Role of Salivary Immune Parameters in Patients With Primary Sjögren’s Syndrome

Yu-Hung Hung,Yung-Hung Lee,Pei-Pei Chen,Yuan-Zhao Lin,Chia-Hui Lin,Jeng-Hsien Yen 대한진단검사의학회 2019 Annals of Laboratory Medicine Vol.39 No.1

Background: Several factors, including clinical manifestations and laboratory data, have been used to evaluate the disease activity of Sjögren’s syndrome (SS). We investigated saliva indicators of disease activity in primary SS patients. Methods: We enrolled 138 Taiwanese patients with primary SS and 100 Taiwanese normal controls. Interleukin (IL)-6, IL-17A, tumor necrosis factor-alpha (TNF-α), and rheumatoid factor (RF)-IgA levels in saliva samples were measured using ELISA or fluorescent enzyme-linked immunoassay. Serum IgG, IgA, and IgM levels were measured by nephelometry. Erythrocyte sedimentation rate (ESR) was measured with an automatic ESR analyzer. The t-test and Pearson correlation test were used. Results: IL-6 level was higher in primary SS patients than in normal controls (14.23±14.77 vs 9.87±7.32, P=0.012), but there were no significant differences in IL-17A, TNF-α, and RF-IgA levels. In primary SS patients, IL-6 level correlated weakly with ESR and IgG levels (r=0.252, P=0.015, and r=0.248, P=0.017, respectively), and TNF-α level correlated weakly with IgG level (r=0.231, P=0.024). Conclusions: IL-6 may play a role in SS pathogenesis. Saliva IL-6 might be an indicator of disease activity in primary SS patients.

Optimal Dynamic Asset Allocation with Capital Gains Taxes and Stochastic Volatility

Yuan Hung Hsuku 한국증권학회 2008 한국증권학회지 Vol.37 No.1

Apoptotic effects of 1,5-bis-(5-nitro-2-furanyl)-1,4-pentadien-3- one on Drosophila SL2 cells

Yuan-Hang Ren,Hong Jin,Ke Tao,Tai-Ping Hou 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.2

n recent years, concerns over the potential impact of synthetic pesticides on the environment have promoted the research and development of environmentally friendly “green” pesticides. In the current study, we utilized a green biomimetic insecticide, 1,5-bis- (5-nitro-2-furanyl)-1,4-pentadien-3-one (compound C), to examine its cytotoxicity on an insect cell line, Drosophila melanogaster (SL2). Results from MTT assay showed cells treated with 100 μM of compound C for 48 h significantly inhibited the growth of SL2 cells by 87.71±0.96%. We subsequently attempted to illustrate the act on mechanism of compound C at the cellular level and found that it initiated apoptosis through a mitochondrial-dependent mechanism that increased the activity of caspase-3 and altered the cell cycle. These results suggest that the green biomimetic insecticide, compound C, is a novel and potent inducer of insect cell apoptosis.

Optimal Dynamic Asset Allocation with Capital Gains Taxes and Stochastic Volatility

Yuan Hung Hsuku 한국증권학회 2008 Asia-Pacific Journal of Financial Studies Vol.37 No.1

Research on the Impact of Calling on Subjective Career Success: The Mediating Effect of Job Engagement and the Moderating Effect of Self-Efficacy

Hang-Yuan Guo,Soo-Jin Chung 한국무역연구원 2021 무역연구 Vol.17 No.3

Purpose Targeting China’s in-service staff and considering the influence of calling on subjective career success, this research aims to further understand the mediating role of job engagement and the moderating role of self-efficacy. It expects to arouse organizations’ more attention to the whole process of innovation and stimulate the maximum creativity of employees. Design/Methodology/Approach Based on the previous research, this research applies mature scales to devise a suitable questionnaire. Also, questionnaire survey method is adopted to collect data from Chinese employees. SPSS 23.0 and Amos 23.0 are applied as the statistical analysis tools. Also, In order to verify the validity and reliability, element analysis and reliability analysis were carried out. In order to understand the correlation, the relationship analysis and the regression analysis of the influence relationship were carried out. Findings Calling has a positive impact on subjective career success. Job engagement plays an mediating role in the relationship between calling and subjective career success. Self-efficacy plays a significant moderating role. Research Implications This research is focused on the impact of calling on subjective career success which from the perspective of personal psychology. It can help improve the feeling for personal subjective career success by increasing the degree of job engagement. Organizations must recognize the influence of the guiding force of Calling on the attitude of employees. And pay more attention to the cultivation and exploration of calling. It can enhance the job engagement of employees and improve the feeling about subjective career success. If employees perceive self-efficacy, the chance of success will increase accordingly for their subjective career.

Patient and Clinical Variables Account for Changes in Health-related Quality of Life and Symptom Burden as Treatment Outcomes in Colorectal Cancer: A Longitudinal Study

Hung, Hsiu-Chi,Chien, Tsui-Wei,Tsay, Shiow-Luan,Hang, Hewi-Ming,Liang, Shu-Yuan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Objective: The aim of the current study was to evaluate changes in treatment outcomes in terms of health-related quality of life (HRQoL) and symptom burden at zero, one, three, and six months after an initial diagnosis of colorectal cancer. The demographic and clinical characteristics that account for outcome changes in patients were investigated using a repeated measures framework. Methods and Materials: A cohort study was performed of 134 colorectal cancer patients followed from diagnosis to 6 months post-treatment in Central Taiwan. HRQoL and symptoms were assessed at diagnosis and one, three, and six months thereafter. The Functional Assessment of Cancer Therapy-Colon (FACT-C) questionnaire, VAS pain, and the Memorial Symptom Assessment Scale (MSAS) were used for data collection. A generalized estimating equation (GEE) was applied for statistical analysis. Results: The majority of the patients were male (55%) and married (91.5%). The mean age was 60.4 years (SD = 11.71). Most were diagnosed stage III and IV colorectal cancer (54.5%). All underwent surgery; some also received chemotherapy (CT) or concurrent chemoradiation therapy (CCRT). The results of the GEE showed that overall, the HRQoL, pain, and symptoms of the patients significantly improved over the treatment period. Patients with stage IV disease who had received surgery and CCRT showed the worst HRQoL. Females, patients with comorbidity, and stage IV patients had higher pain scores over time. Female and stage IV patients had more severe physical symptoms, whereas stage II and IV patients had worse psychological symptoms over time. Conclusion: The patients' HRQoL, pain, and symptoms significantly improved over the 6-month treatment period. Certain patient and clinical variables accounted for changes in treatment outcomes regarding HRQoL and symptom burden in colorectal cancer patients.

AUV hull lines optimization with uncertainty parameters based on six sigma reliability design

Yuan hang Hou,Xiao Liang,Xu yang Mu 대한조선학회 2018 International Journal of Naval Architecture and Oc Vol.10 No.4

Autonomous Underwater Vehicle (AUV), which are becoming more and more important in ocean exploitation tasks, needs energy conservation urgently when sailing the complex mission path in long time cruise. As hull lines optimization design becomes the key factor, which closely related with resistance, in AUV preliminary design stage, uncertainty parameters need to be considered seriously. In this research, Myring axial symmetry revolution body with parameterized expression is assumed as AUV hull lines, and its travelling resistance is obtained via modified DATCOM formula. The problems of AUV hull lines design for the minimum travelling resistance with uncertain parameters are studied. Based on reliability-based optimization design technology, Design For Six Sigma (DFSS) for high quality level is conducted, and is proved more reliability for the actual environment disturbance.

Improvement of Electrical Performance of InGaZnO/HfSiO TFTs with 248-nm Excimer Laser Annealing

Hau-Yuan Huang,Shui-Jinn Wang,Chien-Hung Wu,Chien-Yuan Lu 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.5

The influence of 248-nm KrF excimer laser annealing (ELA) with energy density between 0 and 400 mJ/cm2 on the electrical behavior of indium gallium zinc oxide (InGaZnO) thin-film transistors (TFTs) is investigated. The experimental results show that the saturation mobility and subthreshold swing are improved from 12.4 cm2/Vs and 100 mV/dec without ELA to 17.8 cm2/Vs and 75 mV/dec, respectively, by applying a 300 mJ/cm2 laser pulse after the source/drain deposition, while maintaining an almost unchanged turn-off voltage. Such improvements are attributed to the increase in the oxygen vacancies and reduction in the bulk traps in the InGaZnO channel.

AUV hull lines optimization with uncertainty parameters based on six sigma reliability design

Hou, Yuan hang,Liang, Xiao,Mu, Xu yang The Society of Naval Architects of Korea 2018 International Journal of Naval Architecture and Oc Vol.10 No.4

Autonomous Underwater Vehicle (AUV), which are becoming more and more important in ocean exploitation tasks, needs energy conservation urgently when sailing the complex mission path in long time cruise. As hull lines optimization design becomes the key factor, which closely related with resistance, in AUV preliminary design stage, uncertainty parameters need to be considered seriously. In this research, Myring axial symmetry revolution body with parameterized expression is assumed as AUV hull lines, and its travelling resistance is obtained via modified DATCOM formula. The problems of AUV hull lines design for the minimum travelling resistance with uncertain parameters are studied. Based on reliability-based optimization design technology, Design For Six Sigma (DFSS) for high quality level is conducted, and is proved more reliability for the actual environment disturbance.

The Feasibility of Using Simulated Targets in the Stomachs of Live Pigs for Full Endoscopic Submucosal Dissection Training

( Horng Yuan Wang ),( Shou Chuan Shih ),( Chien Yuan Hung ),( Chia Yuan Liu ),( Tze Yu Shieh ),( Ming Jen Chen ) 대한소화기학회 2014 Gut and Liver Vol.8 No.6

Background/Aims: In endoscopic submucosal dissection (ESD) training, only a flat target lesion can usually be simulated in the normal mucosa. This study aimed to evaluate the feasibility of simulated targets in the stomachs of live pigs for complete training. Methods: Six trained endoscopists with hands-on experience with ex vivo, isolated pig stomachs were enrolled in this pilot study. An endoscopic banding device was used to create a polyp that was snared, leaving an ulcerated lesion. This simulated target model was used to perform ESD in pigs. The en bloc resection rate, procedure time, complications, quality of resection, and participants` opinions on the simulated targets were compared with the conventional model. Results: En bloc resections were achieved in all six simulated targets and six conventional models. The mean size of the resected specimens was 32.2 mm (range, 20 to 39 mm) in the simulated target group and 23.5 mm (range, 11 to 40 mm) in the conventional group. The target model had a high quality of resection and had a high satisfaction rate for margin identification and correct peripheral marking. Conclusions: Good identification of the lesion and ease of periphery marking in the target model may improve resection quality. (Gut Liver 2014;8:619-624)