http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lim, J.Y.,Won, T.J.,Hwang, B.Y.,Kim, H.R.,Hwang, K.W.,Sul, D.,Park, S.Y. North-Holland ; Elsevier Science Ltd 2010 european journal of pharmacology Vol.642 No.1
Neuroinflammation with prolonged microglial activation leads to increased levels of pro-inflammatory mediators and subsequently contributes to neuronal dysfunction and neuronal loss. Therefore, pharmacological suppression of neuroinflammation would theoretically slow the progression of neurodegenerative disease. In this study, we investigated the anti-inflammatory effects and possible mechanisms of isodojaponin D (19-hydroxy-1α,6-diacetoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide), a new diterpene isolated from Isodon japonicus against lipopolysaccharide(LPS)-induced microglial activation in BV2 cells. Results from RT-PCR and Western blot showed that pretreatment with isodojaponin D (5 and 10μg/ml) prior to treatment with LPS (1μg/ml) significantly decreased LPS-induced production of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in a dose-dependent manner. In addition, LPS-induced pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α, were also decreased by pretreatment with isodojaponin D. This effect was accompanied by a decrease in translocations of Nuclear Factor-KappaB (NF-κB) p50 and p65 from the cytoplasm to the nucleus and by a decrease in I kappaB (IκB) degradation. In addition, pretreatment with isodojaponin D significantly attenuated LPS-induced mitogen-activated protein kinase (MAPK) activation. Taken together, these results suggest that isodojaponin D suppressed LPS-induced microglial activation and production of pro-inflammatory mediators by inhibition of the NF-κB signaling pathway and phosphorylation of MAPKs. These results suggest that isodojaponin D could play a beneficial role in treatment of neurodegenerative disease.
RF 스위치 적용을 위한 박막 PZT 엑추에이터의 d<SUB>31</SUB> 구동과 d<SUB>33</SUB> 구동 특성 비교
신민재(M. J. Shin),서영호(Y. H. Seo),최두선(D-S. Choi),황경현(K-H. Hwang) 한국정밀공학회 2006 한국정밀공학회 학술발표대회 논문집 Vol.2006 No.5월
In this work, we present the comparison between d<SUB>31</SUB> and d<SUB>33</SUB> mode characterization using the PZT micro-actuator for large displacement. The PZT micro-actuator consisted of Si, PZT, and Pt layer on SOI wafer. The electrode shapes were laminated and interdigitated for d<SUB>31</SUB> and d<SUB>33</SUB> mode, respectively. In order to characterize the actuation mode, we measured the displacement using laser interferometer. The maximum displacement of d<SUB>31</SUB> mode was 12.2㎛ at 10V, the actuation characterization of d<SUB>31</SUB> was better than that of d<SUB>33</SUB> mode. We estimated that displacement of d<SUB>33</SUB> mode would be larger than that of d<SUB>31</SUB> above 30V.
Nam, S.M.,Choi, J.H.,Yoo, D.Y.,Kim, W.,Jung, H.Y.,Kim, J.W.,Kang, S.Y.,Park, J.,Kim, D.W.,Kim, W.J.,Yoon, Y.S.,Hwang, I.K. Pergamon Press ; Elsevier Science Ltd 2013 Experimental Gerontology Vol.48 No.11
Valeriana officinalis is used in herbal medicine of many cultures as mild sedatives and tranquilizers. In this study, we investigated the effects of extract from valerian root extracts and its major component, valerenic acid on memory function, cell proliferation, neuroblast differentiation, serum corticosterone, and lipid peroxidation in adult and aged mice. For the aging model, d-galactose (100mg/kg) was administered subcutaneously to 6-week-old male mice for 10weeks. At 13weeks of age, valerian root extracts (100mg/kg) or valerenic acid (340μg/kg) was administered orally to control and d-galactose-treated mice for 3weeks. The dosage of valerenic acid (340μg/kg), which is the active ingredient of valerian root extract, was determined by the content of valerenic acid in valerian root extract (3.401+/-0.066mg/g) measured by HPLC. The administration of valerian root extract and valerenic acid significantly improved the preferential exploration of new objects in novel object recognition test and the escape latency, swimming speeds, platform crossings, and spatial preference for the target quadrant in Morris water maze test compared to the d-galactose-treated mice. Cell proliferation and neuroblast differentiation were significantly decreased, while serum corticosterone level and lipid peroxidation in hippocampus were significantly increased in the d-galactose-treated group compared to that in the control group. The administration of valerian root extract significantly ameliorated these changes in the dentate gyrus of both control and d-galactose-treated groups. In addition, valerenic acid also mitigated the d-galactose-induced reduction of these changes. These results indicate that valerian root extract and valerenic acid enhance cognitive function, promote cell proliferation and neuroblast differentiation, and reduce serum corticosterone and lipid peroxidation in aged mice.
대학생의 인터넷중독 및 스마트폰 중독 정도와 미술 치료 인식에 대한 조사 연구
박혜원,송승윤,윤하영,이경현,이소영,이지원,진예은,최시온,허은서,황다빈,신주현,이인영 이화여자대학교 간호학회 2018 이화간호학회지 Vol.- No.52
Purpose: Investigate the level of Internet and smart phone addiction of college students and difference of their perception on the art therapy. Method: Data was collected using 4 categories of questionnaires. Participants of this study were 383 college students who are currently attending universities located in seoul, Kyung-Ki and Incheon. The Chi-square test, One-way Analysis of Variance, Scheffé test were performed using IBM SPSS Statistics 23.0 Result: First, the study has established that the status of attending universities, grade, people who living with, age affected the level of Internet addiction of college students. In terms of the level of smart phone addiction of college students, the status of attending universities, gender, age were the affective factors. Second, there was a significant difference on the perception of the advantages of the art therapy and the level of acknowledging it, depending on the level of Internet addiction. Finally, depending on the level of smartphone addiction, there was a significant difference in the level of perception of the art therapy, expectation toward the art therapy and the helpfulness of art therapy. The more the participants are close to the addicted level, the more they want to experience the art therapy. Conclusion: These results suggest. First, it is necessary to use bigger group of participants. Second, it is necessary to improve the research methods for college students. Third, nurse should offer holistic care toward the patients regarding their general characteristics by adapting this study. Finally, it is necessary to improve the art therapy programs for the college students who are addicted to the Internet and smartphone and to develop researches proving the effectiveness of these programs.
도덕희(Doh D. H),황태규(Hwang T.G),조용범(Cho Y.B),백태실(Baek T. S),편용범(Pyun Y.B.) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.4
3D-PTV measurement was conducted on the wake of a sphere. The Reynolds number is 1130 with the diameter(d=30mm). The measurement system consisted of three CCD cameras, an image grabber, an Ar-Ion laser and a host computer. An eigenvalue analysis was introduced for the analysis on the wake. Statistical turbulent properties were quantitatively clarified using the time-consecutive instantaneous three-dimensional vectors obtained by the 3D-PTV system. The spatial distributions of the sphere wake showed strong elations with spiral motions of the vortcies shedded from the surface of the sphere.
OGLE-2017-BLG-0173Lb: Low-mass-ratio Planet in a “Hollywood” Microlensing Event
Hwang, K.-H.,Udalski, A.,Shvartzvald, Y.,Ryu, Y.-H.,Albrow, M. D.,Chung, S.-J.,Gould, A.,Han, C.,Jung, Y. K.,Shin, I.-G.,Yee, J. C.,Zhu, W.,Cha, S.-M.,Kim, D.-J.,Kim, H.-W.,Kim, S.-L.,Lee, C.-U.,Lee, American Astronomical Society 2018 The Astronomical journal Vol.155 No.1
<P>We present microlensing planet OGLE-2017-BLG-0173Lb, with planet-host mass ratio of either q similar or equal to 2.5 x 10(-5) or q similar or equal to 6.5 x 10(-5), the lowest or among the lowest ever detected. The planetary perturbation is strongly detected, Delta chi(2) similar to 10000, because it arises from a bright (therefore, large) source passing over and enveloping the planetary caustic: a so-called 'Hollywood' event. The factor similar to 2.5 offset in q arises because of a previously unrecognized discrete degeneracy between Hollywood events in which the caustic is fully enveloped and those in which only one flank is enveloped, which we dub 'Cannae' and 'von Schlieffen,' respectively. This degeneracy is 'accidental' in that it arises from gaps in the data. Nevertheless, the fact that it appears in a Delta chi(2) = 10000 planetary anomaly is striking. We present a simple formalism to estimate the sensitivity of other Hollywood events to planets and show that they can lead to detections close to, but perhaps not quite reaching, the Earth/Sun mass ratio of 3 x 10(-6). This formalism also enables an analytic understanding of the factor similar to 2.5 offset in q between the Cannae and von Schlieffen solutions. The Bayesian estimates for the host mass, system distance, and planet-host projected separation are M = 0.39(-0.24)(+0.40) M circle dot, D-L = 4.8(-1.8)(+1.5) kpc, and a(perpendicular to) = 3.8 +/- 1.6 au, respectively. The two estimates of the planet mass are m(p) = 3.3(2.1)(+3.8) M circle plus and m(p) = 8(6)(+11) M circle plus. The measured lens-source relative proper motion mu = 6 mas yr(-1) will permit imaging of the lens in about 15 years or at first light on adaptive-optics imagers on next-generation telescopes. These will allow one to measure the host mass but probably will not be able to resolve the planet-host mass-ratio degeneracy.</P>
간호 전공과 비 간호 전공 여대생의 여성 갱년기에 관한 지식, 태도 및 어머니와 친밀감에 대한 연구
이다영,이다은,이정원,김봄경,황은주,류정미,김하연,신은지,박혜미,임은지 이화여자대학교 간호과학대학 2015 이화간호학회지 Vol.- No.49
Purpose: This study investigated the difference of menopausal knowledge, attitude between nursing students and non-nursing students. The relationships of the level of menopausal knowledge and attitude and the level of closeness to mother were investigated. Methods: A correlational descriptive design was used with a convenience sample. The survey was conducted with 206 female college students, 106 nursing and 100 non-nursing students, between September 1 and September 14, 2014. The instruments were the Knowledge of Menopause scale, the Menopausal Attitude Measurement scale, and the Level of Closeness to Mother scale. SPSS v22.0 is used to statistical analysis of descriptive statistics, independent t-tests, correlation and χ2-tests. Results: The difference in menopause knowledge between nursing students and non-nursing students is statistically significant (t=6.085, p<001). Nursing and non-nursing college students’ menopause knowledge had a positive relationship with attitude (r = 0.241, p<001). In closeness to mother, there is no significant difference was shown between nursing and non-nursing college students, even though the levels of menopause knowledge are different (t=1.336, p=.183). Conclusion: Results showed having menopausal knowledge positively influences students’ attitudes about menopause. Educators should develop programs imparting menopausal knowledge for non-nursing college students to increase positive menopausal attitude.