Plyometric Training과 비타민 C 투여가 남고생의 체력, 혈중 젖산, 암모니아 및 젖산탈수소효소에 미치는 영향

장준원,김세종,이현미,서혜림,조현숙,고정림,염종우,예정복,백영호 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

The purpose of this was to examine the effect of plyometric training and vitamin C ingestion on physical fitness and fatigue substance....

Platinum sensitive 재발성 난소암에서 Carboplatin/Paclitaxel의 효과

장혜진,유희석,임윤경,문세희,장기홍,이정필 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

목적 : 재발성 난소암에서 platinum 감수성을 기준으로 2차 항암요법으로 사용한 Carboplatin과 Paclitaxel의 효과를 알아보기 위하여 본 연구를 진행하였다. 연구방법 : 1998년 1월 1일부터 2003년 8월 31일까지 만 5년 8개월 간 아주대학교병원 산부인과에 재발성 난소암으로 입원한 환자 중에서 최초 수술로 난소암을 확진한 후 Cisplatin 또는 Carboplatin 등 platinum 제재가 포함된 항암치료를 받은 후 6개월 이후에 재발한 환자 29명을 대상으로 Carboplatin은 5 AUC를 그리고 Paclitaxel은 175 mg/m^(2)를 투여하였으며, 최소 3회에서 최고 16회까지 투여하였다. 치료효과의 판정은 CT, MRI, Ultrasonography등 영상진단상 암종괴의 크기가 완전히 소실되었을 경우를 완전반응(complete response)으로, 50%이상 감소되었을 경우를 부분반응(partial response)으로, 50% 미만으로 감소되었거나 20% 미만 증가하였을 경우를 불변(stable disease)으로, 그리고 20% 이상 증가되었을 경우를 진행(progressive disease)로 정의하였다. 결과 : 대상 환자에서 완전반응은 6명(21%), 부분반응은 11명(38%), 그리고 불변은 5명(17%)로 전체 반응율 (overall response rate)은 59% 그리고 임상적 유용성(clinical benefit=CR+PR+SD)은 76%이었다. 결론 : 재발성 난소암환자에서 기왕에 사용한 Platinum 제재에 민감한 환자에서는 Carboplatin과 Paclitaxel의 병행 투여가 효과적이었다. Objective : To ascertain the effect of Carboplatin and Paclitaxel combination as a second line regimen for recurrent ovarian carcinoma based on platinum sensitivity. Methods : From January 1st, 1998 through to August 31st, 2003, 29 patients were retrospectively reviewed who had previously underwent primary cytoreductive surgery and adjuvant chemotherapy with Cisplatin or Carboplatin for ovarian carcinoma, and who had later recurred during follow up. All 29 patients had recurred at least 6 months after therapy, and thereafter received second line chemotherapy consisting of Carboplatin (5 AUC) and Paclitaxel (175 mg/㎡) for a minimum of least 3 cycles and a maximum of 16 cycles. Treatment efficacy was assessed by imaging studies including Computerized tomography, Magnetic Resonance Imaging, or Ultrasonography. Complete response was determined as complete disappearance of tumor, partial response at least than 50% reduction in tumor volume, stable disease as less than 50% reduction or less than 20% increase in tumor volume, and progressive disease as more than 20% increase. Results : There was complete response in 6 (21%) patients, partial response in 11 (38%), stable disease in 5 (17%), showing an overall response rate of 59%. The clinical benefit (CR+PR+SD) was 76%. Conclusion : The combination of Carboplatin and Paclitaxel administration seems to be an effective mode of second line therapy in patients with recurrent ovarian carcinoma who had been sensitive to prior platinum based chemotherapy.

교육무용 활성화를 위한 방향모색

임혜자,장경진 韓國舞踊敎育學會 1995 韓國舞踊敎育學會誌 Vol.5 No.-

Under the current dance educational system, it is difficult to expect a dance from to emerge which would satisfy the educational needs of the future society in its seeking for creativity. In order to establish the necessary position for a dance education fromat which it aimed at the 2000's, current training courses, dance instructors, associated educational system and facilities have been analyzed, and the following conciusions derived. Dance, with respect to training course, must be an independently taught and marked subject in primary, middle and high schools and, to improve the quality of dance instruction dance instructors must be properly qualified and certified, and through the appontment of teachers in charge of dance to positions as dance choreographers, the entire system surrounding and driving dance must improve. In addition, school dance facilities must be expanded by providing more dance practice and performance rooms and y installing such facilities as T.V and VTR equipment. Only when such conditions are satisfied, future dance education be expected to receive due recognition for its importance within the realm of true higher education.

이사도라 던컨의 무용사상과 그 현대적 의의

임혜자,장경진 韓國舞踊敎育學會 1996 韓國舞踊敎育學會誌 Vol.6 No.-

As the 20th century sets in, beauty of dance was becoming more formalized and excessively specialized. Attempts to get not of dissatisfaction with this tendency brought about the birth of modern dance which tried to express the stream of movements by using all parts of body, fully free from forms techniques, music, shoes and dresses. Thanks to its unique characteristic of making dance part of a human life for children, adults, laymen and professional dancers, modern dance has had immense effects on the field of dance as an education-purposed dance. The root of the so-called modern dance must be found in the history of American modern dance, and the origin of modern dance must be attributed to Isadora Duncan's ideology on dance. To understand Duncan's ideology on dance, this study tried to investigate her true character based on her autobiography entitled "MY LIFE". In addition, this study tried to explore the origin of her dance and its meaning by understanding Duncan herself and her ideology In order to illuminate her marvelous traces and brilliant lessons for today's dance development, this study drew the following conclusion from its findings about her life and ideology. Duncan suggested possibility of dance to develop into an independent art free from music, literature, or fine art by discovering the intrinsic meaning of physical movements. She also expanded the scape of expression abilities of dance by discovering the world of mind. Since Duncan's dance is characterized as expression of human emotions, she should be seen as the pioneer of our today's 'modern dance'. In addition, she was not only the founder of modern dance having systematic techniques but also a great revolutionary who awoke the then dance world by introducing a new choreography. From the perspective of dance history, Duncan's ideology on dance provided the basis to construct the underlying principle of 'modern dance'. Based on this conclusion, this study made the following suggestions, first, under the lifetime education philosophy, dance education should be restructured, escaping from the current technique-based education for fostering professional dancers, to introduce a new concept that dance is part of routine human life, second, since Duncan's spirit of dance based on soul expression through natural movements, not on techniques, casts a great meaning to modern dance education, the mission of modern dancers, choreographers, and educators is to inherit Duncan's spirit by keeping and developing a living dance.

KS H ISO 1242 표준의 평가 : 라반딘 정유의 산값 측정

전혜림,이은지,장혜진,손현화,김건,김남선,전명숙,이동선 서울여자대학교 2010 자연과학연구논문집 Vol.22 No.-

The acid value (AV) as well as the ester value of essential oil is an important index to evaluate quality of essential oil. The official standard analytical method of KS H ISO 1242 dealing with “Essential oils - Determination of acid value” was assessed experimentally using two lavandin essential oils obtained in France as an example. One French lavandin oil sample showed the results of AV= 0.9 by both indicator method and potentiometry. Another sample showed AV = 1.9 by indicator method and AV = 1.6 by potentiometry. Latter lavandin oil sample exhibited significantly higher acid value than maximum value of 1 described in the standard. This result suggests that latter lavandin oil was contaminated, because this oil was contained in an orange juice bottle. Results of this study proved that KS H ISO 1242 could be used as a suitable scientific standard for the determination of acid value of essential oils.

복수과 진료 환자의 중복 처방에 대한 분석 및 평가

이지은,장혜경,오지영,유윤경,김현지,임숙인,연숙희,강진숙,최귀령 한국병원약사회 2003 병원약사회지 Vol.20 No.1

In an aging society, there is an increasing possibility of the duplication of the drugs given to patients because they take many kinds of drugs. Among the prescriptions given to the patients who was treated at multiple ambulatory clinics in St. Mary's hospital for one month of September, 2002, in which drugs that has identical or similar effects are prescribed, we analysed and evaluated them by patients' characteristics, kinds of medication, severity of side effects on a case by case basis. More, we assessed the potential additional costs. As a result of this study, the duplication rate turned out to be 6.69% and it was shown that the proportion of the elderly patients over 60 was high. The gastro-intestinal medications took up a large part and most of the cases showed that the danger caused by double taking of medicine was slight, but there were some examples in which the serious side effects were predicted. Expected additional costs were the average 11.349 won and it ranges from the minimum of 56 won to the maximum of 135,720 won. In conclusion, the management of drug histories of the patients who need the plural treatments is very important and the necessity of the individual and professional guidance of taking medicines for the elderly patients is emerged, too.

光照射에 의한 콩나물의 質的 變化

金明姬,元惠心,李正和,林容順,張美花 효성여자대학교 가정대학 학도호국단 1984 家政大論集 Vol.3 No.-

光의 照射에 의한 콩나물의 質的變化를 調査할 目的으로 光度 및 光質別 處理를 하여 成長狀態, Vitamin C, chlorphnyll, cellulose등의 含量과 質感에 對한 官能檢査를 行하였으며 chlorophyll과 vitamin C의 關係를 chloramphenicol 處理에 의하여 調査해 보았다. 그 結果 白色光의 경우 50 lux와 100 lux 處理로 vitamin C의 含量 增加와 cellulose등의 生成이 促進되었으며 質感이 暗所보다 良好하였다. 그러나 200 lux 하에서는 매우 不良하였다. blue光은 他光보다 cellulose와 vitamin C生成에 效果的 이었다. chlorophyll과 vitamin C의 含量과는 直接的인 關係가 없고 다만 光照射와의 關聯性이 있는 것으로 推定되었다. This study was carried out to evaluate the quality of green soybean sprouts grown under light. The soybean was germinated under light through blue, red and white polyethylene films at 25℃ for 10 hours a day, and light intensity was controlled 50 to 200 lux. The contents of Vitamin C. cellulose and chlorophyll were determined and checked up texture by sensory evaluation of the soybean sprouts soup. In addition, the relationship of chlorophyll and Vitamin C was measured by treatment of chloramphenicol which has inhibitory effect of chloroplast, chlorophyll accumulating site. Vitamin C and cellulose contents were all increased by irradiation of white light at 50 and 100 lux and also texture of the sprouts was better than it of the sprouts grown under darkness while, it was very tough under 200 lux. Blue light was more effective for biosynthesis of Vitamin C and cellulose than white and reg light. Biosynthesis of chlorophyll was not relative to Vitamin C content directly. but the relationship may be concerned with light irradiation.

Acute T cell-mediated rejection after administration of the BNT162b2 mRNA COVID-19 vaccine in a kidney transplant recipient: a case report

Hye-Won Jang,Seongman Bae,Youngmin Ko,Seong Jun Lim,Hye Eun Kwon,Joo Hee Jung,Hae yon Cho,Heounjeong Go,Hyun Wook Kwon,Young Hoon Kim,Sung-Han Kim,Sung Shin 대한이식학회 2021 Korean Journal of Transplantation Vol.35 No.4

The impact of the coronavirus disease 2019 (COVID-19) vaccination on humoral and cellular immunity in transplant recipients remains unknown. We report the case of a 78-year-old kidney transplant recipient who experienced acute T cell-mediated rejection after receiving the second dose of the BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech). She had no history of acute rejection throughout the 13 years after deceased donor kidney transplantation. Fifteen days after receiving the second dose of the BNT162b2 vaccine, the recipient visited our center with a mild headache and fever. Her serum creatinine level had increased from 0.61 to 4.95 mg/dL. Kidney allograft biopsy indicated acute T cell-mediated rejection (grade IB) with no pathologic evidence of antibody-mediated rejection. Anti-severe acute respiratory syndrome coronavirus 2 spike-immunoglobulin G and -immunoglobulin M measurements were weak positive and negative, respectively. Careful monitoring of kidney allograft function is vital for transplant recipients undergoing COVID-19 vaccination.

Loss of β2-spectrin prevents cardiomyocyte differentiation and heart development

Lim, Jeong A.,Baek, Hye Jung,Jang, Moon Sun,Choi, Eun Kyoung,Lee, Yong Min,Lee, Sang Jin,Lim, Sung Chul,Kim, Joo Young,Kim, Tae Hyun,Kim, Hye Sun,Mishra, Lopa,Kim, Sang Soo Oxford University Press 2014 Cardiovascular research Vol.101 No.1

<P><B>Aims</B></P><P>β2-Spectrin is an actin-binding protein that plays an important role in membrane integrity and the transforming growth factor (TGF)-β signalling pathway as an adaptor for Smads. Loss of β2-spectrin in mice (<I>Spnb2<SUP>−/−</SUP></I>) results in embryonic lethality with gastrointestinal, liver, neural, and heart abnormalities that are similar to those in <I>Smad2<SUP>+/−</SUP>Smad3<SUP>+/−</SUP></I> mice. However, to date, the role of β2-spectrin in embryogenesis, particularly in heart development, has been poorly delineated. Here, we demonstrated that β2-spectrin is required for the survival and differentiation of cardiomyocytes, and its loss resulted in defects in heart development with failure of ventricular wall thickening.</P><P><B>Methods and results</B></P><P>Disruption of β2-spectrin in primary muscle cells not only inhibited TGF-β/Smad signalling, but also reduced the expression of the cardiomyocyte differentiation markers Nkx2.5, dystrophin, and α-smooth muscle actin (α-SMA). Furthermore, cytoskeletal networks of dystrophin, F-actin, and α-SMA in cardiomyocytes were disorganized upon loss of β2-spectrin. In addition, deletion of β2-spectrin in mice (<I>Spnb2<SUP>tm1a/tm1a</SUP></I>) prevented proper development of the heart in association with disintegration of dystrophin structure and markedly reduced survival.</P><P><B>Conclusion</B></P><P>These data suggest that β2-spectrin deficiency leads to inactivation of TGF-β/Smad signalling and contributes to dysregulation of the cell cycle, proliferation, differentiation, and the cytoskeletal network, and it leads to defective heart development. Our data demonstrate that β2-spectrin is required for proper development of the heart and that disruption of β2-spectrin is a potential underlying cause of congenital heart defects.</P>

Analysis of Differential BRAFV600E Mutational Status in Papillary Thyroid Carcinoma

( Hye-lim Jang ),( Tai-jeon Kim ),( Jae-ho Shin ),( Chul Kim ) 대한임상검사과학회 2012 대한임상검사과학회지(KJCLS) Vol.44 No.2

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer, accounting for 95% or more of malignancies in Korea. Recently, many thyroid cancers have been detected owing to the widespread useof ultrasonography in health surveillance. The objective of this study was to evaluate the association of known prognostic factors with the BRAFV600E mutation and its association features in Korean patients with papillary thyroid carcinomas. The BRAFV600E mutation was detected in 69.1% (256 of 370) of PTC cases. In univariate analysis, the BRAFV600E mutation was significantly associated with tumor size (p < 0.05) and sex. However, it was not significantly associated with other established risk factors, such as age, extrathyroidal extension, and lymph node metastasis. This finding supports the idea that the BRAF mutation plays a role in the early stage of PTC development. This relationship deserves further investigation to clarify whether BRAFV600E is a useful risk factor or prognostic marker for PTC.