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( Hee Jun Cho ),( Byung Moo Oh ),( Jong-tae Kim ),( Jeewon Lim ),( Sang Yoon Park ),( Yo Sep Hwang ),( Kyoung Eun Baek ),( Bo-yeon Kim ),( Inpyo Choi ),( Hee Gu Lee ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.2
Interleukin-21 is a common γ-chain cytokine that controls the immune responses of B cells, T cells, and natural killer cells. Targeting IL-21 to strengthen the immune system is promising for the development of vaccines as well as anti-infection and anti-tumor therapies. However, the practical application of IL-21 is limited by the high production cost. In this study, we improved IL-21 production by codon optimization and selection of appropriate signal peptide in CHO-K1 cells. Codon-optimized or non-optimized human IL-21 was stably transfected into CHO-K1 cells. IL-21 expression was 10-fold higher for codon-optimized than non-optimized IL-21. We fused five different signal peptides to codon-optimized mature IL-21 and evaluated their effect on IL-21 production. The best result (a 3-fold increase) was obtained using a signal peptide derived from human azurocidin. Furthermore, codon-optimized IL-21 containing the azurocidin signal peptide promoted IFN-γ secretion and STAT3 phosphorylation in NK-92 cells similar to codon-optimized IL-21 containing original signal peptide. Collectively, these results indicate that codon optimization and azurocidin signal peptides provide an efficient approach for the high-level production of IL-21 as a biopharmaceutical.
조인숙,이해혁,김태희,이권해,남계현,이임순,김정식,박성진 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Pelvic inflammatory disease (PID) is a disease that affects young, sexually active, reproductive age women. Most pathogens are Chlamydia trachomatis and Neisseria Gonorrheae transmitted sexually. One of serious acute complication of PID is tubo-ovarian abscess (TOA) that involves the fallopian tube, ovary and adjacent structures (eg, bowel, pelvic peritoneum). The microbiology of TOAs is polymicrobial with anaerobic organisms and causal organisms of PID. Common anaerobic organisms are Peptostretococcus spp, Bacteriodes spp, Prevotella spp, Escherichia coli and aerobic streptococci. Treatment is necessary to admission for intravenous broad-spectrum antibiotics and surgery is often reserved for patients with suspected rupture or patients who fail to respond to antibiotics. So, we reported this case found pelvic abscess due to ruptured tube-ovarian abscess.
조철희,류태용,박광용 한국공업화학회 2004 응용화학 Vol.8 No.2
Stilbene derivatives, which are of great interests due to their potent biological and optical activities (e.g. using emitting materials in OELD's and non-linear optical (NLO) materials), were produced via the nickel-catalyzed cross-coupling reactions of polymer-bound stilbenesulfonates with aryl Grignard reagents employing solid-phase organic synthesis (SPOS). This traceless method would be useful for preparing unfunctionalized arene library in solid-phase parallel synthesis.
조인숙,김태의,김정식,이해혁,이권해,김희경,남계현 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
A case of omental mass during Pregnancy Omental cyst is a rare lesion and occur primarily during childhood and young adulthood. When encountered, most of them are benign and intraabdominal masses. It shows a large mass but not palpable and often asymptomatic. The precise diagnosis is made by most commonly at surgery or during pathologic examination. So, we report this case with brief review of literatures.
경정맥 신우조영술중 파열된 자궁의 악성혼합뮬러리안 종양 1예
조희정,김태희,김정식,이해혁,남계현,김희경 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
The Malignant Mixed Mullerian Tumor(MMMT) of uterus, a biphasic malignant tumor composed of both epithelial and stromal component, is rare but very aggressive and generally lethal. Most of these tumors arise spontaneously in the sixth to eighth decade of life, but certain proportions are known to be occurred in women, who had received pelvic irradiation. But, the precise role of irradiation in the genesis of uterine neoplasia remains uncertain. We experienced a case of MMMT of uterus which ruptured during intravenous pyelogram and she had received pelvic irradiation 40years ago.
조태경,송인명,권영준,이희복 공주대학교 사범대학 과학교육연구소 1994 과학교육연구 Vol.25 No.1
물질의 결정구조를 연구하는 데에는 일반적으로 X-선 회절상의 분석방법을 가장 많이 사용한다. 따라서 대학교육과정에서 고체물리학, 결정학, 재료과학 등 여러 분야에서 X-선 분광법에 대하여 공부한다. 그러나 실제 강의에서 X-선 회절의 이론을 X-선 회절상의 분석 방법과 직접 대응시켜 설명하기란 쉽지 않다. 본 논문은 MathCAD란는 software을 써서 X-선 회절 이론식으로 부터 간단하게 원하는 결정의 X-선 회절상을 계산하는 방법을 제시하고, X-선 결정구조 분석에 관한 학습과 연구에 활용할 수 있는 자료가 되도록 하였다. The most available technique for the study of the crystal structure is the analysis of X-ray diffraction patterns. For this reason lectures on X-ray diffractions have been given at universities in various subjects such as solid state physics, crystallography, material science, etc. However, it is not easy to teach the theory of X-ray diffraction in conjunction with the analysis X-ray diffraction patterns. In this study, we have used MathCAD software to calculate angles, intensities, and patterns of the X-ray diffraction of crystal using formula given in the theory without any complication. The program has shown in the study will be useful for research on crystallography as well as for teaching the subject.
조태희,최경규,박상혁,박상진 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.3
The objectiveness of this study was to evaluate whether low-viscosity composite can bond effectively to dentin surface without bonding resin. The low-viscosity composites being 50wt% filler content were made by the inclusion of bonding resin of two self-etching systems(Clearfil SE Bond, Unifil Bond) varied with contents as 0, 10, 20, 30, 40, 50wt%. Exposed dentin surfaces of extracted 3rd molars are used. Dentin bond strengths were measured. The tests were carried out with a micro-shear device placed testing machine at a CHS of 1mm/min after a low-viscosity composite was filled into an iris cut from micro tygon tubind with internal diameter approximately 0.8mm and height of 1.0mm. 1. Flexural strength and modulus was increased with the addition of bonding resin. 2. Micro-shear bond strength to dentin was improved according to content of bonding resin irrespective of applying or not bonding resin in bonding procedure, and that of Clearfil SE Bond groups was higher than Unifil Bond. 3. There were no significant difference whether use of each bonding resin in bonding procedure for S-40, S-50, U-50(p>0.05). 4. In SEM examination, resin was well infiltrated into dentin after primed with self-etching primer only for S-50 and U-50 in spite of the formation of thinner hybrid layer. Low viscosity composite including some functional monomer may be used as dentin bonding resin without an intermediary bonding agent. It makes a simplified bonding procedure and foresees the possibility of self-adhesive restorative material.
한글 텍스트에서의 효율적인 스트링 매칭 알고리즘에 관한 연구
조희열,양태천 慶星大學校 1995 論文集 Vol.16 No.2
In they thesis, we study the efficient string matching algorithms for hangul text. There are many the String Matching Algorithms such as the Knuth-Morris-Pratt's Algorithm, the Boyer-Moore's Algorithm, and Rabin-karp's Algorithm. However, no efficient algorithm is know in hangul text. We propose the efficient string matching algorithm in Hangul text by experiments result.