비알코올성 지방간의 중증도에 따른 혈중 Ghrelin 농도 변화

유태우 ( Tae Woo Yoo ),조용균 ( Yong Kyun Cho ),강문수 ( Mun Su Kang ),오세용 ( Se Yong Oh ),박정호 ( Jung Ho Park ),김홍주 ( Hong Joo Kim ),박동일 ( Dong Il Park ),손정일 ( Chong Il Sohn ),전우규 ( Woo Kyu Jeon ),김병익 ( Byung I 대한내과학회 2006 대한내과학회지 Vol.71 No.1

목적: ghrelin은 주로 위에서 분비되는 새로운 peptide로서 음식물 섭취 및 식욕을 증가시키고 최근 인슐린 저항성 및 대사 증후군과의 관련성에 대해 많은 연구 결과가 보고되고 있다. 비알코올성 지방간은 인슐린 저항성 및 대사 증후군이 그 원인으로 잘 알려져 있는바 저자들은 비알코올성 지방간의 중증도에 따른 혈중 ghrelin 농도의 변화를 관찰하여 그들의 관련성에 대해 알아 보고자 하였다. 방법: 정상 성인 남성 65명(나이: 54.3±6.3세, 범위 42~70세)을 대상으로 하여 간 초음파 및 공복 혈중 ghrelin 농도를 측정하였다. 간 초음파 소견상 지방간의 유무 및 중증도에 따라 대상자를 세 군(Group I: 정상 27명, Group II: 경증: 24명, Group III: 중등도 이상의 지방간: 14명)으로 분류하였고, 세 군 간의 혈중 ghrelin 농도의 차이를 ANOVA test로 검정하였다. 또한 인슐린 저항성 지표인 HOMA 및 체질량 지수, 허리 둘레, 엉덩이 둘레, 허리-엉덩이 둘레비 등 인슐린 저항성 관련 인자와 혈중 ghrelin 농도와의 독립적인 상관성을 다중 회귀 분석으로 검정하였다. 결과: 간 초음파 소견상 지방간의 정도가 심해짐에 따라 혈중 ghrelin 농도가 낮아지는 경향을 보였으나 (Group I: 정상 230.9±94.3, Group II: 경증 195.2±97.2, Group III: 중등도 이상 지방간 164.3±71.4 pmol/L) 통계적으로 의미있는 결과를 얻지는 못하였으며(p=0.081), 인슐린 저항성 지표인 HOMA 및 체질량 지수, 허리 둘레, 엉덩이 둘레, 허리-엉덩이 둘레비 등 인슐린 저항성 관련 인자는 혈중 ghrelin 농도와 독립적인 관련성을 관찰할 수 없었다. 결론: 본 연구의 결과로 인슐린 저항성과 혈중 ghrelin 농도의 관련성을 증명하지는 못하였다. 하지만 간 초음파 소견상 지방간의 중증도가 심해질수록 혈중 ghrelin 농도가 낮아지는 경향을 관찰할 수 있었다. 따라서 향후 추가적인 연구로 이들의 관련성에 대한 증명이 필요할 것으로 생각한다. Background: Recently, ghrelin has been reported to be associated with insulin resistance. Nonalcoholic fatty liver disease (NAFLD) is a condition in which insulin resistance relatively plays a pivotal role. The aim of this study was to evaluate the change of serum ghrelin concentration according to severity of hepatosteatosis. Methods: Sixty five apparently normal male adults who underwent health screen examinations were classified into three groups, Group I: normal (27 subjects), Group II: mild (24 subjects) and Group III: moderate to severe fatty liver (14 subjects), according to ultrasonographic findings of liver. We analyzed the association between serum ghrelin concentration and severity of hepatosteatosis by ANOVA test. And the independent correlation between serum ghrelin concentration and insulin resistance related factors, HOMA (homeostatic model assessment), BMI (body mass index), WC (waist circumference), HC (hip circumference), WHR (waist to hip circumference ratio) were analyzed by multiple linear regression analysis. Results: Serum ghrelin concentration tended to decrease according to severity of hepatosteatosis (Group I: 230.9±94.3, Group II: 195.2±97.2, Group III: 164.3±71.4 pmol/L). But this was statistically insignificant (p=0.081). The independent correlation between serum ghrelin concentration and insulin resistance related factors were not observed. Conclusions: Our study did not prove the correlation between insulin resistance related factors and serum ghrelin concentration in NAFLD according to severity of hepatosteatosis. However, we found a tendency to decrease serum ghrelin concentration according to severity of hepatosteatosis. So, further studies are required for certification these correlations.(Korean J Med 71:45-51, 2006)

수종의 식물섬유의 급이가 고콜레스테롤 혈증 흰쥐의 지질 대상 미치는 영향 : 2. 주요장기의 지방산 조성 2. Fatty Acid Composition in Principal Organ tissue

강훈이,서인숙,이호신 麗水水産大學校 産業技術硏究所 1995 産業基術硏究所 論文集 Vol.4 No.-

This study was designed to observe the effects of feeding dietary fiber on the improvement of the fatty acid metabolism in brain, heart and lung in dietary hypercholesterolemic rats. Experimental groups with 5% level of cellulose(A group as control group), chinese cabbage root(B group),tora stalk (C group)and sweet potato stalk (D group)were adminstered to the male rats of the Sprague-Dawley for 4 weeks. The results obtaind are as follows. In the fatty acid composition of total lipid, phospholipid in the brain, the docosahexaenoic acid in the PUFA was major fatty acid. In the fatty acid composition of total lipid, phospholipid in the brain, the docosahexaenoic acid in the PUFA was major fatty acid. While in the fatty acid composition total lipid and phospholipid in the heart, the eicosapentaenoic acid in the PUFA was major fatty acid. And in the fatty acid composition of total lipid and phospholipid in the lung, the content of palmitic acid and oleic acid were higer than other fatty acid. These fats were influenced by the fatty acid composition of the test lipids. From the above result, the feeding of chinese root was effective on the improvement of the lipid compositions in principal organ tissue.

전기용랑법에 의한 박막의 자기변형 측정

이용호,신용돌,김희중,강일구 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.16 No.-

기판위에 자성박막을 증착한 시료를 자장속에 넣을 때 박막의 자기변형에 의하여 생기는 시료의 굴곡을 전기용량으로 변환하여 측정하는 방법을 써서 Ni의 다결정 박막의 자기변형을 측정하였다. 유리기판위에 18150 Å의 Ni 박막을 증착한 시료의 포화자기변형은 38 × 10 exp (-6) 이었으며 bulk 시료의 값과 대체적으로 일치하였다. 고능률의 소형 전자석과 디지탈 기억의 순간 측정법에 의하여 온도변화의 측정 장해요소는 크게 감소되었다. Thin film magnetostriction is measured with capacitance method. A Ni film 18150 Å thick is vacuum deposited on a glass substrate. The sample is cantilevered on a flat metallic holder and bends under applied magnetic field by magnetostriction of the film. Change of capacitance between the film and holder is measured with transformer bridge method. Magnetostriction of the sample is calculatd with sample geometry, Young's moduli of the film and substrate and the change of capacitance. The magnetostriction of the Ni film turns out to be 38 × 10 exp (-6) which is almost same as that of bulky sample. Temperature, change of the sample is minized with using high efficiency small electromagnet and instantaneous measuring method by digitizing oscilloscope.

정신분열병 환자에서 가상현실을 이용한 추론과제 수행 중 활성화된 뇌영역과 현존감과의 관계 : 기능자기공명영상 연구

최수희,김재진,박일호,김소영,구정훈,이형래,윤강준,김인영,김선일 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.3

Objectives : Virtual reality has been increasingly used in the psychiatric field. Presence, the sense of “being there,” is an essential concept in terms of the effectiveness of the virtual reality. The present study aimed to investigate the characteristics of the presence-related brain regions in patients with schizophrenia. Methods : Using fMRI, brain activities were measured while performing the virtual reality tasks m fifteen healthy normal subjects and fifteen patients with schizophrenia. The tasks consisted of listening to some stories and inferring the content of the previous events. Ambiguous information was given for the experimental task, whereas clear information was given for the control task. Correlations between the image contrast values and the presence scores were analyzed. Result : The presence-related brain regions in healthy controls were identified in the two discrete region groups that could be referred to as the cognitive neural correlates and the perceptual neural correlates. The former included the anterior cingulate, the left inferior temporal gyrus, the right lingual gyrus, and the right cuneus, whereas the latter consisted of the right posterior cingulate, the left lingual gyrus and the right fusiform gyrus. Compared with healthy controls, regional correlation patterns were different in patients with schizophrenia, including that the posterior cingulate had significant correlations. Conclusion : These results suggest that patients with schizophrenia utilize perceptual apparatus for the presence more than the cognitive aspect. A peculiar pattern of the presence in schizophrenia may be related to increased correlations between the posterior cingulate and other brain regions.

Interactions Between Innate Immunity Genes and Early-Life Risk Factors in Allergic Rhinitis

Seo, Ju-Hee,Kim, Hyung Young,Jung, Young-Ho,Lee, Eun,Yang, Song-I,Yu, Ho-Sung,Kim, Young-Joon,Kang, Mi-Jin,Kim, Ha-Jung,Park, Kang Seo,Kwon, Ji-Won,Kim, Byung-Ju,Kim, Hyo-Bin,Kim, Eun-Jin,Lee, Joo-Shi The Korean Academy of Asthma, Allergy and Clinical 2015 Allergy, Asthma & Immunology Research Vol.7 No.3

<P><B>Purpose</B></P><P>Allergic rhinitis (AR) is a common chronic disease. Many factors could affect the development of AR. We investigated early-life factors, such as delivery mode, feeding method, and use of antibiotics during infancy, which could affect the development of AR. In addition, how interactions between these factors and innate gene polymorphisms influence the development of AR was investigated.</P><P><B>Methods</B></P><P>A cross-sectional study of 1,828 children aged 9-12 years was conducted. Three early-life factors and AR were assessed by a questionnaire. Skin prick tests were done. Polymorphisms of <I>TLR4</I> (rs1927911) and <I>CD14</I> (rs2569190) were genotyped.</P><P><B>Results</B></P><P>Use of antibiotics during infancy increased the risk of AR (aOR [95% CI] 1.511 [1.222-2.037]) and atopic AR (aOR [95% CI], 1.565 [1.078-2.272]). There were synergistic interactions between caesarean delivery, formula feeding, and use of antibiotics in the rate of atopic AR (aOR [95% CI], 3.038 [1.256-7.347]). Additional analyses revealed that the risk for the development of AR or atopic AR subjects with the <I>TLR4</I> CC genotype were highest when all the 3 early-life factors were present (aOR [95% CI], 5.127 [1.265-20.780] for AR; 6.078 [1.499-24.649] for atopic AR). In addition, the risk for the development of AR or atopic AR in subjects with the <I>CD14</I> TT genotype were highest when all the 3 early-life factors were present (aOR [95% CI], 5.960 [1.421-15.002] for AR; 6.714 [1.440-31.312] for atopic AR).</P><P><B>Conclusions</B></P><P>Delivery mode, feeding method, and use of antibiotics during infancy appeared to have synergistic interactions in the development of AR. Gene-environment interactions between polymorphism of innate genes and early- life risk factors might affect the development of AR.</P>

Pesticide residue monitoring in livestock products by GC-ECD

Ho-Won Chang,Nam Suk Kang,Yoon Jung Kang,Do Hyeong Kim,Se Ra Won,Hyang Min Ahn,Su Jin Kim,Su Zie Choi,Kyeong Jun Kim,Si Woo Bark,Gil Ran Kang,Jae I Kim,Woo Seong Kim,Dong-Sul Kim 한국분석과학회 2017 학술대회논문집 Vol.2017 No.11

Distribution of Alexandrium tamarense in Drake Passage and the Threat of Harmful Algal Blooms in the Antarctic Ocean

Ho, King-Chung,Kang, Sung-Ho,,Lam Ironside H.Y.,Ho, dgkiss I.John Korea Institute of Ocean ScienceTechnology 2003 Ocean and Polar Research Vol.25 No.4

While phytoplankton diversity and productivity in the Southern Ocean has been widely studied in recent years, most attention has been given to elucidating environmental factors that affect the dynamics of micro-plankton (mainly diatoms) and nano-plankton (mainly Phaeocystis antarctica). Only limited effects have been given to studying the occurrence and the potential risks associated with the blooming of dinoflagellates in the relevant waters. This study focused on the appearance and toxicological characteristics of a toxic dinoflagellate, Alexandrium tamarense, identified and isolated from the Drake Passage in a research cruise from November to December 2001 The appearance of A. tamarense in the Southern Ocean indicates the risk of a paralytic shellfish poisoning (PSP) outbreak there and is therefore of scientific concern. Results showed that while the overall quantity of A. tamarense in water samples from 30meters below the sea surface often comprised less than 0.1% of the total population of phytoplankton, the highest concentration of A. tamarense (20 cells $L^{-1}$) was recorded in the portion of the Southern Ocean between the southern end of South America and the Falkland Islands. Waters near the Polar Front contained the second highest concentrations of 10-15 cells $L^{-1}$. A. tamarense was however rarely found in waters near the southern side of the Polar Front, indicating that cold sea temperatures near the Antarctic ice does not favor the growth of this dinoflagellate. One strain of A. tamarense from this cruise was isolated and cultured for further study in the laboratory. Experiments showed that this strain of A. tamarense has a high tolerance to temperature variations and could survive at temperatures ranging from $5-26^{\circ}C$. This shows the cosmopolitan nature off. tamarense. With regard to the algal toxins produced, this strain of A. tamarense produced mainly C-2 toxins but very little saxitoxin and gonyailtoxin. The toxicological property of this A. tamarense strain coincided with a massive death of penguins in the Falkland Islands in December 2002 to January 2003.

Pesticide Residue Monitoring in Livestock Products by GC-MSMS

Ho-Won Chang,Nam Suk Kang,Yoon Jung Kang,Se Ra Won,Hyang Min Ahn,Su Jin Kim,Chan Woong Park,Jae Yun Jeon,Seok Hwan Lee,Si Woo Bark,Gil Ran Kang,Jae I Kim,Woo Seong Kim,Dong-Sul Kim 한국농약과학회 2018 한국농약과학회 학술발표대회 논문집 Vol.2018 No.10

Finite element modeling of a deteriorated R.C. slab bridge: lessons learned and recommendations

Ho, I-Kang,Shahrooz, Bahram M. Techno-Press 1998 Structural Engineering and Mechanics, An Int'l Jou Vol.6 No.3

The test results from non-destructive and destructive field testing of a three-span deteriorated reinforced concrete slab bridge are used as a vehicle to examine the reliability of available tools for finite-element analysis of in-situ structures. Issues related to geometric modeling of members and connections, material models, and failure criteria are discussed. The results indicate that current material models and failure criteria are adequate, although lack of inelastic out-of-plane shear response in most nonlinear shell elements is a major shortcoming that needs to be resolved. With proper geometric modeling, it is possible to adequately correlate the measured global, regional, and local responses at all limit states. However, modeling of less understood mechanisms, such as slab-abutment connections, may need to be finalized through a system identification technique. In absence of the experimental data necessary for this purpose, upper and lower bounds of only global responses can be computed reliably. The studies reaffirm that success of finite-element models has to be assessed collectively with reference to all responses and not just a few global measurements.

일반연제 발표 : 비당뇨성 만성 사구체 신염환자에서 ACE 억제제 또는 Angiotensin 2 수용체 차단제가 사구체 선택적 투과도에 미치는 영향

강이화 ( Kang I Hwa ),김형종 ( Kim Hyeong Jong ),김범석 ( Kim Beom Seog ),김현진 ( Kim Hyeon Jin ),최훈영 ( Choe Hun Yeong ),신석균 ( Sin Seog Gyun ),강신욱 ( Kang Sin Ug ),최규헌 ( Choe Gyu Heon ),이호영 ( Lee Ho Yeong ),한대석 ( 대한신장학회 2003 춘계학술대회 초록집 Vol.22 No.1