Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models

Kim, Si-Hyung,Choi, In-Sun,Cho, Jin-Hwa,Park, Eun-Ju,Jang, Il-Sung,Choi, Byung-Ju,Kim, Hyun-Jung,Kim, Young-Jin,Nam, Soon-Hyeun The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injucted control animals. Field potential recordings were used to monitor amplitude and numbers population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5mg/kg;phenytoin 40, 60mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.

다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예

최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

파노라마 방사선 사진에 있어서 하악골 위치에 따른 상의 변화 (Ⅰ)

최순철,안형규 慶北大學校 齒科大學 1987 慶北齒大論文集 Vol.4 No.1

The authors have observed image distortion according to the rotation of the mandible while the chin remained centered in the chin rest in the panoramic radiographs using Panelipse Ⅱ of the dry mandible with a dental age of 7 years. The radiopaque steel balls were inserted into the the portion of the tooth crypts, which were removed artifically, of the lateral incisor, canine,premolars, and the second molar and into the bifurcation area of the first molar. The dry mandible was placed in seven altered positions as follows; Position 1. The standard position Position 2. Rotation of the mandible 5°to the right Position 3. Rotation of the mandible 10°to the right Position 4. Rotation of the mandible 5°to the left Position 5. Rotation of the mandible 10°to the left Position 6. Rotation of the mandible 10°to the right inferiorly Position 7. Rotation of the mandible 10°to the left inferiorly The results were as follows; When compared with the image in the standard position: 1) The image distortion in the Position 2 through Position 5 was not greatly changed on all portions excluding molar portion 2) The horizontal distortion in the Position 6 was greatly increased but the vertical distortion was not greatly changed except molar portion 3) The image distortion in the Position 7 was not greatly changed.

오존산화에 의한 염색폐수의 색도 제거에 관한 연구

정순형,최준호 대한위생학회 2003 대한환경위생공학회지 Vol.18 No.4

This study was conducted to remove the color in dyeing wastewater by ozone oxidation process, and the results were summarized as follows ; The 18.3% of BOD and 56.3% TOC were removed as decreasing with pH 1 in dyeing wastewater, containing the polyester reducing process. It showed that terephthalic acid was precipitated at low pH. The color of dyeing wastewater was removed by the first order reaction, and the reaction rate constants at pH 3, 7, 12 were investigated 0.234 min^(-1), 0.215 min^(-1) and 0.201 min^(-1) respectively. It showed that color was more effectively removed with direct reaction of ozone than radical reaction(non-direct reaction). As increasing of the water temperature, the reaction rate constants were increased slightly. It indicated that activity of ozone was improved at high water temperature.

Cytochrome b 유전자분석법을 이용한 동물의 종 식별

김순희,강필원,백형순,이양한,최상규,한면수 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

질화규소와 베어링강의 미끄럼 마모형태도

김형자,최형순 釜慶大學校 1998 釜慶大學校 論文集 Vol.3 No.2

The tribological properties of silicon nitride in unlubricated sliding contact were investigated using a ball on disk wear apparatus at room temperature and normal load. The tribological behaviour can be classifled into two groups as follows : (1) The wear state of silicon nitride ball is divided into 3 parts, the formation of minute irragular surface resulted from plastic flow rupture, the formation of fracture surface of grain boundary and the formation of slippery surface resulted from chemical reaction. (2) The frication from of bearing steel disk is divided into 4 parts, the formation of the surface that the surface layer is shed resulted from friction wear, the formation of the surface that the microscopic friction particles are accululated resulted from corrosive wear and formation of surface that the slippery oxide tunic is created.

실험적 골파괴와 골형성에 대한 방사선학적 연구

안형규,최순철 大韓口腔顎顔面 放射線學會 1988 Imaging Science in Dentistry Vol.18 No.1

Bone destruction was induced experimentally by the insertion of a bit of the arsenic compound into the pulp chambers of the right premolars and the artificial bone defects were produced in the periapical regions of the left premolars in 7 dogs. The serial standardized periapical radiographs using aluminum stepwedge attached to the XCP instruments and resin bite blocks were taken following insertion of arsenic compound and at 2,4,7,10,14,17,21,24 and 28 days in case of bone destruction and following bone injury and weekly thereafter for a total of 14 weeks in case of bone formation. The errors of the method were determined with error estimators described by the Duinkerke. All radiographs were evaluated by the visual examination after joint evaluation by three dental radiologists and analysed with densitometer. The following results were obtained; 1. Analysis of the bone destruction process 1) The error of the method in estimating two distances proved to be small (S.D. for the measuring error; 0.04mm, S.D. for the over-all error; 0.06mm, S.D. for the positioning error; 0.05mm) 2) The radiographic changes were observed after 7 days in 6 cases, 4 days in 1 case and 10 days in 1 case by the visual examination. 3) Aluminum equivalent values were diminished after 2 days and the diminution of 0.58±0.19mm was demanded to be detected by the visual examination. 2. Analysis of the bone formation process 1) The error of the method in estimating two distances proved to be small (S.D. for the measuring error; 0.03mm, S.D. for the over-all error; 0.04mm, S.D. for the positioning error; 0.04mm) 2) The radiographic changes were observed after 2 weeks in 5 cases and 3 weeks in 2 cases by the visual examination. 3) Aluminum equivalent values were increased after 1 week and the increase of 0.45±0.15mm was demanded to be detected by the visual examination. 4) Aluminum equivalent values were increased continuously for 7 or 9 weeks but there was only extremely small change after 10 weeks.

죽음 준비교육이 일 노인복지관 노인들의 죽음불안, 태도 및 생활만족도에 미치는 영향

김형철,최길순,정영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

Objectives: The purpose of this study was to find out the level of death-anxiety, death-attitude and life-satisfaction of elderly's before and after offering a education program about how to die. Method: The subjects were sampled from the members of the Elderly Welfare Center in Gwangju Park. Total number was 148, 74 for the control group and 74 for the experimental group. The study was carried out after a non-equivalent pretest-posttest design. Data were collected from July 7th to August 23, 2004. The How-to-Die education was applied only to the experimental group for 50 minutes weekly, for 8 weeks. Results: 1) The fear of deathCt=4.631, p=.000) , avoidance react to death(t=1.987, p=.048) were significantly decreased in the experimental group. 2) The time and way of deathCt=3.101, p=.002), handling a dead bodyCt=-3.583, p=.000) were significantly increased in the experimental group. 3) The extent of life-satisfaction of the experimental group was significantly increased after the education(t=2.306, p=0.023). Conclusion: From the above results, the How-to-Die education for the elderly is an effective nursing intervention to decrease the level of death-anxiety, increase the level of death-attitude and life satisfaction.

멀티 프레임 PRA를 이용한 움직임 추정

김형종,이성순,최영일,조금배,한승조 조선대학교 동력자원연구소 1997 動力資源硏究所誌 Vol.19 No.1

We discuss the theory of motion estimation and motion compensation. The proposed algorithm uses more information from the input video image sequence than the traditional two-frame pel-recursive algorithms. And it uses fewer assumptions on the motion vectors among different video frame pairs. This paper shows two three-frame pel-recursive algorithm for predictive motion compensation which can estimate the d₁(from the previous frame f_t-1 to current frame, f_t) and d₂(from the frame before the previous frame f_t-2 to the previous frame, f_t-1) simultaneously, and three frame information to update the motion vector d₁when the past motion vector d₂is available.