"이순신" 멀티미디어 정보 시스템 설계 및 구현

이혜정,박원환,박두순 순천향대학교 부설 산업기술연구소 2000 순천향 산업기술연구소논문집 Vol.6 No.1

The purpose of this paper is service system development which enables to carry out the mission of preserving worldwide Korean cultural relics, internationally to contact the informations about our country's cultural relics on the Cyber space, to make atmosphere that makes it possible to appreciate them, and to provide information service by performing mutimedia service which is related to Soon-sin Lee using Virual Reality. For that, creating Virtual Reality information and Video Informaion which is related to Soon-sin Lee, especially Gubooksun by using Virtual Reality technique, 3-Degree image manufacture technique, animation manufacture technique, video manufacture and service technique and Internet/Web technique, and then manufacturing and storing them in the digital data type, and carry out Information Service through connecting the system of serving these informations with the Information SuperHighway

마우스 胎仔 小腸의 杯狀細胞 出顯에 關한 硏究

李惠星,金淳會 梨花女子大學校 韓國生活科學硏究院 1986 韓國生活科學硏究院 論叢 Vol.37 No.-

소장의 배상세포는 장선에서 발생되고 이들은 융모상피로 이주 한 후에 장내강으로 탈락되는 것으로 알려져 있다. 그런데 이와 같은 사실은 모두 성체(adult)에서 밝혀졌으며 장선과 융모가 형성되기 이전의 태생기에 배상세포의 출현과 분화과정에 대해서는 밝혀진 바 없다. 이에 본 연구에서는 태생기 배상세포의 출현시기와 동태를 파악하기 위하여 마우스 태자 소장을 광학 및 전자현미경으로 관찰하여 다음과 같은 소견을 얻었다. 1. 마우스 태자의 소장에서 보통배상세포와 과립점액세포는 다같이 태령 15일부터 나타났으며, 이때에 대부분의 이들 세포들은 소수의 점액과립을 함유하고 있었다. 2. 태령 16,17일 태자의 배상세포 수는 급격히 증가하며 그 이후 태생말기까지는 비슷한 수준을 유지하였다. 3. 각 태령에서 보통배상세포와 과립점액세포의 출현율은 각각 약 80% 및 20% 정도로서 태령에 따른 차이는 없었다. 4. 태생 말기에 과립점액세포에서는 변형된 분비과립의 수가 증가하였다. 5. 보통배상세포와 과립점액세포는 태생말기에 과립의 분비상태를 나타냈고, 보통배상세포는 융모의 상피에서 장내강으로 탈락되는 경우도 있었다. It is known that the goblet cell in the small intestine of a mouse originated from the crypt base cells of gland and migrated to the upper part of the villus and that it is extruded into lumen of the intestine. But these facts have been observed in the adult small intestine. However, the origin and the process of differentiation of the goblet cell in the fetus prior to the formation of the glands and villi are not known. The present experiment was performed to clarify the developmental stages and the behaviors of the goblet cell in the small intestine of fetal mouse by means of light and electron microscopy. The results obtained could be summarized in five items as follows; 1. Both the ordinary goblet cells and granular mucous cells were identified in the small intestinal epithelia of the 15-day-old fetuses. Most of both these cells contained only a small amount of mucous globules. 2. The number of the goblet cells was markedly increased in the small intestinal epithelia of the 16-and 17-day-old fetuses and it was maintained to the end of the fetal life on the approximately equal level. 3. The frequency of the ordinary goblet cells and granular mucous cells were about 80% and 20%, respectively, regardless of the fetal ages. 4. Toward th end of the fetal life, the number of modified secretory granules of granular mucous cells was increased. 5. Again, toward the end of the fetal life, the ordinary goblet cells and granular mucous cells displayed the secretory states. In addition, the ordinary goblet cells were occasionally extruded into the lumen from the villus tip

당근조직으로부터 salt hypersensitivity에 의해 유도되는 Anthocyani 대량 생산

이인순,문혜연 大邱大學校 科學技術硏究所 1999 科學技術硏究 Vol.5 No.5

The carrot callus in salinity stress was subjected to various levels of salinity conditions(NaCl, Na-gluconate, KCI, K-gluconate). Salinity stress was measured by anthocyanin and proline products. The carrot callus was induced by MS(Murashig & Skoog, 1962, pH 5.8)medium containing 0.5mg/I IAA, 2.Omg/I kinetin, and 3% sucrose. Callus was cultured during 20 days at dark condition, 25℃. The carrot callus was treated at various concentration of salinity during 10 days. The product of anthocyanin was separated high value at 200mM K-gluconate. A large amount of anthocyanin was produced from 2 days to 8 days of culture time in the case of Na^(+) ion and it was was observed from 2 days to 5 days of culture time in the case of K^(+) ion. These results were due to Cl- ion. The movement from cytosol to vacuole of Cl^(-) ion was occurred homeostasis because the ions of sodium and potassium were different to function in affinity of ion transporter. The product of proline was separated high value at 2OOmM KCl. Proline metabolism in callus has attracted in the response to hyperosmotic stress. This amino acid is the most common organic osmoprotectant. The concentration of osmolytes such as proline increases, the K^(+) ion concentration decreases because the KCl and K-gluconate has high value.

정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구

이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.

플라보노이드의 세포 신호전달 조절

이응룡,강근호,강용진,김우열,최혜연,김봉우,정효순,조쌍구 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

Many studies revealed the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. The plausible mechanistic interpretation of the various effects of flavonoids was concentrated on the anti-oxidant or free radical-scavenging properties of these phytochernicals, both in model systems and under in vivo conditions. While there has been a major focus on the anti-oxidant properties. there is an emerging view that flavonoids and their in vivo metabolites. do not act as conventional hydrogen-donating anti-oxidants. but they may exert regulatory functions in cells through actions at protein kinase or lipid kinase signaling pathways. Flavonoids and more recently their metabolites. have been reported to act at phosphoinositide 3-kinase(PI 3-kinase). Akt/protein kinase B(Akt/PKB), protein kinase C (PKC), mitogen activated protein kinase(MAP kinase), and various tyrosine kinases signaling cascades. Inhibitory or stimulatory actions at these pathways are likely to affect cellular function profoundly by altering the phosphorylation state of target molecules and by modulating gene expression. A clear understanding of the mechanisms of action of flavonoids, either as anti-oxidants or modulators of cellular signaling pathways, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anti-cancer agents, cardio-protectants, and inhibitors of neurodegeneration.

알타리 무 동치미 제조시 젖산균 첨가가 숙성중 품질에 미치는 영향

이혜정,오순덕 동아시아식생활학회 2002 동아시아식생활학회지 Vol.12 No.1

This study examined the chemical and sensory characteristics of Altari Dongchimi with inoculation of Leuconostoc citreum IH22. Dongchimi was stored at room temperature for the first day and at 4℃ from 2nd to 28th day. The pII was somewhat lower in Altari Dongchimi when first inoculated with Leuconostoc citreum IH22 than non-treated Dongchimi. As fermentation proceeded, titratable acidity of Altari Dongchimi significantly increased. The patterns of microfloral changes in both the inoculated and the control were similar during fermentation: the total number of bacteria increased at the beginning, but rapidly decreased right after the optimum ripening point. The hardness and fracturability of both Dongchimi's decreased gradually during fermentation. The evaluation of the sensory qualities showed that the sour taste and fresh taste resulted in similar scores in both Dongehimi's but overall acceptability of the control was higher than that of inoculated one with Leuconostoc citreum IH22.

고려수지요법을 이용한 손 마사지가 항암 화학요법을 받는 암 환자의 오심·구토 및 식욕부진에 미치는 효과

이현숙,성기월,손보경,김지선,이혜정,이순영 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: The purpose of this study was to examine the effect of hand massage through Korean hand acupuncture therapy on nausea, vomiting and anorexia induced by chemotherapy in cancer patients. Method: Subjects consisted of 40 patients with cancer who were hospitalized and had chemotherapy at D university hospital in D city, Korea. These subject were assigned randomly to a hand massage throght Korean Hand Acupuncture Therapy (experimental group: n=20, control group: n=20). The data were collected from April 1 to September 15 in 2005. All the patients were assessed for their nausea, womiting and anorexia; Nausea and vomiting were measured with Rhodes INVR(index of Nausea, Vomiting by Rhodes and McDaniel) and Anorexia was measured with VAS(Visual Analogue Scale). As an experimental treatment, the hand massage through Korean Hand Acupuncture Therapy was applied three times a day for three consecutive days. The data were collected at the time of 4 hours before the start of chemotherapy, 24hours and 48hours after hand massage respectively. The data were analyzed with SPSS/WIN 11.5 program using frequency, percentage, χ²-test, t-test, repeated Measures ANOVA. Reslt: Severity of nausea and vomiting in hand massage through Korean Hand Acupuncture Therapy group was significantly less than of control group(F=28.10, P=.000). Severity of anorexia in hand massage through Korean Hand Acupuncture Therapy group was also significantly less than that of control group(F=31.24, P=.000). Conclusion: Hand massage through Korean Hand Acupuncture Therapy is effective for relieving patients' nausea, vomiting and anorexia during chemotherapy. Therefore, it is proposed that hand massage through Korean Hand Acupuncture Therapy can be applied as a supportive as a supportive nursing arbitration method to relieve naussa, vomiting and anorexia in patients who are getting chemotherapy.

인진호(茵蔯蒿) 성분의 간세포 유리기 생성에 미치는 영향

이정규,김순신,김혜경 慶星大學校 1998 論文集 Vol.19 No.1

Artemisiae iwayomogii Herba, the aerial part of Artemisia iwayomogi Kitamura(=A.messer-schimidtiana Besser, Compositae), which is commonly called as 'Injinho' in Korea, is widely used as choleretic, antiinflammatory or diuretic remedy in oriental region. According to the result of preliminary study on antitoxidant activities author tried to confirm the effects on free radicals generation in liver cells. Among eight constituents isolated chlorogenic acid as well as jaceosidin showed prominent inhibitory activity against free radical generation in cultured liver cells. The activities in sequence of strength were chlorogenic acid 〉 jaceosidin 〉 2,4-dihydroxy-6-methoxy acetophenone 4-O-glucoside 〉 scopolin 〉 apigenin 7,4'-dimethyl ether.

한문학 작품의 수행평가 실천 연구 : 고등학교<한문고전>을 중심으로 Laying Stress on High School Classical Chinese Works

이혜순,최난영 이화여자대학교 사범대학 교과교육연구소 2004 교과교육학연구 Vol.7 No.3

The purpose of this thesis is to examine whether performance assessment of Chinese literary works is useful and whether the test enhances students' understanding and interest in Chinese literary works. The first chapter presents the reason why performance assessment of Chinese literature is necessary as a means of expanding students' understanding and interest in Chinese literature, study purpose, and study method. The second chapter seizes the nature of performance assessment and examines the situation, direction, and necessity of performance assessment in education of Chinese literary works. In the third chapter, the assignments were given : for 'A Pearl Swallowed by A Goose(an anecdote by Yoonhwe, 尹淮)', 'to write your own experience related with the topic' : for 'Chinese poems, Gyujong(閨情) and Sangsamong(想思夢)', 'to rewrite the two poems in the form of letters' : and for 'Goungseol(鏡說)', 'to rewrite the essay with different viewpoint'. The forth chapter collects a questionnaire in order to seize whether the assignments played a role for the students to understand Chinese literary works and to take an increasing interest in them after the assignment. The results were analyzed in search of any problem for some improvement in performance assessment. The following facts are revealed from the analysis : (1) The plan of performance assessment of Chinese literary works helped the students understand the works. (2) The plan played a stimulating role in arousing their interest in the works. (3) If the plan is supplemented, the plan could become a teaching-learning plan and an evaluation plan. However some problems are revealed from the analysis in spite of the above affirmative effects : There is the tendency that the students are unable to do their assignments in a creative and varied way because they are conscious of their tests. The students are pressed for time to do their assignments and the teacher' office hours are also insufficient, The students do not come close to Chinese literary works but they regard them only as an evaluation. These problems could be solved only after more of teaching-learning method and evaluation plans by which the students come close to the works with earnest interest are formed.

유아교육기관의 운영관리 및 유아기 프로그램 평가

이소은,하진희,류혜선,박영주,주은혜,이종순 충북대학교 교육생활연구소 2001 생활과학연구논총 Vol.4 No.-

This purposes of this study were to assess the state of current administration and program contents in early childhood institutes. Using APECP(Assessnt Profile for Early Childhood Programs), assesment data were gathered from 27 apprentices in child care centers and 6 apprentices in Kindergarten in Cheongju. Descriptive statistics and Mann-Whitney test were used to analyze data. The result were as follows : (1) The distribution of percentile rate in administration was from 55% to 78%, and the area of Program Development scored the lowest. The assessments for Kindergarten were higher than those of child care center in the areas of Physical Facility, Food Service, and Program Management. (2) As for the program contents, percentile rate was from 62% to 80%, and generally the assessments for Kindergarten were higher than those of child care center. It appears that the certification and assessment system for ealry childhood institutions should be supervised more strongly in order to improve the qulaity of those institutions.