프로젝트관리 시스템을 위한 범위관리 알고리즘 개발

신호균,전승호,김만균 대한설비관리학회 2004 대한설비관리학회지 Vol.9 No.2

This study present the method to cope with the limitations of the existing study that has uniformly been customizing the methodology by only project's complexity. We show how the applied model(ODW) is implemented in PMS using knowledgebase and modelbase which are designed for a scope management algorithm. An ODW model is used for implementation of a WBS identification module and regression model is used for measuring project's complexity. Scope management algorithm is simulated in MS-Excel for estimating its effectiveness and the interrelationship among the knowledgebase, modelbase and database is derived.

주근단공의 조건에 따른 Root ZX의 정확성 평가

박신영,이동균,황호길 大韓齒科保存學會 2012 Restorative Dentistry & Endodontics Vol.37 No.2

Objectives: The purpose of this study was to assess the accuracy of Root ZX (J. Morita Corp.) according to the location of major foramen and open apex. Materials and Methods: 81 mandibular premolars with mature apices were selected. After access preparation, 27 teeth were instrumented to simulate open apices. 54 teeth were classified according to location of major foramen under surgical microscope (x16). The file was fixed at the location of apical constriction by Root ZX using glass ionomer cement. The apical 4 mm of the apex was exposed and photo was taken and the distance from file tip to the major foramen was measured by calibrating metal ruler on graph paper. The results were statistically analyzed using ANOVA and Scheffe test at p < 0.05 level. Results: mean distance from file tip to major foramen was 0.308 mm in Tip foramen group (Ⅰ), 0.519 mm in Lateral foramen group (Ⅱ) and 0.932 mm in open apex group (Ⅲ). Root ZX located apical constriction accurately within ± 0.5 mm in group Ⅰ of 85.71%, in group Ⅱ of 59.09%, and in group Ⅲ of 33.33%. There was a statistically significant difference between group Ⅰ and Ⅲ (p < 0.05). Conclusion: Root ZX located apical constriction accurately regardless of location of major foramen. However, Root ZX couldn't find it in open apex. Clinicians have to use a combination of methods to determine an appropriate working length at open apex. It may be more successful than relying on just electronic apes locator. (Restor Dent Endoe 2012;37(2):68-73)

불안장애환자가 나타내는 사고내용의 특성

원호택,신현균,박현순,권석만 서울大學校 社會科學大學 心理科學硏究所 1996 心理科學 Vol.5 No.1

본 연구는 인지내용이 정서장애에 영향을 미친다는 인지적 내용-특수성 가설에 근거하여 불안장애환자의 사고내용을 조사하고자 했다. 사고내용에 있어서, 불안장애 환자들이 정상인 또는 비불안 정신장애환자와 어떤 차이점이 있는지를 조사했으며 나아가서 불안장애의 하위유형인 공황장애환자와 비공황 불안장애환자간에 어떤 차이점이 있는지를 탐색하고자 했다.이를 위해서 공황장애환자 34명, 비공황 불안장애환자 24명, 비불안 정신장애환자 34명을 포함한 92명의 정신장애 환자와 60명의 정상인을 대상으로 하여 그들의 사고내용을 측정하였다. 이들의 사고내용은 불안민감성 척도(ASI), 광장공포인지 질문지(ACQ), 신체감각 질문지(BSQ)를 사용하여 측정되었다. 각 집단별 사고내용을 정밀하게 비교하기 위하여 각 척도의 개별문항에 대해서 차이비교검증을 실시하였다.본 연구의 주된 결과는 다음과 같다. 첫째, 공황 장애를 비롯해 불안장애 환자집단은 정상인 집단에 비해 세 척도에서 측정된 불안유발 사고내용을 현저하게 많이 가지고 있었다. 둘째, 공황장애 환자집단은 비불안 정신장애 환자(우울증 및 신체화) 집단에 비해 신체적 증상에 대해서 더 예민하고 이를 위협적인 것으로 평가하는 경향성이 있었다. 셋째, 공황장애 환자들은 비공황 불안장애 환자나 비불안 정신장애환자에 비해 극단적이고 파국적인 위험과 관련된 사고내용을 많이 가지고 있었다. 특히 공황장애 환자들은 다양한 신체적 증상과 변화에 예민하고 이를 죽음이나 통제상실상태와 같이 극단적이고 파국적인 것으로 해석하는 사고경향이 있는 반면, 비공황 불안장애 환자들은 대인관계에서의 부적절한 대처나 능력에 대한 부정적 평가와 같이 일반적이며 비파국적인 위험이나 위협과 관련된 사고내용을 많이 갖는 경향이 있었다.ABSTRACT The aim of the present study is to investigate some characteristics of patients with anxiety disorders in their thought contents from the theoretical perspective of the cognitive content-specificify hypothesis that cognitive contents influence emotional disorders. For this, differences in thought contents between patients with panic and non-panic anxiety disorder as well as between patients with anxiety disorders and non-anxiety psychiatric patients or nomal controls were examined.The data were collected from 92 psychiatric patients (34 panics, 24 non-panics, 34 non-anxiety psychiatric patients) and 60 normal controls. Their thought contents were measured with the Anxiety Sensitivity Inventory, Agoraphobic Cognition Questionnaire, and Body Sensation Questionnaire. The difference between groups in the individual item of the three measures was tested using ANOVA and multiple comparison tests.The main findings in the present study are as follows: First, the patients with anxiety disorders reported significantly more thoughts with anxiety-provoking contents than normal controls. Second, the patients with panic disorders tended to be more sensitive to physical symptoms and to interpret these as being threatening than the non-anxiety psychiatric patients. Third, the patients with panic disorder had more thoughts with contents related to extreme and catastrophic danger than those with non-panic anxiety disorders. In particular, those with panic disorder had strong tendency to be senstive to physical symptoms or changes and to interpret these as suggesting extreme and catastrophic danger such as death or loss of control, whereas those with non-panic anxiety disorders tended to have thoughts with contents related to general and non-catastrophic danger or threats such as inadequate coping in interpersonal situations or negative evaluation about their ability.

Ciprofloxacin 제제의 생물학적 동등성에 관한 연구

최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1

국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.

제2형 근관의 확대에 따른 최종근관장파일 크기의 비교

정은주,이동균,백신영,황호길 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.5

제2형의 근관형태를 갖는 치아에서 각각의 근관을 모두 근관장까지 확대한 경우,여러 확대기구에 따른 최종근관장파일의 크기를 상호 비교하여 얼마나 많은 변화가 있었는지를 분석하고자 치근 우식이 없고 치근단공 형성이 완료되었으며 2개의 근관 입구에서 시작하여 하나의 치근단공을 갖는 제 2형의 근관형태를 보이는 상악 소구치,상악 대구치의 근심협측 치근 및 하악 대구치의 근심 치근을 선택하여 확대기구에 따라 KF 군, PT 군,HS 군, K3 군으로 분류하고 치경부 조기 확대를 시행하였다. 초기근관장파일이 15번 크기인 지아를 각 군당 20개씩 무작위로 선택하였고,모든 근관을 각 군에 해당되는 30번 크기의 파일까지 제조회사의 지시에 따라 확대를 시행한 후,촉감과 universal testing machine을 이용하여 최종근관장파일의 크기를 결정하였다. 각 군의 최종근관장파일의 크기와 제거 시 요구되는 힘의 크기에 대한 유의성 검증은 one-way ANOVA를 이용하여 비교 분석하였으며,사후검정은 Tukey HSD test를 이용하여 0.05의 유의수준에서 분석하였다. 본 연구의 결과 제2형의 근관형태를 갖는 치아의 근관확대 시,모든 근관을 각각의 근관장으로 확대하는 방법은 확대에 마지막으로 이용된 기구의 크기보다 한,두 단계 정도 증가된 최종근관장파일을 나타냈다. 그러므로 제2형 근관형태를 나타내는 치아의 근관치료 시 임상가들은 근관충전에 앞서 치근단 받침을 다시 확인하고 형성하는 과정이 필요하리라 사료된다. Type II root canal was defined that two canals leave the chamber and merge to form a single canal at short of the apex. The aim of this study was to analyse the master apical file (MAF) size according to various instrumentation techniques in the type II root canal when each canal was enlarged to working length. Eighty mesial roots of molar with ISO #15 initial apical file (IAF) size in type II root canals were randomly divided into four experimental groups with 20 teeth each. According to enlarging instruments, four groups are: K-FLEXOFILE^(?) (KF), engine-driven Ni-Ti PRoT_(APER)^(?)(PT), HERO Shaper^(?)(HS), K³™ (K3). All canals were enlarged to each working length with ISO #30 size: #30 in KF, F3 in PT, .04/30 in HS, and .06/30 in K3. The master apical file (MAF) size was confirmed by tactile sensation and universal testing machine (EZ test, Shimadzu Co., Kyoto, Japan). The mean MAF size was statistically compared using one-way ANOVA and Tukey HSD test at the 0.05 probability level. These results show that the MAF size was appeared one or two sizes larger than the final enlarging instrument when all canal in type II configuration were enlarged to each working length. Therefore, the clinician have to confirm the apical stop once more after instrumentation of type II root canal.

조직학적 진단된 chronic necrotizing pulmonary aspergillosis 2예

김연숙,정숙인,기현균,김춘관,김신우,한정호,김성민,백경란,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

CNPA는 기존의 폐질환 및 폐절제술로 인해 국소방어기전에 저하가 있거나 비특이적 전신면역상태저하를 갖고 있는 환자들에게서 주로 발생하는 만성적인 공동성 폐질환이다. 현재까지 우리나라에서는 CNPA의 보고가 없는 상태이고, 저자들은 최근 조직학적으로 진단된 CNPA 2예를 경험하였기에 보고하는 바이다. 저자들이 경험한 CNPA 환자들은 만성알코올 중독 및 기관지확장증과 같은 기저질환과 폐절제술을 받은 병력이 있었다. Aspergillus가 폐실질을 침윤하고 있는 조직소견과 조직배양에서 Aspergillus가 검출되어 조직학적 진단이 가능하였고, amphotericin B의 정주요법 및 경구 itraconazole 투여와 폐절제술 등으로 성공적으로 치료되었다. 아직 많은 임상의들에게는 낯선 질환인 CNPA의 치료성적은 환자의 동반질환 및 CNPA 자체의 중증도, 진단과 치료 시작의 지연 등에 의해 크게 좌우되므로 만성적으로 진행하는 공동성 폐병변을 갖고 있는 환자에게서 CNPA를 감별하는 것이 중요하다. Chronic necrotizing pulmonary aspergillosis (CNPA) is a chronic cavitary form of pulmonary aspergillosis. Dozens of CNPA cases have been reported in patients with systemic immunologic dysfunction or altered local defense mechanism from preexisting pulmonary disease. Review of literatures revealed that no CNPA cases have been reported in Korea yet. We experienced two cases of CNPA proven by lung biopsy. A 53-year-old alcoholic male in poor nutritional state was admitted with generalized weakness and weight loss. Chest CT revealed a cavitary nodule surrounded with ground-glass attenuation. CT-guided fine needle aspiration and biopsy was done. The biopsy specimen demonstrated dichotomously branching septated hyphae consistent with those of Aspergillus sp. Another case was a 39-year-old man with bronchiectasis who was admitted with persistent hemoptysis. He had a past history of pulmonary tuberculosis. A parahilar lesion with intracavitary soft tissue mass was incidentally detected in high-resolution GT. Left lingular segmentectomy was done due to uncontrolled hemoptysis and CNPA was histologically diagnosed. Both patients were successfully treated with intravenous amphotericin B followed by oral itraconazole. Even though CNPA is unfamiliar to most clinicians, it should be included in differential diagnoses of chronic progressive cavitary pulmonary lesion, especially in patients with immunologic dysfunction.

Clinical significance of nuclear factor κB and chemokine receptor CXCR4 expression in patients with diffuse large B-cell lymphoma who received rituximab-based therapy

( Ho Cheol Shin ),( Jongwon Seo ),( Byung Woog Kang ),( Joon Ho Moon ),( Yee Soo Chae ),( Soo Jung Lee ),( Yoo Jin Lee ),( Seoae Han ),( Sang Kyung Seo ),( Jong Gwang Kim ),( Sang Kyun Sohn ),( Tae In 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.6

Background/Aims: This study investigated the expression of nuclear factor κB (NF-κB) and the chemokine receptor (CXCR4) in patients with diffuse large B-cell lymphoma (DLBCL) who received rituximab-based therapy. Methods: Seventy patients with DLBCL and treated with rituximab-CHOP (R-CHOP) were included, and immunohistochemistry was performed to determine the expression of NF-κB (IκB kinase α, p50, and p100/p52) and CXCR4. To classify DLBCL cases as germinal center B-cell-like (GCB) and non-GCB, additional immunohistochemical expression of CD10, bcl-6, or MUM1 was used in this study. The expression was divided into two groups according to the intensity score (negative, 0 or 1+; positive, 2+ or 3+). Results: The median age of the patients was 66 years (range, 17 to 87), and 58.6% were male. Twenty-seven patients (38.6%) had stage III or IV disease at diagnosis. Twenty-three patients (32.9%) were categorized as high or high-intermediate risk according to their International Prognostic Indexs (IPIs). The overall incidence of bone marrow involvement was 5.7%. Rates of positive NF-κB and CXCR4 expression were 84.2% and 88.6%, respectively. High NF-κB expression was associated with CXCR4 expression (p = 0.002), and 56 patients (80.0%) showed coexpression. However, the expression of NF-κB or CXCR4 was not associated with overall survival and EFS. On multivariate analysis that included age, gender, performance status, stage, and the IPI, no significant association between the grade of NF-κB or CXCR4 expression and survival was observed. Conclusions: The current study suggests that the tissue expression of NF-κB and CXCR4 may not be an independent prognostic marker in DLBCL patients treated with R-CHOP.

An Exploratory Study on the Relationship between Smart Work Type Preference and Smart WorkAttributes

Ho-Kyun Shin(신호균) 한국로고스경영학회 2013 로고스경영연구 Vol.11 No.3

Seasonal production of dinoflagellate cysts in relation to environmental characteristics in Jinhae-Masan Bay, Korea: One-year sediment trap observation

Shin, Hyeon Ho,Li, Zhun,Lim, Dhongil,Lee, Kyun-Woo,Seo, Min Ho,Lim, Weol Ae Academic Press in association with the Estuarine a 2018 Estuarine, coastal and shelf science Vol.215 No.-

<P><B>Abstract</B></P> <P>To investigate dinoflagellate cyst production and seasonality in relation to major environmental factors, such as water temperature, salinity, chlorophyll-<I>a</I> (chl-<I>a</I>) and dissolved nutrients, and to propose dinoflagellate cysts as possible biological indicators for the reconstruction of past environmental conditions, a sediment trap study was conducted for one year, from March 2011 to February 2012, in Jinhae-Masan Bay, Korea. Marked increases in dinoflagellate cyst production were documented in Jinhae-Masna Bay during two distinct seasons (summer and late autumn) characterized by different environmental conditions. Summer (July and August) was characterized by relatively high water temperature, dissolved inorganic nitrogen (DIN), and chl-<I>a</I> concentrations and low salinity, whereas late autumn (November and December) exhibited high dissolved inorganic phosphorus, low water temperature and high salinity, compared to those of the summer. Fourteen dinoflagellate cyst taxa were identified. These assemblages were dominated by <I>Brigantedinium</I> species (round brown cyst), cysts of <I>Scrippsiella</I> species, <I>Spiniferites</I> species and cysts of <I>Alexandrium</I> species (ellipsoidal cyst). The total flux of dinoflagellate cysts ranged from 781 cysts m <SUP>−2</SUP> day <SUP>−1</SUP> to 5602 cysts m <SUP>−2</SUP> day <SUP>−1</SUP>, and the production of autotrophic dinoflagellate cysts was mainly restricted to the warmest months (July–September) and autumn. Multivariable analysis revealed that the production of major dinoflagellate cysts, excluding those of <I>Brigantedinium</I> species, can be enhanced by environmental conditions during summer in Jinhae-Masan Bay. In particular, the increased production of cysts of <I>Scrippsiella</I> species was related to increased water temperature, and the increased production of <I>Spiniferites</I> species was associated with lower salinity. Two peaks in cyst production of <I>Alexandrium</I> species in August and November corresponded with significant increases in DIN and DIP; however, no significant relationship was found between the production of <I>Brigantedinium</I> species and environmental factors in Jinhae-Masan Bay. These results suggest that the cysts of <I>Scrippsiella</I> species, <I>Spiniferites</I> species and cysts of <I>Alexandrium</I> species present in sediment samples from Jinhae-Masan Bay can be used as biological indicators to reconstruct past environmental conditions involving relatively high water temperature, low salinity and enhanced nutrient level.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sediment trap study provides reliable information for dinoflagellate cyst production related to environmental conditions. </LI> <LI> Cysts of <I>Scrippsiella</I> species, <I>Spiniferites</I> species and cysts of <I>Alexandrium</I> species are most abundant in the warmest months. </LI> <LI> Cysts of <I>Scrippsiella</I> species, <I>Spiniferites</I> species and cysts of <I>Alexandrium</I> species can be used as biological indicators. </LI> </UL> </P>

Comparative analysis of treatment outcomes with CHOP regimen in adult patients with hemcphagceytic lymphohistiocytosis

Shin, Ho-Jin,Chung, Joo Seop,Lee, Je-Jung,Sohn, Sang Kyun,Choi, Young Jin,Kim, Yeo-Kyeoung,Yang, Deok-Hwan,Kim, Hyeoung-Joon,Back, Jin Ho,Kim, Jong Gwang,Joo, Young Don,Lee, Won Sik,Sohn, Chang Hak,Le 부산대학교 병원 암연구소 2007 부산대병원학술지 Vol.- No.21

목적: 림프종이나 Ebstein Barr 바이러스와 연관된 혈구탐식증후군에서 CHOP 항암화학요법의 치료성적에 관한 보고는 현재까지 거의 보고된 바 없다. 이에 본 연구에서는 성인 혈구탐식증후군 환자에서 CHOP 항암화학요법 뿐만 아니라 etoposide와 corticosteroid 병합요법 그리고 prednisolone 단독 치료의 치료성적을 비교분석하고자 하였다. 대상과 방법: 16세 이상의 46명의 성인환자들이 혈구탐식증후군으로 진단되었다. 이들 중 CHOP 항암화학요법 치료를 시행받은 환자 18명, etoposide와 corticosteroid 병합요법 치료를 시행받았던 6명, 그리고 prednisolone 단독치료를 시 행받았던 6명의 환자들이 분석가능하였다. 결과: CHOP 항암화학요법 치료를 시행받은 환자 중 완전관해 27.8% (5/18), 부분관해 27.8% (5/18) 를 보였으며, 전체생존율은 55.6% 였다. Etoposide 와 corticosteroid 병합요법에서는 50% (3/6)에서 부분관해를 보였으나 완전관해는 한 명도 없었다. Prednisolone 단독치료로는 16.7% (1/6) 에서 완전관해와 부분관해를 보였다. 중앙추적기간은 132주 였으며, CHOP 항암화학요법치료를 시행받은 환자에서 중앙반응기간은 아직 도달하지 않았고, 3년 추정 반응기간은 68.57% 였다. Etoposide 와 corticosteroid 병합요법과 prednisolone 단독치료군에서 중앙 반응기간은 각각 3주와 1주였다. CHOP 항암화학요법 치료를 시행받은 환자군의 중앙생존기간 16주, 3년추정 생존율이 40.63%로 etoposide 와 corticosteroid 병합치료와 prednisolone 단독치료군에 비해 통계학적으로 유의하게 높았다(p = O.OO16). 결론: CHOP 항암화학요법은 성인 혈구탐식증후군 환자에서 유용할 수 있을 것으로 사료된다.