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Comparative Effectiveness of Distilled Water and Isotonic Saline in a Rat Model of Dry Eye
Tae Myoung Kim, Jae Myun Ryu, Im Kwon Seo, Dongsun Park, Sun Hee Lee, Dae-Kwon Bae, Goeun Yang, Yun-Hui Yang, Tae Kyun Kim, Ehn-Kyoung Choi, Seock-Yeon Hwang, Yun-Bae Kim 충북대학교 동물의학연구소 2010 Journal of Biomedical and Translational Research Vol.11 No.4
본문참고
Solandelactones A-I, Lactonized Cyclopropyl Oxylipins Isolated from the Hydroid Solanderia secunda
Seo, Youngwan,Cho, Ki Woong,Rho, Jung-Rae,Shin, Jongheon,Kwon, Byoung-Mog,Bok, Song-Hae,Song, Jun-Im 이화여자대학교 생명과학연구소 1996 생명과학연구논문집 Vol.7 No.-
Solandelactones A-Ⅰ(1-9), cyclopropyl and lactone containing novel docosanoids have been isolated from the hydroid Solanderia secunda. The structures of these compounds have been elucidated by combined spectral and chemical studies. Configuration of the cyclopropyl ring has been assigned as the opposite of related oxylipins by NOESY experiments. Absolute stereochemistry has been determined on the basis of chemical transformations and CD measurements of synthetic derivatives. In addition, the biogenetic origin of solandelactones has been discussed. Solandelactones C,D and G exhibited moderate inhibitory activity against Farnesyl Protein Transferase.
유채유 함유사료가 쥐의 혈청 및 간의 지질조성에 미치는 영향
서은숙,김인숙,임일순,권태봉 한국식품영양학회 1994 韓國食品營養學會誌 Vol.7 No.3
본 실험은 시판되고 있는 유채유의 지방산 조성을 분석하고 유채유의 함량에 따른 체중증가와 혈청 및 간조직의 지질농도에 미치는 영향을 알아보기 위하여 Sprague-Dawely계 수컷 흰쥐를 42일간 유채유 함유 사료로 사육하여 다음과 같은 결과를 얻었다. 시판 유채유의 지방산 조성은 oleic acid가 29.43%로 가장 많았고 erucic acid (26.52%), linoleic acid(20.39%), linolenic acid(8.68%)의 순으로 나타났다. 체중 증가량은 대조군이 138.10g인데 비하여 RSO_5군은 13.58g, RSO_10군은 132.00g, RSO_15군은 135.34g, RSO_20군이 127.07g으로 유채유 함량에 따라 약간 차이가 있으나 대조군보다는 모두 낮았다. 각 장기의 중량에 있어서 간의 대조군이 2.970g인데 비하여 PSO_10군이 3.249g(p<0.01), RSO_15군과 RSO_20군은 각각 3.479g과 3.478g(p<0.01)으로 유의차를 나타내었고 갑상선도 RSO_15군과 RSO_20군이 각각 0.023g과 0.030g(p<0.01)으로서 유의차를 나타내었으나 심장, 신장, 비장, 고환에서는 유의한 차이가 없었다. 혈청의 total lipid 함량은 대조군(324.29㎎/㎗)에 비하여 RSO_20군(378.60㎎/㎗)이 유의적으로 높았으며(p<0.01) 간조직에서는 군간에 유의차가 없었다. 혈청의 triglyceride함량은 대조군(84.14㎎/㎗)에 비하여 RSO_20군(122.00㎎/㎗)이 유의적으로 높았으며(p<0.01), 간조직에서는 RSO_20군(33.77㎎/g)이 가장 높았으나 대조군(29.76㎎/g)에 비하여 유의차는 없었다. 혈청의 phospholipid함량은 모든군에서 거의 비슷한 수준이었으나 간조직에서는 대조군(8.42㎎/g)에 비하여 RSO_5(7.34㎎/g)군이 유의적으로 가장 낮았다(p<0.001). Total-cholesterol 함량은 혈청과 간조직에서 대조군에 비하여 RSO_20군이 가장 높은 수준이었으나 유의차는 없었다. Ester-cholesterol함량은 혈청중에서 RSO_5군(46.82㎎/㎗)이 대조군(52.29㎎/㎗)에 비하여 유의적인 차이(p<0.05)를 나타내었으며 간조직에서는 모든 군이 같은 수준이었으며 혈청의 Free-cholesterol과 LDL-cholesterol함량은 군간에 유의성이 없었다. 간조직의 관찰에서는 RSO_20군에서만 약간의 지방침착이 발견되었을 뿐 나머지 군은 모두 정상이었다. The fatty acid composition of a rapeseed oil being on the market was analyzed and the effect on gain of the body weight and lipid levels in serum and liver tissue of male rats of Sprague-Dawely strain fed the diet containing the rapeseed oil were studied. The fatty acid components of marketed rapeseed oil was oleic acid 29.4%, erucic acid 26.52%, linoleic acid 20.39% and linolenic acid 8.68%. The contents of total lipid in serum was significantly higher in RSO_20 group than control group(p<0.01). But that in the liver tissue did not show significant differences. The contents of triglyceride in serum was control group 84.14㎎/㎗, RSO_15 group 100.33㎎/㎗ and RSO_20 group 122.00㎎/㎗ and showed significant difference between each group, but that in the livertissue did not show significant differences. The contents of phospholipid in serum did not show significant differences. But that in the liver tissue showed significant difference between the control group 8.42㎎/g and RSO_20 group 7.34㎎/g(p<0.001). The contents of total-cholesterol and free-cholesterol in serum and liver tissue of the RSO_20 group showed the highest levels compared with control group, but there did not show significant differences. The contents of ester-cholesterol in serum showed significant difference between the control group 52.29㎎/㎗ and RSO_5, group 46.86㎎/㎗ (p<0.05). But that in the liver tissue did not show significant difference. The contents of HDL-cholesterol and LDL-cholesterol in serum did not show significant difference. A bit of fat diposit was obserbed only in liver tissue of RSO_20 group.
Im, Moon-Sun,Kim, Hack-Lyoung,Kim, Sang-Hyun,Lim, Woo-Hyun,Seo, Jae-Bin,Chung, Woo-Young,Zo, Joo-Hee,Kim, Myung-A,Park, Kyung-Woo,Koo, Bon-Kwon,Kim, Hyo-Soo,Chae, In-Ho,Cho, Dong-Ju,Ahn, Youngkeun,Jeo Elsevier 2016 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.221 No.-
<P>Background: Initial left ventricular (LV) systolic function is a main determinant of clinical outcomes in patients with acutemyocardial infarction (AMI). This study was performed to investigate whether AMI patients have different prognostic factors according to their baseline LV systolic function. Methods: A total of 12,988 patients with AMI from a nationwide database were analyzed. Major adverse cardiovascular events (MACEs) within 12 months of AMI, including death, nonfatal myocardial infarction (MI), and revascularization, were assessed. Results: Patients were stratified into two groups according to LV ejection fraction (LVEF): those with LVEF < 40% and those with LVEF >= 40%. Patients with LVEF < 40% (n = 1962, 15.1%) were older and had more unfavorable cardiovascular risk factors than those with LVEF >= 40% (n= 11,026, 84.9%). The rate of MACE was higher in patients with LVEF < 40% than in those with LVEF >= 40% (26.8% vs 11.4%, p < 0.001). Independent predictors of 12-month MACEs in patients with LVEF >= 40% were history of MI, high Killip stage, three-vessel disease, and lower renal function, which are already known as risk factors. However, diabetes mellitus (hazard ratio [HR], 1.68; 95% confidence interval [CI], 1.17-2.40; p = 0.008), and the use of rennin-angiotensin system (RAS) blockers (HR, 0.63; 95% CI, 0.41-0.95; p = 0.029) were independent factors for 12-month MACE in patients with LVEF < 40%. Conclusions: Prognostic factors determining 12-month MACE after AMI are different according to LVEF. Management following AMI should be tailored according to their LV systolic function. (C) 2016 Elsevier Ireland Ltd. All rights reserved.</P>
서광섭,김구영,임병욱,채선애,강남훈,유광렬,김창훈,권영우,김호정 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1
In 1988 Menetner described polyadenomes en nappe also known as hypertrophic or hyperplastic gastropathy, giant hypertrophic gastritis, and giant hypertrophy of gastric rugae. Moderate to severe hypoproteinemia and hypochlorhydria are often encountered. Radiographically and grossly, the condition can be confused with malignant lymphoma and carcinoma. Microscopically there is a striking foveolar hyperplasia accompanied by tortuosity. The glandular content is diminished, and the stroma is edematous and inflamed. Carcinoma may develop in a stomach affected by Menetnets disease, but the incidence is differently appreciate by authors.
Pharmaceutical Evaluation of Genistein-loaded Pluronic Micelles for Oral Delivery
Kwon, Suk-Hyung,Kim, Sun-Young,Ha, Kyoung-Wook,Kang, Myung-Joo,Huh, Jin-Seo,Im, Tae-Jong,Kim, Yong-Min,Park, Young-Mi,Kang, Kyoung-Hoon,Lee, Sang-Kil,Chang, Jung-Yun,Choi, Young-Wook,Lee, Jae-Hwi 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
The purpose of the present study was to determine whether Pluronic F127 polymeric micelles could improve the oral bioavailability of a poor water-soluble drug, such as genistein. Genistein is a phytoestrogen that has estrogenic activity. F127 triblock copolymer consists of $PEO_{100}-PPO_{65}-PEO_{100}$. Genistein was incorporated in the Pluronic F127 polymeric micelles by a solid dispersion method. The genistein release of genistein-loaded polymeric micelles was studied in vitro (in pH 1.2 and pH 6.8). And the oral bioavailabilities of genistein powder and genisteinloaded micelles were estimated at a dose of 4.0 mg/kg as genistein in rats. Drug loading amount and drug loading efficiency were 11.18% and 97.41%, respectively. The average size of the genistein-loaded polymeric micelles was 27.76 nm. And genistein release of the genistein-loaded polymeric micelles in vitro was 58% (pH 1.2) and 82% (pH 6.8). The bioavailability of genistein-loaded polymeric micelles was better than genistein powder. Consequently, Pluronic F127 polymeric micelles are an effective delivery system for the oral administration of genistein.
Kwon, Jee Young,Weon, Jong-Il,Koedrith, Preeyaporn,Park, Kang-Sik,Kim, Im Soon,Seo, Young Rok National Hellenic Research Foundation 2013 ONCOLOGY REPORTS Vol.30 No.3
<P>Cadmium and nickel have been classified as carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. Given their prevalence in the environment, the fact that cadmium and nickel may cause diseases including cancer even at low doses is a cause for concern. However, the exact mechanisms underlying the toxicological effects induced by low-dose exposure to cadmium and nickel remain to be elucidated. Furthermore, it has recently been recognized that integrative analysis of DNA, mRNA and proteins is required to discover biomarkers and signaling networks relevant to human toxicant exposure. In the present study, we examined the deleterious effects of chronic low-dose exposure of either cadmium or nickel on global profiling of DNA copy number variation, mRNA and proteins. Array comparative genomic hybridization, gene expression microarray and functional proteomics were conducted, and a bioinformatics tool, which predicted signaling pathways, was applied to integrate data for each heavy metal separately and together. We found distinctive signaling networks associated with subchronic low-dose exposure to cadmium and nickel, and identified pathways common to both. ACTB, HSP90AA1, HSPA5 and HSPA8, which are key mediators of pathways related to apoptosis, proliferation and neoplastic processes, were key mediators of the same pathways in low-dose nickel and cadmium exposure in particular. CASP-associated signaling pathways involving CASP3, CASP7 and CASP9 were observed in cadmium-exposed cells. We found that HSP90AA1, one of the main modulators, interacted with HIF1A, AR and BCL2 in nickel-exposed cells. Interestingly, we found that HSP90AA1 was involved in the BCL2-associated apoptotic pathway in the nickel-only data, whereas this gene interacted with several genes functioning in CASP-associated apoptotic signaling in the cadmium-only data. Additionally, JUN and FASN were main modulators in nickel-responsive signaling pathways. Our results provide valuable biomarkers and distinctive signaling networks that responded to subchronic low-dose exposure to cadmium and nickel.</P>