Proximity Effect Correction by Pattern Modified Stencil Mask in Large Field Projection Electron-Beam Lithography

Hideo Kobinata,Hiroshi Yamashita,Eiichi Nomura,Hiroshi Nozue 대한전자공학회 1998 International Conference on Electronics, Informati Vol.- No.-

Kinetics of Morphological Transition from Lamella to Cylinder in Polystyrene-block-poly(ethylene-co-but-1-ene)-block-polystyrene Triblock Copolymer

Hideo Umeda,Shinichi Sakurai,Shunji Nomura 한국고분자학회 1999 한국고분자학회 학술대회 연구논문 초록집 Vol.24 No.2

Impact of Tumor Location on the Quality of Life of Patients Undergoing Total or Proximal Gastrectomy

Fujisaki Muneharu,Nomura Takashi,Yamashita Hiroharu,Uenosono Yoshikazu,Fukunaga Tetsu,Otsuji Eigo,Takahashi Masahiro,Matsumoto Hideo,Oshio Atsushi,Nakada Koji 대한위암학회 2022 Journal of gastric cancer Vol.22 No.3

Purpose Most studies have investigated the differences in postgastrectomy quality of life (QOL) based on the surgical procedure or reconstruction method adopted; only a few studies have compared QOL based on tumor location. This large-scale study aims to investigate the differences in QOL between patients with esophagogastric junction cancer (EGJC) and those with upper third gastric cancer (UGC) undergoing the same gastrectomy procedure to evaluate the impact of tumor location on postoperative QOL. Methods The Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45) questionnaire was distributed in 70 institutions to 2,364 patients who underwent gastrectomy for EGJC or UGC. A total of 1,909 patients were eligible for the study, and 1,744 patients who underwent total gastrectomy (TG) or proximal gastrectomy (PG) were selected for the final analysis. These patients were divided into EGJC and UGC groups; thereafter, the PGSAS-45 main outcome measures (MOMs) were compared between the two groups for each type of gastrectomy. Results Among the post-TG patients, only one MOM was significantly better in the UGC group than in the EGJC group. Conversely, among the post-PG patients, postoperative QOL was significantly better in 6 out of 19 MOMs in the UGC group than in the EGJC group. Conclusions Tumor location had a minimal effect on the postoperative QOL of post-TG patients, whereas among post-PG patients, there were definite differences in postoperative QOL between the two groups. It seems reasonable to conservatively estimate the benefits of PG in patients with EGJC compared to those in patients with UGC. Purpose Most studies have investigated the differences in postgastrectomy quality of life (QOL) based on the surgical procedure or reconstruction method adopted; only a few studies have compared QOL based on tumor location. This large-scale study aims to investigate the differences in QOL between patients with esophagogastric junction cancer (EGJC) and those with upper third gastric cancer (UGC) undergoing the same gastrectomy procedure to evaluate the impact of tumor location on postoperative QOL. Methods The Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45) questionnaire was distributed in 70 institutions to 2,364 patients who underwent gastrectomy for EGJC or UGC. A total of 1,909 patients were eligible for the study, and 1,744 patients who underwent total gastrectomy (TG) or proximal gastrectomy (PG) were selected for the final analysis. These patients were divided into EGJC and UGC groups; thereafter, the PGSAS-45 main outcome measures (MOMs) were compared between the two groups for each type of gastrectomy. Results Among the post-TG patients, only one MOM was significantly better in the UGC group than in the EGJC group. Conversely, among the post-PG patients, postoperative QOL was significantly better in 6 out of 19 MOMs in the UGC group than in the EGJC group. Conclusions Tumor location had a minimal effect on the postoperative QOL of post-TG patients, whereas among post-PG patients, there were definite differences in postoperative QOL between the two groups. It seems reasonable to conservatively estimate the benefits of PG in patients with EGJC compared to those in patients with UGC.

Improved β-glucan Yield Using an Aureobasidium pullulans M-2 Mutant Strain in a 200-L Pilot Scale Fermentor Targeting Industrial Mass Production

Naoyuki Moriya,Yukiko Moriya,Hideo Nomura,Kisato Kusano,Yukoh Asada,Hirofumi Uchiyama,Enoch Y. Park,Mitsuyasu Okabe 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.6

β-(1→3)-D-glucans with β-(1→6)-glycosidiclinked branches are known to be immune activation agentsand are incorporated in anti-cancer drugs and healthpromotingsupplements. β-Glucan concentration was 9.2 g/Lin a 200-L pilot scale fermentor using mutant strainAureobasidium pullulans M-2 from an imperfect fungalstrain belonging to A. pullulans M-1. The culture broth ofA. pullulans M-2 had a faint yellow color, whereas that ofthe wild-type had an intense dark green color caused by theaccumulation of melanin-like pigments. β-Glucan producedby A. pullulans M-2 was identified as a polysaccharide ofD-glucose monomers linked by β-(1→3, 1→6)-glycosidicbonds through GC/MS and NMR analysis. When aconventional medium was used in the culture of A. pullulansM-2 in a 3-L jar fermentor, β-glucan concentration was1.4-fold that produced by the wild-type. However, when amedium optimized by statistical experimental design wasused with dissolved oxygen at 10%, the β-glucan concentrationwas 9.9 g/L with a yield of 0.52 (g β-glucan/g consumedsucrose), 2.9-fold that of the wild-type. This level ofproductivity was reproduced when the fermentation wasscaled up 200-L. The industrial production of high β-glucan without melanin-like pigments is highly expected,as a health-promoting supplement or functional food.

Photofield-Effect in Amorphous In-Ga-Zn-O (a-IGZO) Thin-Film Transistors

Tze-Ching Fung,Chiao-Shun Chuangc,Kenji Nomura,Han-Ping David Shieh,Hideo Hosono,Jerzy Kanicki 한국정보디스플레이학회 2008 Journal of information display Vol.9 No.4

We studied both the wavelength and intensity dependent photo-responses (photofield-effect) in amorphous In-Ga-Zn-O (a-IGZO) thin-film transistors (TFTs). During the a-IGZO TFT illumination with the wavelength range from 460~660 nm (visible range), the off-state drain current (IDS_off) only slightly increased while a large increase was observed for the wavelength below 400 nm. The observed results are consistent with the optical gap of ~3.05eV extracted from the absorption measurement. The a-IGZO TFT properties under monochromatic illumination (λ=420nm) with different intensity was also investigated and IDS_off was found to increase with the light intensity. Throughout the study, the field-effect mobility (μeff) is almost unchanged. But due to photo-generated charge trapping, a negative threshold voltage (Vth) shift is observed. The mathematical analysis of the photofield-effect suggests that a highly efficient UV photocurrent conversion process in TFT off-region takes place. Finally, a-IGZO mid-gap density-of-states (DOS) was extracted and is more than an order of magnitude lower than reported value for hydrogenated amorphous silicon (a-Si:H), which can explain a good switching properties observed for a-IGZO TFTs.

Photofield-Effect in Amorphous In-Ga-Zn-O (a-IGZO) Thin-Film Transistors

Fung, Tze-Ching,Chuang, Chiao-Shun,Nomura, Kenji,Shieh, Han-Ping David,Hosono, Hideo,Kanicki, Jerzy The Korean Infomation Display Society 2008 Journal of information display Vol.9 No.4

We studied both the wavelength and intensity dependent photo-responses (photofield-effect) in amorphous In-Ga-Zn-O (a-IGZO) thin-film transistors (TFTs). During the a-IGZO TFT illumination with the wavelength range from $460\sim660$ nm (visible range), the off-state drain current $(I_{DS_off})$ only slightly increased while a large increase was observed for the wavelength below 400 nm. The observed results are consistent with the optical gap of $\sim$3.05eV extracted from the absorption measurement. The a-IGZO TFT properties under monochromatic illumination ($\lambda$=420nm) with different intensity was also investigated and $I_{DS_off}$ was found to increase with the light intensity. Throughout the study, the field-effect mobility $(\mu_{eff})$ is almost unchanged. But due to photo-generated charge trapping, a negative threshold voltage $(V_{th})$ shift is observed. The mathematical analysis of the photofield-effect suggests that a highly efficient UV photocurrent conversion process in TFT off-region takes place. Finally, a-IGZO mid-gap density-of-states (DOS) was extracted and is more than an order of magnitude lower than reported value for hydrogenated amorphous silicon (a-Si:H), which can explain a good switching properties observed for a-IGZO TFTs.

The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice

Goto, Tsuyoshi,Hirata, Mariko,Aoki, Yumeko,Iwase, Mari,Takahashi, Haruya,Kim, Minji,Li, Yongjia,Jheng, Huei-Fen,Nomura, Wataru,Takahashi, Nobuyuki,Kim, Chu-Sook,Yu, Rina,Seno, Shigeto,Matsuda, Hideo,A American Society for Biochemistry and Molecular Bi 2017 The Journal of biological chemistry Vol.292 No.22

<P>Obesity causes excess fat accumulation in white adipose tissues (WAT) and also in other insulin-responsive organs such as the skeletal muscle, increasing the risk for insulin resistance, which can lead to obesity-related metabolic disorders. Peroxisome proliferator-activated receptor-alpha (PPAR alpha) is a master regulator of fatty acid oxidation whose activator is known to improve hyperlipidemia. However, the molecular mechanisms underlying PPAR alpha activator-mediated reduction in adiposity and improvement of metabolic disorders are largely unknown. In this study we investigated the effects of PPAR alpha agonist (fenofibrate) on glucose metabolism dysfunction in obese mice. Fenofibrate treatment reduced adiposity and attenuated obesity-induced dysfunctions of glucose metabolism in obese mice fed a high-fat diet. However, fenofibrate treatment did not improve glucose metabolism in lipodystrophic A-Zip/F1 mice, suggesting that adipose tissue is important for the fenofibrate-mediated amelioration of glucose metabolism, although skeletal muscle actions could not be completely excluded. Moreover, we investigated the role of the hepatokine fibroblast growth factor 21 (FGF21), which regulates energy metabolism in adipose tissue. In WAT of WT mice, but not of FGF21-deficient mice, fenofibrate enhanced the expression of genes related to brown adipocyte functions, such as Ucp1, Pgc1a, and Cpt1b. Fenofibrate increased energy expenditure and attenuated obesity, whole body insulin resistance, and adipocyte dysfunctions in WAT in high-fat-diet-fed WT mice but not in FGF21-defi-the fenofibrate-mediated improvement of whole body glucose metabolism in obese mice via the amelioration of WAT dysfunctions.</P>