충남대학교 기초과학분야의 효율적 육성에 관한 연구

윤화중,진성일,윤민중,윤혜수,이영하,최철규,이천배,신대현 충남대학교 자연과학연구소 1986 忠南科學硏究誌 Vol.13 No.2

Chungnam National University (CNU) is located in Daeduk Science Town, a center of science and technology in Korea, and it is expected to play an important role in the development of science in Korea. With this in mind, the basic natural sciences at CNU should be more actively supported in both education and research. Accordingly analysis and comparison of the basic science program at major college in Korea as well as those in the USA and Europe has been performed. The current cooperative relationship between CNU and research institutes in the science town has also been analyzed. This study has resulted in propositions to make more efficient the upbringing of the basic sciences at CNU, by focusing on the following points ; a) to improve academic affairs, b) to make graduate studies substantial, c) to secure highly qualified faculty members, d) to increase cooperation in research between CNU and reserch institutes, e) to enlarge research laboratories and acquire more equipment and facilities.

갈락토오스혈증에 대한 신생아 선별검사의 사용 시약 및 검체 보관에 따른 영향

최태윤,윤혜란 德成女子大學校 藥學硏究所 2007 藥學論文誌 Vol.18 No.-

Classic galactosemia is caused by impaired galactose-1-phosphate uridyltransferase (GALT EC 2.7.712). If discovered and treated within the first days of life, the acute problems of hepatocellular damage, sepsis, and death are prevented. However, chronic problems such as ataxia, tremor, dyspraxic speech, and ovarian failure may occur. The study was devised to determine whether galactosemia assay method, period of specimen storage, and reagent from different commercial company used affect result of the assay for screening newborns After different concentration level of in-house made galactose was spotted onto control blood specimen it was distributed to the 15 clinical testing laboratories, galactose assay results were received by mail. Correlation coefficient of inter-laboratory and between-laboratory was analyzed depending on period of specimen storage. 6 laboratories was used reagent from ICN, 8 from BioRad, and 1 from Perkin Elmer for galactose testing. For normal reference range from ICN was less than 8, 10, or 12 mg/dL, from BioRad was less than 8, 11, 12 or 13 mg/dL, from Perkin Elmer was less than 10 mg/dL. In case of enzyme colourimetric method, inter-laboratories correlation coefficient was 14 % on the concentration of 1.7 mg/dL, 9 % on the concentration of 2.7 mg/dL, 12 % on the concentration of 4.1 mg/dL, 9 % on the concentration of 7.7 mg/dL, 3 % on the concentration of 14.1 mg/dL, 9 % on the concentration of 34.0 mg/dL for normal negative control specimen, and 10-16% for positive control specimen. After 1 year of storage in refregerator, repeating testing showed within 20 % difference of correlation coefficient, however, results did not show significant difference in both statistics and diagnosis. As a result of our study, each laboratory using different reagent and different assay method ought to determine it's own reference range, is necessary to store newborn screening specimen for 2 years in the refregerator.

농장 사육되는 타조에서 나타난 다리 기형의 증례 보고

최종윤,손화영,전무형,조성환,김혜성,류시윤,박배근,이영원,윤원기 충남대학교 수의과대학 동물의과학연구소 2001 動物醫科學硏究誌 Vol.9 No.-

Two farmed young ostrich chicks were applied to pathology laboratory at Chungnam National University. Grossly, one ostrich showed rotated tibiotarsus, the other showed rolled toes. Case 1 ostrich was hypertrophy of fibualis longus and tibial cranialis tendon and gastrocnemius tendon in crus, inflammation of flexor digitorum longus. In histopathological views, myocytes of fiburalis longus were showed hypertrophy and hyperplasia. It is not found any specific feature in X-ray of the case 2 ostrich. Limb deformities were detected frequently in farmed ostrich chicks in 2- to 3 weeks old. Limb deformities were an important cause of mortality in farmed ostrich chicks during the first 10weeks after hatch. Cause of limb deformities were considered a nutrition problem.

전통조각보의 색채, 면구성을 응용한 패턴의 감성이미지 연구

최윤혜,은영자 한국의류산업학회 2004 한국의류산업학회지 Vol.6 No.3

This study is on the sensitive image of pattern expressed in the color & formative types of traditional Jokakbo(scraps of cloth). The object of this research is Korean traditional scraps of cloth in the latter period of Chosun Dynasty. This study is to be classified into 10 formative types like square type 1, square type 2, diagonal type, diamond type, many color striped type, concentric circle type, pinwheel type, vertical line type, cintamani pattern type, and free style type to apply the design of Jokakbo to Korean design. And color group is divided into vivid tone and pale tone. And it constitutes 17 patterns from the combination of these two types. As for the factors of constitution of scraps of cloth, it consists of factors like revelation, attraction, temperature sense, abstract, and rigidity. In the emotional image in the pat-terns, both vivid tone and pale tone showed dynamic and warm emotion together. Also, the factors of revelation and attraction were evaluated as opposite images, and it evaluated the plain and dim emotion as more attractive emotion. They preferred the pale tone to the vivid tone. "They preferred the cintamani pattern in the vivid tone, and the diamond pattern in the pale tone most. From the research result above, this study made the abstract image of scraps of cloth standardized and prepared for a basis to execute it essentially. This research will be used as basic data to make traditional Korean image spotlighted in the world fashion markets as well as it will be helpful to the development of pattern design for the scraps of cloth essentially.

갈락토오스혈증 선별검사 양성인 신생아에 대한 정밀검사 결과 분석

최태윤,윤혜란 덕성여자대학교 약학연구소 2010 藥學論文誌 Vol.21 No.-

Background & object : Generally, blood spots of newborn have been sent to the 2n d institution for differential confirmatory test, who showed positive through newborn screening for galactosemia. So far no report on the investigative analyses on confirmatory test results of positive Galactosemia results of newborn blood spots, who have been born in General Hospital. We have investigated the proportion of blood spotsamples that gave positive screen results of newborn blood spots born in Soonchynhyang University Hospital. Methods: We investigated and analyzed through examining medical records of newborns who were born or transferred in Soonchunhyang University Hospital in 2009. Newborn born blood spots obtained were from what was transferred to our Hospital for confirmatory tests or from what was visited to our Hospital for the total galactose, free galactose, galactose-1-phosphate, and Beutler tests. Results : Out of 252 newborns who received secondary confirmatory tests, the newborn blood spots who showed abnormal was as follows; 66 (26.2%) for total galactose, 10 (4.0%) for free galactose, 32 (12.7%) for galactose-1-phosphate and, 0 for Beutler tests. Among 96 newborns who have seen attending physician 18 (19.1 %) showed abnormal, and finally 5 (2.0%) was diagnosed as Galactosemia and 15 was transient Galactosemia. Out of 18 newborns who have been transferred to secondary confirmatory test 3 have been diagnosed as Galactosemia. Finally five (2.0%) was diagnosed as Galac tosemia out of 252 born at Soonchunhyang University Hospital in 2009. From these results we expect there might be more than 7 newborns with Galactosemia, though 7 Galactosemia newborn patients have already been registered at community health center. Conclusions : For the prevention of mental retardation and effective therapy over Galactosemia, secondary confirmatory test ought to be performed right away if the result of newborn screening for Galactosemia is positive. 갈락토오스혈증은 갈락토오스 분해효소의 결핍으로 인하여 섭취한 갈락토오스를 우리 몸에서 에너지 원으로 이용되는 포도당으로 바꾸지 못하여 체내에 갈락토오스가 축적되는 유전성 질환으로 신생아 시기에 치료하지 않으면 발육부전 및 정신지체가 발생 하고 심한 경우 사망하기도 한다. 신생아 때 발견하여 치료하면 정신지체를 예방할 수 있는 유전성 대사질환에 대한 신생아 선별검사가 1985년 국내에 처음 도입된 이후 갈락토오스혈증에 대한 신생아 선별검사가 2006년부터 정부 지원사업으로 채택되어 모든 신생아를 대상으로 무료로 실시되고 있다. 갈락토오스혈증에 대한 선생아 선별검사가 시작된 이후 양성자들에 대한 확인검사를 통하여 갈락토오스혈증 환자가 진단되고 있지만 아직까지 우리나라에서의 발생빈도는 정확히 알 수 없다. 신생아 선별검사에서 갈락토오스혈중 양성인 신생아들은 확인검사 기관에서 정밀검사를 받지만 검밀검사에서 진단된 환아가 얼마나 되는지 정확히 알 수 없고, 진단된 환아 중 몇 명이 보건소에 동록되는지 알 수 없다. 확인검사를 통하여 진단된 환아 중 보건소에 사후관리자로 등록된 환자를 근거로 산출한 2006부터 2009년까지 4년간 갈락토오스혈증의 발생빈도는 51,419명당 1 명이다. 최태윤 등은 2005년도 신생아 선별검사결과를 근거로 산출한 갈락토오스혈증 발생 빈도가 39,314명당 1명으로 보고하였다. 저자들은 갈락토오스혈증에 대한 신생아 선별검사에서 양성인 신생아 중 확인검사를 받기 위하여 정밀검사 기관으로 내원한 신생아들 대상으로 확인검사 결과를 실시하고 그 결과를 분석하여 보고하는 바이다.

Effect of p-Phenylenediamine Application to Rat Skin on the Liver Oxygen Free Radical Systems

윤종국,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2003 Journal of biomedical laboratory sciences Vol.9 No.2

To evaluate the influence of hepatic oxygen free radical systems on liver injury by topical p-phenylenediamine (PPD) application on rat skin. PPD (25mg/16.5㎠) was topically applied to the abdominal region 5 times every other day and sacrificed. By PPD treatment, increasing rate of liver weight/body weight(%), serum activities of alanine aminotransferase and aspartate aminotransferase and decreasing rate of microsomal glucose-6-phosphatase activity were higher in the rats fed tungstate supplemented diet than those fed a standard diet. These findings indicate that group fed tungstate supplemented diet have more severe liver injury compared with group fed standard diet on topical PPD application. However, the activities of oxygen free radical generating enzymes such as xanthine oxidase (XO) and cytochrome P450 dependent aniline hydroxylase and those of oxygen free radical scavenging enzymes were not found to be different between these two animal groups. In the present study, a novel monitoring method to detect the generating of oxygen free radicals in liver extract was devised. Throughout this method, the oxidized PPD produced by oxygen free radicals was determined colorimetrically. The increasing rate of PPD oxidation by liver homogenate was higher in tungstate fed animals than in standard diet fed ones. Among the fractionations of liver extract, the mitochondria1 and postmitochondrial fractions in the liver extract of tungstate fed animals led to a higher availability of PPD oxidation by PPD treatment compared with standard diet fed ones. In conclusion, these results suggest that an enhanced liver injury in tungstate fed animals treated with PPD may be due to oxygen free radicals produced in other systems except oxygen free radicals generating from cytosolic XO system. Especially, oxidative availability by PPD can be used for oxygen free radical detection in some tissue.

디지털 기술의 건강보험 보장방법에 대한 고찰: 5개 국가 중심

엄혜은,김지혜,한승진,최연미,최윤정 건강보험심사평가원 2022 HIRA RESEARCH Vol.2 No.1

골반강 종괴로 재발한 악성 난소 갑상선종

최수임,윤혜경 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Malignant struma ovarii is a rarely reported disease and the diagnostic criteria is still in debate. A 43 years old woman admitted to our hospital because of palpable lower abdominal mass in 1993. On ultrasonography, a cystic mass, measuring 6.1cm in long diameter, was found in the left ovary, and laparoscopic left salpingo-oophorectomy was performed. Submitted left ovarian tissue consisted of multiple fragments, and focal yellowish brown nodules were seen along the inner side of the cystic mass. Microscopically, mature cystic teratoma with focal thyroid tissues exhibiting usual nodular hyperplasia of thyroid gland or follicular adenoma of fetal type and positive reaction for thyroglobulin was observed. Neither cytologic atypia of follicular cells nor mitosis were found in the thyroid tissue, but thyroid tissue showed focal infiltrative borders into ovarian stroma and evidence of vascular invasion. The thyroid function test was within normal limit, and no abnormal finding was noted on thyroid scan at that time. In 2002, TAH with right salpingo-oophorectomy was done because of hypermenorrhea and palpable lower abdominal mass. A cystic mass and multiple small yellowish brown nodular lesions were found along the serosal surface of the uterus. Microscopically findings suggesting papillary carcinoma of thyroid gland, follicular variant, were noted. In 2003, segmental resection of small intestine and rectum were performed, and nodular lesion involving the rectal wall showed features suggesting follicular carcinoma of thyroid gland. We report a case of malignant struma ovarii recurred in the pelvic cavity, 9 years after left oophorectomy.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

朝鮮時代 服飾紋樣에 관한 硏究 : 대칭적 구성양식을 중심으로 In reference to the symmetrical mode

최윤혜,殷英子 啓明大學校 生活科學硏究所 1993 科學論集 Vol.19 No.-

We classify a symmetric pattern shown in the dress and its ornaments of Chosun dynasty by right-to-left, up-to-down and round-shaped symmetry, and then we look over its unique aesthetic effect. The conclusion is as follows : 1. Most of symmetric patterns are right-to-left symmetrical, and they have the most various pattern and drawing. It is the most basic and simplest symmetry because a human being's figure and natural form take a right-to-left symmetry. 2. Most of symmetric patterns were used to draw animals. In its form the symmetric elements take an intermittence because it is fit to express animal's independence. Especially the mode of round-shaped symmetry is shown only in the animal pattern. 3. A bat pattern and sujamun (long life-invoking design) of kilsangumun (fortune-invoking letters design) show their possibilities of expression beyond the mere reapperance and are extremely simple and abstract. 4. The unsymmetric elements are used properly in the mode of symmetric pattern. An unsymmetry, a unique aesthetic sense of Chosun dynasty, was expressed in a Chinese phoenix and crane pattern. The parts of tail and neck were given a little transformation respectively to take a change and rhythem because of monotony of symmetry. Entirely it keeps its unity of symmetry and motion in control. 5. Even if the technique and space of drawing took a pattern of the same theme, there exists a little difference. Most of symmetric patterns were described by embroidery and foiling, and the daring omission, sketch and realistic picture took a main parts to express vividity in embroidery. It was so difficult for the technique of foiling to express the natural and realistic feeling, and it gave an importance meaning instead of figure. Also it took a regular form almost without changes. The dress, ornaments and necessaries gave a change an arrangement and mode of symmetric pattern.