Cellulase생산을 위한 Verticillium sp.의 배양조건의 검토

홍대희,진효상,오두환,유주현 연세대학교 산업기술연구소 1986 논문집 Vol.18 No.1

The cultivation conditions on wheat bran of verticillium sp. were optimized to produce cellulase as much as possible. The highest cellulase activity was shown, as verticillium sp. was cultivated at 27℃ for 5 days on wheat bran media with 1.2㎖/g wheat bran of water content and supplementation of NaNo and FeSo, in concentration of 0.1% and 0.2-0.3%, respectively.

천추 갈색종양(Brown tumor)으로 발현된 부갑상선 기능항진증 1예

홍우정,구본정,이재민,한상우,이효진,나소영,노흥규,김영건,송민호 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

부갑상선 기능항진증에 의한 골병변으로 갈색종양이 있다. 갈색종양은 주로 장골을 침범하고 척추골에서의 발생은 매우 드물다. 국내의 보고에서 갈색종양의 장골 침범은 있었으나, 척추골에서의 발생은 보고된바 없다 .저자들은 부갑상선 기능항진증으로 인하여 척추골의 천추에 발생된 갈색종양 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The bony involvement in primary hyperparathyroidism present as browm tumor or osteitis fibrosa cystica and lead to pathologic fracture. Brown tumor commonly involve long bone such as femur, tibia, fibula, humerus, and radius. Brown tumor of axial skeleton is a rare entity. Previously reported case that involve axial skeleton still not present. We report a 47-year-old male patient that he has a hyperparathyroidism presenting as brown tumor involving sacrum.

미립잠열재를 활용한 축열조로부터 방열특성연구

이효진,홍재창 한밭대학교 산업과학기술연구소 2001 논문집 Vol.5 No.-

An experimental study has conducted to understand the characteristics of heat releasing system in which Micro-PCM(microencapsulated Phase Change Materials) slurry is adopted for its storage media mixed with distilled water. Tetradecane(C_14H_30, T_m=5.5℃) as a core, is encapsulated and covered with melamin. For the test, a storage tank, which is 10 ㎝ in diameter and 20 ㎝ of its length, is fabricated with bakelite insulated with glass fiber, 2 ㎝ thick, to protect its heat loss. In order to measure the temperature changes during the heat releasing, 9 T-type thermocouples are embedded at three places in the axial direction and three at radial direction. The size of particles is well-controlled under 10 ㎛ in the way of in-situ polymerization with melamine-formaldehyde resin. For the experiment, the concentrations of slurries are prepared for 20 wt%, 30 wt%, and 40 wt%. The results are compared with those of water and 100% tetradecane oil. MicroPCM slurries are required relatively longer period of time for their phase change than pure phase change materials. That is, the entrained MicroPCM particles control its heat transfer in terms of natural convection and conduction to them.

1~2기 본태성 고혈압 환자들에서 Imidapril 대 Enalapril의 항고혈압 효과를 평가하기 위한 무작위, 이중맹검 임상시험

최영진,손대원,김용진,이홍자,채인호,김효수,김철호,오병희,이명묵,박영배,채윤식,이영우 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.11

압출용 다이스의 Melt-고분자 열유동 기초연구

정효희,김재열,최진호,유신,윤성운,홍철,김종문 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

As importance part of extruder, hopper(Hopper) been raw material supply wealth, main frame that screw and barrel that transformation of supply raw material attains are because deformed raw material is fearful finally extrusion to done dies attain. Extruder is divided by greatly above 3 but hopper has assembled in dehumidification of raw material and supply of smooth raw material, and make in Melt state as raw material is stabilized because main frame consists of screw and barrel and Melt does anaphora as done material is stabilized. And dies that is last part between barrel with screw anaphora done Melt material as is stabilized without causing change that is much depending on anaphora of screw from dies way out as correct product produce make to. In this treatise, make anaphora can present ideal dies basis design using CFdesign that is heat & flow analysis programs so that can produce detailed product through pipe channel flow analysis of stable dies applying anaphora value of do polymer raw material in Screw.

BaFBr:Eu^2+ 형광체의 열발광 및 광자극발광 특성

도시홍,서효진,강갑중,김영국,김도성,김성환,김찬중,이병화,김완,강희동 한국센서학회 2002 센서학회지 Vol.11 No.5

BaFBr:Eu^2+ 형광체를 제조하고, 이 형광체의 열발광 특성과 광자극발광 특성을 조사하였다. 이 형광체의 열발광 g1ow 피이크 온도는 352K와 448K였으며, 주 피이크(352K)에 관여하는 트랩의 활성화에너지는 약 0.96eV이었다. 또한 이 형광체의 광자극발광 스펙트럼의 파장범위는 350~450nm 사이였으며, 광자극발광에 기여하는 트랩의 활성화에너지는 약 0.98eV이었다. 열발광트랩과 광자극발광 트랩의 활성화에너지는 실험오차 내에서 일치하였다. BaFBr:Eu^2+ phosphors were prepared, and the thermoluminescence(TL) and photostimulatedluminescence(PSL) of the prepared phosphors were measured. Two glow peaks around 352 and 448 K are observed for x-ray irradiated BaFBr:Eu^2+ phosphors, and the activation energy of the main glow peak(352 K) was about 0.96 eV. The spectral range of the PSL was 350 ~450 nm, and the activation energy of the trap giving rise to PSL was about 0.98 eV. The activation energy of the traps giving rise to TL is agreed to those giving rise to PSL within experimental error.

SrCI_2:Eu^2+ 형광체의 광발광 및 광자극발광 특성

도시홍,서효진,김영국,김도성,김성환,김찬중,이병화,김완,강희동 한국센서학회 2002 센서학회지 Vol.11 No.6

고상반응법으로 SrCl_2:Eu^2+ 형광체를 제작하고, 제작한 형광체의 광자극발광과 광발광 특성을 조사하였다. SrCl_2:Eu^2+ 형광체와 광발광 및 광자극발광은 Eu^2+ 의 5d->4f 천이에 기인되었으며, 355 nm의 광으로 여기시켰을 때 광자극발광과 광발광 스펙트럼의 파장범위는 모두 380~440nm이었고, 피이크 파장은 407nm이었다. SrCl_2:Eu^2+형광체의 선량의존성은 2.5 mGy~200mGy영역에서 우수한 선형성을 나타내었으며, 상온에서 광자극발광의 fading은 20분에 60%이었다. SrCl_2:Eu^2+ phosphors were prepared by the solid phase reaction method, and their photostimulated luminescence(PSL) and photoluminescence(PL) characteristics were investigated. The PSL and PL peak of the SrCl_2:Eu^2+ phosphors are due to the 5d->4f transition of Eu^2+ ions in phosphors. The PSL and PL spectrum obtained by the 355 nm exitation was observed in 380~440 nm region with the peak at 407 nm. The dose response of the PSL phosphors were linear within 2.5 mGy ~ 200 mGy of 100kV X-ray. The fading of the phosphors at room temperature was approximately 60% after 20 min.

HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절

김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.

바이폴라 공정으로 집적화된 압력센서 제작 및 평가

이유진,김건년,박효덕,이종홍 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

실리콘 마이크로머시닝 기술과 바이폴라 공정으로 집적화된 압력센서를 제작하고 동작특성 평가를 수행하였다.센서부 보상파라미터를 추출하였고 트리밍 공정을 통하여 출력전압의 보상을 수행하였다.센서 특성은 압저항 위치, 마스크 정렬 오차, 다이어프램 정밀두께제어 정도, 보호막의 과도식각 정도 등에 의하여 민감하게 좌우됨을 알 수 있었다.웨이퍼별 샘플추출을 통하여 센서부 감도는 평균 0.653mV/kPa, 감도의 온도계수는 -2078.8ppm/℃, 옵셋전압은 30.78mV, 옵셋전압의 온도계수는 32.11uV/℃로 측정되었다.추출된 샘플의 다이어프램 두께오차는 27±2.5㎛였다.센서부 특성평가 결과를 통하여 신호처리회로의 옵셋 및 스팬보상, 온도보상을 위한 트리밍 공정을 수행한 결과 개발사양을 만족하는 결과를 얻을 수 있었다.

인공신경망 이론을 이용한 충주호의 수질예측

정효준,이소진,이홍근 한국환경과학회 2002 한국환경과학회지 Vol.11 No.3

This study was carried out to evaluate the artificial neural network algorithm for water quality forecasting in Chungju lake, north Chungcheong province. Multi-layer perceptron(MLP) was used to train artificial neural networks. MLP was composed of one input layer, two hidden layers and one output layer. Transfer functions of the hidden layer were sigmoid and linear function. The number of node in the hidden layer was decided by trial and error method. It showed that appropriate node number in the hidden layer is 10 for pH training, 15 for DO and BOD, respectively. Reliability index was used to verify for the forecasting power. Considering some outlying data, artificial neural network fitted well between actual water quality data and computed data by artificial neural networks.