재발성 복부 통증을 호소한 환자에서 복벽에 발생한 자궁내막증 1예

홍현진,박성한,이준식,배용목,김지연,안광순,박선자 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Endometriosis is the abnormal growth of endometrial tissue outside the uterine cavity. Endometriosis in the abdominal scar following cesarean section is very rare condition among the extrapelvic endometriosis. The frequency of abdominal wall endometriosis secondary to cesarean section is from 0.03% to 0.8% in some reports. It is difficult to diagnosed in spite of the typical symptoms. The typical symptom is aching swelling in the area of the surgical scar, which is influenced by the phases of menstruation. The definitive diagnosis is established by pathologic analysis. Surgical excision remains the treatment of choice. The majority of patients presented from 1 to 2 years after the precipitating operation. We experienced an unusual case of abdominal wall endometriosis presented over 10 years after cesarean section, who was admitted to our hospital complaining of recurrent left lower abdominal pain. So, we report this case with a brief review of the concerned literatures.

Meckel 게실의 합병증으로 수술 받은 환아의 임상양상

김현아,최금자,한후재 이화여자대학교 2003 EMJ (Ewha medical journal) Vol.26 No.2

Objectives : The purpose of study is to assess the clinical characteristics of complicated Meckel's diverticulum in children. Methods : A retrospective review of pediatric cases of complicated Meckel's diverticulae that were surgically treated at Ewha Womans University Hospital from 1985 was performed. The charts were reviewed for the age and sex of the patients, operation finding, treatment, and outcome. Results : A total 13 patients with a complicated Meckel's diverticulum were identified. There were 8 boys(61.5%) and 5 girls (38.5%) with a mean age of 5.3 years (range, 1month to 14years). Presenting signs and symptoms included digestive hemorrhage (6), intestinal obstruction(4), perfora-tion (1), intussusception due to inverted Meckel's diverticulum (1) and diverticulitis (1). A ^(99m) technetium pertechnetate scintiscan was positive in 3 of 4 patients. Barium contrast studies and colonoscopys were not diagnostic. The mean distance from the ileocecal valve to the diverticulum was 47.0±15.7cm. Average length of the diverticulum was approximately 4.7±3.0cm. Segmen-tal small bowel resection including Meckel's diverticulum (84.6%) or wedge excision(15.4%) was done for treatment. In the bleeding group, ectopic gastric mucosa was present in 5 of 6 patients. Postoperative morbidity and mortality was each 0%. Conclusion : The results of this study draw attention to the fact that the complicated Meckel's diverticulum must be suspected in children with acute abdomen or gastrointestinal bleeding. 목적: Meckel 게실의 합병증의 원인이 되어 수술적 치료를 받은 소아 환자들의 임상적 증상과 수술소견, 병리학적 소견을 분석하여 이들의 특징을 알아보고자 하였다. 방법 : 1985년 이후 이화대학교의료원에서 Meckel 게실의 합병증으로 수술을 받은 15세 이하의 소아들 대상으로 하여 의무기록과 조직병리 검사 결과를 조사하였다. 결과: 총 13명의 환아가 Meckel 게실의 합병증으로 수술을 받았으며 남녀의 비는 1.6:1로 남아에서 호발하는 경향을 보였으며, 수술 시 평균 연령은 5.3세였다. 수술의 원인이 된 Meckel 게실의 진단은 장출혈 6예, 장폐색 4예,Meckel 게실의 천공 1예, 장중첩 1예, 게실염 1예였다. 회맹판에서 게실까지의 평균길이는 47.0±15.7cm이었으며, 소장부분절제술과 쐐기절제술이 각각 84.6%와 15.4%에서 시행되었다. 장출혈을 나타내었던 환아 6명 중 5예에서 병리조직에서 이소성 위 점막이 관찰되었다. 술 후 합병증과 사망예는 없었다. 결론 : 소아에서 외과적 급성 복증이나 장출혈의 증상이 나타날 경우, Meckel 게실의 합병증의 가능성에 대한 외과의의 인식이 필요하다.

3-페닐시드논유도체의 전기화학적 연구

金日光,韓順種,千賢子 圓光大學校 基礎自然科學硏究所 1984 基礎科學硏究誌 Vol.3 No.2

The electrochemical reduction of 3-phenyl sydnone derivatives in nonaqueous media(acetonitrille) has been examined by polarography, cyclic voltammetry, controlled potential coulometry Half-wave potentials in two reaction series, 3-phenyl sydnones substituted on the 3-phenyl group in position 4(para) and 3-phenyl sydnone substituted on the sydnone ring in position 4(carbon) were measured, Their values fit to the modified Hammett equation, E_(1/2)=ρ_χRσ_P The electroreduction of the sydnones proceeded by protonation and electron transfer. The cleavage of nitrogen-oxygen bond is observed at near -1.8 volts vs. Ag-AgCl. Substituted phenyl hydrazine and phenyl glycine were a major products.

가족이 인지한 호스피스 환자의 간호요구 : Q방법론 적용 Q Methodology

용진선,한성숙,홍현자 가톨릭대학교 간호대학 호스피스 교육연구소 2003 호스피스논집 Vol.7 No.-

Purpose: The purpose of the study was to identify types of care needs of hospice patients from the family caregivers perspective through Q-methodology. Method: Twenty three Q-statements concerning care needs were collected through in-depth interviews of hospice patients. Data were collected from twenty family caregivers by sorting 23 Q-statements into 9 points standard from December 2002 to February 2003. Date analysis was performed by using a QUANL program. Result: Principal component analysis identified five types of care needs of the hospice patients which family caregiver perceived. Type 1 was named 'physical care needs type' and family caregivers perceived that their patients greatest need is physical care to be painless and comfortable. Type 2 was named 'care needs type for the future life after death' and family caregiver perceived that their patients need spiritual care for having hope about the next world. Type 3 was named 'emotional care needs type' and family caregivers perceived that their patients need emotional care for opening their minds and becoming stable. Type 4 was named 'religious service needs type' and family caregivers perceived that their patients need to have religious services such as mass, receiving prayers and the sacraments. Type 5 was named 'social care needs type' and family caregivers perceived that their patients need encouragement to go beyond themselves and to give loving services to others. In summary, family caregivers perceived that care for patients 'physical comfort is the priority. After achievingphysical care, family caregivers could perceive other aspects of care such as spiritual, social, and emotional care needs. In conclusion, we need to conduct further research to compare these results with the care needs of hospice patients themselves.

우측 대장에 발생한 연소성 용종 1예

이준식,박성한,홍현진,안광순,김지연,배용목,이은영,박선자 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Juvenile polyp, also known as a retention polyp because they contain mucin cysts, is a relatively common hamartomatous lesion in chlidhood. It occurs in 1-2% of children and young adults; however it is uncommon in adulthood. Juvenile polyp is rare in the first year of life and is thus presumed to be acquired and not congenital. It is pedunculated, 2-3 cm in size, red-tan in colour, smooth and always shows fluid filled cystic spaces on cut surface. Histologically, Juvenile polyps are hamartomatous with distended, mucus-filled glands, often with cystic dilatation and edematous lamina propria containing abundant vasculature. The most common manifestation is rectal bleeding produced by auto-amputation of the polyp. Juvenile polyp has been considered not to be at increased risk of developing carcinoma. However, atypical epithelium is observed in some lesions, especially in larger polyps, which may give rise to adenoma and subsequent malignant transformation. Therefore the diagnosis of solitary juvenile polyp should not be made only with colonoscopy and biopsy, but should be totally resected endoscopically for pathologic evaluation. About 90% of the lesions are solitary and localized within 20cm from anal verge. In Korea, there are some reports of juvenile polyps located in the rectosigmoid colon. We report one case of juvenile polyp in adolescent that presented as a hematochezia & abdominal pain, which is located at right colon.

두경부 암환자의 항암화학요법에 따른 삶의 질 변화

신혜숙,박혜자,박명희,연기순,김훈교,문한림,송혜향 가톨릭대학교 가톨릭대학교 간호대학 호스피스 교육연구소 1999 호스피스논집 Vol.4 No.-

The purpose of this study was to assess the changes in quality of life wish elapse of chemotherapy in head and neck cancer patients. This study was a longitudinal descriptive design. The subjects were 9 patients who had stage III and stage IV head and neck cancer and received neoadjuvant cisplatin and 5-fluorouracil chemotherapy. Linear Analogue Self Assessment Scale (LASA) of the QOL which it includes eleven items(seven physical items appetite, nausea/vomiting, physical well-being, vigor activity, energy, sleepiness, fatigue and four mental items anger, anxiety, depression & vital power) were used to assess the quality of life eleven times(once in the prechemotherapy period and from the 1st day to 10th day postchemotherapy). The means of scores at each time were analyzed by repealed measures of ANOVA and Bonferroni multiple comparison method. The results are as follows : 1. The degree of appetites decreased significantly on the period between third and sixth day compared with that of appetites on the prechemotherapy day (p<0.001). 2. The degree of physical well-being decreased significantly on the period between first and fifth day compared with that of physical well-being on the prechemotherapy day (p<0.001). 3. The degree of nausea/vomiting decreased significantly on the period between first and fourth day compared with that of appetites on the prechemotherapy day (p<0.001). 4. The degree of anger decreased significantly on the second, fourth, eighth and ninth day after chemotherapy compared with that of anger on the prechemotherapy day(p<0.001). 5. The degree of fatigue decreased significantly on the fourth day compared with that of fatigue on the prechemotherapy day(p<0.001). 6. The increment of nausea/vomiting and poor appetite started on the 2.89th day and 3.67th day after chemotherapy, respectively. 7. The increment of sleepiness started on the 2.56th day after chemotherapy. 8. The increment of depression and anxiety started on the 2.33th day and 3.33th day after chemotherapy, respectively. 9. The lowest degrees of nausea/vomiting and poor appetite were 37.00±17.9 % and 28.64±14.94 % after chemotherapy compared with those of nausea/vomiting and poor appetite on the prechemotherapy day, respectively. 10. The lowest degrees of anger and vigor activity were 48.12±28.3 % and 39.83±24.9 % after chemotherapy compared with those of anger and vigor activity on the prechemotherapy day, respectively. 11. The recovery rates of eight items of quality of life (appetite, vigor activity, energy, fatigue, anger, anxiety, depression & vital power) were shown to reach a peak on the tenth day after chemotherapy and be reached to almost 84 % compared with those of quality of life on the prechemotherapy day. 12. The recovery rates of physical well-being and sleepiness were shown to reach to 67.75 % and 95.68 % on the 10th day after chemotherapy compared with those of physical well-belong and sleepiness on the prechemotherapy day. 13. The recovery rates of seven physical items were faster than those of four mental items on the 10th day after chemotherapy. In conclusion, it is suggested that nursing care strategies to improve the quality of life in patients with chemotherapy would be established both physically and mentally, and be extended at least ten days when patients stayed their home after chemotherapy.

진행성 위암환자에서 Capecitabine/Cisplatin 치료군과 Fluorouracil/Cisplatin 치료군 간의 삶의 질 비교

유희원,신은정,이광자,한현주,손인자 韓國病院藥師會 2004 병원약사회지 Vol.21 No.1

The improvement of medical treatment and anticancer drug has led a complete recovery and prolonged survival time of cancer patients. And recent study of cancer has included evaluation of quality of life. This study was performed to evaluate quality of life between Capecitabine/Cisplatin arm and Fluorouracil/Cisplatin arm. This study was performed in the Seoul National University Hospital from August to October 2003. A total of 8 AGC patients on adjuvant chemotherapy successfully completed this study. Method of study is questionnairing by EORTC QLQ-C30, cancer specific questionnaire. The questionnaire consists of Functional, Symptom, Global health quality of life scale. Patients eligible for this study had histologically confirmed stage III or IV AGC. Patients were to be between 18 and 60 years old, and have performance status of 1. Patients were ineligible if they had a history of 6 months prior or concomitant chemotherapy, radiotherapy. Statistically significant differences favoring the Fluorouracil/Cisplatin arm was noted in the physical scale. In addition, patients in the Fluorouracil/Cisplatin arm reported an improvement in physical functioning after one cycle chemotherapy.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

Standardization of measurement of cervical elastography, its reproducibility, and analysis of baseline clinical factors affecting elastographic parameters

( Hyun-joo Seol ),( Ji-hee Sung ),( Won Joon Seong ),( Hyun Mi Kim ),( Hyun Soo Park ),( Hayan Kwon ),( Han-sung Hwang ),( Yun Ji Jung ),( Ja-young Kwon ),( Soo-young Oh ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.1

Objective To provide a standardized protocol for the measurement of cervical strain elastography, present its reproducibility, and analyze baseline clinical factors affecting the measurement of elastographic parameters. Methods This study was performed by the Korean Research Group of Cervical Elastography. We enrolled pregnant women according to our study protocol. After measuring the cervical length, elastography was performed using the E-Cervix™ quantification tool to measure the strain of the cervix using intrinsic compression. We evaluated 5 elastographic parameters, namely, the strain of the internal os of the cervix (IOS), strain of the external os of the cervix (EOS), ratio of the strain of IOS and EOS, elasticity contrast index, and hardness ratio. For baseline clinical factors, we examined the maternal body mass index, blood pressure, heart rate, uterine artery Doppler indices, and fetal presentation. Results We established a specific protocol for the measurement of cervical elastography using the E cervix program. For all elastographic parameters, the intra-observer intraclass correlation coefficient (ICC) ranged from 0.633 to 0.723 for single measures and from 0.838 to 0.887 for average measures, and the inter-observer ICC ranged from 0.814 to 0.977 for single measures and from 0.901 to 0.988 for average measures. Regression analysis showed that the measurement of the elastographic parameter was not affected by baseline clinical factors. Conclusion We present a standardized protocol for the measurement of cervical elastography using intrinsic compression. According to this protocol, reproducibility was acceptable and the measurement of elastographic parameters was not affected by the baseline clinical factors studied.

Inhibition of IL-32 Signaling by Bamboo Salt Diminishes the TSLP Production and Macrophage Differentiation in Human Monocyte Cell Line, THP-1 Cells

Hyun-Ja Jeong,Sun-Young Nam,Hyun-A Oh,Na-Ra Han,Young-Sick Kim,Il-Sook Choi,Phil-Dong Moon,Hyung Min Kim 한국식품영양과학회 2012 한국식품영양과학회 학술대회발표집 Vol.2012 No.10