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Soohyun Kwon 한국음운론학회 2020 음성·음운·형태론 연구 Vol.26 No.3
This study examines the articulatory properties of the glide /w/ in Korean, using ultrasound. While some claim that there is no dorsal glide, others argue that glides have two designated articulators, and that /w/ is both [Dorsal] and [Labial]. The results of this study reveal that /w/ in Korean consists of both lip and tongue gestures, and that the primary articulatory correlate of /w/ is lip protrusion while tongue dorsum raising serves as a secondary but important articulatory feature. The findings are discussed in terms of phonological representations and articulatory implementation of glides.
Testing the productivity of the short-a tensing rule in Philadelphia: The computational framework
Soohyun Kwon 한국음운론학회 2019 음성·음운·형태론 연구 Vol.25 No.3
In this article, I address the learnability problem of linguistic rules with a large number of exceptions, using a computational framework. I investigate how children in Philadelphia learn short-a tensing, a rule subject to complex conditioning and many exceptions. Based on corpus statistics from the CHILDES database, I show that the tensing rule can be productively applied by children, confirming the Tolerance Principle (Yang 2005, Yang 2016), a computational model that makes quantitative predictions about the productivity of rules based on the distribution of input data. Also, I simulate a child’s acquisition of the short-a tensing rule with heterogeneous inputs and demonstrate that the Tolerance Principle correctly predicts that children receiving limited input may fail to master the rule.
Prevalence of Epstein-Barr virus in oral lichen planus in Korea.
( Soohyun Kwon ),( Jieun Kwon ),( Youchan Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: EVB infection varies by race and region, and the cause of LP also varies by genetic, psychological, and infectious factors. Until now, the correlation between EBV and OLP has been the discussed by a few studies. Actinic cheilitis (AC) is sometimes difficult to clinically and histologically distinguish from OLP on the lip. Objectives: To evaluate the prevalence of EBV between in histologically diagnosed OLP cases and AC cases as control. Methods: The study was conducted of 30 OLP cases and 30 AC cases. We also evaluated the medical records including age, gender, localization and the histopathological type. The presence of EBV was investigated with in situ hybridization. With each specimen, known EBV positive tissue was used as positive control tissues. Results: A total of 30 cases of OLP and 30 cases of AC were included in the study. The average age of patients was 64 years and 54, and the total sex ratio (M:F) was 9:21 and 21:9 respectively. In OLP patients, 20 patients had lesions in buccal mucosa and 10 in lower lip. On the other hand, all AC patients had lesions in lower lip. In in situ hybridization analysis of EBV, all case revealed the absence of EBV virus both in OLP and AC. Conclusion: Unlike the results of other studies to demonstrate that the EBV virus is involved in the etiopathogenesis of OLP, in this study, EBV was found in neither OLP nor AC. Therefore, the LP lesion of Korean patients has few possibility with pathologically related to EVB.
GDSL lipase-like 1 regulates systemic resistance associated with ethylene signaling in Arabidopsis
Kwon, Sun Jae,Jin, Hak Chul,Lee, Soohyun,Nam, Myung Hee,Chung, Joo Hee,Kwon, Soon Il,Ryu, Choong-Min,Park, Ohkmae K. Blackwell Publishing Ltd 2009 The Plant journal Vol.58 No.2
<P>Summary</P><P>Systemic resistance is induced by necrotizing pathogenic microbes and non-pathogenic rhizobacteria and confers protection against a broad range of pathogens. Here we show that Arabidopsis GDSL LIPASE-LIKE 1 (GLIP1) plays an important role in plant immunity, eliciting both local and systemic resistance in plants. GLIP1 functions independently of salicylic acid but requires ethylene signaling. Enhancement of <I>GLIP1</I> expression in plants increases resistance to pathogens including <I>Alternaria brassicicola</I>, <I>Erwinia carotovora</I> and <I>Pseudomonas syringae</I>, and limits their growth at the infection site. Furthermore, local treatment with GLIP1 proteins is sufficient for the activation of systemic resistance, inducing both resistance gene expression and pathogen resistance in systemic leaves. The <I>PDF1.2</I>-inducing activity accumulates in petiole exudates in a GLIP1-dependent manner and is fractionated in the size range of less than 10 kDa as determined by size exclusion chromatography. Our results demonstrate that GLIP1-elicited systemic resistance is dependent on ethylene signaling and provide evidence that GLIP1 may mediate the production of a systemic signaling molecule(s).</P>
Sungsanpin, a Lasso Peptide from a Deep-Sea Streptomycete
Um, Soohyun,Kim, Young-Joo,Kwon, Hyuknam,Wen, He,Kim, Seong-Hwan,Kwon, Hak Cheol,Park, Sunghyouk,Shin, Jongheon,Oh, Dong-Chan American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.5
<P>Sungsanpin (<B>1</B>), a new 15-amino-acid peptide, was discovered from a <I>Streptomyces</I> species isolated from deep-sea sediment collected off Jeju Island, Korea. The planar structure of <B>1</B> was determined by 1D and 2D NMR spectroscopy, mass spectrometry, and UV spectroscopy. The absolute configurations of the stereocenters in this compound were assigned by derivatizations of the hydrolysate of <B>1</B> with Marfey’s reagents and 2,3,4,6-tetra-<I>O</I>-acetyl-β-<SMALL>d</SMALL>-glucopyranosyl isothiocyanate, followed by LC-MS analysis. Careful analysis of the ROESY NMR spectrum and three-dimensional structure calculations revealed that sungsanpin possesses the features of a lasso peptide: eight amino acids (-Gly<SUP>1</SUP>-Phe-Gly-Ser-Lys-Pro-Ile-Asp<SUP>8</SUP>-) that form a cyclic peptide and seven amino acids (-Ser<SUP>9</SUP>-Phe-Gly-Leu-Ser-Trp-Leu<SUP>15</SUP>) that form a tail that loops through the ring. Sungsanpin is thus the first example of a lasso peptide isolated from a marine-derived microorganism. Sungsanpin displayed inhibitory activity in a cell invasion assay with the human lung cancer cell line A549.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-5/np300902g/production/images/medium/np-2012-00902g_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np300902g'>ACS Electronic Supporting Info</A></P>
Kwon, Joseph,Oh, Jeehyun,Park, Chiyoul,Cho, Kun,Kim, Seung Il,Kim, Soohyun,Lee, Sunghoon,Bhak, Jong,Norling, Birgitta,Choi, Jong-Soon Elsevier 2010 Journal of chromatography A Vol.1217 No.3
<P><B>Abstract</B></P><P>The identification of membrane proteins is currently under-represented since the trans-membrane domains of membrane proteins have a hydrophobic property. Membrane proteins have mainly been analyzed by cleaving and identifying exposed hydrophilic domains. We developed the membrane proteomics method for targeting integral membrane proteins by the following sequential process: in-solution acid hydrolysis, reverse phase chromatographic separation, trypsin or chymotrypsin digestion and <I>nano</I>-liquid chromatography–Fourier transform mass spectrometry. When we employed total membrane proteins of <I>Synechocystis</I> sp. PCC 6803, 155 integral membrane proteins out of a predictable 706 were identified in a single application, corresponding to 22% of a genome. The combined methods of acid hydrolysis-trypsin (AT) and acid hydrolysis-chymotrypsin (AC) identified both hydrophilic and hydrophobic domains of integral membrane proteins, respectively. The systematic approach revealed a more concrete data in mapping the repertoire of cyanobacterial membrane and membrane-linked proteome.</P>