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기업가적 지향성이 연구개발능력을 통하여 기술사업화 성과에 미치는 영향 연구
한규형(Gyu-Heung Han),서영욱(Young-Wook Seo) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.12
기술기반 기업의 기술사업화성과에 영향을 미치는 요인에 대하여 선행연구에서는 기업가적 지향성, 연구개발능력, 기술사업화능력 등의 변수가 다루어져 왔으나 이들 변수들이 통합된 연구는 거의 없었다. 이에 본 연구는 기술기반 중소기업의 기업가적 지향성이 학습기능, 연구개발기능, 외부네트워크기능으로 구성된 연구개발능력을 통하여 기술사업화성과에 미치는 영향을 분석하고자 한다. 설문은 리서치전문회사에 의뢰하여 조사 하였고 SPSS 26.0, Smart PLS 3.0 툴로 분석하였다. 기업가적 지향성은 연구개발능력의 학습기능, 연구개발기능, 외부네트워크기능에 긍정적인 영향을 미치는 것으로 나타났다. 또한 학습기능, 연구개발 기능은 기술사업화능력을 통하여 기술사업화 성과에 긍정적인 것으로 나타났다. 연구개발능력은 기술사업화능력 간의 관계에서 상당한 영향을 미쳐 중소기업 사업 확장에 중요한 역할을 한다는 것을 알 수 있다. 기업가적 지향성이 연구개발능력을 통하여 기술사업화능력을 향상 시키고 기술사업화성과라는 과제에 잘 부합된다고 할 수 있다. 기술사업화능력을 통하여 기술사업화성과에 긍정적으로 영향을 미치는 것으로 나타났다. 본 연구결과를 바탕으로 기술사업화 성과를 위해 기업이 갖추어야 할 요인에 대하여 시사점을 제시하였다. This study intends to analyze the effect of entrepreneurial orientation of technology-based SMEs on the technology commercialization performance through R&D capability. The R&D capability considered is composed of the learning function, R&D function, and external network function. The survey conducted as part of the study was commissioned by a research company and analyzed using SPSS 26.0 and Smart PLS 3.0 tools. The analysis results suggest that entrepreneurial orientation was found to positively affect the learning function, R&D function, and external network function of R&D capability. In addition, the learning function and R&D function were found to be positive for the technology commercialization performance through the technology commercialization ability. It can be seen that R&D capability has a significant effect on the relationship between technology commercialization capabilities and plays an important role in the business expansion of SMEs. It was also found that the technology commercialization ability has a positive effect on the technology commercialization performance. Based on the results of this study, implications were presented on the factors that companies should have for technology commercialization performance.
Han-Yong Kim,Myoung-Seok Lee,Byoung-Man Kang,Dong-Jun Chang,Woo-Jung Choi,Kyu-Nam An,Oh-Do Kwon,Heung-Gyu Park,Hae-Ryoung Shin 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04
Climate warming has the potential to deteriorate grain yield and quality of rice (Oryza sativa L.), offsetting the stimulative effects of elevating CO2. To know how the change in sink-source balances by reducing sink-size (RSS) may affect grain yield and quality of rice grown under various climate change scenarios, we conducted a temperature gradient chamber experiment with/without CO2 fumigation systems which were established in paddy field. Rice crops (cv. Ilmybyeo) were exposed to either ambient (396ppmV) or elevated CO2 of 673ppmV in three levels of air temperature [(Ta), local ambient Ta (24.8℃), 1.3℃ and 2.4℃ above ambient Ta] over whole seasons. Thus, the experiment was a 2×3 factorial design with three replicate plots of each CO2×Ta combination. At flowering, for two hills from each combination treatment total thirty (10 per each top, middle and basal parts of panicle) spikelets per panicle were removed with order of panicle appearance by scissors. This corresponded to a 25% reduction of total sink-size per hill. In ambient Ta and CO2 , grain yield decreased with RSS by 23.4%, approximately mirroring the reduced sink-size. With rising Ta, however, the yield reduction by RSS was significantly mitigated (-5.6% in 1.3℃ above ambient Ta), and the yield rather increased with RSS by 9.3% in 2.4℃ above ambient Ta. This was due primarily to the increased single grain mass with RSS. A similar response fashion of grain mass and yield with RSS to Ta was found in elevated CO2, but not CO2×Ta interaction. For brown rice, the fraction of normal rice was linearly reduced with rising Ta, ranging from 78.5~79.2% in local ambient Ta to 48.2~55.5% in 2.4℃ above ambient Ta over CO2 treatments. However, this deteriorative effect of rising Ta was significantly alleviated with RSS; the fractions of normal rice were a 81.9~84.1%, 75.9~77.2% and 64.0~66.3% in local ambient Ta, 1.3℃ and 2.4℃ above ambient Ta, respectively. The alleviative effect of RSS on rice quality was due mainly to the reduced immature rice, and was more conspicuous as Ta rises. These results suggest that current rice cultivars in Korea, at least cultivars tested in this experiment, will likely to be prone to source-limitation in the future projected warming with elevating CO2, and thereby will be needed a cultivar having either a greater source ability or a less sink size compared with current cultivars, in order to ensure a rice quality in the future warming conditions.
Effect of A Sinusoidal Field in a Switching Magnet for a Proton Beam Accelerator
Heung-Sik Kang,Chun-Kil Ryu,이희석,Hong-Gi Lee,Hong-Sik Han,Hyung-Seok Suh,Jinhyuk Choi,Ki-Hyeon Park,MunGyung Kim,Seong-Hun Jeong,Tae-Yeon Lee,Young-Gyu Jung 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.4
The 100-MeV Proton Engineering Frontier Project (PEFP) proton linac will provide two proton beam extraction lines at the 20-MeV and the 100-MeV end for users’ experiments. Each extraction line will be branched to 5 beamlines. To distribute the proton beam to each beamline, a switching magnet will be used. A conventional resonant AC-type power supply for the switching magnet, which supplies a current with a sinusoidal variation, causes some problems of sinusoidal field variation during the beam pulse duration and of magnet hysteresis. The effect of sinusoidal field variation is analyzed with the TRACE code by using the equivalent Twiss parameters. The effect of the magnet hysteresis is also described, and its solution is proposed.8消
Han-Yong Kim,Myoung-Seok Lee,Byoung-Man Kang,Dong-Jun Chang,Woo-Jung Choi,Kyu-Nam An,Oh-Do Kwon,Heung-Gyu Park,Hae-Ryoung Shin 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04
To know how interacting climate drivers may affect rice quality, we investigated physio-chemical properties of brown and milled rice. Rice crops (Oryza sativa L., cv. Ilmybyeo and Pyounganbyeo) were grown under either ambient [370ppmV (2008)/396ppmV (2009)] or elevated CO2 of 650ppmV (2008)/673ppmV (2009) in three levels of air temperature [(Ta), local ambient Ta [25.9℃ (2008)/24.8℃ (2009)], 1.3℃ and 2.4℃ above ambient Ta] over whole seasons, using six temperature gradient chambers established in paddy fields. Over 2 years, thus the experiments were a 2×3 factorial design with three replicate plots of each CO2×Ta combination. The fractions of normal brown rice were reduced with elevating CO2 by 8% (Ilmybyeo)~14% (Pyounganbyeo), and with rising Ta by 16% (+1.3 ℃)~27% (+2.4℃) in Ilmybyeo and by 27% (+1.3℃)~42% (+2.4℃) in Pyounganbyeo (p=0.015, 0.000, 0.059, 0.000 and 0.017 for CO2, Ta, CO2×Ta, cultivar and Ta×cultivar, respectively). With respect to immature rice, elevating CO2 increased milky-white rice, white-based rice and white-belly rice across cultivars. Warming also significantly increased all immature rice across cultivars, though no CO2×Ta interaction was observed. Over 2 years, the deteriorative effect of warming on brown rice quality was significantly greater in Pyounganbyeo than in Ilmybyeo. Across cultivars, protein contents of milled rice were decreased (c. 5~9%) with elevating CO2 but increased (c. 5%) with warming, though no CO2×Ta interaction was found (p=0.119). Elevating CO2 significantly increased whiteness of milled rice over cultivars but not amylose contents and gloss value of cooked rice, while warming had a strong affect these properties all related rice quality. Overall, our results suggest that warming and elevating CO2, in each alone or in combination, may have the potential to deteriorate physio-chemical properties of rice related to quality.
사구체 신염 환자들에게 말초혈액 단핵세포의 Cytokine들의 유전자 발현에 대한 ACE Inhibitor의 영향
김홍수,김상돈,이한민,김승정,마경애,신규태,지석배,김도헌 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.1
Angiotensin II(ANG II) has been known to induce systemic and glomerular hypertension, which leads to renal tissue injury and progressive fibrosis of kidney. Some effects of ANG II may be mediated by its effect on the cytokine synthesis. In the present study, we investigated the effect of ANG II inhibition on the expression of various cytokines implicated in the pathogenesis and progression of the kidney disease. Blood samples of 11 patients with glomerulonephritis were obtained before the ACE inhibitor therapy and then while they were taking ACE inhibitors. Using peripheral blood mononuclear cells(PBMC) harvested from the samples, RT-PCR was performed to evaluate the changes in mRNA expression of TGF-β1, IL-6, TNF-α and IL-10. The ratios of target cytokines and β-actin were calculated. TGF-β1 mRNA expression was decreased in five pat ients after ANG II inhibition with ACE inhibitors, while it was increased in the remaining six patients. ACE inhibitors consistently decreased IL-6 mRNA expression in all 11 patients. IL-10 expression was decreased in 4 patients, and increased in 3 patients after ANG II inhibition. It was not expressed in 4 patients. TNF-α expression was increased in 8 patients, and decreased in only 1 patient. In two patients, it was not changed while on ACE inhibitors. Conclusion:ACE inhibitors attenuate IL-6 expression consistently in all 11 patients. This is the first-time demonstration of the in vivo inhibitory effect of ACE inhibitors on IL-6 mRNA expression in humans. The lack of significant suppression of TGF-β1 in PBMC suggests that the in vivo attenuating effect of ACE inhibitors on TGF-β1 may be derived from renal hemodynamic changes. The tendency of heightened expression of TNF-α confirms the previous investigations in which IL-6 was shown to down regulate TNF-αexpression.
( Seung Gyu Lee ),( Kang Wook Lee ),( Tae Heung Park ),( Ji Yeong Park ),( Nam Soo Han ),( Jeong Hwan Kim ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.4
LAB were isolated from makgeolli locally produced around Jinju, Gyeongnam, S. Korea during spring of 2011. Randomly selected 11 isolates from MRS agar plates were identified first by API CHL 50 kits and then 16S rRNA gene sequencing. All 11 isolates were identified as Lactobacillus plantarum. Among them, ST4 grew in MRS broth with ethanol up to 10%, showing the highest alcohol resistance. L. plantarum ST4 was moderately resistant against acid and bile salts. When cellular proteins of L. plantarum ST4 under ethanol stress were analyzed by two-dimensional gel electrophoresis (2DE), the intensities of 6 spots increased, whereas 22 spots decreased at least 2-fold. Those 28 spots were identified by peptide mass fingerprinting (PMF). FusA2 (elongation factor G) increased 18.8-fold (6% ethanol) compared with control. Other proteins were AtpD (ATP synthase subunit beta), DnaK, GroEL, Tuf (elongation factor Tu), and Npr2 (NADH peroxidase), respectively. Among the 22 proteins decreased in intensities, lactate dehydrogenases (LdhD and LdhL1) were included.