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Nguyen Hoang Loc,Truong Thi Phuong Lan,Nguyen Duc Huy,Nguyen Ngoc Luong,Hoang Tan Quang,Trinh Huu Tan,Le Thi Anh Thu,Nguyen Xuan Huy 한국식물생명공학회 2019 JOURNAL OF PLANT BIOTECHNOLOGY Vol.46 No.3
The aim of this study is to evaluate the effect of yeast extract (YE) and salicylic acid (SA) on the expression of curcuminoid-biosynthesis genes (CzDCS and CURS1-3), and accumulation of curcumin in Curcuma zedoaria cell cultures. The results showed that, in cells treated with YE or SA, the expression levels of curcuminoid genes were 1.14- to 3.64-fold higher than the control (untreated cells), in which the YE exhibited a stronger effect in comparison with SA. Curcumin accumulation also tended to be similar to gene expression, curcumin contents in YE- or SA-treated cells were 1.61- to 2.53-fold higher than the control. The SA treatment at the fifth day of culture stimulated the curcumin accumulation and expression in all four genes compared to that at the beginning. While the YE treatments gave different results, the CzCURS1 and CzCURS3 genes were expressed strongly in cells that were treated at the beginning. However, the CzDCS and CzCURS2 genes showed the opposite expression pattern, they were activated strongly in the treatments at day five of the culture. However, the content of curcumin reached its maximum value on the fifth day of culture in all investigations.
New Alkaloids and Anti-inflammatory Constituents from the Leaves of Antidesma ghaesembilla
Van Kiem, Phan,Cuong, Le Canh Viet,Trang, Do Thi,Nhiem, Nguyen Xuan,Le Tuan Anh, Hoang,Tai, Bui Huu,Huong, Le Mai,Van Minh, Chau,Lee, Taek Hwan,Kim, Sun Yeou NATURAL PRODUCT COMMUNICATIONS 2017 Natural product communications Vol.12 No.1
Kiem, Phan Van,Anh, Hoang Le Tuan,Nhiem, Nguyen Xuan,Minh, Chau Van,Thuy, Nguyen Thi Kim,Yen, Pham Hai,Hang, Dan Thuy,Tai, Bui Huu,Mathema, Vivek Bhakta,Koh, Young-Sang,Kim, Young Ho The Pharmaceutical Society of Japan 2012 Chemical & pharmaceutical bulletin Vol.60 No.2
<P>The rhizomes of <I>Hedychium coronarium</I> have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, two new labdanes, 15-methoxylabda-8(17),11<I>E</I>,13-trien-16,15-olide (<B>1</B>) and 16-methoxylabda-8(17),11<I>E</I>,13-trien-15,16-olide (<B>3</B>), named hedycoronens A and B, as well as four known, labda-8(17),11,13-trien-16,15-olide (<B>2</B>), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (<B>4</B>), coronarin A (<B>5</B>), and corronarin E (<B>6</B>) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds <B>1</B>—<B>3</B> were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC<SUB>50</SUB> ranging from 4.1±0.2 to 9.1±0.3 μ<SMALL>M</SMALL>. Compounds <B>1</B> and <B>3</B> showed moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC<SUB>50</SUB> values of 46.0±1.3 and 12.7±0.3 μ<SMALL>M</SMALL>. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from <I>H. coronarium</I>.</P>
Free-Positioning Wireless Power Transfer Using a 3D Transmitting Coil for Portable Devices
Nam Ha-Van,Hoang Le-Huu,Minh Thuy Le,Kwangsuk Park,Chulhun Seo 한국전자파학회JEES 2020 Journal of Electromagnetic Engineering and Science Vol.20 No.4
The free-positioning wireless power transfer (WPT) system has drawn attention in recent years. Traditionally, a WPT system can transfer energy in one or two directions on the same plane, but it leads the restrictions of angle and axis misalignment between a transmitter and a receiver coil. In this paper, we propose a free-positioning WPT system using a three-dimensional cubic-shaped transmitting coil for portable device charging. A small receiving coil is placed inside the transmitter to achieve the transferred energy through the magnetic resonant coupling. In addition, the equivalent circuit and the mutual inductance between the Tx and Rx coils are analyzed. Finally, a practical experiment is implemented to verify the transfer performance, which can reach up to about 50% power transfer efficiency. The proposed system can charge in spatial freedom.
A New Dimeric Lignan from the Stems of Willughbeia edulis
Nguyen, Hai Xuan,Do, Truong Nhat Van,Le, Tho Huu,Dang, Phu Hoang,Nguyen, Mai Thanh Thi,Nguyen, Nhan Trung The Korean Society of Pharmacognosy 2022 Natural Product Sciences Vol.28 No.2
As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acid-catalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show 𝛼-glucosidase inhibitory activity with an IC<sub>50</sub> value > 250 𝜇M.
Inhibitory Activity of Plantago major L. on Angiotensin I-converting Enzyme
Nguyen Xuan Nhiem,김영호,Bui Huu Tai,Phan Van Kiem,Chau Van Minh,Nguyen Xuan Cuong,Nguyen Huu Tung,Vu Kim Thu,Trinh Nam Trung,Hoang Le Tuan Anh,조성훈,장해동,권영인 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.
Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities
Chau Van Minh,Nguyen Xuan Nhiem,Hoang Thi Yen,Phan Van Kiem,Bui Huu Tai,Hoang Le Tuan Anh,Truong Thi Thu Hien,박선주,김나영,김승현 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.8
One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-b-D-glucopyranoside (5), chrysoeriol-7- O-b-D-glucopyranoside (6), 10a-cucurbita5,24-dien-3b-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 lM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 lM.