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      • KCI등재

        비용의 발생에 대한 후성유전학적 관점

        박일호,이흥만 대한비과학회 2018 Journal of rhinology Vol.25 No.1

        Nasal polyposis is a multi-factorial disease associated with chronic inflammation of the paranasal sinuses. Myofibroblast differentiation and extracellular matrix (ECM) accumulation are involved in the pathogenesis of nasal polyposis. Epigenetics, DNA methylation, and chromatin modifications are critical for generating cellular diversity and for maintaining distinct gene expression profiles. Based on our recent study that evaluated the inhibitory effect of Trichostatin A on myofibroblast differentiation in nasal polyposis, we hypothesized that HDAC inhibition is associated with myofibroblast differentiation and extracellular matrix accumulation in nasal polyposis and suggested that Trischostatin A may be useful as an inhibitor of nasal polyp growth and thus has potential to be used as a novel treatment option for nasal polyposis. In this review, we present general concept of epigenetics and results of recent research that elucidate the role of epigenetics in the pathogenesis of nasal polyps.

      • KCI등재후보

        예술과 경제

        박일호 현대미술학회 2009 현대미술학 논문집 Vol.1 No.13

        There are two contrary perspectives in approaching the relationship between art and economy. One is a negative point of view that it will only impede creativity, a primary and essential function of arts and culture, to apply an economical logic to them and operate arts organizations pursuing a concept of administrative efficiencies. The other is a supportive opinion that there is no reason for the arts and cultural organizations to make an exception and should follow the general trend of rational and efficient operation since they are run by public funds of taxpayer's precious money. This thesis takes a side of the latter, saying it is time for the arts and cultural organizations to grope for more effective operational schemes. In this perspective, it will examine reciprocal relationship between art and economy, focusing on the features of that relationship as well. And it will further scrutinize the relationship by dividing it into a few areas that needs a particular attention in the context of the relationship between art and economy. Can public support for the arts be justified? The thesis examines the economical effects on society of the arts and takes some instances of analyzing phenomena related to artistic activities, groping for the efficient managerial schemes for the arts and cultural organizations. As a conclusion, it will try to explain that the quests for an operational efficiency are needs of the times by taking an example of R. Krauss' emphasis on industrialization of the museum in the late capitalism. Meanwhile, in the conclusion, I point out that economic principle and an idea of efficiency should not become an absolute criterion for the arts and culture, but an useful reference as an way for the arts and cultural organizations to avoid a chronic deficit and emerge from financial sufferings. It is in the context that it is not desirable to focus only on the economical effects and GDP on which the arts can bring an impact, ignoring the inherent value of it. There are two contrary perspectives in approaching the relationship between art and economy. One is a negative point of view that it will only impede creativity, a primary and essential function of arts and culture, to apply an economical logic to them and operate arts organizations pursuing a concept of administrative efficiencies. The other is a supportive opinion that there is no reason for the arts and cultural organizations to make an exception and should follow the general trend of rational and efficient operation since they are run by public funds of taxpayer's precious money. This thesis takes a side of the latter, saying it is time for the arts and cultural organizations to grope for more effective operational schemes. In this perspective, it will examine reciprocal relationship between art and economy, focusing on the features of that relationship as well. And it will further scrutinize the relationship by dividing it into a few areas that needs a particular attention in the context of the relationship between art and economy. Can public support for the arts be justified? The thesis examines the economical effects on society of the arts and takes some instances of analyzing phenomena related to artistic activities, groping for the efficient managerial schemes for the arts and cultural organizations. As a conclusion, it will try to explain that the quests for an operational efficiency are needs of the times by taking an example of R. Krauss' emphasis on industrialization of the museum in the late capitalism. Meanwhile, in the conclusion, I point out that economic principle and an idea of efficiency should not become an absolute criterion for the arts and culture, but an useful reference as an way for the arts and cultural organizations to avoid a chronic deficit and emerge from financial sufferings. It is in the context that it is not desirable to focus only on the economical effects and GDP on which the arts can bring an impact, ignoring the inherent value of it.

      • KCI등재
      • KCI등재

        원초적 확률주의와 베이즈 인수

        박일호,Park, Il-Ho 한국논리학회 2008 論理硏究 Vol.11 No.2

        원초적 확률주의자들은 명제가 경험을 표상한다는 것을 거부한다. 그러나 경험의 영향은 다른 믿음에 전파되고, 다른 사람과 소통될 수 있어야 하기 때문에 명제와 다른 방식으로 경험, 혹은 경험의 영향을 표상할 수 있는 대안을 찾아야 한다. 그들이 제안하는 경험의 영향을 표상하는 유력한 대안은 베이즈 인수이다. 왜냐하면 베이즈 인수는 사전확률의 영향을 제외하고 있으며, 교환성 역시 성립하기 때문이다. 본 논문은 베이즈 인수만이 그런 역할을 하는 것이 아니라고 주장한다. 즉 베이즈 인수의 대안으로 제시된 q(E|$N_p$) 역시 사전확률의 영향이 제외되어 있으며, 교환성 또한 성립한다는 것을 보인다. 그리고 더 나아가 q(E|$N_p$)는 베이즈 인수가 결여한 프래그마틱한 장점을 가진다고 주장한다. The radical probabilitists deny that propositions represent experience. However, since the impact of experience should be propagated through our belief system and be communicated with other agents, they should find some alternative protocols which can represent the impact of experience. The useful protocol which the radical probabilistists suggest is the Bayes factors. It is because Bayes factors factor out the impact of the prior probabilities and satisfy the requirement of commutativity. My main challenge to the radical probabilitists is that there is another useful protocol, q(E|$N_p$) which also factors out the impact of the prior probabilities and satisfies the requirement of commutativity. Moreover I claim that q(E|$N_p$) has a pragmatic virtue which the Bayes factors have not.

      • KCI등재
      • KCI등재
      • KCI등재

        논문 : 부분적 믿음 갱신과 조건화

        박일호 한국과학철학회 2013 과학철학 Vol.16 No.1

        이 논문은 베이즈주의 믿음 갱신 규칙, 그 중에서 제프리 조건화의 적용 범위를 확장하는 것을 목표한다. 특히 필자는 그 동안 제프리 조건화의 적용 범위 밖에 있다고 여겨졌던 부분적 믿음 갱신이 제프리 조건화를 통해서 다루어 질 수 있다는 것을 논증한다. 이를 위해서 2절에서는 부분적 믿음 갱신과 관련된 몇가지 정의와 그에 맞는 부분적 믿음 갱신 사례를 제시할 것이다. 그리고 3절에서 JC와 부분적 믿음 갱신 사이의 관계를 설명할 것이다. 특히, JC를 이용한 단일 믿음 갱신으로는 부분적 믿음 갱신을 다룰 수 없다는 것이 증명된다. 마지막 4절에서 필자는 부분적 믿음 갱신에 JC를 적용할 수 있는 방안을 모색한다. 필자는 우선 부분적 믿음 갱신이 증거적 믿음 갱신과 교정적 믿음 갱신으로 구성된 연속적 믿음 갱신으로 간주될 수 있다는 것을 논증하며, 이를 바탕으로 부분적 믿음 갱신을 다룰 수 있는 제프리 규칙을 제안한다.

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