조직확장법,술중 조직확장법 및 술전 봉합법의 임상적 응용에 관한 비교 연구

오석준,하지운,김응춘,서인석,조세흠 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.3

The purpose of soft tissue defect reconstruction is minimal scar with aesthetic and functional good results. Reconstruction of head and neck, upper extremity, chest, and lower extremity defects has been reported with standard available tissue expansions. Various surgical methods have been used in an attempt to achieve a normallooking skin color, texture, sensation, thickness and same skin adenexa. Therefore, in accordance with defect size and location, the operative method was considered so we select adequate method. Authors achieved good results from 48 cases of tissue expansion, 18 cases of ISLE (intraoperative sustained limited expansion), and 35 cases of presuturing technique. 1)The most common cause of reconstruction for soft tissue defect was post grafted scar 51cases(51%), next was tattoo 20 cases(19.6%), traumatic soft tissue defect 16cases(15.7% ) and nevus 8 cases(7.8%)in order. 2)Males(55.9%)were affected more often than females(44.1%)in the ratio 1, 3 : 1 and the most frequently affected group was the age of 20 to 30 years as 36% . 3)The distribution of incidence and location were as follow : face(39.2%), upper extremity(25.5%), scalp(17.6%), lower extremity(9.8%) and trunk(7.8%). 4)The cause and distribution were scalp in 20 cases(39.2%), face in 40 cases(29.4%) in the post grafted scar, upper extremity 18 cases(90.0%) in the tattoo, upper extremity 4 cases(50.0%), face 2 cases(25.0%) in the nevus and even distribution in the traumatic soft tissue defects. 5)The presuturing technique was best recommended method for soft tissue defect in 4cm diameter lesion on extremity, but ISLE method was used in the open traumatic soft tissue defect. Over 9cm wide scar was resurfaced by expanded skin using tissue expander.

각종 성장인자 (GROWTH FACTORS)가 골아 세포주 MC 3T3-E1에 미치는 효과

서인석,이두형 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2

Bone formation is a complex process which involves a large number of cellular functions directed toward the synthesis and mineralization of bone matrix. Bone formation is regulated by systemic hormones and by systemic and local growth factors which influence bone replication, differentiation and the actual performance of specialized activities. The effects of hormones on bone metabolism have been studied extensively by a number of investigators and, recently, information about growth factors and their role in bone formation and bone resorption has become available. Our laboratory has been interested in the study of factors produced locally by the skeletal tissue. The aim of this study is to investigate the effects of various growth factors on the growth of osteoblastic clone MC 3T3-El cells. Maximum stimulation of proliferation of osteoblastic cells, relative to corresponding controls, was seen at 0.1%-1% serum and the effects was dose-dependent. With various growth factors, such as IGF-Ⅰ,IGF-Ⅱ,EGF, and FGF, sustained the growth of calvarial cells in culture during multiple passages at 0.1% serum. In DNA synthesis assays, all growth factors stimulate cell proliferation. Stimulation of DNA synthesis peaked at 20ng/㎖ of IGF-Ⅰ, 50ng/㎖ of IGF-Ⅱ, and 20ng/㎖ of EGF, while higher concentrations were inhibitory or stationary. PTH-sensitive adenylate cyclase was stimulated by all growth factors. But the alkaline phosphatase activity decreased slowly in cells grown in all growth factors.

임상 가검물에서 분리된 균(대장균과 황색 포도균)의 약제 내성

김중명,김재식,김경선,김재룡,전동석,최성만,서상철,김인자,김재숭,이건일,김경숙 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.2

1981년 1월에서 12월말까지 임상 제료에서 분리한 Escherichia coli (E. coli)와 Staphylococcus aureus (S. aureus) 중에서 무작위로 각 50주 씩 선택하여 원판 확산법과 평판 희섭법으로 그 내성주를 조사하여 다음과 같은 성적을 얻었다. 전체적으로 볼 때에 Teteracyclin (TET), Chloramphenicol (CM) 및 Ampicillin (AMP)에 대한 내성주가 가장 많았고, Amikacin (AMK)에 대한 내성주는 가장 적어다. 이것을 균종별로 보면 E. coli에 있어서는 TET, AMP 및 CM는 원판 확산법으로서 74∼76%, 평판 희석법으로서는 78∼94%가 내성주임을 나타내었고, 또 Cephalothin(CEP)은 원판 확산법에서는 8%가 내성주로 나타났으나, 평판 의석법에서는 52%가 내성주로 나타났다. S. aureus에 있어서는 TET는 원판 확산법으로 82%, 평판 희석법으로서는 78%가 내성주로 나왔고 Penicillin (P)은 원판 확산법에서는 56% 평판 희석법으로는 22%의 내성주가 나왔으며, GM과 CM은 원판확산법에서는 18∼44%, 평판 희석법에서는 56∼58%가 내성주로 나왔다. Each 50 strains of Escherichia coli and Staphylococcus aureus were selected at random out of the stock cultures which were isolated from the clinical materials in the bacteriological laboratory of the department of clinical pathology. Kyungpook National University Hospital from the first of January to the end of December in 1982, and their resistance against eight antibiotics were as follows; Escherichia coli and Staphylococcus aureus had the most resistant pattern against tetracyclin, chloramphenicol, and ampicillin, while they had the most sensitive pattern against amikacin in general. Escherichia coli revealed resistant pattern to tetracyclin, ampicillin, and chloramphenicol 74-76% by the disk diffusion method and 78-94% by the plate dilution method, and revealed resistant pattern to cephalothin 8% by the disk diffusion and 52% by the plate dilution. Staphylococcs aureus disclosed resistant pattern to tetracyclin 82% by the disk diffusion and 78% by the plate dilution, and disclosed resistant pattern to penicillin 56% by the disk diffusion and 22% by the plate dilution, and to gentamicin and-chloramphenicol 18-44% by the disk diffusion and 56-58% by the plate dilution.

INVERTED MATTRESS SUTURE를 이용한 선천성 이개연골 변형의 교정

하지운,최병욱,서인석 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.1

There are many kinds of congenital auricular deformities but some congenital deformities have no lack or excess of cartilage, which are mild to a moderately constricted ear, cryptotia and Stahl's ear etc. Even if some kinds of surgical treatments, such as cartilage graft, cartilage turn over and cartilage flap were reported for the correction of them but they were comlex and sometimes unsatisfactory. The method of inverted mattress suture to correct the cartilage deformities is not a new method and some authors reported it previously to correct ear cartilage deformities. Authors have tried to correct several kinds of congenital ear deformities, 2 constricted ears, 5 cryptotias, 2 stahl's ears. 1 satyr ear by using of simple inverted cartilage mattress suture and added Z-plasty or V-Y advancement to corrcet the auricular skin in each cases, respectively. The result was promising without recurrences during average 3 months folloe up periods. This method is immediative, simple, easy to perform and a very useful procedure for the correcton of congenital ear auricular cartilage deformities.

발목관절 가쪽인대의 형태계측과 자기공명영상

정인혁,이혜연,서진석,이우형,장준섭 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.2

백시니아 바이러스(Vaccinia Virus) 란내 증식에 관한 연구

金慶浩,朱秀永,趙成萬,徐俊錫,姜寅求 國立保健硏究院 1970 국립보건연구원보 Vol.7 No.-

최기형 물질로 유도된 구개열에 있어서 구개판의 변화에 대한 실험적 연구

徐錫煥,鄭仁赫,李英浩,申泰善 연세대학교 의과대학 1984 연세의대논문집 Vol.17 No.1

안면부골절의 진단에서 전산화단층촬영(C-T)과 단순방사선 촬영과의 비교

서인석,김홍래,이두형 大韓成形外科學會 1983 Archives of Plastic Surgery Vol.10 No.1

Efficacy and Accuracy of CT in initial evaluation of the facial bone fracture was compared with the conventional radiographic studies in 36 patients. The results are as follows; 1) CT provides more accurate information than plain x-rays in diagnosis of facial bone fracture. ① CT Showed the herniation of intraorbital soft tissue into the maxillary sinus and orbit floor fractures in blowout fractures. ② CT visualized the inijuries of intraorbital soft tissue in detail.(esp. EOM mm., Optic nerve) ③ Zygomatic bone fracture combined with fracture of the postero-lateral wall of the maxillary sinus was well visualized in CT findings. 2) CT provides a simple and accurate information of fractures of the facial bones in terms of location and extent of the injuries. By analysing CT information, it was possible to study injured portions of the facial bone in detail with a few, but special view of the conventional radiographic studies. 3) CT evaluation of facial bone frctures was possible without added risks in patients with suspected CNS injuries at the same time of CT evaluation of suspected brain trauma. 4) CT had definite advantage in diagnosis, treatment and follow-up in facial bone fractures.

Optical Bleaching Behaviour of Neutron Irradiated KCI Single Crystal

Suh, In-Suck Korean Nuclear Society 1973 Nuclear Engineering and Technology Vol.5 No.4

Hydroxide free KCI single crystals are prepared and doped with samall amounts of KSH or $K_2$S. The samples are subjected to neutron irradiations while keeping them under the condition of liquid nitrogen temperature in the dark. The irradiated ones are then bleached by using a U.V. lamp and analysed as four different kinds of chemical forms in $^{35}$ S whose valence states are -2, 0, +4 and +6. It semms that the sulphide fraction of $^{35}$ S in doped crystals is higher than that in pure crystals. In addition, two distinct patterns in bleaching process up to 30 minutes results in a fast increase in the sulphide fraction and then the sulphide levels off to a slowly increasing region upon prolonged bleaching. A detailed description on the distribution of $^{35}$ S valence states will be made in connection with point defects in the crystals.

선천성 수부기형의 임상적 고찰

서인석,이두형,이용호,김홍래 대한성형외과학회 1981 Archives of Plastic Surgery Vol.8 No.1

60 Patients of the congenital anomalies of the hand were operated at the Dept. of Plastic surgery in Kyung Hee Medical Center during the last 9 years from Oct., 1972 to Sept., 1980. These patients were clinically reviewed and the results were as follows : 1. Male was more frequent than female, of the ratio in 1. 3 : 1. 2. The most common type of hand anomalies was polydactyly, and the incidence of each anomalies was as follows : polydactyly in 23 cases (38.3%), Trigger finger in 17 cases(28.3%), syndactyly in 16 cases(26.6%), Cleft hand in 1 case (1.6%), Floating thumb in 1 case (1.6%), Ring constriction band in 2 cases(3.2%). 3. Radial side extra thumb was the most common form of the polydactly and the left, of the ratio in 2. 3 : 1. The unilateral polydactyly was also more frequent than the bilateral, of the ratio in 6. 6 : 1. The most frequent type of polydactyly the duplicated distal phalangeal type. 4. In syndactyly, the left syndactyly was more frequent than the right, of the ratio in 1. 7 : 1 and the incidence of unilateral and bilateral syndactyly was not different. The most common affected site of syndactyly was 3rd web spaces, The most common type of syndactyly was single partial simple. 5. Average age of the time of operation was 4. 5 years old in polydactyly, 10. 9 years old in syndactyly. 6. Postoperative results were favorable as follows : 87.0% in polydactyly, 90.5% in syndactyly.