열대 지역에서 통일형 초다수성 벼 품종의 생육 및 수량성 비교

이지윤,준현,성환,손영보,송유천,한상익,박동수,권영업,이철원,이종희 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

갑상선 종양에서 thrombin receptor (PAR-1)의 발현 양상

박지영,목지오,김여주,박형규,김철희,변동원,서교일,유명희,조현득,오미혜,김상진 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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다발성 근염 환자에서 발생한 스테로이드 근병증 1예

이지훈,현신영,김충기,이수환,최아라,김성우,박성혜,이찬희 영남대학교 의과대학 2011 Yeungnam University Journal of Medicine Vol.28 No.2

Polymyositis is diffuse, inflammatory myopathy with proximal-muscle weakness due to lymphocyte infiltration to the muscle layer. The exact cause of the muscle weakness is unclear but may be related with an immunologic mechanism. Using high-dose steroid is the treatment of choice for polymyositis. It is difficult to distinguish steroid-resistant polymyositis from steroid myopathy, however, in the course of high-dose steroid therapy. These authors encountered a steroid myopathy patient during polymyositis treatment with high-dose steroid. A 57-year-old woman was diagnosed with polymyositis and was treated with high-dose steroid. Her condition was initially improved, but in the course of the treatment, her symptom was aggravated without increasing the muscle enzymes. Her muscle weakness was improved by reducing the steroid dosage.

투사형 전조등의 광학적 분석

성희진,홍사용,류지욱 公州大學校 基礎科學硏究所 1999 自然科學硏究 Vol.8 No.-

투사형 전도등의 특성을 조사하기 위해 광선 추적법으로 광학계를 분석하고 그 결과를 포물경 전도등과 비교하였다. 포물경 전도등의 경우 광학계가 단순한 장점이 있지만 광원의 일부분 만을 반사하며 실제 광원의 크기와 위치를 고려할 때 높은 수차가 불가피 했다. 투사형 전도등은 여러개의 광학부품 사용하는 복잡함과 전체적 길이가 길어지는 단점이 있지만 포물경 전도등 보다 40%이상의 빛을 더 활용하며 전체적인 수차도 상당히 줄일 수 있었다. 그러나 투사형 전도등 광학계의 성능은 비구면 렌즈의 형태에 매우 민감한 것으로 나타났다. To investigate characteristics of the projection type headlights for automobiles, we used ray tracing methods and compared the results with those from parabolic type headlights. The parabolic type headlights are simple but have two limits: first, they require large apertures. To reflect 50% of a source light, the aperture must be 4 times of focal length and to have more reflected light, apertures must grow geometrically. second, a parabolic mirror have large aberration when a source is away from a focus, since output of a headlight cannot be divergent, a source should locate far side from a mirror and moreover a light source has a finite size, large aberration is unavoidable. The projection type headlights have many optical components and longer depth compared with parabolic types, but their apertures can be made small. Advantage of using a ellipsoidal mirror is to reduce beam divergence by half and displace a focal position to another focal point, so that spherical aberration free and short focal length aspherical lens can be placed in proper position. In our study, we adopt a commercially available aspheric lens and the results were quite good compared with those from parabolic types but not optimal since output experienced total reflection at an aspheric lens. We found to improve performance of headlights, proper design of an aspheric lens was crucial.

인터넷을 통한 교원 원격연수의 활성화 방안

지명희,박성식 금오공과대학교 2005 論文集 Vol.26 No.-

노래부르기 음악프로그램이 정신질환자의 자아존중감과 대인관계에 미치는 영향

홍상희,윤지원,이재금,김지연 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: The objective of this study was to verify the effects of the Singing program for psychiatric patients on their self-esteem and interpersonal relationship, and to provide data for the nursing intervention that is necessary for making their life better. Method: The subjects were 10 in-patients with psychotic disorders at C university hospital in Seoul, from july 3 to September 18 im 2005, and the methodology was one group pre experimental- post experimantal design. The instrument for the measurement of self-esteem is Rosenberg Self-Esteem Scale(1973), which was translated by Chun Byung Jae(1974) and the measurement of interpersoral relationship is Schleim & Guerney Relationship Change Scale(1971) which was translated by Mun Seok Mo(1980) and revised by Chun Seok Gyun(1994). SPSS program was used for the analysis of the collected data, which were analyzed by the paired t-test and one-way ANOVA. Result: Singing therapy had an effect on improvement of the self-esteem, and seemed to be more effective as the frequency of the program increased. Singing therapy had an effect on improvement of the interpersonal relatinship, and seemed to ne more effecive as the frequency of the program increased. Comclusion: Singing therapy is found out to be effective program affecting the improvement of both the self-esteem and interpersonal relationship of the psychiatric patients. Therefore the nurses can use the Singing therapy as the nursing intervention for imtrovement of the self-esteem and interpersonal relationship of the psychiatric patients in clinical practice.

유치원과 초등학교 연계교육에 대한 교사와 학부모의 인식과 요구

정지영, 이성희 培材大學校 人文科學硏究所 2011 人文論叢 Vol.28 No.-

The purpose of this research is to investigate parents' perception on the educational continuity between the kindergarten and elementary school and their opinion on the educational program for continuity. This study would provide basic information for better strategy for developing educational continuity between kindergartens and elementary schools. The subjects of this study were 200 parents and teachers of a kindergarten located in D city and 200 parents and teachers of elementary schools. 800 questionnaires were distributed and finally 542 were returned (122 from kindergarten parents, 149 from elementary school parents, 122 from kindergarten teachers, 149 from elementary school teachers). The data was analyzed with SPSS WIN 16.0 and frequency, percentage, Chi-square, F value were calculated. The results of this research can be summarized as follows: First, it was found that both teachers and parents were positive on the need for the educational continuity but teachers were more positive than parents. This means that kindergartens have settled down as one of educational institutions and feel more educational continuity. Second, both parents and teachers replied that present programs for educational continuity were effective but parents were more positive than teachers. This is because teachers have not understood well about the curriculum of the counterpart. Third, both parents and teachers were positive on the application of parents' opinions on the educational continuity programs. Finally, regarding the focus of educational continuity programs, both parents and teachers were positive most on the development of basic life habits and both of them thought that even though basic learning was made in kindergartens, it must be repeated in elementary schools.

실험적 대장염에서 Tripotassium Dicitrato Bismuthate의 효과

송인상,송규상,설지영,장일성,배진선,윤완희 대한대장항문학회 1995 Annals of Coloproctolgy Vol.11 No.1

액시드 캅셀(니자티딘 150 mg)에 대한 넥스 캅셀의 생물학적 동등성

김지만,이상봉,전성실,신영희 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

The purpose of the present study was to evaluate the bioequivalence of two nizatidine capsules, Axid (Lilly Korea Pharm. Co., Ltd.) and Nex (Bi-nex Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The nizatidine release from the two nizatidine capsules in vitro was tested using KP Apparatus method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solutions and water). The dissolution profiles of two nizatidine capsules were very similar at all dissolution media. Twenty four normal male volunters were divided into two groups with a randomized 22 cross-over study. After two capsules (300 ㎎ nizatidine) were orally administrated, blood as taken and the concentrations of nizatidine in serum were determined using HPLC with UV detector. The pharmacokinetic parameters such as AUC_(t), C_(max) T_(max) were determined. The result showed that the differences in AUC_(t), C_(max) and T_(max) between two nizatidine capsules absed on the Axid were-6.16%, -8.26% and -1.82%, respectively. There were no sequence effects between two capsules in these parameter. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25)(e.g., log(0.91) ∼log(0.97) and log(0.85)∼log(0.99) for AUC_(t) and C_(max), respectively), indicating that Nex capsule is bioequivalent to Axid capsule.

백화사설초 메탄올 추출물에 의한 HL-60 세포고사과정에 있어서의 transcriptional factors 활성변화 연구

박상구,이지현,문구,문석재,원진희,박래길 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1

Objective : Hedyotis diffusa has been used as an arnicancer agent for several decades in oriental medicine. We test whether the methanol extract of the herb affects transcriptional activation factors including NF-κB and AP-l. Methods : 1. HL-60 cells were treated with various concentrations(from 200 to 50ug/ml) of methanol extract and H_2O extract(200ug/ml)of hedyotis diffusa, After 48h later, the cells were tested for viability by MTT assay. 2. The HL-60 cells were treated with 200ug/ml of methanol extract for the indicated periods. First. Nuclear extracts were isolated and incubated with oligonucleotide probe of NF-κB and AP-l. Second. Nuclear extracts were isolated and reacted with p50, p65. c-rel par-Jun, c-Jun, JunB. JunD antibody on ice for 30min. Finally The cell lnates were prepared and analyzed by westem blotting using anti-Fas, anti-FasL and anti-p53 antibdy. Results : l. The methanol extract decreases the viability of human lymphoid origin leukemia HL-60 cells in a dose-depemdemt manner. 2. NF-κB is rapidly activated by the addition of the methanol extract, reaches a peak at 30min and gradually returns to resting level. We confirm tha NF-κB is a heterodimer mainly composed of p65 subunit with c-Rel. 3. Transcriptional activation of AP-1 is detected at 30min and reaches a maximum at lhr after stimulation of the cells with the methanol extract. AP-l is mainly composed with Jur-D and partially Jug-B proteins. 4. the methanol extract of Hedyotis diffusa induces the expression of Fas, Fas ligand and p53 proteins of HL-60 cells in a time dependent fashion. Conclusions : These results suggest that the methanol extract of Hedyotis diffusa exerts anticancer effects to induce the death of human leukomic HL-60 cells via activation of trascriptional factors such a NF-κB and AP-1, increase in expression of Fas mediated signaling proteins, and induction of tumor suppressor gene. p53