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( Hyunjung Hwang ),( Ji Young Shin ),( Kyu Ree Park ),( Jae Ouk Shin ),( Kyoung Hwan Song ),( Joonhyung Park ),( Jeong Woong Park ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Background: The adverse effects of the phosphodiesterase-4 inhibitor roflumilast, appear to be more frequent in clinical practice than what was observed in chronic obstructive pulmonary disease (COPD) clinical trials. Thus, we designed this study to determine whether adverse effects could be reduced by starting roflumilast at half the dose, and then increasing a few weeks later to 500 μg daily. Methods: We retrospectively investigated 85 patients with COPD who had taken either 500 μg roflumilast, or a starting dose of 250 μg and then increased to 500 μg. We analyzed all adverse events and assessed differences between patients who continued taking the drug after dose escalation and those who had stopped. Results: Adverse events were reported by 22 of the 85 patients (25.9%). The most common adverse event was diarrhea (10.6%). Of the 52 patients who had increased from a starting dose of 250 μg roflumilast to 500 μg, 43 (82.7%) successfully maintained the 500 μg roflumilast dose. No difference in factors likely to affect the risk of adverse effects, was detected between the dose-escalated and the discontinued groups. Of the 26 patients who started with the 500 μg roflumilast regimen, seven (26.9%) discontinued because of adverse effects. There was no statistically significant difference in discontinuation rate between the dose-escalated and the control groups (p=0.22). Conclusion: Escalating the roflumilast dose may reduce treatment-related adverse effects and improve tolerance to the full dose. This study suggests that the dose-escalated regimen reduced the rate of discontinuation. However, longer-term and larger-scale studies are needed to support the full benefit of a dose escalation strategy.
Hwang, Hyunjung,Shin, Ji Young,Park, Kyu Ree,Shin, Jae Ouk,Song, Kyoung-hwan,Park, Joonhyung,Park, Jeong Woong The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Background: The adverse effects of the phosphodiesterase-4 inhibitor roflumilast, appear to be more frequent in clinical practice than what was observed in chronic obstructive pulmonary disease (COPD) clinical trials. Thus, we designed this study to determine whether adverse effects could be reduced by starting roflumilast at half the dose, and then increasing a few weeks later to $500{\mu}g$ daily. Methods: We retrospectively investigated 85 patients with COPD who had taken either $500{\mu}g$ roflumilast, or a starting dose of $250{\mu}g$ and then increased to $500{\mu}g$. We analyzed all adverse events and assessed differences between patients who continued taking the drug after dose escalation and those who had stopped. Results: Adverse events were reported by 22 of the 85 patients (25.9%). The most common adverse event was diarrhea (10.6%). Of the 52 patients who had increased from a starting dose of $250{\mu}g$ roflumilast to $500{\mu}g$, 43 (82.7%) successfully maintained the $500{\mu}g$ roflumilast dose. No difference in factors likely to affect the risk of adverse effects, was detected between the dose-escalated and the discontinued groups. Of the 26 patients who started with the $500{\mu}g$ roflumilast regimen, seven (26.9%) discontinued because of adverse effects. There was no statistically significant difference in discontinuation rate between the dose-escalated and the control groups (p=0.22). Conclusion: Escalating the roflumilast dose may reduce treatment-related adverse effects and improve tolerance to the full dose. This study suggests that the dose-escalated regimen reduced the rate of discontinuation. However, longer-term and larger-scale studies are needed to support the full benefit of a dose escalation strategy.
Poster Session : PS 1236 ; Pulmonology : A Case of Primary Pulmonary Amyloidosis
( Hyunjung Hwang ),( Kyoung Hwan Song ),( Eunkyung Kang ),( Sang Pyo Lee ),( Jeong Woong Park ),( Sung Hwan Jeong ),( Sun Young Kyung ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Amyloidosis is a systemic disease of unknown origin which is characterized by extracellular deposit of proteins with a speci. c structural conformation hat gives them a characteristic apple-green birefringence when stained with Congo-red. Isolated pulmonary amyloidosis is a rare localized form of amyloidosis, characterized by amyloid deposits restricted to the lungs. Case: A 79-year-old male was admitted due to hemoptysis and dyspnea for several months. On physical examination, he had crackes in both lungs. The chest tomography showed multiple nodular consolidations and nodules in both upper and right middle lobes and consolidations in both lower lungs. Pulmonary function test revealed moderate restrictive pattern of ventilation. Bronchoscopy showed in. ltrative mucosal lesion and partial obliteration of lateral segmental bronchus of right middle lobe. Pathologic evaluation of the bronchial mucosal biopsy revealed apple-green birefringent amyloid on Congo-red staining. There was no hypergammaglobulinemia on protein electrophoresis and bone marrow biopsy sections showed normocellular. The patient was diagnosed isolated pulmonary amyloidosis with endobronchial involvement. Conclusion: We report a rare case of primary pulmonary amyloidosis presenting with hemoptysis.
Hwang, Eunhee,Mi Lee, Sae,Bak, Sora,Min Hwang, Hee,Kim, Hyunjung,Lee, Hyoyoung Elsevier 2018 Tetrahedron letters: the international organ for t Vol.59 No.44
<P><B>Abstract</B></P> <P>The first methodology of CH arylation of heteroarene via 2D transition metal dichalcogenides that have catalytically active edge functional groups was described. The terminal sulfur groups could effectively catalyze a formation of an azo-linked intermediate with aryl diazonium salts, leading to produce heteroarenes with good yields. This novel methodology using bulk 2D transition metal dichalcogenides that have catalytically active edge functional groups can apply for various reactions to achieve CC bond formation in the fields of heterogeneous catalysis that is easily separable, highly reusable, and inexpensive method.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Unprecedented MoS<SUB>2</SUB> catalyzed for direct CH arylation. </LI> <LI> Catalytically active terminal sulfurs of MoS<SUB>2</SUB> for CH arylation. </LI> <LI> High reusability and simple separation of heterogeneous catalyst. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Comparison of Machine Learning Models According to Data Trends for Predicting Tomato Growth
Hyunjung Hwang,Hyuntae Lee,Seungwoo Cha,Jihyeon Choi,Hwanyong Choi,Sangjun Chung,Seoheui Lee,Junhyuck Jang,Christopher RETITI DIOP EMANE,Yuna Kim,Jongtae Lim,Kyoungsoo Bok,Jaesoo Yoo 한국콘텐츠학회 2022 한국콘텐츠학회 ICCC 논문집 Vol.2022 No.12