학생선수용 체육진로흥미검사지의 다집단 동일성 검증

권형일(Kwon, Hyung-Il),한시완(Han, Si-Wan) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.3

Career should be understood as a process of continuous changes and development, rather than a fixed choice at a certain time (Super, 1990). Career guidance for student-athletes should reflect cultural specificity that both study and exercise are required at the same time, and should be conducted systematically by utilizing proper tools suitable for each development stage. The purpose of this study is to test if sport career interest inventory (SCII) for student-athletes, which was developed in the previous studies (Kwon Hyung-il, Bang Shin-woong, Han Si-wan, Yoo Jeong-ae, 2016), can be used in common by a group, that is, by school and class. For the study, 342 subjects (172 high school students and 170 university students) received multi-group construct invariance test of SCII. As a result, configural invariance and measurement equivalence were tested. These results provide supportive materials for construct invariance of SCII and can be utilized for comparative study by school and class to explore career according to the change in grade of the students.

한국인에서의 CYP2C19m₁과 CYP2C19m₂돌연변이 유전자형의 다형성

권준택,김형기 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The S-mephenytoin 4 -hydroxylase (CYP2C19) metabolizes a number of clinically used drugs and shows a marked interethnic difference in the incidence of the poor metabolizer (PM). In the present study, we genotyped 215 healthy unrelated Koreans (64 females, aged 20-41 yr, residing in Chungcheong province) for functionally defective alleles, CYP2C19m1 and CYP2C19m2 Detection of the normal (CYP2C19wt) and defective alleles was performed by polymerase chain reaction/restriction enzyme analysis. The genomic DNA was isolated from peripheral blood. The allelic frequencies of the wild-type (CYP2C19wt) and CYP2C19m1 were 72.6% and 27.4%, and the wild-type (CYP2C19wt) and CYP2C19m2 were 85.1% and 14.9%, respectively. For each CYP2C19m1 and CYP2C19m2 the observed numbers of three genotypes were similar to those calculated in accordance with the Hardy-Weinberg equation. The frequencies of homozygotes for CYP2C19m1, CyP2C19m2 and compound heterozygotes were 9.7%, 2.8% and 4.2%, respectively. The mutants of CYP2C19 were identified in 36 subjects (16.7%). These results suggest that frequency of mutants of CYP2C19 in Koreans resembled the Orientals rather than Caucasians.

한국인에서의 CYP2E1 유전자형

권준택,김형기,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Cytochrome P4502E1 (CYP2E1) is inducible by ethyl alcohol and activates procarcinogenic N-nitrosodimethylamine (NDMA), benzene, urethane and other lower molecular weight compound. CYP2E1 is also involved in metabolism of certain drugs, for example, alcohol, acetaminophen, tamoxifen, theophylline, fluorinated anesthetics, and chlorozoxazone. CYP2E1 activity was shown to be polymorphically distributed in humans and has been suggested to play a role in hepatocellular carcinoma and alcoholic related disorders. Although genetic predisposition to alcoholism and alcoholic liver disease has been reported, genetic susceptibility to alcoholic pancreatitis is still a matter of debate. The aims of this study were to investigate the allelic frequency of CYP2E1 Rsa I polymorphism in Koreans. We investigated the frequency distribution of CYP2E1 Rsa I polymorphism in 212 unrelated healthy Koreans and 42 hepatocellular carcinoma patients. Detection of the CYP2E1 alleles was performed by polymerase chain reaction and restriction fragment length analysis. The genomic DNA was isolated from peripheral blood with conventional phenol: chloroform extraction method. The allelic frequencies of c1 and c2 in healthy volunteers were 0.85 and 0.15, respectively. The rare type (c2/c2) of CYP2E1 Rsa I polymorphism was 0.005 in healthy volunteers.

잡음환경에서의 음성인식을 위한 전처리의 성능비교

권영옥,김형순 釜山工業大學校 1995 論文集 Vol.37 No.-

One of the ultimate purpose in speech recognition is to recognize all of the arbitrary natural-sentences spoken by arbitrary speaker under any adverse environments. We review the theoretical and experimental foundations of the method, discuss the relationship with auditory perception, and extend to combination of additive noise and convolutional noise. This paper describes that performance comparision of the preprocessing schemes are applied to speech recognition in the adverse environments. Also some experiments of speech recognition are performed for department name of twenty-two that are pronounced one times by fifty Korean adults. The results show an application of the RASTA technique to speech enhancement.

폐암세포에 대한 附子 추출물의 독성 효과

권강범,김은경,문형철,송용선,류도곤 한국전통의학연구소 2006 한국전통의학지 Vol.15 No.1

The aim of this study was to investigate the cytotoxic effect and its mechanism on Radix Aconiti(RA) extract in lung cancer cell lines. RA extract treatment decreased the cell viability in a dose-dependent fashions in lung cancer cells including A549, H460, H23 and H157 cells. Many investigators reported that A549 and H460 cells expressed wild-type p53, but H23 and H157 cells preserved mutated p53. After treatment with RA extract in A549 and H460 cells, we measured the expression of p53 protein levels using Western blot, analysis. In both cells treated with RA extracts, p53 protein expressions were increased in a dose-dependent manner. In our experiments, RA extracts also have cytotoxic effects in H23 and H157, which have mutated p53. Treatment with RA extract decreased bcl-2 protein expressions in both cells. These results suggest that RA extracts have cytotoxic effects via p53 expression increase and bcl-2 inhibitable pathways in A549, H460 cells and H23, H157 cells, respectively.

E-초등학교 어린이의 영구치 맹출시기 및 순서

권정현,최병재,이제호,김성오,손흥규,최형준 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.2

치아 맹출은 나이, 성별, 인종, 시대에 따라 시기 및 순서의 차이가 있으나, 교과서에 인용되어 임상에서 사용되는 영구치 맹출 및 치근 형성에 대한 자료는 1933년 Logan과 Kronfeld가 발표한 것이므로 현재 한국 어린이의 영구치 맹출 경향과 차이가 있을 수 있다. 따라서 이번 연구의 목적은 한국 어린이의 영구치 맹출연령을 구하고, 이를 근거로 맹출순서를 알아보며, 이전 국내외 연구자료와 비교하여 차이를 알아보는 것이다. 이에 1998년부터 2005년까지 연세대학교 치과대학병원 소아치과에 내원하여 구강검진을 시행한 E-초등학교의 어린이 중 만 6세에서 만 12세의 2,619명 (남자 1,307명, 여자 1,312명)의 자료를 수집하여 영구치의 맹출시기 및 순서에 대해 연구 한 바 다음과 같은 결론을 얻었다. 1. 상악의 영구치 맹출시기는 중절치는 남자 만 6.81세, 여자 만 6.73세, 측절치는 남자 만7.78세, 여자 만7.65세, 견치는 남자 만10.48세, 여자 만9.92세, 제1소구치는 남자 만9.76세, 여자 만9.63세, 제2소구치는 남자 만10.66세, 여자 만10.49세, 제1대구치는 남자 만6.39세, 여자 만6.26세, 제2대구치는 남자 만12.13세, 여자 만 12.03세로 나타났다. 2. 하악의 영구치 맹출시기는 중절치는 남녀 모두 정확한 시기의 측정은 불가능하였지만, 만 6.08세 이전에 맹출한다는 것을 추정 할 수 있었고, 측절치는 남자 만6.78세, 여자 만6.65세, 견치는 남자 만9.76세, 여자 만9.05세, 제1소구치는 남자 만9.82세, 여자 만9.59세, 제2소구치는 남자 만10.67세, 여자 만10.52세, 제1대구치는 남자 만6.22세, 여자 만6.12세, 제2대구치는 남자 만11.58세, 여자 만 11.14세로 나타났다. 3. 맹출순서는 상악은 제1대구치, 중절치, 측절치, 제1소구치, 견치, 제2소구치, 제2대구치 순이었고, 하악은 중절치, 제1대구치, 측절치, 견치, 제1소구치, 제2소구치, 제2대구치 순이었다. 4. 모든 영구치에서 남자보다 여자가 빨리 맹출하였으며, 상악은 약 0.19세, 하악은 약 0.29세 먼저 맹출하였다. 5. 남녀 모두 상악은 측절치와 제1소구치 사이, 하악은 측절치와 견치 사이에 휴지기가 있었고, 남자의 휴지기는 상악 1.98년, 하악 2.98년, 여자는 상악 1.98년, 하악 2.40년이었다. The purpose of this study was to present new data on the timing and sequence of permanent teeth emergence and to compare these findings with the results of earlier studies. The dental examinations had been performed to E-elementary school students, who visited the Yonsei University Dental Hospital between 1998 and 2005; 1,307 boys and 1,312 girls with the age ranging from 6 to 12 years old. The followings were concluded. 1. Eruption time of the maxillary permanent teeth is as follows, It was 6.81 years in male and 6.73 years in female for the central incisor, 7.78 years in male and 7.65 years in female for the lateral incisor, 10.48 years in male and 9.92 years in female for the canine, 9.76 years in male and 9.63 years in female for the first premolar, 10.66 years in male and 10.49 years in female for the second premolar, 6.39 years in male and 6.26 years in female for the first permanent molar, and 12.13 years in male and 12.03 years in female for the second permanent molar. 2. Eruption time of the mandibular permanent teeth is as follows. The central incisor could not be determined in this study, but it is assumed to erupt before the age of 6.08. In the mandible, eruption time was 6.78 years in male and 6.65 years in female for the lateral incisor, 9.76 years in male and 9.05 years in female for the canine, 9.82 years in male and 9.59 years in female for the first premolar, 10.67 years in male and 10.52 years in female for the second premolar, 6.22 years in male and 6.12 years in female for the first permanent molar, and 11.58 years in male and 11.14 years in female for the second permanent molar. 3. The eruption sequence is as follows. In the maxilla, the first permanent molar erupted first, followed by the central incisor, the lateral incisor, the first premolar, the canine, the second premolar, and the second permanent molar. In the mandible, the central incisor erupted first, followed by the first permanent molar, the lateral incisor, the canine, the first premolar, the second premolar, and the second permanent molar. 4. Tooth eruption occurred earlier in female compared to male by average of 0.19 year in the maxilla and 0.29 year in the mandible. 5. In both male and female, the hiatus (interval of rest) occurred between the emergence of lateral incisor and first premolar in the maxilla while it was observed between the lateral incisor and canine in the mandible. Male had a hiatus of 1.98 years in the maxilla and 2.90 years in the mandible, while the female's were 1.98 years and 2.40 years, respectively.

한국인에서의 CYP2C19 유전자형의 다형성

권준택,김형기,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The S-mephenytoin 4'-hydroxylase (CYP2C19) metabolizes a number of clinically used drugs and shows a marked interethnic difference in the incidence of the poor metabolizer (PM). In the present study, we genotyped 215 healthy unrelated Koreans (64 females, aged 20-41 yr, residing in Chungcheong province) for functionally defective alleles, CYP2C19_(m1) and CYP2C19_(m2). Detection of the normal (CYP2C19_(wt)) and defective alleles was performed by polymerase chain reaction/restriction enzyme analysis. The genomic DNA was isolated from peripheral blood. The allelic frequencies of the wild-type (CYP2C19_(wt)) and CYP2C19_(m1) were 72.6% and 27.4%, and the wild-type (CYP2C19_(wt)) and CYP2C19_(m2) were 85.1% and 14.9%, respectively. For each CYP2C19_(m1) and CYP2C19_(m2), the observed numbers of three genotypes were similar to those calculated in accordance with the Hardy-Weinberg equation. The frequencies of homozygotes for CYP2C19_(m1), CYP2C19_(m2) and compound heterozygotes were 9.7%, 2.8% and 4.2%, respectively. The mutants of CYP2C19 were identified in 36 subjects (16.7%). These results suggest that frequency of mutants of CYP2C19 in Koreans resembled the Orientals rather than Caucasians.

신경섬유종증 환자에게서 발생한 특발성 혈소판 감소증 1예

권세훈,김형호,강지인,장재혁,원경준,장재현,김상용,배학연 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Idiopathic thrombocytopenic purpura is a disease characterized by thrombocytopenia in peripheral blood with positive anti-platelet antibody titer, no splenomegaly, the presence of megakarocyte. The causes of idiopathic thrombocytopenic purpura were usually related to autoimmune disease, infection and drugs. A 46-years-old man was admitted for evaluation of abdominal mass. He has many cafe-au-lait spots and nodules in almost skin for 30 years. Several years ago, he palpated mass in Lt. inguinal area. hIe has known the abdominal mass after checking abdomen CT in local clinic and visited our hospital for evaluation of abdominal mass. At admission, laboratory tests showed hemoglobin 12.5 g/dL, hematocrit 38.4 %, WBC 5,460 /㎣ (neutrophil 64.5%, lymphocyte 21.7%, monocyte 4.1%, eosinophil 5.4%), reticulocyte 0.7%, Platelet 52,000 /㎣, total protein 6.51 g/dL, albumin 3.80 g/dL, alkaline pohsphatase 161 IU/L, AST 110.7 IU/L, ALT 64.9 IU/L, total bilirubin 0.44 ㎎/dL, BUN 18.4 ㎎/dL, creatinine 0.79 ㎎/dL. Peripheral blood smear showed normocytic normochromic anemia, thrombocytopenia. Bone marrow aspiration smear showed normoplastic myeloid and erythroid precursor. The bone marrow biopsy section shows normocellular marrow (35%) for his age and mildly increasing myeloid cell lineage. We have experienced a case of idiopathic thrombocytopenic purpura in a patient being in neurofibromatosis and therefore reporting it with documentary records. 저자들은 신경섬유종증 환자에서 특별한 원인을 발견할 수 없었음에도 특발성 혈소판 감소증이 발생한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

미소 진폭 파형벽을 가진 유로내에서 응축이 수반되는 초음속유동의 Prandtl-Meyer 팽창에 관한 실험적 연구

권순범,안형준,김병지,선우은 경북대학교 산업기술연구소 1993 産業技術硏究誌 Vol.21 No.-

The characteristics of the Prandtl-Meyer expansion of supersonic flow with condensation through a channel with a small amplitude wavy wall are investigated experimentally. In the present study, for the case of moist air flow in the type of indraft supersonic wind tunnel, the dependency of formation and reflection locations of the oblique shock wave and the distribution of flow properties are clarified by flow visualization and pressure measurement with the variation of the specific humidity and temperature at the entrance of the wavy wall and the attack angle of the wavy wall to the main stream. Also, we confirm that the wavy wall plays an important key role in the formatio of oblique shock wave, and that the effect of condensation on the flow field appears apparently.

항원결합에서 항-Z-DNA 단클론항체 Z44의 재조합 중쇄 및 경쇄 가변영역의 역할

권명희,주민경,서정규,김형일 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

It has long been known that both heavy(VH) and light chain variable region(VL) of antibody are involved in antigen binding. Recently, reports for anti-DNA Abs such as Z22 and Hed-10 have revealed that VH chain is more important than VL in recoginizing antigen. However, it is not certain yet whether the VH chain alone of these specific anti-DNA antibodies has dominant role or such dominance of VH chain can be applicable to other anti-DNA Abs. To investigate this possibility in connection with the role and contribution of VL chain, experiments were performed using mAb Z44 which binds to Z-DNA but rocognizes different epitopes from Z22 which share 95% sequence homology. The recombinant proteins including Z44VH and Z44VL were produced by E.coli. After purification of the these antibodies, the affinity and specificity of recombinant Ab proteins to DNA antigens were tested. The results were as follows; Z44VH bound most strongly to Z-DNA and bound also to ssDNA, whereas Z44VL did not bind to B-DNA, ssDNA, and Z-DNA. In vitro association of Z44VH with Z44VL has increased the affinity to Z-DNA synergistically compared with Z44VVH alone. In the case of association of Z22VH with Z22VL affinity to Z-DNA has showed synergistic increment compared with Z22VH alone. However, the associations of Z44VH with Z22VL or Z22VH with Z44VL did not show any significant increments of affinity. From our findings that Z44VH alone could bind to Z-DNA or to ssDNA and that Z 44VL could not, it could be concluded that Z44VH has dominant role in recognizing the antigen. In addition, it may be suggested that Z44VL can increase the affinity of Z44VH and play some role in changing the specificity of Z44VH.