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Hiroshi Matsumura,Norikazu Kinoshita,Hiroshi Iwase,Akihiro Toyoda,Yoshimi Kasugai,Norihiro Matsuda,Yukio Sakamoto,Hiroshi Nakashima,Hiroshi Yashima,Nikolai Mokhov,Anthony Leveling,David Boehnlein,Kamr 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
In an antiproton production (Pbar) target station of the Fermi National Accelerator Laboratory (FNAL), the secondary particles produced by bombarding a target with 120-GeV protons are shielded by a thick iron shield. In order to obtain experimental data on high-energy neutron transport at more than 100-GeV-proton accelerator facilities, we indirectly measured more than 100-MeV neutrons at the outside of the iron shield at an angle of 50˚ in the Pbar target station. The measurement was performed by using the Au activation method coupled with a low-background γ-ray counting system. As an indicator for the neutron flux, we determined the production rates of 8 spallation nuclides (^(196)Au, ^(188)Pt, ^(189)Ir, ^(185)Os, ^(175)Hf, ^(173)Lu, ^(171)Lu, and ^(169)Yb) in the Au activation detector. The measured production rates were compared with the theoretical production rates calculated using PHITS. We proved that the Au activation method can serve as a powerful tool for indirect measurements of more than100-MeV neutrons that play a vital role in neutron transport. These results will be important for clarifying the problems in theoretical calculations of high-energy neutron transport.
Hiroshi Yashima,Norihiro Matsuda,Yoshimi Kasugai,Hiroshi Nakashima,Yukio Sakamoto,Hiroshi Matsumura,Hiroshi Iwase,Norikazu Kinoshita,David Boehnlein,Gary Lautenschlager,Anthony Leveling,Nikolai Mokhov 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The JASMIN Collaboration has performed an experiment to conduct measurements of nuclear reaction rates around the anti-proton production (Pbar) target at the Fermi National Accelerator Laboratory (FNAL). At the Pbar target station, the target, consisting an Inconel 600 cylinder, was irradiated by a 120 GeV/c proton beam from the FNAL Main Injector. The beam intensity was 3.6 X 10^(12) protons per second. Samples of Al, Nb, Cu, and Au were placed near the target to investigate the spatial and energy distribution of secondary particles emitted from it. After irradiation, the induced activities of the samples were measured by studying their gamma ray spectra using HPGe detectors. The production rates of 30 nuclides induced in Al, Nb, Cu, Au samples were obtained. These rates increase for samples placed in a forward (small angle) position relative to the target. The angular dependence of these reaction rates becomes larger for increasing threshold energy. These experimental results are compared with Monte Carlo calculations. The calculated results generally agree with the experimental results to within a factor of 2 to 3.
Hiroshi Asano,Katsutoshi Oda,Kosuke Yoshihara,Yoichi M Ito,Noriomi Matsumura,Muneaki Shimada,Hidemichi Watari,Takayuki Enomoto 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.4
Background: Poly (adenosine diphosphate)-ribose polymerase (PARP) inhibitors for tumors with homologous recombination deficiency (HRD), including pathogenic mutationsin , have been developed. Genomic analysis revealed that about 20% of uterine leiomyosarcoma (uLMS) have HRD, including 7.5%–10% of alterations and 4%–6% of carcinomas of the uterine corpus, and 2.5%–4% of the uterine cervix have alterations of. Preclinical and clinical case reports suggest that PARP inhibitors may be effective against those targets. The Japanese Gynecologic Oncology Group (JGOG) is now planning to conduct a new investigator-initiated clinical trial, JGOG2052. Methods: JGOG2052 is a single-arm, open-label, multi-center, phase 2 clinical trial to evaluate the efficacy and safety of niraparib monotherapy for a recurrent or persistent rare fraction of gynecologic malignancies with mutations except for ovarian cancers. We will independently consider the effect of niraparib for uLMS or other gynecologic malignancies with mutations (cohort A, C) and HRD positive uLMS without mutations (cohort B). Participants must have 1–3 lines of previous chemotherapy and at least one measurable lesion according to RECIST (v.1.1). Niraparib will be orally administered once a day until lesion exacerbation or unacceptable adverse events occur. Efficacy will be evaluated by imaging through an additional computed tomography scan every 8 weeks. Safety will be measured weekly in cycle 1 and every 4 weeks after cycle 2 by blood tests and physical examinations. The sample size is 16–20 in each of cohort A and B, and 31 in cohort C. Primary endpoint is the objective response rate.
Masumoto, Kazuyoshi,Matsumura, Hiroshi,Kosako, Kazuaki,Bessho, Kotaro,Toyoda, Akihiro The Korean Association for Radiation Protection 2016 방사선방어학회지 Vol.41 No.3
Background: Activation of air and water in the electron linear accelerator for medical use has not been considered severely. By the new Japanese regulation for protection of radiation hazard, it became indispensable to evaluate of activation of air and water in the accelerator room. The measurement of induced activity in air and water components in the electron energy region of 10 to 20 MeV is very difficult, because this energy region is close to the threshold energy region of photonuclear reactions. Then, we measured the photonuclear reaction yields of $^{13}N$, $^{15}O$, and $^{11}C$ by using the electron linear accelerator. Obtained data were compared with the data calculated by the Monte Carlo method. Materials and Methods: An activation experiment was performed at the Research Center for Electron Photon Science, Tohoku University. Highly purified $SiO_2$, $Si_3N_4$, and carbon disks were irradiated for 10 minutes by bremsstrahlung converted by a tungsten plate. Induced activity from C, N, and O was obtained. Monte Carlo calculation was performed using MCNP5 and AERY (DCHAIN-SP) to simulate the experimental condition. Cross section data were adopted the KAERI dataset. Results and Discussion: In our experiment in hospital, calculated values were not agreed with experimental values. It might be three possible reasons as the cause of this deference, such as irradiation energy, calculation procedure and cross section data. Obtained data of this work, calculated and experimental values were good agreement with each other within one order. In this work, we used KAERI dataset of photonuclear reaction instead of JENDL. Therefore, it was found that the photonuclear cross section data of light elements are most important for yield calculation in these reactions. Conclusion: Further improvement for calculation using a new dataset JENDL/PD-2015 and considering electron energy spreading will be needed.
Norio Yasui-Furukori,Hiroshi Murakami,Hideyuki Otaka,Jutaro Tanabe,Miyuki Yanagimachi,Masaya Murabayashi,Koki Matsumura,Yuki Matsuhashi,Hirofumi Nakayama 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.1
Objective: Glycemic control varies based on lifestyle factors and stress coping mechanisms, which are influenced by personality. The psychological factors associated with glycemic control have not yet been established in patients with type 2 diabetes mellitus (T2DM). The relationship between a 5-factor model of personality and glycemic control was evaluated in individuals with T2DM. Methods: The subjects were 503 Japanese outpatients with T2DM. Glycated hemoglobin A1c (HbA1c) levels, depressive status, insomnia and personality traits were assessed. Lifestyle factors of the patients, such as habitual alcohol consumption and smoking, were also included in the analyses. ResultsBecause the influence of insulin therapy on HbA1c is so strong, we stratified the patients according to : insulin use. Simple regression analysis showed a significant correlation between HbA1c and neuroticism in patients who did not use insulin. After adjustment for confounders, multiple regression analyses revealed that none of the personality factors, including neuroticism, were found to be associated with HbA1c. Conclusion: These findings suggest that personality traits do not have a large impact on glycemic control. Further studies are required to confirm the relationships between psychological factors and glycemic control using a longitudinal study design.
Masahiro Nakamura,Takeshi Yanagita,Tatsushi Matsumura,Takashi Yamashiro,Seiji Iida,Hiroshi Kamioka 대한치과교정학회 2016 대한치과교정학회지 Vol.46 No.6
We report a case involving a young female patient with severe mandibular retrognathism accompanied by mandibular condylar deformity that was effectively treated with Le Fort I osteotomy and two genioplasty procedures. At 9 years and 9 months of age, she was diagnosed with Angle Class III malocclusion, a skeletal Class II jaw relationship, an anterior crossbite, congenital absence of some teeth, and a left-sided cleft lip and palate. Although the anterior crossbite and narrow maxillary arch were corrected by interceptive orthodontic treatment, severe mandibular hypogrowth resulted in unexpectedly severe mandibular retrognathism after growth completion. Moreover, bilateral condylar deformities were observed, and we suspected progressive condylar resorption (PCR). There was a high risk of further condylar resorption with mandibular advancement surgery; therefore, Le Fort I osteotomy with two genioplasty procedures was performed to achieve counterclockwise rotation of the mandible and avoid ingravescence of the condylar deformities. The total duration of active treatment was 42 months. The maxilla was impacted by 7.0 mm and 5.0 mm in the incisor and molar regions, respectively, while the pogonion was advanced by 18.0 mm. This significantly resolved both skeletal disharmony and malocclusion. Furthermore, the hyoid bone was advanced, the pharyngeal airway space was increased, and the morphology of the mandibular condyle was maintained. At the 30-month follow-up examination, the patient exhibited a satisfactory facial profile. The findings from our case suggest that severe mandibular retrognathism with condylar deformities can be effectively treated without surgical mandibular advancement, thus decreasing the risk of PCR.