Risk Factors, Patterns, and Outcomes of Late Recurrence after Liver Resection for Patients with Hepatocellular Carcinoma (Analysis of a Multicenter Cohort over 15 Years)

( Xin-fei Xu ),( Jiong-jie Yu ),( Ju-dong Li ),( Hao Xing ),( Jun Han ),( Zhen-li Li ),( Han Wu ),( Han Zhang ),( Jian-hong Zhong ),( Yi- Sheng Huang ),( Ya-hao Zhou ),( Ting-hao Chen ),( Hong Wang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Late recurrence (> 2 years) after liver resection of hepatocellular carcinoma (HCC) is usually considered as multi-centric tumors or de novo cancer formation. We aimed to investigate risk factors, patterns and outcomes of late recurrence after HCC resection. Methods: From a multicenter database from 2001 to 2015, 734 patients who were alive and recurrence-free at 2 years after curative resection of initial HCC were enrolled into this retrospective study. Univariate and multivariate Cox-regression analysis were used to identify independent risk factors of late recurrence. Patterns, treatments and outcomes of late recurrence were investigated and analyzed. Results: During a median follow-up of 78.0 months after surgery, 303 patients (41.3%) developed late recurrence. Multivariate analysis revealed that cirrhosis, macroscopic vascular invasion, satellites, and tumor size > 5cm were independent risk factors of late recurrence. Among them, 273 (90.1%) were sole intrahepatic recurrence, 30 (9.9%) were concurrent intrahepatic and extrahepatic recurrence, and none of them was sole extrahepatic recurrence; 165 (54.4%) patients received curative treatments for recurrent HCC, including re-resection, transplantation and local ablation. Multivariate analysis showed regular postoperative surveillance and receiving curative treatments were two independent protective factors of prolonging survival for those patients with late recurrence. Conclusions: Late recurrence is correlated with cirrhosis and certain tumor-related characteristics of initial HCC. The patterns of late recurrence suggest that postoperative surveillance after 2 years of surgery could be adjusted and more targeted. Regular postoperative surveillance improves the probability to receive curative treatments again, yielding to better outcomes for patients with late recurrence.

A Location Context Awareness Personalized Mobile Service Prediction Model and it's Algorithm : Design and Implementation

Minjun Xin,Liyuan Zhou,Han Cao,Zhihua Niu 보안공학연구지원센터 2014 International Journal of Grid and Distributed Comp Vol.7 No.6

With the expansion of mobile Internet, location-based services have become a hot spot in Internet industry. To improve the accuracy and efficiency of the location-based services discovery, researchers in web services recommendation area are still busy looking for method. In this paper, it proposes a LCAMSP model (Location Context Awareness Mobile Service Prediction, LCAMSP) under mobile Internet environment, aims to meet the exact personal requirements of users’ current location and preference. Then, the similar users’ grouping is also a important thread to predict the continuous movement for mobile users. Because each user has own preference, a dynamic calculation function for the weight of each attribute is discussed in this paper. Finally, taking the hotel reservation service as an example, a verification algorithm will be applied to measure the performance of LCAMSP method. With the premise of increasing limited time, the accuracy of LCAMSP algorithm is significantly improved under the mobile service environment.

Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy

Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.

Optimization of Antifungal Lipopeptide Production from Bacillus sp. BH072 by Response Surface Methodology

Xin Zhao,Zhi-jiang Zhou,Ye Han,Xi-qian Tan,Jin Wang 한국미생물학회 2014 The journal of microbiology Vol.52 No.4

Antifungal lipopeptide produced by Bacillus sp. BH072 wasextracted from fermentation liquor and determined as iturinA by liquid chromatography-mass spectrometry (LC-MS). For industrial-scale production, the yield of iturin A wasimproved by optimizing medium components and fermentationconditions. A one-factor test was conducted; fermentationconditions were then optimized by response surfacemethodology (RSM) to obtain the following: temperature,29.5°C; pH 6.45; inoculation quantity, 6.7%; loading volume,100 ml (in 500 ml flasks); and rotary speed, 150 rpm. Underthese conditions, the mass concentration of iturin A was increasedfrom 45.30 mg/ml to 47.87 mg/ml. The followingcomponents of the medium were determined: carbon sources(glucose, fructose, sucrose, xylose, rhamnose, and solublestarch); nitrogen sources (peptone, soybean meal, NH4Cl,urea, and ammonium citrate); and metal ions (Zn2+, Fe3+,Mg2+, Mn2+, Ca2+, and K+). The effects of these componentson iturin A production were observed in LB medium. Weselected sucrose, soybean meal, and Mg2+ for RSM to optimizethe conditions because of several advantages, includingmaximum iturin A production, high antifungal activity,and low cost. The optimum concentrations of these componentswere 0.98% sucrose, 0.94% soybean meal, and 0.93%Mg2+. After iturin A production was optimized by RSM, themass concentration reached 52.21 mg/ml. The antifungal specificactivity was enhanced from 350.11 AU/mg to 513.92AU/mg, which was 46.8% higher than the previous result. The present study provides an important experimental basisfor the industrial-scale production of iturin A and the agriculturalapplications of Bacillus sp. BH072.

Research on the Attenuation of Blast Wave by Groups of Filled Cracks in Surrounding Rock of Cavern

Xin Liu,Hong-fa Xu,Peng-xian Fan,Jian-nan Zhou,Han-sheng Geng,Jia-quan Mo,Tao-lin Zhang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.7

This study introduces an approach for constructing groups of filled cracks in the surroundingrock to achieve anti-blasting and wave elimination protection for underground caverns. Toverify the attenuation effect of the explosion wave by the filled cracks, two models, a no-crackmodel, and a filled-crack model, were constructed using a certain proportion of analoguematerials based on the similarity theory. With the implementation of small equivalentexplosion conditions, the peak pressure of the surrounding rock of the cavern and thevibration acceleration of the cavern wall under different explosion conditions were measured. To accurately judge the attenuation efficiency of the filled cracks, the peak pressure attenuationpercentages between different measuring points were calculated. Furthermore, thecorresponding numerical simulation analysis process was performed according to the testconditions. The results show that not only the peak pressure attenuation percentages, but alsothe value of vibration acceleration, were significantly reduced due to the existence of filledcracks in the model. This indicates that filled cracks in the surrounding rock of the cavern caneffectively attenuate the peak pressure and vibration acceleration caused by the explosionwave, thereby achieving the protection engineering goal of anti-explosion and wave elimination.

The Effects of Resource Investments and Diversification Strategy on Firm Value

Han-Mo Oh(오한모),Young-Mo Kwon(권영모),Zhou Xin(주흠) 한국국제회계학회 2019 국제회계연구 Vol.0 No.83

많은 기업들은 혁신과 마케팅에 대한 자원투자와 다각화와 같은 전략을 통해 경쟁우위를 달성하고 기업 가치를 창출해 왔다. 그러나 기업의 규모는 자원 할당, 위험 감수, 전략 수립 등과 같은 기업 의사결정에 영향을 줄 수 있기 때문에 대기업과는 달리 어떻게 중소벤처기업들이 가치를 창출할 수 있는가를 규명하는 연구가 필요하다. 이러한 관점에서 본 논문에서는 자원우위 경쟁이론에 기반을 두고 중소기업의 환경에서 자원 투자와 다각화 전략이 기업가치 창출에 기여하는지를 설명하는 실증분석이 가능한 모형이 제시되었다. 이 모형은 KONEX에 상장되어 있는 한국의 중소벤처기업 재무회계 자료를 바탕으로 실증적으로 검증되었다. 혁신 집중도과 마케팅 몰입은 각각 연구개발비용과 광고선전비로 측정되었고 기업 다변화는 제품 다변화의 정도로 측정되었다. 분석결과 한국 중소벤처기업들의 혁신 집중도와 마케팅 몰입은 기업가치창출에 긍정적인 영향을 주었다. 그러나 이러한 벤처기업들의 다각화 정도는 기업가치에 유의미한 영향은 나타나지 않았다. 마지막으로 본 논문에서는 한국 중소벤처기업들의 기업 가치 창출을 위한 혁신과 마케팅, 다각화 전략에 대한 학술적이고 실무적인 토론이 제시되었다. Many firms can create value by attaining a competitive advantage through resource-investments in innovation and marketing, and strategy such as diversification. Because firm size can influence resource allocation, risk taking, and firm strategies, it is necessary to investigate how, unlike large enterprises, small-and medium` sized ventures create value. Depending prominently on the resource -advantage theory of competition, we developed an empirically testable model that could explain the effects of resource-investments and diversification strategy on firm value in the context of small- and medium- sized ventures in Korea. The model was tested with financial and accounting data of small- and medium- sized ventures listed in the Korea New Exchange. The results of a multiple regression analysis are mixed. On one hand, these ventures’ resource-investments such as innovation intensity reflected in R&D expense and marketing commitment reflected in advertising expenditure may positively influence firm value. On the other hand, the ventures’ diversification strategy has an insignificant impact on firm value. Finally, this manuscript concluded with a discussion of academic and managerial implications for small- and medium-sized firms’ resource-investments in marketing, innovation, and diversification strategies for creating value.

First report of Bradysia difformis (Diptera: Sciaridae) Damage to Phalaenopsis orchid in China

Qun Xin Han,Dong Mei Cheng,Juan Luo,Cui Zuan Zhou,Qing Sheng Lin,Mei Mei Xiang 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.1

Phalaenopsis orchid is among the most valuable ornamental flowering plants in the world. Since visible damage substantially decreases its amenity, limited damage is allowed in its production. An unknown insect species (Diptera: Sciaridae)was found to cause serious damage to the seedling of the Phalaenopsis orchid in greenhouses in Guangdong, China. The insect occurred in high populations in almost all greenhouses that grow Phalaenopsis orchid and the number of sciarid adults trapped on a yellow sticky card could reach as many as 303 in 24 h. An effectivemanagement strategy on any pest requires an accurate identification. Therefore, it is urgent to identify this pest correctly to mitigate its damage to the industry. Damage to Phalaenopsis orchid and morphological characteristics of the pest was described in this study. Molecular analyses based on the 488-bp portion of the mitochondrialDNA fromthe cytochrome oxidase I(mt COI) regionwere conducted to supplementmorphological characteristics in identifying this pest. Bothmorphological characteristics and phylogenetic tree constructedwith mt COI genes identified this sciarid as Bradysia difformis Frey, 1948 (= Bradysia paupera Tuomikoski, 1960) (Diptera: Sciaridae). A literature search indicated that B. difformis has been a common pest of greenhouse and forestry nurseries in Europe and South Africa. Our study is the first record of B. difformis damaging Phalaenopsis orchid in China.

Prevalence and Risk Factors of Cerebral Small Vessel Disease in a Chinese Population-Based Sample

Fei Han,Fei-Fei Zhai,Quan Wang,Li-Xin Zhou,Jun Ni,Ming Yao,Ming-Li Li,Shu-Yang Zhang,Li-Ying Cui,Zheng-Yu Jin,Yi-Cheng Zhu 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.2

Background and Purpose Epidemiological data of cerebral small vessel disease (CSVD) in the general population of China are lacking. We report on the prevalence of lacunes, white matter hyperintensity (WMH), and cerebral microbleeds (CMBs) in a community-based sample in China and compare the results with those of other studies. Methods This was a cross-sectional analysis of the population-based Shunyi Study in China. A total of 1,211 stroke-free participants (mean age, 55.6±9.3 years; 37.4% men) with available 3 Tesla (3T) magnetic resonance images were included in this analysis. Demographic information and risk factor data were assessed. The overall and age-specific prevalence of lacunes, WMH, and CMBs was evaluated. Associations between cardiovascular risk factors and the presence of these lesions were analyzed by multiple logistic regression. Results Our study showed a prevalence of 14.5% for lacunes, 72.1% for periventricular hyperintensity (PVH), 65.4% for deep white matter hyperintensity (DWMH), and 10.6% for CMBs. When compared with other community-based samples, individuals in the same age group showed a higher burden of lacunes and a relatively lower prevalence of CMBs. Advanced age was independently associated with the prevalence of these CSVD markers, while the presence of hypertension increased the risk of lacunes, PVH/DWMH, and CMBs in deep or infratentorial locations. Conclusions A higher burden of lacunes but a relatively lower prevalence of CMBs was observed in this Chinese population. This notable result highlights the challenge of CSVD prevention in China. Chinese have a risk factor profile for CSVD similar to those in other populations.

Recent Changes in Heavy Precipitation Events in Northern Central China and Associated Atmospheric Circulation

Tingting Han,Xinyi Guo,Botao Zhou,Xin Hao 한국기상학회 2021 Asia-Pacific Journal of Atmospheric Sciences Vol.57 No.2

Northern Central China (NC China) is a seriously arid region. Precipitation variations are vital for environmental protection and socio-economical development. This study investigates the recent changes in summer heavy precipitation (HP) events over NC China and associated atmospheric circulation anomalies. Compared with the period of 1986–2002, the HP amount and frequency both significantly increase during 2003–2016, contributing to the shift to increase in total summer precipitation amount. After the early 2000s, the Northwest Pacific subtropical high becomes intensified and shifts westward and northward, leading to significant moisture convergence anomalies over NC China and divergence anomalies over Northwest Pacific. Therefore, the net moisture budget dramatically increases since the early 2000s. Further results show that the strengthened net moisture influx across the southern boundary contributes dominantly to the increased net moisture budget, especially at the lower level. Despite a relatively small magnitude, the intensified westerly current across western boundary makes a dominant contribution at middle and upper layers. Additionally, the strengthened westerly and easterly anomalies occupy northern and southern China, respectively, along with the eastward expansion of westerly jet stream region. Thus, the lower-level convergence and upper-level divergence both intensify, and further trigger enhanced ascending movement. These conditions jointly contribute to the inter-decadal change in HP events over NC China after the early 2000s.

Urchin-like alkaline nickel–cobalt carbonate derived Ni3S4/Co3S4 nanoparticles anchored on rGO for lithium/sodium-ion batteries with enhanced capacity

Bo-Han Zhang,Yu-Qian Wang,Fen Gao,Hua-Ying Wang,Wan-Xin Wen,Yun-Lei Hou,Jing-Zhou Chen,Dong-Lin Zhao 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

Transition metal sulfides (TMS) have emerged as promising anode materials for lithium and sodium ionbatteries due to their high theoretical capacity and low cost. However, the severe volume expansion duringthe conversion reaction causes rapid collapse inevitability when used as anode material. Herein, wepertinently fabricated nanoscale Ni3S4/Co3S4 with uniform particle size homogeneously dispersedbetween pleated graphene (Ni3S4/Co3S4@rGO) through facile hydrothermal assisted by cationic surfactants. The construction of 3D nanocomposites significantly shortens ion migration distances and enricheselectronic pathways, accelerating charge transfer kinetics while maintaining good stability. Uniformlydistributed bimetallic sulfides and rGO limit each other’s aggregation, allowing the excellent structuralproperties of the material to be maintained over time. Thus, the Ni3S4-Co3S4@rGO electrodes deliver ahigh reversible capacity of 972.5 mAh/g upon 200 cycles at 100 mA g1 in Lithium-ion battery and487.5 mAh/g upon 150 cycles at 100 mA g1 in Sodium-ion battery, as well as excellent rate capacityin both. These excellent properties show the potential for expansion of this simple synthetic methodin the field of alkali metal batteries.