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Noh, Sung Hyun,Kim, Kyung Hyun,Shin, Dong Ah,Park, Jeong Yoon,Yi, Seong,Kuh, Sung Uk,Kim, Keung Nyun,Chin, Dong Kyu,Kim, Keun Su,Yoon, Do Heum,Cho, Yong Eun Elsevier 2019 SPINE JOURNAL Vol.19 No.2
<P><B>Abstract</B></P> <P><B>BACKGROUND CONTEXT</B></P> <P>Because of the scarcity of atypical spinal meningioma, there is a lack of research on this type of tumor or its associated metastases.</P> <P><B>PURPOSE</B></P> <P>The aim of this study was to investigate the biological behavior of atypical spinal meningioma and identify its prognostic factors by reviewing surgical and clinical outcomes of patients with these tumors.</P> <P><B>STUDY DESIGN</B></P> <P>A retrospective chart review was performed.</P> <P><B>PATIENT SAMPLE</B></P> <P>We retrospectively reviewed the data from all patients who underwent spinal cord tumor excision between 1994 and 2017. Seventeen patients were pathologically proven to have atypical spinal meningioma.</P> <P><B>OUTCOME MEASURES</B></P> <P>We examined patients’ neurologic status by determining their Nurick scores before and after surgery. Moreover, imaging studies, laboratory data, and the employed surgical method were analyzed retrospectively, as was the Ki-67 index and prognosis following postoperative radiation therapy.</P> <P><B>METHODS</B></P> <P>The ranges, locations, and pathologic diagnoses of the tumors were extracted from the radiological and pathological records of each patient. The extent of surgery and progression of disease were confirmed using postoperative enhanced magnetic resonance imaging. Patients were divided into two atypical spinal meningioma groups: primary and metastatic. The demographics, age, sex, presenting symptom duration, tumor location, Simpson resection grade, Ki-67, radiotherapy, recurrence, overall survival, and progression-free survival of patients in both groups were compared.</P> <P><B>RESULTS</B></P> <P>Seventeen patients were included in the analysis, of whom 12 (70%), 4 (24%), and 1 (6%) had tumors in the thoracic, cervical, and sacral regions, respectively. Complete and subtotal resections were achieved in 15 (88%) and 2 (12%) patients, respectively. Overall and progression-free survival rates in patients who underwent complete resection were longer than those in patients who underwent subtotal resection (p<.001). Four patients (24%) had metastatic meningiomas in the brain, among whom three were administered adjuvant radiotherapy after surgery. Two patients with intramedullary atypical spinal meningioma had metastatic tumors and experienced poorer prognoses. The 5-year overall and progression-free survival rates were 84.4% and 85.2%, respectively. The Simpson resection grade, Ki-67 index, and preoperative neurologic status were found to be important prognostic factors on univariate Cox regression analysis (p<.05).</P> <P><B>CONCLUSIONS</B></P> <P>Complete resection should be considered as a primary treatment modality for individuals with atypical spinal meningioma. If subtotal resection is performed, adjuvant therapy can be administered.</P>
Artificial Intelligence for Neurosurgery : Current State and Future Directions
Sung Hyun Noh,Pyung Goo Cho,Keung Nyun Kim,Sang Hyun Kim,Dong Ah Shin 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.2
Artificial intelligence (AI) is a field of computer science that equips machines with human-like intelligence and enables them to learn, reason, and solve problems when presented with data in various formats. Neurosurgery is often at the forefront of innovative and disruptive technologies, which have similarly altered the course of acute and chronic diseases. In diagnostic imaging, such as X-rays, computed tomography, and magnetic resonance imaging, AI is used to analyze images. The use of robots in the field of neurosurgery is also increasing. In neurointensive care units, AI is used to analyze data and provide care to critically ill patients. Moreover, AI can be used to predict a patient’s prognosis. Several AI applications have already been introduced in the field of neurosurgery, and many more are expected in the near future. Ultimately, it is our responsibility to keep pace with this evolution to provide meaningful outcomes and personalize each patient’s care. Rather than blindly relying on AI in the future, neurosurgeons should gain a thorough understanding of it and use it to enhance their patient care.
Risk factors for recurrence of node-negative breast cancer with less than 1cm (초)
( Kwon Ji Hyun ),( Kim Yu Jung ),( Oh Do Youn ),( Park So Yeon ),( Kim Jee Hyun ),( Chie Eui Kyu ),( Kim Sung Won ),( Won Shik Han ),( Im Seock Ah ),( Kim In Ah ),( Kim Tae You ),( Park In Ae ),( Noh 대한내과학회 2008 대한내과학회 추계학술대회 Vol.2008 No.-
Noh, Jin Young,Park, Gyeong Jin,Na, Yu Jeong,Jo, Hyun Yong,Lee, Seul Ah,Kim, Cheal The Royal Society of Chemistry 2014 Dalton Transactions Vol.43 No.15
<P>A new, highly selective and sensitive colorimetric chemosensor <B>1</B> for detection of Cu<SUP>2+</SUP> ions in aqueous solution was developed. Receptor <B>1</B> detected Cu<SUP>2+</SUP> ions by changing its color from colorless to yellow. Moreover, the Cu<SUP>2+</SUP>-sensitive compound was used as a colorimetric pH detector based on a color change due to <B>1</B>–Cu<SUP>2+</SUP> complex formation identifiable by the naked eye.</P> <P>Graphic Abstract</P><P>A highly selective and sensitive colorimetric Cu<SUP>2+</SUP>-chemosensor and pH probe for practical use in water has been developed. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3dt53637h'> </P>
Effect of genetic background differences between FVB and C57BL/6 mice in SARS-CoV-2 infection
Ah-Reum Kang,Hyun Ah Noh,Jae Hyung Son,Sun-Min Seo,Ji-Hun Lee,Na-Won Kim,Eun-Seon Yoo,Han-Bi Jeong,Da In On,Ji Yun Jang,Jun-Won Yun,Jun Won Park,Kang-Seuk Choi,Ho-Young Lee,Jun-Young Seo,Ki Taek Nam,J 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.7
Mothers and their infants’ health from gestational exposure to the Hebei Spirit oil spill
Hyun Sook Bae(배현숙),Su Ryeon Noh(노수련),Jung Ah Kim(김정아),Gwi Heum Eom(엄귀흠),Eun Kyoung Yang(양은경),Young-Hyun Choi(최영현),Mina Ha(하미나),Hae-Kwan Cheong(정해관),Eun-Hee Ha(하은희) 환경독성보건학회 2013 한국독성학회 심포지움 및 학술발표회 Vol.2013 No.10
( Miri Hyun ),( Chang In Noh ),( Seong Yeol Ryu ),( Hyun Ah Kim ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.3
Background/Aims: Klebsiella pneumoniae is second most common organism of gram-negative bacteremia in Korea and one of the most common cause of urinary tract infection, and intra-abdominal infection. Methods: We compared clinical and microbiological characteristics about K. pneumoniae bacteremia in a tertiary hospital between 10 years. Group A is who had K. pneumoniae bacteremia at least one time from January 2004 to December 2005. Group B is from January 2012 to December 2013. We also analyzed antibiotic resistance, clinical manifestation of the K. pneumoniae bacteremia divided into community-acquired infections, healthcare associated infections, and nosocomial infections. Results: The resistance for ampicillin, aztreonam, cefazolin, and cefotaxime significantly increased compared to 10 years ago. Extended spectrum β-lactamase positivity surged from 4.3% to 19.6%. Ten years ago, 1st, 2nd cephalosporin, and aminoglycoside were used more as empirical antibiotics. But these days, empirical antibiotics were broad spectrum such as 3rd and 4th cephalosporin. In treatment outcome, acute kidney injury decreased from 47.5% to 28.7%, and mortality decreased from 48.9% to 33.2%. In community-acquired infections, there was similar in antimicrobial resistance and mortality. In healthcare-associated and nosocomial infections, there was significantly increasing in antibiotic resistance, decreasing in mortality, and acute kidney injury. Conclusions: In community-acquired infections, broader antibiotics were more used than 10 years ago despite of similar antimicrobial resistance. When K. pneumoniae bacteremia is suspected, we recommend to use the narrow spectrum antibiotics as initial therapy if there are no healthcare-associated risk factors, because the antibiotic resistance is similar to 10 years ago in community-acquired infections.