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Lee Su-Kyung,Oh Su Jin,Choi Seoheui,Choi Soo Han,Shin Seon-Hee,Lee Eun Jin,Cho Eun-Jung,Hyun Jungwon,Kim Hyun Soo 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.2
Background: Rotaviruses are a major cause of pediatric gastroenteritis. The rotavirus P[6] genotype is the most prevalent genotype isolated from Korean neonates but has rarely been reported in other countries. Histo-blood group antigen (HBGA) is known to play an important role in rotavirus infection. We investigated the relationship between rotavirus genotype and HBGA-Lewis blood type in Korean children and explored the reasons for the predominance of rotavirus P[6] strain in Korean neonates. Methods: Blood and stool samples were collected from 16 rotavirus-infected patients. Rotavirus G (VP7) and P (VP4) genotyping was performed using reverse transcription-PCR and sequencing. Lewis antigen phenotypes (Lea/Leb) were tested, and HBGA-Lewis genotype was determined by sequencing the secretor (FUT2) and Lewis (FUT3) genes. Deduced amino acid sequences and three-dimensional structures of the VP8* portion of the rotavirus VP4 protein were analyzed. Results: All P[6] rotaviruses were isolated from neonates under one month of age, who were negative or weakly positive for the Leb antigen. However, 10 of the 11 non-P[6] rotaviruses were isolated from older children who were Leb antigen-positive. The VP8* amino acid sequences differed among P[6], P[4], and P[8] genotypes. Korean P[6] strains showed a unique VP8* sequence with amino acid substitutions, including Y169>L169, which differed from the sequences of P[6] strains from other countries. Conclusions: The predominance of the rotavirus P[6] genotype in Korean neonates may be related to the interaction between HBGA-Lewis antigen and the VP8* portion of the VP4 protein, and this information will be helpful in future neonatal vaccine development.
Prediction of Crop Growth Using Transformer for Greenhouse Decision Making
Yuna Kim,Hyuntae Lee,Seungwoo Cha,Jihyeon Choi,Hwanyong Choi,Sangjun Chung,Seoheui Lee,Hyunjung Hwang,Junhyuck Jang,RETITI DIOP EMANE Christopher,Jongtae Lim,Kyoungsoo Bok,Jaesoo Yoo 한국콘텐츠학회 2022 한국콘텐츠학회 ICCC 논문집 Vol.2022 No.12
Influence Analysis of Environmental Data for the Growth of Paprika
Jongtae Lim,Hyuntae Lee,Seungwoo Cha,Jihyeon Choi,Hwanyong Choi,Sangjun Chung,Seoheui Lee,Hyunjung Hwang,Junhyuck Jang,Christopher RETITI DIOP EMANE,Yuna Kim,Kyoungsoo Bok,Jeonghyun Baek,Jaesoo Yoo 한국콘텐츠학회 2022 한국콘텐츠학회 ICCC 논문집 Vol.2022 No.12
Comparison of Machine Learning Models According to Data Trends for Predicting Tomato Growth
Hyunjung Hwang,Hyuntae Lee,Seungwoo Cha,Jihyeon Choi,Hwanyong Choi,Sangjun Chung,Seoheui Lee,Junhyuck Jang,Christopher RETITI DIOP EMANE,Yuna Kim,Jongtae Lim,Kyoungsoo Bok,Jaesoo Yoo 한국콘텐츠학회 2022 한국콘텐츠학회 ICCC 논문집 Vol.2022 No.12