Identification of novel d-lactam base histone deacetylase (HDAC) inhibitors : Evaluation of the antiproliferative activity via induction of p21WAF1/Cip1 and gelsolin

Kwon Hyoung Keun,Seo Ji Young,Park Se Hong,Kim Hyoun Jung,Jung Hwa Young,Han Gyoon Hee,Cho Eun-Jung,Lee Hyang Woo,Han Jeung Whan 대한약학회 2004 大韓藥學會 總會 및 學術大會 Vol.2004 No.1

중년 여성의 갱년기 증상과 우울에 관한 연구

권숙희,김영자,문길남,김인순,박금자,박춘화,배정이,송애리,여정희,정은순,정향미 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

This study was done for the purpose of analyzing the relationship between menopausal symptoms and depression. Data was collected by a questionaire from November 28 to December 30, 1995. The subjects were 134 women between 40-61 years of age. The instruments used for this study were The Menopausal symptom scale by Neugartom and Depression scale by Zung. The results of the study were as follows. 1. Mean score of menopausal symptoms was 1.59. Mean score orders of experienced symptoms were $quot;$quot;Back pain and joint pain$quot;$quot;(2.02), $quot;$quot;General weakness$quot;$quot; (1.98), $quot;$quot;Nervousness$quot;$quot;(1.96). The most serious menopausal symptom was psycho-somatic symptom.(1.88). Total score orders of experienced symptoms was 27.9 and over 90.3% of women complained menopausal symptom, 2. Mean score orders of depression was 39.13. It was normal range of depression. 85.1% of the women was normal range of depression and 14.2% of women mild depression. 3. The relationship between menopausal symptoms and depression was statistically significant(r=0.5307, P=0.000). When the relationship among three demensions of menopausal symptoms were explored the psycho-somatic symptom(r=0.4090, P=0.000), Physical symptom(r=0.319, P=0.000) were statistically significant. 4. General characteristic variable were significantly related to the level of menopausal symptoms as follows : enviroment of living (F=2.89, p=0.038). religion (F=4.18 p=0.007), times of birth(F=2.66, p=0.043). The analysis of this study have implication for management of middle aged women's health, to solve the nursing problems, and to prevent and relieve climacteric symptoms.

장기투석을 받은 만성 신부전 환자에서 발생한 종양에 관한 고찰

황정화,이혜경,홍현숙,박재성,김대호,권귀향,최득린,황승덕,이희발 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

The authors tried to evaluate tumor occurrence in long-term dialysis patients with chronic renal failure. Among 359 patients, 20 patients (about 5.6%) were diagnosed with malignancy during long-term dialysis from the period of 1983 to 1995 at our nephrology department. The ultrasonographic and computed tomographic findings including the clinical features of 20 patients that were retrospectively reviewed. The mean age of the patients was 53 (37-75)years old and the ratio of male to female was 9:1. Among the 20 cases, 7 cases of hepatoma (35%) were developed. Among them, urinary tract tumors such as renal and bladder cancer were developed in 4 (20%) and 2 (10%) of the cases. Other malignant tumors were lymphoma, stomach cancer, uterine cervical cancer, cholangiocarcinoma, lung cancer, meningioma, and acoustic neuroma one case of each (each of 5.3%). The most common tumor in patients with chronic renal failure, who were receiving long-term dialysis, was hepatoma and the second most common tumor was cancer of the urinary tract such as kidney and bladder.

지방간에 대한 혈청 r-glutamyl transferase ( GGT ) 의 진단적 유용성 및 다른 인자와의 상관관계

최권(Kwon Choi),김병익(Byung Ik Kim),조용균(Yong Kyun Cho),박창영(Chang Young Park),손정일(Jung Il Sohn),전우규(Woo Kyu Jeon),김향(Hyang Kim),정을순(Eul Soon Chung),금동극(Dong Geuk Keum),이화영(Hwa Young Lee),이상종(Sang Jong Lee) 대한내과학회 1999 대한내과학회지 Vol.57 No.6

N/A Background : Gamma-glutamyl transferase(GGT) has found wide application as a diagnostic test in hepatobiliary disease, and has been used as the best single marker of alcohol intake. In spite of the wide use of GGT in clinical practice, knowledge concerning the distribution and the determinants of this risk factor in the normal population is spared in Korea. We tried to obtain a better evaluation of specificity of serum GGT by analysis of a large population of health examination. Methods : GGT was measured in 17,140 males aged 17-86 years and 12,125 females aged 18-90 years screened in a health survey program. Results : In multiple regression analyses, serum GGT level showed strong positive association with fatty liver, body mass index, serum levels of AST, ALT triglyceride, uric acid, alkaline phosphatase, systolic blood pressure, and diastolic blood pressure, and weakly positive association with serum levels of creatinine, total cholesterol, and fasting blood sugar. In females, menopause were positively associated with GGT. Conclusions : An elevated serum GGT levels is a strong indicator of hepatobiliary dysfunction or fatty liver. However, proper interpretation of a serum GGT elevation should be carefully considered in correlation with clinical data and laboratory findings. (Korean J Med 57:1006-1013, 1999)

강우량 추정 캠페인

Soohyun Kwon,GyuWon Lee,Sung-Hwa Jung,Hyang-Suk Park,Mi-Kyung Suk,Joo Wan Cha,Choong-Ke Lee 한국기상학회 2013 한국기상학회 학술대회 논문집 Vol.2013 No.4

돌미나리씨 추출물에 의한 3T3-L1 지방전구세포의 분화 억제

지향화(Hyang Hwa Ji),정현영(Hyun Young Jeong),진수정(Soojung Jin),권현주(Hyun Ju Kwon),김병우(Byung Woo Kim) 한국생명과학회 2012 생명과학회지 Vol.22 No.12

돌미나리(Oenanthe javanica)는 뛰어난 해독작용과 항균작용으로 예로부터 약재로 사용되어 왔으나 돌미나리씨의 활성은 아직 밝혀지지 않았다. 본 연구에서는 3T3-L1 지방전구세포를 사용하여 돌미나리씨 메탄올 추출물(OJSE)의 지방세포분화에 미치는 영향과 그 기전에 대해 조사하였다. 세포독성이 없는 농도(1~200 μg/ml)의 OJSE를 지방세포 분화유도제와 동시에 지방전구세포에 처리하여 분화시킨 후 Oil Red O 염색을 한 결과 세포 내 lipid droplet 생성 및 triglyceride 축적이 OJSE 농도의존적으로 감소되었으며, 지방세포분화과정에 중요한 역할을 하는 지방세포특이적 마커인 CCAAT/enhancer binding proteins α, β (C/EBPα, C/EBPβ) 및 peroxisome proliferator-activated receptor γ (PPARγ)의 발현이 현저하게 저하되었다. 이는 OJSE에 의해 지방세포 분화 관련 전사인자의 발현이 효과적으로 억제되어 지방세포로의 분화가 저해되고 결과적으로 지방세포내 lipid droplet 생성 및 triglyceride 축적이 억제되었다는 것을 시사한다. 또한 OJSE처리에 의해 mitotic clonal expanstion 단계에서의 세포증식이 저해되었으며, 세포주기의 변화를 분석한 결과, OJSE처리에 의해 지방전구세포의 G1 arrest가 유발됨을 확인하였다. 세포주기 관련 단백질 발현을 분석한 결과, OJSE 농도의존적으로 Cdk inhibitor인 p21의 발현이 현저하게 증가되었으며, 반면 cyclin E, Cdk2, E2F-1 및 phospho-Rb의 발현은 저하됨을 알 수 있었다. 이러한 연구 결과들에 의해 OJSE는 지방전구세포의 G1 arrest를 유도하고 지방세포분화 관련 단백질의 발현을 억제하여 지방세포로의 분화를 억제하는 항비만 효능을 갖는 천연 소재임을 확인하였고, 본 연구는 이를 활용한 향후 지속적인 연구를 위한 기초자료로 그 가치가 매우 높을 것으로 생각된다. Oenanthe javanica has been used as a food source and also in traditional folk medicine for its detoxifying properties and anti-microbial effects since ancient times. In this study, we evaluated the effect and mechanism of O. javanica seed methanol extract (OJSE) on adipocyte differentiation by 3T3-L1 preadipocytes. Under non-toxic conditions, OJSE treatment resulted in a dose-dependent inhibition of lipid droplet generation and triglyceride accumulation by suppressing adipocyte differentiation, which are associated with the decreased expression of key proadipogenic transcription factors including CCAAR/enhancer binding protein α, β (C/EBPα, C/EBPβ) and peroxisome proliferator-activated receptor γ (PPARγ). OJSE also significantly inhibited proliferation and differentiation of 3T3-L1 preadipocytes through G1-phase arrest, indicating that OJSE blocked mitotic clonal expansion during adipocyte differentiation. Investigation of the alteration of G1 phase arrest-related proteins indicated a dose-dependent increase in the expression of p21 and reduction in expression of cyclin E, Cdk2, E2F-1 and phospho-Rb by OSJE. Taken together, these results suggest that OJSE inhibits adipocyte differentiation by blocking the mitotic clonal expansion, which is accompanied by preadipocyte cell cycle arrest.

감염병 대유행(코로나-19) 시대의 비대면 집단상담 사례연구 : 교사들의 직무 스트레스를 중심으로

윤향숙(Hyang-Suk YOON),고희경(Hee-Kyung KO),장성화(Sung-Hwa JANG),김신권(Shin-Kwon KIM) 한국상담심리교육복지학회 2021 상담심리교육복지 Vol.8 No.3

이 연구는 2019년부터 시작된 COVID-19라는 감염병 시대의 비대면 집단상담 사례연구로 교사들의 직무 스트레스 대처에 대한 효과성과 가능성을 살펴보는데 목적이 있다. 최근 감염병 대유행으로 인한 사회적인 거리두기, 집합금지 등의 조치가 육체적, 정신적 고립을 만들고 이에 따르는 우울과 불안이라는 정신건강의 위기를 초래하는 상황에서 사회적 단절의 문제점을 해결하기 위한 여러 가지 방법이 요청되고 있다. 그 가운데 감염의 위험을 최소화 하는 비대면 집단상담이 정신건강과 감염병의 문제를 함께 대처하는 중요한 상담 방식으로 인식되고 있다. 이 연구는 비대면이라는 특정한 환경과 줌(zoom)이라는 플랫폼을 통해 교사대상의 집단상담을 진행하였다. 심리검사와 교사들의 주관적 평가를 종합적으로 고려하였을 때, 이 집단에게서 비대면 집단상담의 효과를 확인할 수 있었다. 이 결과를 바탕으로 감염병 대유행 시대에 비대면 집단상담이 가지는 의의와 후속 연구를 위한 방안을 제안하였다. The purpose of this research is to examine practical efficacy of online group psychotherapies that were conducted for school teachers who were suffering from rapid increase of work stress level by the COVID-19 that broke out in 2019. The pandemic has influenced the mental health of general public by imposing strict social-distancing policies for preventing the epidemic, which makes people suffer from significant levels of depression and anxiety issues. Therefore, the practice of online group psychotherapy is requested to help people who are experiencing mental issues caused by social isolation without worries of contagion. This research investigates the possibilities of online group psychotherapy by focusing on psychological tests and personal evaluations of participants who had to encounter a particular online platform(zoom) that made group psychotherapy sessions without physical contact. As a result, the research confirms effectiveness of the online group therapy and suggests the practical ways in which further researches can be conducted.

Subtle Pleural Metastasis without Large Effusion in Lung Cancer Patients: Preoperative Detection on CT

Jung Hwa Hwang,Koun-Sik Song,Seung-Il Park,Tae-Hwan Lim,Kui Hyang Kwon,Dong Erk Goo 대한영상의학회 2005 Korean Journal of Radiology Vol.6 No.2

Objective: We wanted to describe the retrospective CT features of subtle pleural metastasis without large effusion that would suggest inoperable lung cancer. Materials and Methods: We enrolled 14 patients who had open thoracotomy attempted for lung cancer, but they were proven to be inoperable due to pleural metastasis. Our study also included 20 control patients who were proven as having no pleural metastasis. We retrospectively evaluated the nodularity and thickening of the pleura and the associated pleural effusion on the preoperative chest CT scans. We reviewed the histologic cancer types, the size, shape and location of the lung cancer and the associated mediastinal lymphadenopathy. Results: Subtle pleural nodularity or focal thickening was noted in seven patients (50%) having pleural metastasis and also in three patients (15%) of control group who were without pleural metastasis. More than one of the pleural changes such as subtle pleural nodularity, focal thickening or effusion was identified in eight (57%) patients having pleural metastasis and also in three patients (15%) of the control group, and these findings were significantly less frequent in the control group patients than for the patients with pleural metastasis (p = 0.02). The histologic types of primary lung cancer in patients with pleural metastasis revealed as adenocarcinoma in 10 patients (71%) and squamous cell carcinoma in four patients (29%). The location, size and shape of the primary lung cancer and the associated mediastinal lymphadenopathy showed no significant correlation with pleural metastasis. Conclusion: If any subtle pleural nodularity or thickening is found on preoperative chest CT scans of patients with lung cancer, the possibility of pleural metastasis should be considered.

어린이집 입학상담의 지금-여기(here and now)

김수향(Soo Hyang Kim),권은주(Eun Joo Kwon),정경화(Kyung Hwa Chung),이영림(Young Rim Lee) 한국아동학회 2011 아동학회지 Vol.32 No.3

The purpose of study is to understand how a principal of a child-care center and parents accept different episodes and experiences in admission counselling and their use of metaphorical expressions about this, and to illuminate the current state of play by examining the requirements of parents in selecting a child-care center. The subjects were 10 principals of private child-care centers located in the Gyeongsangbuk province of Korea, and the research materials for episodes and metaphors were collected and analyzed by means of in-depth and telephone interviews during an application period. In terms of the overall climate of the admission counselling, as shown in the various episodes, our results indicated that an increase of parents`` demands occurred through a primarily consumer-centered environment, and the sudden increase in a fathers`` participation, the inside circumstances of admission counselling in progress throughout the year, the non-existence of respect and credibility and the continuity of conflicts and were all observed to co-exist. In terms of the emotional meaning of counselling via metaphors, the following emotions could be inferred; hopelessness, anger, lethargy, stress, fear and eagerness. It is anticipate that this study will make a meaningful contribution to better illuminating and improving the current climates of here and now admission counselling.

만성폐쇄성폐질환의 급성악화와 회복기에서 유도객담 내 Nuclear Factor-κB (NF-κB)의 활성도와 IL-6, IL-8 및 TNF-α의 농도 변화

송소향 ( So Hyang Song ),김치홍 ( Chi Hong Kim ),권순석 ( Soon Seog Kwon ),김영균 ( Young Kyoon Kim ),김관형 ( Kwan Hyoung Kim ),문화식 ( Hwa Sik Moon ),송정섭 ( Jeong Sup Song ),박성학 ( Sung Hak Park ) 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.2

연구배경 : COPD의 급성악화는 세균에 의한 감염, 바이러스성 상기도 감염, 대기오염, 기후변화 등에 의하며, COPD의 급성악화 시에 객담 내 호중구의 증가, IL-6와 IL-8 농도의 증가, 그리고 산화질소의 증가는 NF-κB의 활성화와 관련된 것으로 알려져 있다. 그러므로 COPD의 병인 및 급성악화의 기전에 NF-κB 활성도와 IL-6, IL-8 및 TNF-α가 관련이 있는지 연구하고자 하였다. 방법 : 정상대조군 및 COPD로 입원하였던 환자 Background : Exacerbations of chronic obstructive pulmonary disease (COPD) are thought to be associated with increased airway inflammation, and the NF-κB is known to be an indicator of cellular activation and of inflammatory mediator production. This stud