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박선주,김용태,전유진 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.4
Reactive oxygen species (ROS) generation is linked to dynamic actin cytoskeleton reorganization, which is in-volved in tumor cell motility and metastasis. Thus, inhibi-tion of ROS generation and actin polymerization in tumor cells may represent an effective anticancer strategy. However, the molecular basis of this signaling pathway is currently unknown. Here, we show that the Ecklonia cava-derived antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein 2 (WAVE2)-mediated invasive migration of B16 mouse mela-noma cells. Steady-state intracellular ROS levels were higher in malignant B16F10 cells than in parental, nonmetastatic B16F0 cells. Elevation of ROS by H2O2 treatment increased migration and invasion ability of B16F0 cells to level similar to that of B16F10 cells, suggesting that intracellular ROS signaling mediates the prometastatic properties of B16 mouse melanoma cells. ROS levels and the cell migration and invasion ability of B16 melanoma cells correlated with Rac1 activation and WAVE2 expression. Over-expression of dominant negative Rac1 and depletion of WAVE2 by siRNA suppressed H2O2-induced cell invasion of B16F0 and B16F10 cells. Similarly, dieckol attenuates the ROS-mediated Rac1 activation and WAVE2 expression, resulting in decreased migration and invasion of B16 melanoma cells. In addition, we found that dieckol decreases association between WAVE2 and NADPH oxidase subunit p47phox. Therefore, this finding suggests that WAVE2 acts to couple intracellular Rac1/ROS signaling to the invasive migration of B16 melanoma cells, which is inhibited by dieckol.
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정신보건심판위원회 계속입원치료 심사제도 운영현황 및 개선방안
박선주,남윤영,황태연,조근호,전진용,김은진,김철응 한국보건행정학회 2017 보건행정학회지 Vol.27 No.4
Background: The recent revision of South Korea’s Mental Health Law emphasizes the role of the Mental Health Review Board. For this study, we examined the current status of continuing hospitalization judgement in Mental Health Review Board at the national level and aimed to determine the directions of improvement. Methods: Using a qualitative case study as the research method, we interviewed 30 Mental Health Review Board members and analyzed the results. Results: Each municipality had very different continuing hospitalization judgement methods. In our systematic review, which consisted of document inspection, we identified reliability problems due to limitations in Mental Health Review Board’s operating systems, discharge orders, etc. Additionally, continuing hospitalization judgement needs to improve the objectivity, fairness, and effectiveness of their screening examinations. Conclusion: Based on the results of this study, we suggest policy proposals to improve these systems, such as standardizing examination processes, strengthening on-site inspections, increasing the independence and neutrality of judgment in Mental Health Review Board, building community mental health infrastructures, and establishing integrated management systems.
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연구광이온 검출기와 전해전기전도도 검출기를 이용한 기체 크로마토그래피에 의한 물 중의 휘발성 유기물 분석
박선주,이상학,배준웅,음철헌,전치완,정혜영 경북대학교 환경과학연구소 1995 環境科學硏究所論文集 Vol.9 No.1
A method to determine 60 volatile organic compounds simultaneously by gas chromatography using electrolytic conductivity detector(ELCD) and photoionization detector(PID) has been developed. Volatile organic compounds were adsorped to an adsorption trap installed in the dynamic thermal sripper by passing helium gas. The adsorption Probe was then detatched and moved to the thermal desorption unit installed in the injection port of gas chromatograph. The organic compounds were desorped and passed through the Vocol capillary column and gas chromatograms were obtained using the on-line detector system where an ELCD and a PID are connected. The very volatile compounds such as dichlorofluoromethane, chloromethane, bromomethane and chloroethane were not quantitatively detected by either of the detectors. On the other hand, the rest of the compounds investigated in this study could be detected with excellent sensitivity by the ELCD or/and PID. For dibromomethane, bromoform, bromobenzene and 1.2-dibromo-3-chloropropane, the method detection limits for the determination using the electrolytic conductivity detector were in the range of 0.5-w4.0 ug/L. However, the values for the rest of the compounds detectable were found to be in the range of 0.01-0.08 tlg/L.
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박선주,문재원,김현지,조민정 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.8
Purpose:Childhood obesity is a problem that places a child at great risk for becoming an obese adult. To prevent obesity, it is important to focus on early life risk factors that may contribute to childhood obesity. The aim of this study is to find obesity-causing infantile risk factors in preschool children. Methods:A total of 223 children aged 3 to 5 years old from Busan were the subjects of this study. We calculated their body mass index (BMI) and classified them into two groups (normal weight and overweight/obese children). Information regarding parental weight and height, mother's educational level and employment status, birth weight, feeding patterns, start time of weaning, duration of night feeding, and fosterer was obtained by using questionnaires. Results:There were 68 (30.5%) overweight/obese children and 155 (69.5%) normal weight children. Overweight/obese children were significantly associated with formula milk feeding, rapid weight gain during the first 6 months, and maternal obesity (P<0.05). There were no statistical differences in paternal obesity, mothers educational level and employment status, birth weight, start time of weaning, duration of night feeding, and fosterer between the normal and overweight/obese children. Conclusion:Although healthy diet and regular exercise will remain the cornerstones of weight management in obese children, our data supports the view that education about maintaining a normal weight could be introduced much earlier in families with high-risk children. (Korean J Pediatr 2008;51:804-811) Purpose:Childhood obesity is a problem that places a child at great risk for becoming an obese adult. To prevent obesity, it is important to focus on early life risk factors that may contribute to childhood obesity. The aim of this study is to find obesity-causing infantile risk factors in preschool children. Methods:A total of 223 children aged 3 to 5 years old from Busan were the subjects of this study. We calculated their body mass index (BMI) and classified them into two groups (normal weight and overweight/obese children). Information regarding parental weight and height, mother's educational level and employment status, birth weight, feeding patterns, start time of weaning, duration of night feeding, and fosterer was obtained by using questionnaires. Results:There were 68 (30.5%) overweight/obese children and 155 (69.5%) normal weight children. Overweight/obese children were significantly associated with formula milk feeding, rapid weight gain during the first 6 months, and maternal obesity (P<0.05). There were no statistical differences in paternal obesity, mothers educational level and employment status, birth weight, start time of weaning, duration of night feeding, and fosterer between the normal and overweight/obese children. Conclusion:Although healthy diet and regular exercise will remain the cornerstones of weight management in obese children, our data supports the view that education about maintaining a normal weight could be introduced much earlier in families with high-risk children. (Korean J Pediatr 2008;51:804-811)
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군위안부와 엠마 보바리의 조우 : 서벌턴성의 트랜스내셔널한 의미
박선주 이화여자대학교 한국여성연구원 2015 여성학논집 Vol.32 No.1
The purpose of this paper is to read comparatively and transnationally the overlapped layers of comfort women, with Chang-rae Lee’s novel A Gesture Life and Gustav Flaubert’s Madame Bovary. Comfort women are the typical examples of the ‘unspeakable’ subaltern and this ‘unspeakability’ has been constructed by the regime of nation-state. Their narrative has been produced and consumed mainly as a group narrative rather than an individual one. Change-rae Lee’s A Gesture Life and Gustav Flaubert’s Madame Bovary, comparatively read, illuminate the transnational nature and historicity of this silence; it enables us to read the different nature of this ‘unspeakability’ according to the transformation within the regime of the nation-state through 19th and 20th century. The comparative reading also suggests how to conceptualize the subaltern’s memory, trauma, death and mourning, and, more importantly, how to approach/represent this ‘unspeakability’ in an ethical and responsible way. 이 논문은 창래 리(Chang-rae Lee)의 소설 『제스쳐 인생』과 플로베르(Flaubert)의 『보바리 부인』을 교차하여 읽으면서 서벌턴으로서의 군위안부의 의미를 짚어보고 이들의 ‘말할 수 없음’이 갖는 역사적이고 현재적인 의미를 되짚어보고자 하는 비교학적이고 트랜스내셔널한 시도이다. 군위안부의 ‘말할 수 없음’은 20세기 초반 일본제국의 전시 성적 착취로 인한 동아시아 식민지 여성의 기억과 언어 상실의 현상일 뿐 아니라, 19세기에서 20세기 후반을 거쳐 21세기까지 길게 이어지는 근대국민국가체제의 구성, 진화, 전지구적 확장이라는 역사적 맥락 속에서 보아야 한다. 군위안부의 ‘말할 수 없음’은 또한 서벌턴성과 정체성 정치가 맺는 밀접한 관계 밖에서 사유될 필요가 있다. 군위안부는 ‘민족’ 혹은 ‘여성’ 등 집단정체성을 대표하는 추상적 트라우마가 아니라 지극히 개인적이고 단독적인 기억이기도 하기 때문이다. 『보바리 부인』과 『제스쳐 인생』의 교차 속에서, 19세기 프랑스의 부르조아 계급의 부인네와 20세기 초 아시아의 식민지 여성, 20세기 후반 미국의 ‘시민’은, 또 그들의 ‘말할 수 없음’은 역사적, 문학적으로 얽혀있다. 플로베르가 『보바리 부인』에서 사용하는 아이러니, 동일시-타자화의 반복과 진동, “몰개성화” 등의 수사 전략은 이 ‘말할 수 없음’을 재현하고자 하는 예술적 시도이면서 궁극적으로는 그 재현의 실패를 표현하는 윤리적인 태도이기도 하며, 이는 21세기 서벌턴과 ‘말할 수 없음’의 재현작업에 대한 시사점을 제공한다.
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