fluid. (Ann Dermatol 29(2) 194∼199, 2017)