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Evidence Based Analysis of Cisplatin for Treating Patients with Cutaneous Squamous Cell Carcinoma
Shao, Xiao-Hong,Xu, Yun-Sheng,Zhang, Xue-Qi,Li, Wen-Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: This analysis was conducted to evaluate the efficacy and safety of cisplatin based chemotherapy for treating patients with cutaneous squamous cell carcinoma. Methods: Clinical studies evaluating the efficacy and safety of cisplatin based regimens on response and safety for patients with cutaneous squamous cell carcinoma were identified using a predefined search strategy. Pooled response rates (RR) of treatment were calculated. Results: In cisplatin based regimens, 4 clinical studies which including 50 patients with advanced cutaneous squamous cell carcinoma were considered eligible for inclusion. Regimens included cisplatin, doxorubicin, or vindesine. Pooled analysis suggested that, in all patients, the pooled RR was 60% (30/50) in cisplatin based regimens. Nausea and vomiting were the main side effects. No grade III or IV renal or liver toxicity were observed. No treatment related death occurred with the cisplatin based treatments. Conclusion: Evidence based analysis suggests that cisplatin based regimens are associated with a good response rate and acceptable toxicity for treating patients with cutaneous squamous cell carcinoma.
An Improved PSO-based of Harmony Search for Complicated Optimization Problems
LI Hong-qi,LI Li,Tai-hoon Kim,XIE Shao-long 보안공학연구지원센터 2008 International Journal of Hybrid Information Techno Vol.1 No.1
As an optimization technique, particle swarm optimization (PSO) has obtained much attention during the past decade. It is gaining popularity, especially because of the speed of convergence and the fact that it is easy to realize. To enhance the performance of PSO, an improved hybrid particle swarm optimization (IPSO) is proposed to solve complex optimization problems more efficiently, accurately and reliably. It provides a new way of producing new individuals through organically merges the harmony search (HS) method into particle swarm optimization (PSO). During the course of evolvement, harmony search is used to generate new solutions and this makes IPSO algorithm have more powerful exploitation capabilities. Simulation results and comparisons with the standard PSO based on several well-studied benchmarks demonstrate that the IPSO can effectively enhance the searching efficiency and greatly improve the search quality.
An Improved PSO-based of Harmony Search for Complicated Optimization Problems
LI Hong-qi,LI Li,Tai-hoon Kim,XIE Shao-long 보안공학연구지원센터 2008 International Journal of Hybrid Information Techno Vol.1 No.3
As an optimization technique, particle swarm optimization (PSO) has obtained much attention during the past decade. It is gaining popularity, especially because of the speed of convergence and the fact that it is easy to realize. To enhance the performance of PSO, an improved hybrid particle swarm optimization (IPSO) is proposed to solve complex optimization problems more efficiently, accurately and reliably. It provides a new way of producing new individuals through organically merges the harmony search (HS) method into particle swarm optimization (PSO). During the course of evolvement, harmony search is used to generate new solutions and this makes IPSO algorithm have more powerful exploitation capabilities. Simulation results and comparisons with the standard PSO based on several well-studied benchmarks demonstrate that the IPSO can effectively enhance the searching efficiency and greatly improve the search quality.
The solvent-free modification of butyl rubber in the medium of NaH
Ying Feng,Yan Xia Wang,Hong Qi Shao,En Hua Zhang,Zhen Wang,Jiruo Zhao 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.1
A novel improved butyl rubber (PMIIR) was prepared in a solvent free process, using sodium hydride(NaH) as activating agent and maleic anhydride (MAH) as modifier by processing modificationtechnology in a conventional polymer processing equipment of an internal mixer. The structure ofproducts was characterized by 1H NMR and FT-IR. In this process, polar sodium carboxylate functionalgroup and unsaturated carbon–carbon double bonds were successfully introduced onto the chains of IIRon one step. The reaction mechanism was investigated in detail. It was found that the functionalizationexperienced two modified mechanisms: addition and substitution modified mechanisms. The reactionefficiency and content of MAH were evaluated. Polymer isolation and purification operations werereduced out due to the result of solvent free. Curing and mechanical properties of products wereinvestigated. It was found that PMIIR has greatly increased curing rate due to the incorporation of polargroup and carbon–carbon double bond.
Nai-Bin Chen,Bo Qiu,Jun Zhang,Meng-Yun Qiang,Yu-Jia Zhu,Bin Wang,Jin-Yu Guo,Ling-Zhi Cai,Shao-Min Huang,Meng-Zhong Liu,Qun Li,Yong-Hong Hu,Qi-Wen Li,Hui Liu 대한암학회 2020 Cancer Research and Treatment Vol.52 No.1
Purpose The purpose of this study was to compare the survival and toxicities in cervical esophageal squamous cell carcinoma (CESCC) treated by concurrent chemoradiothrapy with either three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) techniques. Materials and Methods A total of 112 consecutive CESCC patients were retrospectively reviewed. 3D-CRT and IMRT groups had been analyzed by propensity score matching method, with sex, age, Karnofsky performance status, induction chemotherapy, and tumor stage well matched. The Kaplan- Meier method and Cox proportional hazards model were used for overall survival (OS) and progression-free survival (PFS). Toxicities were compared between two groups by Fisher exact test. Results With a median follow-up time of 34.9 months, the 3-year OS (p=0.927) and PFS (p=0.859) rate was 49.6% and 45.8% in 3D-CRT group, compared with 54.4% and 42.8% in IMRT group. The rates of grade ! 3 esophagitis, grade ! 2 pneumonitis, esophageal stricture, and hemorrhage were comparable between two groups, while the rate of tracheostomy dependence was much higher in IMRT group than 3D-CRT group (14.3% vs.1.8%, p=0.032). Radiotherapy technique (hazard ratio [HR], 0.09; 95% confidence interval [CI], 0.01 to 0.79) and pretreatment hoarseness (HR, 0.12; 95% CI 0.02 to 0.70) were independently prognostic of tracheostomy dependence. Conclusion No survival benefits had been observed while comparing IMRT versus 3D-CRT in CESCC patients. IMRT with fraction dose escalation and pretreatment hoarseness were considered to be associated with a higher risk for tracheostomy dependence. Radiation dose escalation beyond 60 Gy should be taken into account carefully when using IMRT with hypofractionated regimen.