영양유전체학(Nutrigenomics)의 최근 경향

최봉혁(Bong-Hyuk Choi),김종배(Jong-Bae Kim),도명술(Myoung-Sool Do) 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.10

With the decoding of human genome in 2004 and the recent development in nutritional science, there has been an integration of molecular biology and nutrition. As a consequence a new word “molecular nutrition” has been formed and recently the word ‘nutrigenomics’ is coined and widely being used. The field of science that showed the most positive result from grafting the science of nutrition and nutrigenomics is obesity. In 1994, Jeffrey Friedman from Rockeffeler University announced that ob gene and obesity has a close relationship and since then there’s been a huge research done on genes related to obesity from the molecular nutrition’s point of view. Even now there are many genes presented which are supposed to be related to obesity and big efforts are put into finding what exactly those genes do. Moreover studying only in the context of genes was not enough so functional genomics, which is the study of the functions of cells and the functions and effects between genes and protein products, is being studied. This review article discusses the relationship between nutrition and genes and the general idea of nutrigenomics. The article also discusses about the current research status on these subjects.

비·부비동 종양의 신생혈관 형성에서 COX-2 및 VEGF의 역할

도남용,박성용,조성일,윤혁수,박선홍,박영균,권대승,임성철 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : COX-2, the inducible form of cyclooxygenase(COX), is upregulated in transformed cells and in malignant cells, which have important roles in promotion of colorectal carcinogenesis, invasiveness and angiogenesis. Vascular endothelial growth factor(VEGF) may act as endothelial cell mitogen in various cancer tissues. It will increase tumor growth and angiogenesis. Aims of this study were to asses COX-2/VEGF expression and it's clinical correlation in sinonasal tumors and to investigate the effects on angiogenesis also. Materials and Method : The study samples were obtained from surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IP with malignant transformation(IP-MT), 16 cases of Squamous cell carcinoma(SCC) in sinonasal cavity COX-2 and VEGF expressions were assessed by immunohistochemical staining. Synchronism of COX-2/VEGF expression in one tumor cell was demonstrated with double immunofluorescence technique. Results : The expression rates of COX-2 were 37% in IP, 80% in IP-MT and 100% in SCC. The positive rates of VEGF were 29 6% in IP, 100% in IP-MT and SCC. COX-2 and VEGF expressions were increased as tumor progressed, and there is a positive correlation between COX-2 &EGF expressions. All clinical features which were compared are not associated with COX-2 &EGF expressions except malignant change in IP(p=0 028). Synchronism of COX-2/VEGF expressions was noted in all positive immunostaining samples. Conclusion : These findings suggest the role of COX-2 pathway could be involved in sinonasal tumor angiogenesis, which is modulated by VEGF COX-2 may act as autocrine factor in VEGF expression. There is a potential role for selective COX-2 inhibitors in the treatment of these lesions.

Irbesartan과 Lercanidipine의 병용요법이 고혈압 및 혈관재형성에 미치는 효과

이도형, 임태완, 조은지, 박현수, 정상혁, 한주희, 병창선 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

Hypertension is one of the major risk factor for cardiovascular disease and can lead to or make worse many complications, heart disease, atherosclerosis and diabetes. Thus, managing blood pressure effec tively using therapeutic drugs such as angiotensin II receptor blocker (ARB) and Ca2+ channel blocker (CCB) can be prevent other complications. Therefore, we investigated the synergistic effect of these two drugs, ir besartan and lercanidipine, for antihypertension, cardioprotection and antidiabetes. Irbesartan (28.74 mg/kg, 14.37 mg/kg) or lercanidipine (1.92 mg/kg, 0.96 mg/kg) alone or combination was administered to sponta-neously hypertensive rats (SHRs) and C57BL/6 mice. A two-week treatment of combination with irbesartan and lercanidipine significantly attenuated systolic blood pressure (SBP) and mean arterial pressure (MAP) compared with monotherapy. Futhermore. the combination therapy protected myocardial ischemia reperfusion injury more effectively than monotherapy. In vascular remodeling, combination therapy significantly diminished cuff -induced neointima formation and reduced serum -indllced vascular smooth muscle cells (VSMCs) pro-liferation compared with monotherapy. However, combination therapy had no significant synergistic effect of blood glucose regulation. Taken together, present study suggest that the combination therapy of irbesartan and lercanidipine may be more effective therapeutic strategy for the treatment of hypertension and related complications, myocardial infarction and arterial restenosis than monotherapy

운동 프로그램이 중년남성의 건강관련체력 및 혈중지질에 미치는 영향

김도희,주동엽,김수근,정동혁,서정훈 圓光大學校 附設 體力科學硏究所 2007 體力科學硏究 Vol.29 No.-

The purpose of this study, the blood lipid level, body composition and health-related fitness of middle-aged man. who have not participated in regular exercise programs were analyzed by making them carry out of swim and weight exercise program for twelve weeks. Analysis of health-related fitness of After the swim & resistance exercise program was carried out, body composition were significant differences in body weight, % fat, LBM and BMI. There were significant differences in factor was muscular of back strength, flexibility of sit and reach. But there no significant difference in endurance of sit-up and cardiovascular of VC, VO_(2). Analysis of blood lipid that After the combined exercise program was carried out, blood lipid were significant differences in TC, LDL-C and TG. But there was no significant differences in HDL-C.

치근면에 항균 varnish 처치 전후의 치태 세균 및 치은열구액내 항체수준 변화에 관한 연구

권혁춘,도정욱 大韓齒科保存學會 1993 Restorative Dentistry & Endodontics Vol.18 No.2

In the prevention of root surface caries, antimicrobial therapy for the control of subgingival and supragingival plaque is seriously considered as a long term suppression of pathogenic microflora. Recently, varnishes containing antimicrobial agents have been developed to control the supragingival mocroflora. The purpose of this study was to determine the antimicrobial effects of 20% chlorhexidine varnish and 2.6% silane fouoride varnish with sealant. In clinical experiments, 12 subjects were selected from the periodontally treated patient and divided into 3 groups. after a dental prophylaxis, the subjects were treated with single application of placebo varnish(group 1), 20% cholrhexidine varnish(group II), and 2.6% silane fluoride varnish(group III). Root surface plaque samples were taken before(baseline)and one, two, four, and 8 weeks after the treatments. Microbiological examinations of root surface plaque were performed with culture study and indirect immunoflorescence(I.I.F) study, and immunological examination of gingival crevicular fluid antibody titers was performed with ELISA study. The results were as follows : 1. Pathogenic microflora on the root surface including S. murans, S. sanguis, s. mitis, A. naeslundii, A. viscosus were 24-37% on I.I.F. study. 2. S. mutans, S. sanguis, S. mitis, A. measlundii, A. viscosus of the root surface plaque was significantly reduced from I week to 8 weeks after antimicrobial varnish treatment, but showed generally increasing tendency in control group. 3. Gingival crevicular fluid antibody titers were significantly reduced from 1 or 2 weeks to 4 weeks after antimicrobial varnish treatment.

美國에 있어서 委任立法의 考察

權度爀 慶北工業專文大學 1966 論文集 Vol.3 No.-

According to a celebrated 1952 opinion of the United States supreme Court, the American constitution is inconsistent with the notion of excutive law-making aut hority. "In the frame work of our constitution", declares the opinion refered to, the president's power to see that the laws are faitfully executed refutes the idea that he is to be a law-maker……The founders of this nation entrusted the law-making power to the Congress alone in both good and times." Despite this categorical judicial assertion, it can hardle be gainsaid that the administrative agency today is law-making agency. More and more in recent years, the legislature has been delegation to the administration significant powers of law-making. The modern administrative agency is as been emphasized, characterized by its possession of authority to make rules and regulations having the force of law. Nor should it he thought that the law-maling powers thus vested in the administration are powers of slight import. On the countrary, administrative law -making powers have become fully comparable, both quantitatively and qualitatively speaking, to those exercised eirectly by the elegislature. From a quantitative point of view, it is well known, administrative exercise of powers of delegated (or rule-making power, as it is usually termed by American administrative lawyers, well-nigh dwarfs the direct exercise of legislative authority by the elected representatives of the people . In the words of a leading American officials study, "The promulgation of general regulations by the executive, acting under statutory authority has been a normal feature of Federal administration ever since the Government was established," For many years now, the Federal Register in which delegated legislation in the United States is published has vastly exceeded in size the Statutes at Large in which laws enacted by the congress are published. The authority of administrative agencies to make rules and regulations having statutory effect is a power of enormous consequences. In its e ffect upon the community, its exercise is of scarcely less importance than the actions of the legislature itself. Rules and regulations, no less than statutes, ;ay down patterns of conduct to which those affected must conform. Modern public opinion has more and more required the state to assume a positive duty to eliminate the excesses and injusties that are the inevitable concomitants of a wholly unrestrained industrial economy. Such a positive role could hardly be assumed by mere prohihitions enacted by legislative fiat. On the coutrary, the state has been required, not only to prohibit by legislative decree, but also to assume a contiuiing duty to regulate those subject to its authority. In addition, the state has had to bring ever-increasing parts of the population directly under its fostering guardianship. The representative legislaive assembly is peculiarly inappropriate itself to perform these continuous tasks of regulation and guardianship. It has had to delegate their performance to the administrative process. Indeed, the need for an effective instrument through wich these tasks could be perfprmed has been perhaps the primary reason for the growth of that process. At this date, non but a few extremists will deny the need for delegations by the legislature to the administration. "The truth is," reads the conclusion of the committee on Ministers' powers on this subject, "that if parliament were not willing to delegate law-making power, parliament would be unable to pass the kind and quantity of legislation which modern public opinion requires." Yet, though we must admit the need for delegations of power to adminisitrative agencies, we must not lose sight of the fact that the growth of delegated autyority has its dangers as well as its merits. The key question in this respect was well put in 1953 by Mr.Aneurin Bevan: "There is now general agreement about the necessity for delegislation; the real problem is how this legislation can be reconciled with the processes of democratic consultation, scrutiny, and control." agencies, we may still insist on the overriding need for safeguards. To admit that the devolopment of the administrative process is necessary does not require us to concede that it should be free of checks such as a proper belance between the general security and the individual life has led us to impose on both the legislative and judicial processes. Few will dispute the need for administrative power to cope with modern conditions : at the same time, since all power is of an encroaching nature, it must be controlled by law lest it become arbitrary. In a study on the delegated legislation in the United States of America, this paper considers the necessity for delegated legislation, the mondelegation dectrine, the type and appointees of delegated legislation, an essential condition of existence for delegated legislation, a limit to delegate law-making power and a controll of delegated ligislation etc.

건강과 질병에 대한 저항트레이닝 처방에 관한 탐색

김도희,김수근,정동혁 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.1

Resistance training, also known as strength or weight training, has become one of the most popular forms of exercise both for enhancing an individual's physical fitness and for conditioning athletes. Individuals who participate in a resistance training program expect the program to produce certain benefits, such as increased strength, increased muscle size, improved sports performance, increased fat-free mass, and decreased body fat. A well-designed and consistently performed resistance training program can produce all these benefits. When prescribed appropriately, resistance training is effective for developing physical fitness, health, wellness and for the prevention and rehabilitation of orthopedic injuries. Because resistance training is an integral component in the comprehensive health program promoted by the major health organizations, population-specific guidelines have recently been published. The current research indicates that, for healthy persons of all ages and many patients with chronic diseases, single set programs of up to 15 repetitions performed a minimum of 2 d ·wk-1 are recommended. Each workout session should consist 8-10 different exercises that train the major muscle groups. Single set programs are less time consuming and more cost efficient, which generally translates into improved program compliance. Further, single set programs are recommended for the above-mentioned populations because they produce most of the health and fitness benefits of multiple set programs. The goal of this type of program is to develop and maintain a significant amount of muscle mass, strength, and endurance to contribute to overall physical fitness and health. Patients with chronic diseases may have to limit range of motion for some exercises and use lighter weights with more repetitions. The results of data provided by this research on resistance training for health shows that there is enough existing evidence to conclude that resistance training, particularly when incorporated into a comprehensive fitness program, can offer substantial health benefits which can be obtained by persons of all ages. These benefits, including improvements in functional capacity, translate into an improved quality of life.

대학생의 단극성 우울중 치료를 위한 프로그램의 평가

金道煥,張赫杓,李京任 釜山大學校 學生生活硏究所 1985 硏究報 Vol.21 No.1

The present study was to evaluate the treatment efficacy in a Coping With Depression Curse (psychoeducational group treatment) for unipolar depression among college students. The Coping with Depression Course constructed by Lewinsohn (1979) is based on the social learning theory analyzing depression. It is assumed to be associated with a decrease in pleasant and an increase in unpleasant person-environment interactions. Following these theoretical notions, the goal of treatment (CWD) is to Set the new self-changing skills : relaxation, Pleasant activities, constructive thinking, and social skills. In order to get the changes of the six participants, there were given pre- and post- tests which were consisted of MMPI-D, SCL-D, and BDI tests. According to the results of these tests, there were significant changes between scores on the pre- and post- test. Generally, those results were supported that CWD was an effective program to treat unipolar depression among college students.

民主國家에 있어서의 알 權利

權度爀 慶北工業專門大學 1977 論文集 Vol.14 No.-

私人間에 있어서 基本的人權의 保障

權度爀 慶北工業專門大學 1976 論文集 Vol.13 No.-