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한국판-Gilliam 자폐증 평정척도-2(K-GARS-2) 표준화 연구
진혜경,윤혜주,박진박 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2
Objectives:Autism is one of the most important developmental disorder of childhood, which has been studied in many fields of research. The importance of early detection, diagnosis and early treatment of autism has been emphasized in Korea. However, appropriate diagnostic tools to meet these needs, were insufficient. With increasing number of autistic adults, a need for diagnostic tool which can cover wide range of age has emerged. The Gilliam Autism Rating Scale-2(GARS-2) is based on Autism Society of America and DSM-IV-TR(Diagnostic and Statistical Manual of Mental Disorders-fourth Edition-Text Revision) diagnostic criteria for autism. It is the only available test so far. The target age of this test is from 3 years to 22 years old with autism, therefore this test is thought to be valuable. In this study, Korean-Gilliam Autism Rating Scale-2(K-GARS-2) was standardized, and verified the reliability, validity. Methods:K-GARS-2 was standardized and the reliability, validity was evaluated for 109 patients with autism aged 3 to 22 years. Results:Cronbach’s alpha coefficient of K-GARS-2 is 0.94 in the total 42 items and reliability was verified. KGARS-2 standard scores were highly correlated with scores of CARS and also Items-discrimination coefficients also showed a high correlation. Autism subscale standard score and the Autism quotient also showed a strong correlation. When compared with the other mental disorder groups, autism group show significantly higher scores. Conclusion:With the increasing prevalence of autism, the importance of accurate diagnosis and therapeutic approach is increasing in Korea. In this perspective, K-GARS-2 standardization process is very meaningful.
범가자미, Verasper variegatus의 난황단백질 분리 및 면역학적 특성
백혜자,한창희,김우진,박중연,김진한,김윤 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1
The yolk protein of spotted flounder, Verasper variegatus was purified by precipitation with cold distilled water, followed by Sepharose CL-6B column chromatography. The purified protein was identified as vitellin by Ouchterlony's immunodiffusion test and immunoelectrophoresis. The purified vitellin from ovarian crude extracts has same antigenic determinants with the female specific serum protein, vitellogenin. The molecular weight of purified vitellin was estimated about 550kD by gel filtration. The vitellin was composed of three major subunits with molecular weight of about 108, 85 and 31 kD, and two minor subunits. The vitellin was identified by western blot analysis using anti-vitellin antibody.
윤혜진 ( Hea Jin Yoon ),이성훈 ( Sung Hoon Lee ),고대용 ( Dae Yong Ko ),이용욱 ( Yong Uk Lee ),김영재 ( Young Jae Kim ),김승룡 ( Seung Ryong Kim ),이정한 ( Jung Han Lee ),박문일 ( Moon Il Park ),정성로 ( Sung Ro Chung ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.6
비임신성 웅모 상피암은 매우 드문 질환으로 임신성 융모 상피암에 비하여 화학요법에도 잘 반응하지 않아 예후가 나쁜 것으로 알려져 있다. 따라서 정확한 진단과 적극적인 치료가 요구된다. 저자들은 11세 여아에서 비임신성 순수 난소 융모 상피암을 발견하여 수술 및 복합화학요법 (BEP: bleomycin, etoposied, cisplatin)으로 치료 후 현재까지 무병 생존하고 있는 1예를 경험했기에 문헌 고찰과 함께 보고하는 바이다. Primary ovarian choriocarcinoma is very rare disease. Especially, non-gestational choriocarcinoma of ovary has worse prognosis than gestational tumor. Here, we report a non-gestional pure ovarian choriocarcinoma in 11 years old woman with the review of literature
이혜진 ( Hye Jin Lee ),강병갑 ( Byoung Kab Kang ),김진희 ( Jin Hee Kim ),박혜진 ( Hea Jin Park ),정순대 ( Sun Dae Jeong ),유호룡 ( Ho Ryong Yoo ),김윤식 ( Yoon Sik Kim ),설인찬 ( Ln Chan Seol ),조현경 ( Hyun Kyung Jo ) 대전대학교 한의학연구소 2013 혜화의학회지 Vol.21 No.2
Background: Nowadays, increasing women`s socio-economic activities increased the grandmothers raising grandchildren. Because of the contemporary situation, the health problems of the care giving grandparents is becoming an issue. Purpose: The purpose of this study was to examine correlationship between the incidence of stroke and raising grandchildren. Methode: This article contrasts the ratio of recent experience of raising grandchildren of 195 normal and 323 stroke patients, especially women. Result: There were 43.08% of women raising their grandchildren in the normal group while 13.31% of women of stroke patients group were raising their grandchildren before the onset of stroke. Conclusion: The finding suggests the positive effect of raising grandchildren on reducing the risk for stroke.
Transduced PEP-1-Grb7 Fusion Protein Suppressed LPS-induced COX-2 Expression
An, Jae-Jin,Kim, So-Young,Lee, Sun-Hwa,Kim, Dae-Won,Ryu, Hea-Jin,Yeo, Seung-Il,Jang, Sang-Ho,Kwon, Hyung-Joo,Kim, Tae-Yoon,Lee, Sang-Chul,Poo, Ha-Ryoung,Cho, Sung-Woo,Lee, Kil-Soo,Park, Jin-Seu,Eum, W Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.2
Although the incidence and severity of atopic dermatitis (AD) is steadily increasing at an alarming rate, its pathogenic mechanisms remain poorly understood yet. Recently, we found that the expression of Grb7 protein was markedly decreased in AD patients using proteomic analysis. In the present study, human Grb7 gene was fused with PEP-1 peptide in a bacterial expression vector to produce a genetic in-frame PEP-1-Grb7 fusion protein. The expressed and purified PEP-1-Grb7 fusion proteins transduced efficiently into skin cells in a time- and dose-dependent manner when added exogenously in culture media. Once inside the cells, the transduced PEP-1-Grb7 protein was stable for 48 h. In addition, transduced PEP-1-Grb7 fusion protein markedly increased cell viability in macrophage RAW 264.7 cells treated with LPS by inhibition of the COX-2 expression level. These results suggest that the PEP-1-Grb7 fusion protein can be used in protein therapy for inflammatory skin disorders, including AD.