膵臟吸蟲症에 대한 Niclofolan (Bilevon-R)의 驅蟲效果

朴駿瀅 慶北大學校 1977 論文集 Vol.24 No.-

The domestic animals in Korea, especially Korean native cattle, are suffering from eurytremiasis. For instance, the cattle in Korea show much higher infection rates of Eurytrema spp. than the cattle in any other country. They vary from 50 to 80% depending on the area surveyed. It has to be born in mind that eurytremiasis is a herd problem in Korea. But, there is no report that any suitable therapeutic agents for eurytremiasis of the cattle, sheep and goat. This study was investigated in order to examine the anthelmintic efficacy of Niclofolan (Bilevon-R) against eurytremiasis in goats. Oral administration of Niclofolan (once a day for 2 succeed days, at the rate of 6 mg per Kg of body weight) were completely devoid the fluke eggs in the feces of goats on 3-15 days after treatment. After drug adminstrations, transient side effects are shown such as anorexia, depression, soft feces and accelerated breathing. The possibility that goat eurytremiasis could be treated with only 2 doses of Niclofolan has been proved by this study. Therefore Niclofolan is a very promising drug for treatment against eurytremiasis of the cattle.

부화 전후에 있어서 병아리의 胃腺細胞에 關한 光學的 및 電子顯微鏡的 硏究

朴駿瀅 慶北大學校 1975 論文集 Vol.20 No.-

In the mammals, among others, there are two distinct cellular populations (or types) in the gastric glands, which are responsible for the secretion of acid and pepsin respectively; the parietal or oxyntic cells for acid secretion and the chief or peptic cells for pepsin secretion. On the other hand, the bird does not have separate parietal and chief cells in the glandular stomach, and there exists only a single cell type which secrets both of pepsinogen and acid. Precent study was conducted to know the morphologic changes of the these secretory cells in the proventricular glands during the development of chicken from its embryonal stage, by the light and electron microscopes. The results obtained were summarized as follow: 1. The first appearances of pepsinogen granules in the gland cells of the proventriculi were at 10 hours after hatching by the light microscope, while it was recognized at the 20th incubation day by the electron microspcope. These pepsinogen were gradually increased and reached to the adult chicken level at 96 hours after hatching. 2. The cell organelles were progressively developed (or enriched) during the incubation period, and the smooth and rough surfaced endoplasmic reticulum were further developed and more marked in chicken than embryo. 3. Intracellular canal observed in the mammals was not noted. 4. At 24 hours after start of the feeding, the pepsinogen granules were entirely discharged after hatching and disappeared.

양성과 음성 정신분열증에 관한 연구 : 일반적 특성 병전적응도와 인지기능을 중심으로 Focused on General Characteristics, Premobid adjustment and Cognitive Function

박준형,윤진상,이형영 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.1

Most clinicians agree that the group of disorders called schizophrenia is heterogeneous. Since Kraepelin described dementia praecox, various attempts have been taken to subdivide schizophrenia into several homogeneous subtypes. Recently some investigatiors were interested in the division of schizophrenia by use of positive & negative symptomatology that Hughlings-Jackson had tried. Crow especially hypothesized that there were some differences between the tow prominent symptoms(negative & positive) in respect of premorbid adjustment, response to neuroleptic therapy and underling pathologic process etc. But this hypothesis remains largely untested. Using Andreasen & Olsen's criteria for negative, positive and mixed schizophrenia, we subdivided a consecutive sample of 67 schizophrenic patients into 3 subtypes (negative 21, positive 23, mixed 23). We then evaluated some characteristic aspects among these 3 subtypes. The results are as follow : 1) There was s significant difference in mean age among the three subtypes. In the negative group, the mean age was most high and this was followed by the positive group(p<0.05). 2) There was a significant difference in the duration of education among the three subtypes. In the negative group, the duration of education was least and this was followed by the positive group(p<0.05). 3) There was a significant difference in premorbid adjustment among the three subtypes. The level of premorbid adjustmentwas lowest in the negative group and this was followed by the positive group.(p<0.005). 4) There was a significant difference in the number of previous hospitalizations among the three subtypes. In the negative group, the number of hospitalizations was lowest and this was followed by the positive group.(p<0.005). 5) The experience of previous modern psychiatric treatment was more reare in the negative group and this was followed by the positive group.(p<0.05). 6) The score of mini mental status for evaluation of cognitive function was significantly lower in the negative group and this was followed by the positive group.(p<0.001). 7) The scores of the BPRS for evaluation of psychotic symptoms at the times of admission and 4 weeks later were significantly most high in the positive group and this was followed by the mixied group (p<0.05, respectively). The therapeutic response rated on the BPRS after 4 weeks, was significantly prominent in the positive & mixed groups(p<0.05, respectively), but not in the negative group. 8) Besides these, there were no significant differences in occupation, onset of age, duration of illness and family history among the three subtypes. .

개솔새(Cymbopogen tortilis) 精油가 胃液分泌 및 胃運動에 미치는 影響

朴駿瀅,鄭基坤 慶北大學校 1984 論文集 Vol.38 No.-

Cymbopogen tortilis is native weeds which is widely distributed in Korean fields and mountains and its flower contains a strong aromatic essential oil. It is known that the essential oil of Cymbopogen tortilis contains borneol, cadinene, camphene, and elemicin etc. But, there is no report about the effect of essential oil of Cymbopogen tortilis or its constituents on the gastric secretion and the gastric motility. To examine the effect of essential oil of Cymbopogen tortilis on the gastric secretion in rats and the gastric motility in pigeons, this paper was investigated. The results were as follows. The intraperitoneal administration of 1% essential oil solution of Cymbopogen tortilis at the ratio of 1.0ml, 0.5m1, 0.25ml/l00g B.W. to rat reduced their average gastric secretion volume to 2.1±0.29m1, 4.4±1.02m1, and 4.7±1.04ml respectively. In contrast to 9.5±1.3m1 of control rat's secretion. these numbers show 77.89%, 53.68% and 50.53% of gastric secretion inhibition rate. In pigeons, transient gastric inhibition which can be divided into 2 types was observed by the intraperitoneal injection of the drug at the same ratio to that of rats. In one type, gastric motility was inhibited in the state of transient gastric relaxation after drug administration, it recovered to normal with time. In the other type, gastric motility was inhibited transient gastric relaxation, soon its tone moved into contraction state, maintained this condition for some time, and this condition gradually recovered to normal. In conclusion, the essential oil of Cymbopogen tortilis inhibits strongly gastric secretion in rats and transiently gastric motility in pigeons.

21세기를 위한 한국 사회과교육의 새로운 방향 정립 : Development and Reorientation

박형준 大邱大學校 社會科學硏究所 2000 社會科學硏究 Vol.8 No.1

한편으로 한국 사회과교육은 급변하는 시대적 변화와 요구를 적절하게 반영하여야 한다. 다른 한편으로 한국 사회과교육은 지금까지의 미국 중심 교육이론들을 비판적으로 반성하고 이에 대한 새로운 대안을 모색해야 한다. 이 논문은 이러한 문제의식을 가지고, 먼저 세계화, 정보화, 다원화로 규정될 수 있는 새로운 21세기 사회의 특징들에 대하여 살펴보았다. 다음으로 지난 한국 사회과교육의 전개과정을 사회과교육의 교육목표, 교육과정, 교수학습방법, 연구경향 등을 중심으로 반성해 보았다. 이러한 논의를 바탕으로, 한국 사회과교육이 지향해야 할 몇 가지 방향을 도출해 보았다. 즉, 21세기를 위한 한국의 사회과교육은 사회적 생활 세계를 반영한 교과적 지식을 창출해야 하며, 사회과교육의 연구와 실천에서 한국적 토양을 확대시켜야 한다. 또한, 사회과교육과 가정 및 사회를 연계시키려는 노력이 있어야 하고, 다원화된 사회에 알맞은 시민적 의사결정력의 배양에 힘써야 한다. 그리고, 정보화와 사회과교육을 접목시키는 것도 중요한 과제이다. 이러한 노력의 중심에는 연구자로서의 교사가 무엇보다도 중요하다.

韓牛의 膵臟吸蟲에 대한 生藥의 殺蟲作用에 관한 硏究

朴駿瀅 慶北大學校 1976 論文集 Vol.21 No.-

This study was undertaken in order to examine parasiticidal action of the crude drugs to Eurytrema pancreaticum. For this purpose, Eurytrema pancreaticum was incubated at 37℃ in Hedon-Fleig solution which serial dilution of crude powder, water extact and alcohol extract were added respectively and motility of these organism was checked repeatedly untill cessation of movement was ascertained. The results are as follows. 1. Among 22 crude drugs, Acorus gramineus, Lindera strychnifolia, Inula Helenium Dryopteris crassirhizoma and Sophora angustifolia showed marked parasiticidal activity to Eurytrema pancreaticum. 2. In general, these drugs showed prominent parasiticidal actions in the form of alcohol extract, while less effective or no effective in form of water extract.

石菖浦 精油의 몇가지 藥理作用

朴駿瀅 慶北大學校 1978 論文集 Vol.25-26 No.-

The rhizomes of the Acorus gramineus Soland. have been used as analgesics, sedatives, stomachics and anthelmintics in chinese medicine. It is known that the rhizomes of the Acorus gramineus Soland. contains the essential oil about 0.5-0.8% and this essential oil contains Asarone about 86%. The Asarone possess many pharmacological properties similar to those of reserpine and chlorpromazine. Present paper, some pharmacological actions of the essential oil of the Acorus gramineus Soland. are observed. The results are as follows; 1) The essential oil of Acorus gramineus Soland. increased the sleeping time of the chicken anesthetized with hexobarbital sodium. 2) The essential oil of Acorus gramineus Soland. decreased the spontaneous activity of the chicken and the mouse. 3) The essential oil Acorus gramineus Soland. markedly inhibited the motility of the earth worm and the leech. 4) The essential oil of Acorus gramineus Soland. Showed the mydriatic actions on the isolated frog's eye ball.

TiN 코팅이 전기도금한 교정용 스테인레스스틸 선재의 세포독성에 미치는 영향

최준규,조진형,황현식,박병주 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.4

This study was performed to investigate whether TiN coating could reduce the cytotoxicity of electroplated orthodontic stainless steel wire which had been known to be cytotoxic. Nickel plating was done on stainless steel wire using a electroplating technique. Some of the electroplated wires were coated by TiN film and 4 groups of specimen were prepared (Non-coated electroplated wire, TiN coated electroplated wire, Titanium which was known to have no cytotoxicity, Copper which was known to have high cytotoxicity). Each wire was incubated for 72 hours on the medium. The release of the metal ion was measured by ICP-AES. The incubated medium was diluted 75 %, 50%, 25 % and added on each microplate with Balb/c 3T3 mouse fibroblast for MTT analysis and compared with medium only. Through the measuring of the change in absorbency value of each wire group and the difference of absorbency value according to change of dilution, following results were obtained. 1. The results of ICP-AES analysis showed that lots of nickel ions were isolated from non-coated wires but not isolated from TiN coated wires. 2. The inverted microscope showed that there was a decrease in cell count in non-coated wires but no significant change in TiN coated wires. 3. The results of MTT analysis showed that there was no difference in the absorbency value between TiN coated wires and medium and between titanium and medium but the absorbency value of non-coated wires and copper were lower than that of medium only at all dilution and showed statistically significant differences(p<0.001). 4. Assessment as per ISO 10993, part 5, non-coated wires and copper investigated corresponded to "moderately cytotoxic" and "highly cytotoxic" ; whereas titanium and TiN coated wires were alloted to "non-cytotoxic". The results of the present study indicate that the cytotoxicity of the electroplated orthodontic wire can be changed from "moderately cytotoxic" to "nontoxic" by TiN coating and electroplated wire can be used clinically without the concern of cytotoxicity.

토끼에서 enrofloxacin과 enrofloxacin acetate의 比較藥物動態學

윤효인,박승춘,김창식,김민규,최기섭,신광순,박종일,조준형,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

This study was designed to examine the in vitro antibacterial activities and pharmacokinetics of enrofloxacin acetate (ENFXA) and enrofloxacin (ENFX). Two enrofloxacins had wide spectrum antibacterial activities against Gram positive and negative bacteria, and mycoplasma, showing potent antibacterial activities with low MICs (0.05-3.33 ㎍/㎖ for Gram positives, 0.002 ㎍/㎖ for Gram negatives and 0.02 ㎍/㎖ for mycoplasma). In order to investigate the profiles of two formulations of enrofloxacin we studied comparative pharmacokinetics of them in rabbits. Five rabbits were given 5 ㎎/㎏ body weight of each enrofloxacin formulation intravenously (i.v.) and orally (p.o.) in a cross-over study. Pharmacokinetic parameters of both formulations were calculated by the use of PCNONLIN, a computer program. Their bioavailibility in rabbits, the means of the area under the curve (AUC). After oral administration of each formulation in rabbits, the mean elimination half-lives (t_1/2,ke) were 3.25h (ENFX) and 4.32 h (ENFXA), and mean AUC 4.27 ㎍·h/㎖ (ENFX) and 6.21 ㎍·h/㎖ (ENFXA). Both enrofloxacin formulations seemed to have good tissue distribution and penetration as indicated by large volume of distribution: 4.76 1/㎏ for ENFX and 7.23 1/㎏ for ENFXA. With the results obtained in this study, ENFXA could be used in place of ENFX in rabbits.

Fosfomycin의 항균효과 및 capillary electrophoresis에 의한 측정법에 관한 연구

윤효인,박승춘,이규승,권진욱,조준형,신광순,김무열,허강준,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

Fosfomycin, a low molecular antibiotic, is to be easily synthesized, therefore to be possibly used in veterinary sectors due to econimic reasons. In this study, we determined the antibacterial activities of fosfomycin against some domestic animal-origin pathogens, and its combined effects with some important antibacterials available. We also compared detection methods of fosfomycin from various measuring instruments. The results obtained through this experiment were as follows: 1. Antibacterial activities of fosfomycin against the pathogens used in this experiment were appeared fairly low. We found the antobacterial activities depanded on the kinds of media and the addition of some material thereins, which suggests the importance of appropriate medium so as to judge the antibacterial activity of fosfomycin. 2. Fosfomycin showed varying antibacterial effects in combination with other antibacterials, which should be taken into consideration when combining other antobacterials especially in the clinical settings. Of the combined antivacterials, fosfomycin had synergistic effects in combination with amoxicillin but antagonistic effects with oxytetracyline. 3. Conventional detection methods using HPLC, GC and spectrophotometer were not appropriate to measure fosfomycin. Capillary electrophoresis by the way of the indirect ultraviolet detection method was good enough to detect fosfomycin in the range of expected concentration in tissues, with the limit of quantitation (LOQ) of 1.25 ㎍/㎖. We recommend the eletrophoresis method could be used to detect fosfomycin, thereby being able to set the optimal dosage for animals and providing the measures in relation with the residual concentration in the meat.